Functional analysis of tumor suppressor genes by generating gene-modified mice

• Project/Area Number: 24240120
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Kyushu University
• Principal Investigator: Suzuki Akira 九州大学, 生体防御医学研究所, 教授 (10311565)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥46,540,000 (Direct Cost: ¥35,800,000、Indirect Cost: ¥10,740,000); Fiscal Year 2015: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000); Fiscal Year 2014: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000); Fiscal Year 2013: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000); Fiscal Year 2012: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
• Keywords: Hippo / MOB1 / YAP / TAZ / p53 / PTEN / がん抑制遺伝子 / 遺伝子改変マウス / マウス / MATS / PICT1

Outline of Final Research Achievements

Most of the cancer patients still show bad prognosis, in spite of the tremendous progress of Molecular Biology. Therefore, new molecular targeting drugs are awaited. Functions of cancer suppressor genes should urgently be studied, because they will become the nice targets for the cancer treatment. Among the cancer suppressor genes, p53, PTEN, and Hippo signaling pathways are the most important for the onset of cancers, because these genes are frequently altered in a variety of cancers, and they can cause various cancers by single gene alteration, as oncogenic drivers. We clarified the functions of these cancer suppressor genes by making full use of these gene-altered mice, the tumor spectrum by Hippo pathway alteration, and Hippo pathway-targeted anti-cancer drugs.

Research Products

• [Int'l Joint Research] University of Western Ontario(Canada)
• [Journal Article] Dysregulated YAP1/TAZ and TGF-beta signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice (2016)
  • Author(s): Nishio M, Sugimachi K, Goto H, Wang J, Morikawa T, Miyachi Y, Takano Y, Hikasa H, Itoh T, Suzuki SO, Kurihara H, Aishima S, Leask A, Sasaki T, Nakano T, Nishina H, Nishikawa Y, Sekido Y, Nakao K, Shin-ya K, Mimori K, Suzuki A
  • Journal Title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE USA Volume: 113(1)
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Merlin/NF2-Lin28B-let-7 is a novel tumor-suppressive pathway that is cell density-dependent and Hippo-independent (2016)
  • Author(s): Hikasa H, Sekido Y, Suzuki A
  • Journal Title: CELL REPORTS Volume: 14(12) Pages: 2950-61
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice. (2016)
  • Author(s): Matsushita Y, Sakai Y, Shimmura M, Shigeto H, Nishio M, Akamine S, Sanefuji M, Ishizaki Y, Torisu H, Nakabeppu Y, Suzuki A, Takada H, Hara T.
  • Journal Title: Sci Rep Volume: 未 Issue: 1 Pages: 22991-22991
  • DOI: 10.1038/srep22991
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The AURKA/TPX2 axis drives colon tumorigenesis cooperatively with MYC. (2015)
  • Author(s): Takahashi Y, Sheridan P, Niida A, Sawada G, Uchi R, Mizuno H, Kurashige J, Sugimachi K, Sasaki S, Shimada Y, Hase K, Kusunoki M, Kudo S, Watanabe M, Yamada K, Sugihara K, Yamamoto H, Suzuki A, Doki Y, Miyano S, Mori M, Mimori K
  • Journal Title: Ann. Oncol. Volume: 26(5) Issue: 5 Pages: 935-42
  • DOI: 10.1093/annonc/mdv034
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Leptin improves fatty liver independently of insulin sensitization and appetite suppression in hepatocyte-specific Pten-deficient mice with insulin hypersensitivity. (2015)
  • Author(s): Yamamoto-Kataoka S, Ebihara K, Aizawa-Abe M, Nishio M, Kusakabe T, Yamamoto Y, Aotani D, Sakai T, Zhao M, Ebihara C, Gumbilai VM, Hosoda K, Suzuki A, Nakao K
  • Journal Title: Horm Metab Res Volume: 47 Issue: 03 Pages: 168-175
  • DOI: 10.1055/s-0034-1395531
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex (2014)
  • Author(s): Wang L, Opland D, Tsai S, Luk CT, Schroer SA, Allison MB, Elia AJ, Furlonger C, Suzuki A, Paige CJ, Mak TW, Winer DA, Myers MG Jr, Woo M.
  • Journal Title: Nat. Med. Volume: 20(5) Issue: 5 Pages: 484-92
  • DOI: 10.1038/nm.3527
  • Peer Reviewed
• [Journal Article] A Unified Nomenclature and Amino Acid Numbering for Human PTEN (2014)
  • Author(s): Pulido R, Baker SJ, Barata JT,Carracedo A, Cid VJ, Chin-Sang ID, Dave V, den Hertog J, Devreotes P,Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B et al.
  • Journal Title: Sci Signal. Volume: 7(332) Pe15 Issue: 332 Pages: 1-4
  • DOI: 10.1126/scisignal.2005560
  • Peer Reviewed
• [Journal Article] Nucleolar Stress Induces Ubiquitination-Independent Proteasomal Degradation of PICT1 (2014)
  • Author(s): Maehama T, Kawahara K, Nishio M, Suzuki A, Hanada K
  • Journal Title: J. Biol. Chem. Volume: 289(30) Pages: 20802-12
  • Peer Reviewed
• [Journal Article] Contributions of hepatocytes and bile ductular cells in ductular reactions and remodeling of the biliary system after chronic liver injury. (2014)
  • Author(s): Nagahama Y, Sone M, Chen X, Okada Y, Yamamoto M, Xin B, Matsuo Y, Komatsu M, Suzuki A, Enomoto K, Nishikawa Y
  • Journal Title: Am. J. Pathol. Volume: 184(11) Pages: 3001-12
  • NAID: 120005688776
  • Peer Reviewed
• [Journal Article] Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA (2014)
  • Author(s): Hayashi K, Momoi Y, Tanuma N, Kishimoto A, Ogoh H, Kato H, Suzuki M, Sakamoto Y, Inoue Y, Nomura M, Kiyonar H, Sakayori M, Fukamachi K, Kakugawa Y, Yamashita Y, Ito S, Sato I, Suzuki A, Nishio M, Suganuma M, Watanabe T, Shima H
  • Journal Title: Oncogene Volume: Dec 8 Pages: 398-398
  • Peer Reviewed
• [Journal Article] PICT1 expression is a good prognostic factor in non-small cell lung cancer (2014)
  • Author(s): Okamura K, Takayama K, Kawahara K, Harada T, Nishio M, Otsubo K, Ichijo K, Kohno M, Iwama E, Fujii A, Ota K, Koga T, Okamoto T, Suzuki A, Nakanishi Y
  • Journal Title: Oncoscience Volume: 1 (5) Pages: 375-82
  • Peer Reviewed
• [Journal Article] がんと脂質－PTEN/PI3Kシグナルと発がん (2014)
  • Author(s): 前濱朝彦、鈴木聡
  • Journal Title: THE LIPID Volume: 25(4) Pages: 63-69
  • Peer Reviewed
• [Journal Article] Hippo経路と腫瘍－Hippo経路変異によるがんモデルマウス－ (2014)
  • Author(s): 後藤裕樹、西尾美希、杉町圭史、三森功士、鈴木 聡
  • Journal Title: 医学のあゆみ Volume: 251(5) Pages: 428-435
  • Peer Reviewed
• [Journal Article] Aberrant Expression of Plastin-3 Via Copy Number Gain Induces the Epithelial-Mesenchymal Transition in Circulating Colorectal Cancer Cells. (2014)
  • Author(s): Sugimachi K, Yokobori T, Iinuma H, Ueda M, Ueo H, Shinden Y, Eguchi H, Sudo T, Suzuki A, Maehara Y, Mori M, Mimori K
  • Journal Title: ANNALS OF SURGICAL ONCOLOGY Volume: in press Pages: 0-0
  • Peer Reviewed
• [Journal Article] The expression of PTEN in the development of mouse cochlear lateral wall. (2014)
  • Author(s): Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Hossain MA, Noguchi C, Katagi A, Nishio M, Suzuki A, Tokuda M.
  • Journal Title: NEURO SCIENCE Volume: 258(1) Pages: 263-9
  • Peer Reviewed
• [Journal Article] PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression. (2013)
  • Author(s): Uchi R, Kogo R, Kawahara K, Sudo T, Yokobori T, Eguchi H, Sugimachi K, Maehama T, Mori M, Suzuki A, Komune S, Mimori K.
  • Journal Title: BRITISH JOURNAL OF CANCER Volume: 109(8) Pages: 2199-206
  • Peer Reviewed
• [Journal Article] Capturing the Mammalian Hippo: Elucidating Its Role in Cancer (2013)
  • Author(s): Nishio M, Otsubo K, Maehama T, Mimori K, Suzuki A
  • Journal Title: CANCER SCIENCE Volume: 104(10) Pages: 1271-1277
  • Peer Reviewed
• [Journal Article] Inhibition of PTEN Tumor Suppressor Promotes the Generation of Induced Pluripotent Stem Cells. (2013)
  • Author(s): Liao J, Marumoto T, Yamaguchi S, Okano S, Takeda N, Sakamoto C, Kawano H, Nii T, Miyamato S, Nagai Y, Okada M, Inoue H, Kawahara K, Suzuki A, Miura Y, Tani K.
  • Journal Title: MOLECULAR THERAPY Volume: 21(6) Pages: 1242-50
  • Peer Reviewed
• [Journal Article] Clinical Significance of PICT1 in Patients of Hepatocellular Carcinoma with Wild-Type TP53. (2013)
  • Author(s): Ishibashi M, Kogo R, Shibata K, Ueo H, Uchi R, Matsumura T, Takano Y, Sawada G, Takahashi Y, Mima K, Kurashige J, Akiyoshi S, Iwaya T, Eguchi H, Sudo T, Sugimachi K, Suzuki A, Wakabayashi G, Mori M, Mimori K.
  • Journal Title: ANNALS OF SURGICAL ONCOLOGY Volume: Suppl 3
  • Peer Reviewed
• [Journal Article] Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. (2013)
  • Author(s): Takasuga S, Horie Y, Sasaki J, Sun-Wada GH, Kawamura N, Iizuka R, Mizuno K, Eguchi S, Kofuji S, Kimura H, Yamazaki M, Horie C, Odanaga E, Sato Y, Sato Y, Chida S, Kotani K, Harada A, Katada T, Suzuki A, Wada Y, Ohnishi H, Sasaki T.
  • Journal Title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE USA Volume: 110(5) Pages: 1726-31
  • Peer Reviewed
• [Journal Article] Clinical Significance of PICT1 in Patients of Hepatocellular Carcinoma with Wild-Type TP53. (2013)
  • Author(s): Ishibashi M et al
  • Journal Title: Ann Surg Oncol. Volume: -
  • Peer Reviewed
• [Journal Article] 核小体を起点としp53を制御する新規分子PICT1による細胞増殖制御機構 (2013)
  • Author(s): 西尾美希ら
  • Journal Title: 実験医学増刊号 Volume: 31
• [Journal Article] Epithelial Pten controls acute lung injury and fibrosis by regulating alveolar epithelial cell integrity (2013)
  • Author(s): Miyoshi K, Yanagi S, Kawahara K, Nishio M, Tsubouchi H, Imazu Y, Koshida R, Matsumoto N, Taguchi A, Yamashita S, Suzuki A, Nakazato M
  • Journal Title: Am J Respir Crit Care Med Volume: 187 Issue: 3 Pages: 262-275
  • DOI: 10.1164/rccm.201205-0851oc
  • Peer Reviewed
• [Journal Article] Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine (2012)
  • Author(s): Takasuga , Wada et al.
  • Journal Title: PNAS 110 Volume: 1726-1731 Issue: 5 Pages: 1726-31
  • DOI: 10.1073/pnas.1213212110
  • Peer Reviewed
• [Journal Article] Cancer susceptibility and embryonic lethality in Mobla/lb double-mutant mice. (2012)
  • Author(s): Nishio M.
  • Journal Title: J Clin Invest. Volume: 122 Issue: 12 Pages: 4505-4518
  • DOI: 10.1172/jci63735
  • Peer Reviewed
• [Journal Article] PPARgamma contributes to PKM2 and HK2 expression in fatty liver (2012)
  • Author(s): Panasyuk G et al
  • Journal Title: Nature Commun Volume: 3 Issue: 1 Pages: 672-672
  • DOI: 10.1038/ncomms1667
  • Peer Reviewed
• [Journal Article] A new PICTure of nucleolar stress (2012)
  • Author(s): Suzuki A, Kogo R, Kawahara K, Sasaki M, Nishio M, Maehama T, Sasaki T, Mimori K, Mori M.
  • Journal Title: Cancer Sci Volume: 103 Issue: 4 Pages: 632-7
  • DOI: 10.1111/j.1349-7006.2012.02219.x
  • Peer Reviewed
• [Journal Article] PICT1による核小体ストレス経路を介したp53と腫瘍進展制御～腫瘍予後マーカーや今後の創薬応用にむけて～ (2012)
  • Author(s): 河原康一ら
  • Journal Title: 遺伝子Mook22号 最新疾患モデルと創薬応用研究の最前線 Volume: 22
• [Presentation] Hippo経路による生体制御 (2016)
  • Author(s): 鈴木 聡
  • Organizer: 第3回松島シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-04
• [Presentation] Hippo経路による生体制御 (2016)
  • Author(s): 西尾美希、杉町圭史、新家一男、三森功士、鈴木 聡
  • Organizer: 第7回日本プロティンホスファターゼ研究会 学術集会
  • Place of Presentation: 愛知県岡崎市
  • Year and Date: 2016-01-29
• [Presentation] 動物を用いたがん抑制遺伝子の機能解析研究からがん治療薬開発へ (2015)
  • Author(s): 鈴木 聡
  • Organizer: 星野 孝 先生メモリアルフォーラム
  • Place of Presentation: 京都
  • Year and Date: 2015-12-06
• [Presentation] Measuring phosphoinositides at molecular species level (2015)
  • Author(s): Hiroki Nakanishi, Satoshi Eguchi, Masaki Ishikawa, Akira Suzuki, Junko Sasaki, Takehiko Sasaki
  • Organizer: Biochemistry and Molecular Biology 2015
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] マウス肝臓におけるMOB1の機能解析 (2015)
  • Author(s): 西尾美希、後藤裕樹、大坪孝平、藤 庸子、宮地洋佑、日笠弘基、杉町圭史、三森功士、鈴木 聡
  • Organizer: Biochemistry and Molecular Biology 2015
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] Merlin regulates the let-7 biogenesis via Lin28B suppression in a cell density-dependent manner (2015)
  • Author(s): Hiroki Hikasa, Yoshitaka Sekido, Akira Suzuki
  • Organizer: Biochemistry and Molecular Biology 2015
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] Regulation of chondrogenesis and osteogenesis by Hippo pathway (2015)
  • Author(s): Hiroki Goto, Miki Nishio, Akira Suzuki
  • Organizer: The 25th Hot Spring Harbor International Symposium
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-13
  • Int'l Joint Research
• [Presentation] Function of MOB1A/1B in murine liver (2015)
  • Author(s): Miki Nishio, Yuji Nishikawa, Keishi Sugimachi, Koshi Mimori, Kazuo Shinya, Akira Suzuki
  • Organizer: The 74th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
  • Int'l Joint Research
• [Presentation] MOB1A/1B control lung morphogenesis and maintenance of cancer-initiating stem cells (2015)
  • Author(s): Kohei Otsubo, Miki Nishio, Yoichi Nakanishi, Akira Suzuki
  • Organizer: The 74th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
  • Int'l Joint Research
• [Presentation] Regulation of chondrogenesis and osteogenesis by Hippo pathway (2015)
  • Author(s): Hiroki Goto, Miki Nishio, Hiroshi Nishina, Akira Suzuki
  • Organizer: 1st International Symposium on Cell Competition.
  • Place of Presentation: 京都
  • Year and Date: 2015-09-10
• [Presentation] Function of MOB1A/1B in murine liver (2015)
  • Author(s): Miki Nishio, Hiroki Goto, Keishi Sugimachi, Koshi Mimori, Akira Suzuki
  • Organizer: 1st International Symposium on Cell Competition.
  • Place of Presentation: 京都
  • Year and Date: 2015-09-10
• [Presentation] Hippo signaling regulates cell competition in mammals (2015)
  • Author(s): Shoji Tane, Miki Nishio, Akira Suzuki
  • Organizer: 1st International Symposium on Cell Competition.
  • Place of Presentation: 京都
  • Year and Date: 2015-09-10
• [Presentation] Merlin regulates Lin28B/let-7 biogenesis in cell-density-dependent manner (2015)
  • Author(s): Hiroki Hikasa, Akira Suzuki
  • Organizer: The 18th Retreat Medical Institute of Bioregulation Kyushu University
  • Place of Presentation: 熊本
  • Year and Date: 2015-07-16
• [Presentation] Regulation of chondrogenesis and osteogenesis by MOB1A/1B (2015)
  • Author(s): Hiroki Goto, Miki Nishio, Akira Suzuki
  • Organizer: The 18th Retreat Medical Institute of Bioregulation Kyushu University
  • Place of Presentation: 熊本
  • Year and Date: 2015-07-16
• [Presentation] Function of MOB1A/1B in murine liver (2015)
  • Author(s): Miki Nishio, Hiroki Goto, Keishi Sugimachi, Koshi Mimori, Akira Suzuki
  • Organizer: The 18th Retreat Medical Institute of Bioregulation Kyushu University
  • Place of Presentation: 熊本
  • Year and Date: 2015-07-16
• [Presentation] Inactivation Mob as tumor suppressor gene in salivary glands alters postnatal differentiation and causes hyperplasia (2015)
  • Author(s): Yousuke Miyachi, Miki Nishio, Akira Suzuki
  • Organizer: The 18th Retreat Medical Institute of Bioregulation Kyushu University
  • Place of Presentation: 熊本
  • Year and Date: 2015-07-16
• [Presentation] MOB1による生体制御 (2015)
  • Author(s): 鈴木 聡、西尾美希、後藤裕樹、大坪孝平、藤 庸子、宮地洋佑、日笠弘基、三森功士
  • Organizer: 第24回日本Cell Death学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-07-11
• [Presentation] がん抑制遺伝子の破綻病態と治療戦略～Hippoシグナル経路を中心として～ (2015)
  • Author(s): 鈴木 聡
  • Organizer: 神鋼病院総合医学研究センター第15回研究カンファランス（日本医師会生涯教育講座講演
  • Place of Presentation: 神戸
  • Year and Date: 2015-06-26
  • Invited
• [Presentation] Function of MOB1A/1B in murine liver The Hippo Pathway: Signaling, Development and Disease (2015)
  • Author(s): Miki Nishio, Hiroki Goto, Keishi Sugimachi, Koshi Mimori, Akira Suzuki
  • Organizer: KEYSTONE SYMPOSIA-on Molecular and Cellular Biology
  • Place of Presentation: Taos, New Mexico, USA
  • Year and Date: 2015-05-17
  • Int'l Joint Research
• [Presentation] Hippo経路の破綻による各種疾患と治療戦略 (2015)
  • Author(s): 鈴木 聡
  • Organizer: 第１回京都大学第二内科同門会講演会
  • Place of Presentation: 京都
  • Year and Date: 2015-04-29
  • Invited
• [Presentation] 個体におけるHippoシグナル経路の生理作用と破綻病態 (2015)
  • Author(s): 鈴木 聡
  • Organizer: 富士フイルム社内講演
  • Place of Presentation: 小田原
  • Year and Date: 2015-04-22
  • Invited
• [Presentation] Mob1a/1b control cell differentiation and cancer suppression in mice (2015)
  • Author(s): Akira Suzuki
  • Organizer: 熊本大学医学部大学院セミナー
  • Place of Presentation: 熊本
  • Year and Date: 2015-01-21
• [Presentation] リボゾームRNAの制御によるHippo経路エフェクターYAP/TAZの活性化 (2014)
  • Author(s): 日笠 弘基, 鈴木 聡
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-27
• [Presentation] Nucleolar stress induces ubiqutination-independent proteasomal degradation of PICT1 protein (2014)
  • Author(s): Tomohiko Maehama, Miki Nishio, Koichi Kawahara, Akira Suzuki
  • Organizer: 11th International Conference on Protein Phosphatase
  • Place of Presentation: 仙台
  • Year and Date: 2014-11-12
• [Presentation] Loss of Mob1a/1b in the liver shows immature cholangiocellular hyperplasia and liver carcinomas in mice (2014)
  • Author(s): Miki Nishio, Kazuo Shinya, Akira Suzuki
  • Organizer: The 24rd Hot Spring Harbor International Symposium, Recent Advances in immunology and Inflammation 2014
  • Place of Presentation: 福岡
  • Year and Date: 2014-11-08
• [Presentation] MOB1A/1B control lung morphogenesis and maintenance of cancer-initiation stem cells (2014)
  • Author(s): Kohei Ostubo, Miki Nishio, Yoichi Nakanishi, Akira Suzuki
  • Organizer: The 24rd Hot Spring Harbor International Symposium, Recent Advances in immunology and Inflammation 2014
  • Place of Presentation: 福岡
  • Year and Date: 2014-11-08
• [Presentation] MOB1による肺の形態形成と腫瘍発症制御 (2014)
  • Author(s): 大坪孝平, 西尾美希, 中西洋一, 鈴木 聡
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-18
• [Presentation] 生体イメージング技術による核小体ストレス応答の制御基盤の解明 (2014)
  • Author(s): 河原 康一, 堀口史人, 上条陽平, 山本雅達, 新里能成, 南謙太朗, ｴﾌ･ｴﾑ ﾓｲﾇﾃﾞｨﾝ, 有馬一成, 西尾美希, 佐々木雅人, 前濱朝彦, 鈴木 聡, 古川龍彦
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-16
• [Presentation] Function of cancer suppressor genes MOB1A/1B in the uterus (2014)
  • Author(s): Yoko To, Hironori Tashiro, Miki Nishio, Tohru Kiyono, Hidetaka Katabuchi, Akira Suzuki
  • Organizer: The 73rd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-27
• [Presentation] Mob1a/1b control cell differentiation and cancer suppression in mice. (2014)
  • Author(s): Akira Suzuki, Miki Nishio, Yoko Toh, Kohei Ohtsubo
  • Organizer: The 73rd Annual Meeting of the Japanese Cancer Association ~Symposium~
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-26
• [Presentation] Function of MOB1A/1B in murine liver (2014)
  • Author(s): Miki Nishio, Jia Wang, Yuji Nishikawa, Koshi Mimori, Akira Suzuki
  • Organizer: The 73rd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-26
• [Presentation] Hippo経路による生体制御機構 (2014)
  • Author(s): 鈴木 聡
  • Organizer: 第32回耳鼻咽喉科ニューロサイエンス研究会
  • Place of Presentation: 大阪
  • Year and Date: 2014-08-30
  • Invited
• [Presentation] The Hippo Signaling Pathway: Functions, Disorders, and Therapeutic Application (2014)
  • Author(s): Akira Suzuki
  • Organizer: The UEHARA Memorial Foundation Symposium 2014
  • Place of Presentation: 東京
  • Year and Date: 2014-06-15
• [Presentation] マウスモデルによる癌研究の新展開 (2014)
  • Author(s): 鈴木 聡
  • Organizer: 金沢医科大学私立大学戦略的研究基盤形成支援事業 脂質ワールドの臨床応用を目指す研究拠点形成
  • Place of Presentation: 金沢
  • Year and Date: 2014-05-19
  • Invited
• [Presentation] 核小体ストレスに応答した癌制御因子PICT1のプロテアソーム依存性・ユビキチン非依存性分解
  • Author(s): 前濱 朝彦, 西尾 美希, 鈴木 聡
  • Organizer: 日本プロテインホスファターゼ研究会学術集会
  • Place of Presentation: 津
• [Presentation] 遺伝子改変マウスを利用したがん抑制遺伝子の破綻病態研究
  • Author(s): 西尾 美希、濱田 浩一、河原 康一、佐々木 雅人、佐々木 雄彦、三森 功士、森 正樹、鈴木 聡
  • Organizer: 個体レベルでのがん研究支援活動ワークショップ
  • Place of Presentation: 大津
  • Invited
• [Presentation] リボソームRNA合成阻害剤はHippo経路エフェクターYAP/TAZを活性化する
  • Author(s): 日笠弘基、鈴木 聡
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] Functions of MOB1A/1B in murine uterus and mammary glands
  • Author(s): Yoko To, Miki Nishio, Akira Suzuki
  • Organizer: The 23rd Hot Spring Harbor International Symposium, Recent Advances in Stem Cell Biology 2013
  • Place of Presentation: 福岡
• [Presentation] Functions of MOB1A/1B in murine lung
  • Author(s): Kohei Ohtsubo, Miki Nishio, Yoichi Nakanishi, Akira Suzuki
  • Organizer: The 23rd Hot Spring Harbor International Symposium, Recent Advances in Stem Cell Biology 2013
  • Place of Presentation: 福岡
• [Presentation] 腫瘍促進因子FEATのES細胞における機能
  • Author(s): 小林恭介、河原康一、鈴木聡、谷憲三郎、高橋淳
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Functions of the Mob1A/1B in mice
  • Author(s): Miki Nishio, Jia Wang, Takumi Morikawa, Kohei Otsubo, Yoko Toh, Hiroki Hikasa, Satoshi Itami, Keishu Sugimachi, Koshi Mimori, Akira Suzuki
  • Organizer: 第72回日本癌学会学術総会シンポジウム がん研究とモデル動物
  • Place of Presentation: 横浜
• [Presentation] Dual specificity phosphatases acting on acidic phospholipids
  • Author(s): 佐々木 雄彦, 高須賀 俊輔, 佐々木 純子, 鈴木 聡
  • Organizer: 第86回日本生化学会大会シンポジウム
  • Place of Presentation: 神戸
• [Presentation] 核小体ストレスに応答した癌制御因子PICT1のプロテアソーム依存性・ユビキチン非依存性分解
  • Author(s): 前濱 朝彦, 河原 康一, 西尾 美希, 鈴木 聡, 花田 賢太郎
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] The role of PTEN in the development of interdental cells in mouse postnatal cochlea
  • Author(s): Youyi Dong, Li Sui, Fuminori Yamaguchi, Kazuyo Kamitori, Akram Hossain, Yuko Hirata, Akira Suzuki, Masaaki Tokuda
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] 子宮・乳腺組織特異的Mob1A/Bノックアウトマウスの解析
  • Author(s): 藤 庸子, 田代 浩徳, 西尾 美希, 三森 功士, 片渕 秀隆, 鈴木 聡
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] プロゲステロンレセプター発現組織特異的Mob1A/Bノックアウトマウスの解析
  • Author(s): 藤 庸子、田代浩徳、西尾美希、片渕秀隆、鈴木 聡
  • Organizer: 第12回日本婦人科がん分子標的研究会講演
  • Place of Presentation: 奈良
• [Presentation] Increased cancer susceptibility and embryonic lethality associated with double mutation of the Mob1A and Mob1B in mice
  • Author(s): Miki Nishio, Koichi Hamada, Kensaku Mizuno, Nirikazu Yabuta, Hiroshi Nojima, Yutaka Hata, Hiroshi Nishina, Satoshi Itam, Akira Suzuki
  • Organizer: Keystone symposium
  • Place of Presentation: Monteley USA
• [Presentation] Functions of Mob1 tumor suppressor genes in vivo
  • Author(s): Miki Nishio et al
  • Organizer: The Joint symposium of the 7th International Symposium of the Institute Network
  • Place of Presentation: 仙台
  • Invited
• [Presentation] Role of PICT1 in T cell development and malignancy
  • Author(s): 西尾美希ら
  • Organizer: 第71 回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] Suppression of Pten promotes the generation of induced pluripotent stem cells
  • Author(s): 丸本朋稔ら
  • Organizer: 第71 回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] Functional analysis of tumor suppressor genes Mob1A/1B
  • Author(s): 鈴木聡ら
  • Organizer: 第71 回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Invited
• [Presentation] Characterization of FEAT function in vivo
  • Author(s): 小林恭介ら
  • Organizer: 第71 回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] Mob1A・Mob1B による発生・発がんの制御
  • Author(s): 西尾 美希ら
  • Organizer: 第85 回日本分子生物学会ワークショップ
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 内在性YAP/TAZ 特異的レポーター遺伝子の開発とその応用
  • Author(s): 日笠 弘基ら
  • Organizer: 第85 回日本分子生物学会
  • Place of Presentation: 福岡
• [Presentation] PTEN regulates hair cell proliferation and differentiation of the mouse inner ear
  • Author(s): Youyi Dong et al
  • Organizer: 第85 回日本生化学会大会
  • Place of Presentation: 福岡
• [Presentation] MOB1 による個体発生と腫瘍発症制御
  • Author(s): 西尾美希ら
  • Organizer: 「個体レベルでのがん研究支援活動」ワークショップ
  • Place of Presentation: 大津
  • Invited
• [Book] 機械的刺激によるHippo-YAZ/TAZ経路の活性化、生理作用、腫瘍進展メカニズムと意義 (2016)
  • Author(s): 後藤裕樹、西尾美希、加藤稚子、前濱朝彦、鈴木聡
  • Total Pages: 5
  • Publisher: 生体の科学
• [Book] PTEN:脂質ホスファターゼとしての機能と発がんへの関与 (2015)
  • Author(s): 前濱朝彦, 鈴木 聡
  • Total Pages: 7
  • Publisher: 実験医学
• [Book] 家族性腫瘍学ー家族性腫瘍の最新研究動向ー (2015)
  • Author(s): 前濱朝彦、鈴木 聡
  • Total Pages: 6
  • Publisher: 日本臨床
• [Book] Hippo経路による生体制御機構 (2015)
  • Author(s): 西尾美希、鈴木 聡
  • Total Pages: 5
  • Publisher: 耳鼻咽喉科ニューロサイエンス
• [Book] YAP1/TAZおよびTGFβ経路を介したMOB1A/1B欠損による肝がん発症機構 (2015)
  • Author(s): 西尾美希、鈴木 聡
  • Total Pages: 1
  • Publisher: 肝細胞研究会, ホットトピックス
• [Book] The Hippo Signaling Pathway: A Candidate New Drug Target for Malignant Tumors (2015)
  • Author(s): Nishio M, Goto H, Suzuki M, Fujimoto A, Mimori K, Suzuki A
  • Total Pages: 16
  • Publisher: INNOVATIVE MEDICINE : Basic Research and Development (editted by Nakao K), Springer,
• [Book] INNOVATIVE MEDICINE (2014)
  • Author(s): Nishio M, Goto H, Suzuki M, Fujimoto A, Mimori K, Suzuki A
  • Total Pages: 18
  • Publisher: Springer
• [Book] Hippo経路分子MOB1によるがん発症・進展制御とがん治療戦略 (2013)
  • Author(s): 西尾美希、三森功士、森 正樹、板見 智、鈴木 聡
  • Publisher: 南山堂
• [Book] 疾患モデルの作製と利用 ー がん (2012)
  • Author(s): 西尾美希ら
  • Total Pages: 27
  • Publisher: PTEN変異による発がんモデル
• [Remarks] 九州大学生体防御医学研究所ゲノム腫瘍学分野
  • URL: http://www.bioreg.kyushu-u.ac.jp/hassei/
• [Remarks] ＹＡＰ／ＴＡＺおよびTGFb経路を介したMOB1A/1B欠損による肝がん発症機構
  • URL: http://hepato.umin.jp/hottopics/hottopics014.html