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Development of bone-inducing artificial bone

Research Project

Project/Area Number 24240069
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionThe University of Tokyo

Principal Investigator

Chung Ung-il  東京大学, 工学(系)研究科(研究院), 教授 (30345053)

Co-Investigator(Kenkyū-buntansha) OHBA Shinsuke  東京大学, 大学院工学系研究科, 准教授 (20466733)
SAKAI Takamasa  東京大学, 大学院工学系研究科, 准教授 (70456151)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥46,280,000 (Direct Cost: ¥35,600,000、Indirect Cost: ¥10,680,000)
Fiscal Year 2015: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2014: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2013: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2012: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Keywords生体材料 / トランスレーショナルリサーチ / 人工骨 / 再生 / 骨 / バイオマテリアル / シグナル分子 / 低分子化合物
Outline of Final Research Achievements

In order to treat bone defect and deformity, we need to use artificial bone. We attempted to enhance its performance by clarifying signaling network for bone formation and integrating it with artificial bone. As a result, we succeeded in differentiating pluripotent stem cell into osteoblastic cells in vitro using 4 small-molecule compounds without using serum, protein or gene. By loading these compounds onto artificial bone and controlling their release, we also succeeded in treating bone defect model in animals within a short period.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (29 results)

All 2016 2015 2014 2013 2012 Other

All Int'l Joint Research (1 results) Journal Article (18 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 18 results,  Open Access: 10 results,  Acknowledgement Compliant: 10 results) Presentation (5 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] 南カリフォルニア大学(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Reliable hydrogel with mechanical ‘fuse link’ in an aqueous environment2015

    • Author(s)
      Kondo S, Hiroi T, Han Y, Kim M, Shibayama M, Chung U, Sakai T
    • Journal Title

      Adv Mater

      Volume: 27 Issue: 45 Pages: 7407-7411

    • DOI

      10.1002/adma.201503130

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Design of Hydrogels for Biomedical Applications2015

    • Author(s)
      Kamata H, Li X, Chung U, Sakai T
    • Journal Title

      Adv Healthcare Mater

      Volume: 4 Issue: 16 Pages: 2360-2374

    • DOI

      10.1002/adhm.201500076

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Signaling pathways regulating the specification and differentiation of the osteoblast lineage2015

    • Author(s)
      Hojo H, Ohba S, Chung U
    • Journal Title

      Regenerative Therapy

      Volume: 1 Pages: 57-62

    • DOI

      10.1016/j.reth.2014.10.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Histochemical and Radiological Study of Bone Regeneration by the Combinatorial Use of Tetrapod-Shaped Artificial Bone and Collagen2015

    • Author(s)
      Uryu T, Matsumoto N, Namaki S, Mashimo T, Tamagawa T, Yasumitsu T, Okudera M, Komiyama K, Chung U, Honda K, Arai Y, Yonehara Y
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 24 Issue: 2 Pages: 199-210

    • DOI

      10.2485/jhtb.24.199

    • NAID

      130005065059

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Augmentation of Flat Bone Area Using Tetrapod-Shaped Artificial Bone in Rats2015

    • Author(s)
      Iwata J, Namaki S, Mashimo T, Honda K, Chung U, Yonehara Y
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 24 Issue: 1 Pages: 69-76

    • DOI

      10.2485/jhtb.24.69

    • NAID

      130004848445

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice.2014

    • Author(s)
      Kitaura Y, Hojo H, Komiyama Y, Takato T, Chung UI, Ohba S
    • Journal Title

      PLoS ONE

      Volume: 9(10) Issue: 10 Pages: e109597-e109597

    • DOI

      10.1371/journal.pone.0109597

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Molecular and structural patterns of bone regeneration in surgically created defects containing bone substitutes.2014

    • Author(s)
      Elgali I, Igawa K, Palmquist A, Lennerås M, Xia W, Choi S, Chung U, Omar O, Thomsen P
    • Journal Title

      Biomaterials

      Volume: 35 Issue: 10 Pages: 3229-3242

    • DOI

      10.1016/j.biomaterials.2013.12.084

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free conditions.2014

    • Author(s)
      Kanke K, Masaki H, Saito T, Komiyama Y, Hojo H, Nakauchi H, Lichtler AC, Takato T, Chung UI, Ohba S
    • Journal Title

      Stem Cell Reports.

      Volume: 6 Issue: 6 Pages: 751-760

    • DOI

      10.1016/j.stemcr.2014.04.016

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comparison of the long-term effects on rabbit bone defects between Tetrabone and β-tricalcium phosphate granules implantation.2014

    • Author(s)
      Choi S, Liu IL, Yamamoto K, Honnami M, Ohba S, Echigo R, Sakai T, Igawa K, Suzuki S, Nishimura R, Chung UI, Sasaki N, Mochizuki M
    • Journal Title

      J Artif Organs

      Volume: 14 Issue: 4 Pages: 344-351

    • DOI

      10.1007/s10047-014-0778-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Implantation of tetrapod-shaped granular artificial bones or β-tricalcium phosphate granules in a canine large bone-defect model.2014

    • Author(s)
      Choi S, Liu IL, Yamamoto K, Honnami M, Sakai T, Ohba S, Echigo R, Suzuki S, Nishimura R, Chung UI, Sasaki N, Mochizuki M.
    • Journal Title

      J Vet Med Sci

      Volume: 76 Pages: 229-235

    • NAID

      130003382365

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hedgehog-Gli activators direct osteo-chondrogenic function of bone morp hogenetic protein toward osteogenesis in the perichondrium.2013

    • Author(s)
      Hojo H, et al.
    • Journal Title

      J Biol Chem

      Volume: 288 Issue: 14 Pages: 9924-9932

    • DOI

      10.1074/jbc.m112.409342

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone healing by sterilizable calcium phosphate tetrapods eluting osteoge nic molecules.2013

    • Author(s)
      Maeda Y, Hojo H, et al.
    • Journal Title

      Biomaterials

      Volume: 34 Issue: 22 Pages: 5530-5537

    • DOI

      10.1016/j.biomaterials.2013.03.089

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell-sheet technology combined with a thienoindazole derivative small comnound TD-198946 for cartilage regeneration2013

    • Author(s)
      Yano F, Hojo H, et al.
    • Journal Title

      Biomaterials

      Volume: 34 Issue: 22 Pages: 5581-5587

    • DOI

      10.1016/j.biomaterials.2013.04.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repair of rabbit segmental femoral defects by using a combination of tetrapod-shaped granular artificial bones and basic fibroblast growth factor-binding ion complex gel.2013

    • Author(s)
      Honnami M, Choi S, Liu I, Kamimura W, Taguchi T, Hojo H, Shimohata N, Ohba S, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M
    • Journal Title

      Biomaterials

      Volume: 34 Issue: 36 Pages: 9056-9062

    • DOI

      10.1016/j.biomaterials.2013.08.014

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in Bone Regeneration by Trehalose Coating and Basic Fibroblast Growth Factor after Implantation of Tailor-Made Bone Implants in Dogs2013

    • Author(s)
      Choi S et al.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 75 Issue: 6 Pages: 721-726

    • DOI

      10.1292/jvms.12-0244

    • NAID

      130003362113

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development and evaluation of tetrapod-shaped granular artificial bones2012

    • Author(s)
      Sungjin Choi
    • Journal Title

      Acta Biomaterialia

      Volume: (掲載確定済) Issue: 6 Pages: 2340-2347

    • DOI

      10.1016/j.actbio.2012.02.019

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes2012

    • Author(s)
      Hirata M、Kugimiya F、Fukai A、Saito T、Yano F、Ikeda T、Mabuchi A、Sapkota BR、Akune T、Nishida N、Yoshimura N、NakagawaT、Tokunaga K、Nakamura K、Chung UI、Kawaguchi H
    • Journal Title

      Human Molecular Genetics

      Volume: 21 Issue: 5 Pages: 1111

    • DOI

      10.1093/hmg/ddr540

    • URL

      https://localhost/en/publications/abfc611f-c496-404e-9463-c7714f2b9a40

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Famotidine suppresses osteogenic differentiation of tendon cells in vitro and pathological calcification of tendon in vivo2012

    • Author(s)
      Yamamoto K, Hojo H, 他
    • Journal Title

      J Orthop Res

      Volume: 30 Issue: 12 Pages: 1958-1962

    • DOI

      10.1002/jor.22146

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Introduction of messenger RNA into knee articular cartilages using polyplex nanomicelle2015

    • Author(s)
      Aini H, Itaka K, Chung U, Ohba S
    • Organizer
      2015 World Congress on Osteoarthritis
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gremlin1 induced by excessive mechanical stress loading enhances cartilage degradation2015

    • Author(s)
      Chang S, Kobayashi H, Okada K, Okuma T, Mori Y, Kawata M, Yano F, Kawaguchi H, Chung U, Tanaka S, Saito T
    • Organizer
      2015 World Congress on Osteoarthritis
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of high-performance structural biomaterials through controlling 3D shape2014

    • Author(s)
      鄭 雄一(Chung, Ung-il)
    • Organizer
      日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-07-24 – 2014-07-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 1. Development of implant devices for skeletal reconstruction by precise control of 3D shape2013

    • Author(s)
      Chung U (鄭 雄一)
    • Organizer
      The 4th Asian Biomaterials Congress
    • Place of Presentation
      香港科学技術大学・中国
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] PREVENTION AND REPAIR OF CARTILAGE DEGENERATION BY A NOVEL SMALL THIENOINDAZOLE-DERIVATIVE COMPOUND2012

    • Author(s)
      Fumiko Yano
    • Organizer
      2012 World Congress on Osteoarthritis
    • Place of Presentation
      バルセロナ、スペイン
    • Related Report
      2012 Annual Research Report
  • [Remarks] 鄭 研究室

    • URL

      http://www.tetrapod.t.u-tokyo.ac.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 鄭雄一研究室

    • URL

      http://www.tetrapod.t.u-tokyo.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 鄭 雄一 研究室

    • URL

      http://www.tetrapod.t.u-tokyo.ac.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 鄭 雄一 研究室

    • URL

      http://www.tetrapod.t.u-tokyo.ac.jp/

    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 眼科治療用ゲル材料2016

    • Inventor(s)
      鄭 雄一 他
    • Industrial Property Rights Holder
      鄭 雄一 他
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-000913
    • Filing Date
      2016-01-06
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2013-05-15   Modified: 2022-01-28  

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