| Budget Amount *help |
¥198,640,000 (Direct Cost: ¥152,800,000、Indirect Cost: ¥45,840,000)
Fiscal Year 2016: ¥30,940,000 (Direct Cost: ¥23,800,000、Indirect Cost: ¥7,140,000)
Fiscal Year 2015: ¥36,660,000 (Direct Cost: ¥28,200,000、Indirect Cost: ¥8,460,000)
Fiscal Year 2014: ¥37,570,000 (Direct Cost: ¥28,900,000、Indirect Cost: ¥8,670,000)
Fiscal Year 2013: ¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2012: ¥48,360,000 (Direct Cost: ¥37,200,000、Indirect Cost: ¥11,160,000)
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| Outline of Final Research Achievements |
In research project, we applied our GaInAsP semiconductor photonic crystal nanolasers to sensing biomarkers for medical use. First, we found that an ultrahigh sensitivity of this nanolaser is not arising from the refractive index effect due to light localization but from electrical charge of biomolecules. Secondly we optimized the chemical protection and formation of silane coupling agent in vacuum by employing atomic layer deposition and stabilized the sensing characteristics. Thirdly we established large-scale array technology of nanolaser and developed the automatic measurement system, which enabled the statistical analysis of detection signals. Consequently, we achieved the sensing of streptoavidin (a test protein), prostate-specific antigen (a biomarker for prostatic cancer), and collapsin response mediator protein (a candidate biomarker for Alzheimer disease) from more than two orders lower concentrations than those detectable by conventional technology.
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