Neural basis of syntactic information processing

• Project/Area Number: 24220009
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: Kyoto University
• Principal Investigator: Watanabe Dai 京都大学, 医学研究科, 教授 (90303817)
• Co-Investigator(Renkei-kenkyūsha): Abe Kentaro 京都大学, 医学研究科, 講師 (70462653) ; Hamaguchi Kosuke 京都大学, 医学研究科, 講師 (50415270) ; Matsui Ryosuke 京都大学, 医学研究科, 助教 (80633940) ; Hasegawa Taku 京都大学, 医学研究科, 特定助教 (90713256)
• Project Period (FY): 2012-05-31 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥218,140,000 (Direct Cost: ¥167,800,000、Indirect Cost: ¥50,340,000); Fiscal Year 2016: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000); Fiscal Year 2015: ¥30,160,000 (Direct Cost: ¥23,200,000、Indirect Cost: ¥6,960,000); Fiscal Year 2014: ¥34,450,000 (Direct Cost: ¥26,500,000、Indirect Cost: ¥7,950,000); Fiscal Year 2013: ¥36,010,000 (Direct Cost: ¥27,700,000、Indirect Cost: ¥8,310,000); Fiscal Year 2012: ¥89,830,000 (Direct Cost: ¥69,100,000、Indirect Cost: ¥20,730,000)
• Keywords: ソングバード / 音声学習 / 基底核 / 文法情報 / 文法 / 音声制御 / 神経回路 / 文法規則 / 模倣学習 / 社会学習 / ウイルスベクター

Outline of Final Research Achievements

Songbirds communicate using vocal signals termed "songs" which are postnatally acquired by imitating conspecific adult vocalization like human languages, in addition to "calls" which are generally innate. To explore the development of the vocal system, which enables precise temporal control of vocal signals, we studied using transgenic songbirds. As a result, we found that genetic manipulation of activity of cAMP response element-binding protein (CREB) does not affect call development, while suppression of CREB activity significantly impairs song development. This indicates that neural-activity dependent gene regulation through CREB activity is essential for the establishment of vocalization which is acquired through imitative learning process.

Assessment Rating

Verification Result (Rating)

A-

Research Products

• [Journal Article] Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys. (2017)
  • Author(s): Tohyama, T., Kinoshita, M., Kobayashi, K., Isa, K., Watanabe, D., Kobayashi, K., Liu, M., and Isa, T.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 114 Issue: 3 Pages: 604-609
  • DOI: 10.1073/pnas.1610787114
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] mDia and ROCK mediate actin-dependent presynaptic remodeling regulating synaptic efficacy and anxiety. (2016)
  • Author(s): Deguchi Y, Harada M, Shinohara R, Lazarus M, Cherasse Y, Urade Y, Yamada D, Sekiguchi M, Watanabe D, Furuyashiki T, Narumiya S.
  • Journal Title: Cell Reports Volume: 17 Issue: 9 Pages: 2405-2417
  • DOI: 10.1016/j.celrep.2016.10.088
  • NAID: 120005868496
  • Peer Reviewed / Open Access
• [Journal Article] Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons (2016)
  • Author(s): Imamura, K., Sahara, N., Kanaan, N. M., Tsukita, K., Kondo, T., Kutoku, Y., Ohsawa, Y., Sunada, Y., Kawakami, K., Hotta, A., Yawata, S., Watanabe, D., Hasegawa, M., Trojanowski, J. Q., Lee, V. M.-Y., Suhara, T., Higuchi, M., and Inoue, H.
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 34904-34904
  • DOI: 10.1038/srep34904
  • NAID: 120005850272
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transgenic songbirds with suppressed or enhanced activity of CREB transcription factor (2015)
  • Author(s): Abe, K., Matsui, S., and Watanabe, D.
  • Journal Title: Proc. Natl. Acad. Sci. U.S.A. Volume: 112 Issue: 24 Pages: 7599-7604
  • DOI: 10.1073/pnas.1413484112
  • NAID: 120005672630
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Critical role of the neural pathway from the intermediate medial mesopallium to the intermediate hyperpallium apicale in filial imprinting of domestic chicks (Gallus gallus domesticus) (2015)
  • Author(s): Aoki N, Yamaguchi S, Kitajima T, Takehara A, Katagiri-Nakagawa S, Matsui R, Watanabe D, Matsushima T, Homma KJ.
  • Journal Title: Neuroscience. Volume: 308 Pages: 115
  • DOI: 10.1016/j.neuroscience.2015.09.014
  • URL: https://localhost/en/publications/e6bb06e5-60c6-4bea-baa1-c9e8ba90f66e
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A wireless neural recording system with a precision motorized microdrive for freely behaving animals (2015)
  • Author(s): Hasegawa, T., Fujimoto, H., Tashiro, K., Nonomura, M., Tsuchiya, A., and Watanabe, D.
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 7853-7853
  • DOI: 10.1038/srep07853
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Simultaneous visualization of extrinsic and intrinsic axon collaterals in Golgi-like detail for mouse corticothalamic and corticocortical cells: a double viral infection method (2014)
  • Author(s): Watakabe, A., Takaji, M., Kato, S., Kobayashi, K., Mizukami, H., Ozawa, K., Ohsawa, S., Matsui, R., Watanabe, D., and Yamamori, T.
  • Journal Title: Frontiers in neural circuits Volume: 8 Pages: 110-110
  • DOI: 10.3389/fncir.2014.00110
  • Peer Reviewed / Open Access
• [Journal Article] Viral vector-mediated selective and reversible blockade of the pathway for visual orienting in mice. (2013)
  • Author(s): Sooksawate T, Isa K, Matsui R, Kato S, Kinoshita M, Kobayashi K, Watanabe D, Kobayashi K, Isa T.
  • Journal Title: Frontiers in Neural Circuits Volume: 7 Pages: 162-162
  • DOI: 10.3389/fncir.2013.00162
  • Peer Reviewed
• [Journal Article] A drug screening platform for Alzheimer's disease with intracellular Aβ oligomers using patient-specific iPSCs (2013)
  • Author(s): Kondo, T., (他24名), Murakami, K., Irie, K., Klein, W. L., Mori, H., Asada, T., Takahashi, R., Iwata, N., Yamanaka, S., Inoue, H
  • Journal Title: Cell Stem Cell Volume: 12 Issue: 4 Pages: 487-496
  • DOI: 10.1016/j.stem.2013.01.009
  • Peer Reviewed / Open Access
• [Journal Article] Avian adeno-associated virus vector efficiently transduces neurons in the embryonic and post-embryonic chicken brain. (2012)
  • Author(s): Matsui, R.（第一著者）, Tanabe, Y., and Watanabe, D.
  • Journal Title: PLoS ONE Volume: 7 Issue: 11 Pages: 1-13
  • DOI: 10.1371/journal.pone.0048730
  • NAID: 120005025024
  • Peer Reviewed
• [Journal Article] Genetic dissection of the circuit for hand dexterity in primates (2012)
  • Author(s): Masaharu Kinoshita, Ryosuke Matsui, Shigeki Kato, Taku Hasegawa, Hironori Kasahara, Kaoru Isa, Akiya Watakabe, Tetsuo Yamamori, Yukio Nishimura, Bror Alstermark, Dai Watanabe, Kazuto Kobayashi & Tadashi Isa
  • Journal Title: Nature Volume: 487 Issue: 7406 Pages: 235-238
  • DOI: 10.1038/nature11206
  • Peer Reviewed
• [Journal Article] Drug screening for ALS using patient-specific induced pluripotent stem cells (2012)
  • Author(s): Egawa, N., Kitaoka, S., Tsukita, K., Naitoh, M., Takahashi, K., Yamamoto, T., Adachi, F., Kondo, T., Okita, K., Asaka, I., Aoi, T., Watanabe, A., Yamada, Y., Morizane, A., Takahashi, J., Ayaki, T., Ito, H., Yoshikawa, K., Yamawaki, S., Suzuki, S., Watanabe, D., Hioki, H., Kaneko, T., Makioka, K., Okamoto, K., Takuma, H., Tamaoka, A., Hasegawa, K., Nonaka, T., Hasegawa, M., Kawata, A., Yoshida, M., Nakahata, T., Takahashi, R., Marchetto, M. C. N., Gage, F. H., Yamanaka, S., and Inoue, H
  • Journal Title: Sci. Transl. Med. Volume: 4 Issue: 145 Pages: 1-8
  • DOI: 10.1126/scitranslmed.3004052
  • Peer Reviewed
• [Presentation] CREB-mediated interplay of genes and environment in the postnatal song learning in songbirds (2016)
  • Author(s): Kentaro Abe, and Dai Watanabe
  • Organizer: Neuroscience 2016 (Society for Neuroscience)
  • Place of Presentation: San Diego Convention Center
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys (2016)
  • Author(s): Takamichi Tohyama, Masaharu Kinoshita, Kenta Kobayashi, Kaoru Isa, Dai Watanabe, Kazuto Kobayashi, Meigen Liu, and Tadashi Isa
  • Organizer: Neuroscience 2016 (Society for Neuroscience)
  • Place of Presentation: San Diego Convention Center
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] The Science of Birdsong (2016)
  • Author(s): Dai Watanabe
  • Organizer: Chanel：科学と音楽の出会い
  • Place of Presentation: 京都大学清風荘
  • Year and Date: 2016-09-24
  • Invited
• [Presentation] Genetic and neural circuit basis of learned vocalization (2016)
  • Author(s): 渡邉 大
  • Organizer: 新学術領域「適応回路シフト」国際シンポジウム
  • Place of Presentation: 同志社大学 室町キャンパス 寒梅館
  • Year and Date: 2016-03-03
  • Int'l Joint Research
• [Presentation] 高次脳機能を担う神経回路機構の理解に向けて (2016)
  • Author(s): 渡邉 大
  • Organizer: 平成28年度 京都大学脳神経外科教室同門会 Neuroscience Frontier
  • Place of Presentation: リーガロイヤルホテル大阪
  • Year and Date: 2016-02-13
  • Invited
• [Presentation] 音声スキル獲得・制御の神経回路機構 (2015)
  • Author(s): 渡邉 大
  • Organizer: 生理研研究会「大脳皮質の機能原理を探る」
  • Place of Presentation: 岡崎カンファレンスセンター
  • Year and Date: 2015-12-03
• [Presentation] 音声スキルの獲得と制御の神経機構 (2015)
  • Author(s): 渡邉 大
  • Organizer: ライフサイエンスイノベーション推進機構セミナー
  • Place of Presentation: 福井
  • Year and Date: 2015-02-20
  • Invited
• [Presentation] Neural Basis of Social Learning and Vocal Communication (2015)
  • Author(s): 渡邉 大
  • Organizer: 第１回Neuroscience Network in Kobe シンポジウム「分子から疾患へー基礎と臨床を繋ぐ神経科学研究」
  • Place of Presentation: 神戸
  • Year and Date: 2015-02-06
  • Invited
• [Presentation] モデル生物による音声スキル獲得の神経機構へのアプローチ (2014)
  • Author(s): 渡邉 大
  • Organizer: 第５回札幌神経科学研究会
  • Place of Presentation: 札幌
  • Year and Date: 2014-07-16 – 2014-07-17
  • Invited
• [Presentation] Neural basis of social learning and its disorders (2014)
  • Author(s): Dai Watanabe
  • Organizer: Bristol-Kyoto Symposium
  • Place of Presentation: 京都大学
• [Presentation] サルの皮質脊髄路損傷後の手指巧緻性回復における脊髄固有ニューロンの寄与の検証 (2013)
  • Author(s): 當山峰道 ,木下正治,松井亮介, 加藤成樹, 長谷川拓, 笠原洋紀, 伊佐かおる, 渡邉 大, 小林和人, 里宇明元, 伊佐 正
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 国立京都国際会館
• [Presentation] ウイルスベクター2重感染法を用いた経路選択的遮断法のマウス指向運動制御系を指標とする考察 (2013)
  • Author(s): 伊佐かおる, 松井亮介, 加藤成樹, 木下正治, 小林憲太, 渡邉 大, 小林和人, 伊佐 正
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 国立京都国際会館
• [Presentation] モーター駆動マイクロドライブによる神経活動の無線記録システム (2013)
  • Author(s): 長谷川拓, 田代紘一郎, 野々村万有, 藤本久貴, 土谷 亮, 渡邉 大
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 国立京都国際会館
• [Presentation] 遺伝子改変鳴禽類のさえずり発達 (2013)
  • Author(s): 安部健太郎, 渡邉 大
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 国立京都国際会館
• [Presentation] 音声コミュニケーション獲得・制御の神経および分子基盤 (2013)
  • Author(s): 渡邉 大
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Transgenic zebra finches reveal the role of genetic factors in the postnatal song learning (2013)
  • Author(s): K. Abe, D. Watanabe
  • Organizer: Society for Neuroscience Annual Meeting 2013
  • Place of Presentation: San Diego
• [Presentation] Verified contribution of propriospinal neurons to recovery of hand dexterity after a corticospinal tract lesion in the monkey (2013)
  • Author(s): T. Tohyama, M. Kinoshita, R. Matsui, S. Kato, K. Isa, D. Watanabe, K. Kobayashi, M. Liu, T. Isa
  • Organizer: Society for Neuroscience Annual Meeting 2013
  • Place of Presentation: San Diego
• [Presentation] Neural and Molecular Basis of Learned Vocal Communication (2013)
  • Author(s): Dai Watanabe
  • Organizer: The ETH-EPFL-UZH-Kyoto Joint Symposium
  • Place of Presentation: ETH Zurich and the University of Zurich
• [Presentation] 社会学習による音声スキル獲得・制御の神経基盤 (2013)
  • Author(s): 渡邉 大
  • Organizer: 記憶回路研究会
  • Place of Presentation: 岡崎 生理学研究所
• [Presentation] Perception and control of syntactic vocal signals (2012)
  • Author(s): Dai Watanabe
  • Organizer: The 4th Biennial Symposium on Brain and Mind in the Asia and Pacific (BMAP2012)
  • Place of Presentation: 慶応義塾大学、東京
  • Invited
• [Presentation] Neural basis of syntactic computation in learned vocal communication (2012)
  • Author(s): Dai Watanabe
  • Organizer: Cold Spring Harbor Asia Conferences
  • Place of Presentation: Suzhou Dushu Lake Conference Center、中国
  • Invited
• [Presentation] Neural coding of syntactic vocal signals (2012)
  • Author(s): Dai Watanabe
  • Organizer: 第７回International Chick Meeting
  • Place of Presentation: 名古屋大学、名古屋
  • Invited
• [Presentation] Perception and control of syntax in avian vocal signals
  • Author(s): Dai Watanabe
  • Organizer: シンポジウム“Sensory systems & neural circuits“
  • Place of Presentation: 東京大学 伊藤国際学術センター、東京
  • Invited
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  • URL: http://www.phy.med.kyoto-u.ac.jp/publications.html