|Budget Amount *help
¥46,280,000 (Direct Cost: ¥35,600,000、Indirect Cost: ¥10,680,000)
Fiscal Year 2015: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2014: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2013: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2012: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
|Outline of Final Research Achievements
In order to treat bone defect and deformity, we need to use artificial bone. We attempted to enhance its performance by clarifying signaling network for bone formation and integrating it with artificial bone. As a result, we succeeded in differentiating pluripotent stem cell into osteoblastic cells in vitro using 4 small-molecule compounds without using serum, protein or gene. By loading these compounds onto artificial bone and controlling their release, we also succeeded in treating bone defect model in animals within a short period.