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Function of cell adhesion on protein-adsorbed well-defined nanostructured interface

Research Project

Project/Area Number 24241042
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Nanomaterials/Nanobioscience
Research InstitutionThe University of Tokyo

Principal Investigator

Takai Madoka  東京大学, 大学院工学系研究科(工学部), 教授 (40287975)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥39,650,000 (Direct Cost: ¥30,500,000、Indirect Cost: ¥9,150,000)
Fiscal Year 2015: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2014: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2013: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2012: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Keywordsナノ相分離 / ブロックコポリマー / タンパク質 / 細胞 / 界面 / 相分離構造 / タンパク質吸着 / ブロックポリマー / 親・疎水性 / AFM / 自己組織化相分離構造 / 細胞接着
Outline of Final Research Achievements

In order to create suitable biocompatible materials for various tissue engineering applications, it is important to be able to understand protein adsorption and cell adhesion behaviours on the material surfaces. It is known that the nanoscale distribution of adhesive ligands affects cell adhesion behaviours. However, how nanoscale distribution of adsorbed proteins affect cell adhesion behaviours is still unclear. Therefore, in this study, we investigate the effect of the distribution of adsorbed proteins by the phase reversal of amphiphilic block copolymers composed of protein-adsorptive and non-adsorptive on cell adhesion behaviors. The difference of cell adhesion behaviours between opposite nano phase structures may be caused by the distributions of adsorbed proteins. It was concluded that in addition to the density of adsorbed proteins, the distribution also greatly affects cell adhesion.

Report

(5 results)
  • 2016 Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (90 results)

All 2017 2016 2015 2014 2013 2012 Other

All Int'l Joint Research (1 results) Journal Article (24 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 21 results,  Acknowledgement Compliant: 11 results,  Open Access: 3 results) Presentation (54 results) (of which Int'l Joint Research: 13 results,  Invited: 24 results) Book (6 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results)

  • [Int'l Joint Research] KTH Royal Institute of Technology/Biomedical and X-ray Physics/Department of Applied Physics(Sweden)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Enhancement of Cell Adhesion on a Phosphorylcholine-Based Surface through the Interaction with DNA Mediated by Ca2+ Ions2016

    • Author(s)
      Tomoyuki Azuma, Yuji Teramura, Toru Hoshi, Madoka Takai
    • Journal Title

      J. Phys. Chem. B

      Volume: 120 Issue: 48 Pages: 12272-12278

    • DOI

      10.1021/acs.jpcb.6b08741

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Formation of reversed nanoscale phase-separated structures using poly (2-methacryloyloxyethyl phosphorylcholine)-based amphiphilic block copolymers2016

    • Author(s)
      Yukari Hiraguchi, Keiichiro Kushiro, Madoka Takai
    • Journal Title

      Polymer

      Volume: 99 Pages: 166-172

    • DOI

      10.1016/j.polymer.2016.06.065

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Significant Heterogeneity and Slow Dynamics of the Unfolded Ubiquitin Detected by the Line Confocal Method of Single-Molecule Fluorescence Spectroscopy2016

    • Author(s)
      Masataka Saito, Supawich Kamonprasertsuk, Satomi Suzuki, Kei Nanatani, Hiroyuki Oikawa, Keiichiro Kushiro, Madoka Takai, Po-ting Chen, Eric H.-L. Chen, Rita P.-Y. Chen, Satoshi Takahashi
    • Journal Title

      J. Phys. Chem. B

      Volume: 120 Issue: 34 Pages: 8818-8829

    • DOI

      10.1021/acs.jpcb.6b05481

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Simultaneous characterization of protein–material and cell–protein interactions using dynamic QCM-D analysis on SAM surfaces2016

    • Author(s)
      Keiichiro Kushiro, Chih-Hao Lee and Madoka Takai
    • Journal Title

      Biomaterials Science

      Volume: - Issue: 6 Pages: 989-997

    • DOI

      10.1039/c5bm00613a

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Cellular Response to Non-contacting Nanoscale Sublayer: Cells Sense Several Nanometer Mechanical Property2016

    • Author(s)
      Tomoyuki Azuma, Yuji Teramura, Madoka Takai
    • Journal Title

      ACS Appl. Mater. Interfaces

      Volume: 8 Issue: 17 Pages: 10710-10716

    • DOI

      10.1021/acsami.6b01213

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Unanchored Micro-Tumors in an Ultrasonic Actuated Multi-Well Microplate with Protein Repellent Coating2016

    • Author(s)
      Olofsson K, Carannante V, Frisk T, Kushiro K, Takai M, Wiklund M
    • Journal Title

      20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016)

      Volume: 1 Pages: 409-410

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 両親媒性ブロックコポリマーによるナノ相分離構造表面上でのタンパク質吸着と細胞接着挙動解析2016

    • Author(s)
      平口侑香里、久代京一郎、高井まどか
    • Journal Title

      表面科学

      Volume: 37 Pages: 207-212

    • NAID

      130005154325

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Polymer brush biointerfaces for highly sensitive biosensors that preserve the structure and function of immobilized proteins2015

    • Author(s)
      Kenji Takasu, Keiichiro Kushiro, Katsuyoshi Hayashi, Yuzuru Iwasaki, Suzuyo Inoue, Emi Tamechika and Madoka Takai
    • Journal Title

      Sensors and Actuators B: Chemical

      Volume: 216 Pages: 428-433

    • DOI

      10.1016/j.snb.2015.04.056

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Stable surface coating of silicone elastomer with phosphorylcholine and organosilane copolymer with cross-linking for repelling proteins2015

    • Author(s)
      Koji Nagahashi, Yuji Teramura, Madoka Takai
    • Journal Title

      Colloid Surface B

      Volume: 94 Pages: 384-391

    • DOI

      10.1016/j.colsurfb.2015.07.040

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Interfacial Water in Protein Adsorption onto Polymer Brushes as Studied by SFG Spectroscopy and QCM2015

    • Author(s)
      Daiki Nagasawa,Tomoyuki Azuma, Hidenori Noguchi, Kohei Uosaki, Madoka Takai
    • Journal Title

      J. Phys. Chem. C

      Volume: 119 Issue: 30 Pages: 17193-17201

    • DOI

      10.1021/acs.jpcc.5b04186

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Slope-Dependent Cell Motility Enhancements at the Walls of PEG-Hydrogel Microgroove Structures2015

    • Author(s)
      Keiichiro Kushiro, Takamasa Sakai and Madoka Takai
    • Journal Title

      Langmuir

      Volume: 31 Issue: 37 Pages: 10215-10222

    • DOI

      10.1021/acs.langmuir.5b02511

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] マイクロ生化学チップの表面修飾・改質技術2015

    • Author(s)
      高井まどか
    • Journal Title

      クリーンテクノロジー

      Volume: 25 Pages: 38-42

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 高機能バイオセンシングマテリアルの設計と作製2015

    • Author(s)
      高井まどか
    • Journal Title

      Electrochemistry

      Volume: 82 Pages: 1091-1095

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Effect of the distribution of adsorbed proteins on cellular adhesion behaviors using surfaces of nanoscale phase-reversed amphiphilic block copolymers2014

    • Author(s)
      Yukari Hiraguchi,Koji Nagahashi,Takashi Shibayama,Tomohiro Hayashi,Takaaki Yano,Keiichiro Kushiro,Madoka Takai
    • Journal Title

      Acta Biomaterialia

      Volume: 10 Issue: 7 Pages: 2988-2995

    • DOI

      10.1016/j.actbio.2014.03.019

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lectin-tagged Fluorescent Polymeric Nanoparticles for Targeting of Sialic Acid on the Living Cells2014

    • Author(s)
      Jaebum Cho, Keiichiro Kushiro, Yuji Teramura, Madoka Takai
    • Journal Title

      Biomacromolecules

      Volume: 15 Issue: 6 Pages: 2012-2018

    • DOI

      10.1021/bm500159r

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design of soft-interface materials for highly sensitive bio-sensing devices2014

    • Author(s)
      Madoka TAKAI
    • Journal Title

      Materials Research Society Symposium Proceedings

      Volume: 1599 Pages: 1-6

    • DOI

      10.1557/opl.2014.512

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 3次元ナノ構造体を用いた高感度・迅速バイオセンサ2014

    • Author(s)
      高井まどか
    • Journal Title

      応用物理

      Volume: 83 Pages: 478-481

    • NAID

      130007718636

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] タンパク質吸着に及ぼす材料界面の水分子構造ー和周波発生分光法による解析からー2014

    • Author(s)
      高井まどか、長澤大樹、東倫之、野口秀典、魚崎浩平
    • Journal Title

      表面科学

      Volume: 35 Pages: 492-497

    • NAID

      130004691165

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Colorimetric microchip assay using our own whole blood collected by a painless needle for home medical care2013

    • Author(s)
      Madoka Takai, Masao Nagai, Yuji Morimoto, Kunihiko Sasao, Akio Oki, Jun Nakanishi, Hiromichi Inokuchi, Chia-Hsien Chang, Jun Kikuchi, Hiroki Ogawa and Yasuhiro Horiike
    • Journal Title

      Analyst

      Volume: 138 Issue: 21 Pages: 6469-6469

    • DOI

      10.1039/c3an00881a

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Emergency Life Support System aiming preprimed oxygenator2013

    • Author(s)
      Takashi Isoyama, Koki Ariyoshi, Kyosuke Nii, Itusro Saito, Kazuyoshi Fukunaga, Usuke Inoue, Toshiya Ono, Kohei Ishii, Shintaro Hara, Kou Imachi, Madoka Takai, and Yusuke Abe
    • Journal Title

      35th Annual International Conference of the IEEE EMBS

      Volume: 35th Pages: 5731-5734

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct electron transfer with enzymes on nanofiliform titanium oxide films with electron-transport ability.2013

    • Author(s)
      Lee S, Matsuno R, Ishihara K, Takai M
    • Journal Title

      Biosens Bioelectron

      Volume: 40 Pages: 289-293

    • DOI

      10.1016/j.bios.2012.08.037

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zone electrophoresis of proteins in poly(dimethylsiloxane) (PDMS) microchip coated with physically adsorbed amphiphilic phospholipid polymer2013

    • Author(s)
      Kyosuke Nii, Kenji Sueyoshi , Koji Otsuka, Madoka Takai
    • Journal Title

      Microfluid Nanofluid

      Volume: 14 Issue: 6 Pages: 951-959

    • DOI

      10.1007/s10404-012-1102-8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nonbiofouling surfaces covered by bio-inspired 2-methacryloyloxyethyl phosphorylcholine polymer brush by use of polymeric photoiniferter2012

    • Author(s)
      James Sibarani, Tomohiro Konno, Madoka Takai, and Kazuhiko Ishihara
    • Journal Title

      Nano LIFE

      Volume: 2 Issue: 04 Pages: 1242003-1242003

    • DOI

      10.1142/s1793984412420032

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生体親和性高分子表面の構築による界面水の役割2012

    • Author(s)
      高井まどか
    • Journal Title

      化学工業

      Volume: 63 Pages: 66-72

    • NAID

      40019247953

    • Related Report
      2012 Annual Research Report
  • [Presentation] 界面ナノ制御による高性能バイオデバイス創成2017

    • Author(s)
      高井まどか
    • Organizer
      杜の都女性研究者エンパワーメント推進事業 第21回情報バイオトロニクス研究会、電気通信研究所共同プロジェクト研究会 「ナノ・バイオおよびナノ・有機融合分野で活躍する女性達」
    • Place of Presentation
      電気通信研究所 ナノ・スピン総合研究棟、東北大学、仙台市
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Advanced interface of polymeric biomaterials for biomedical devices2016

    • Author(s)
      Madoka Takai
    • Organizer
      JSPS-DST Asian Academic Seminar 2016
    • Place of Presentation
      Tokyo Univ., Tokyo
    • Year and Date
      2016-12-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Surface modification of biocompatible polymer on silicone for medical use2016

    • Author(s)
      Madoka Takai, Shu Yun Yeh, Koji, Nagahashi, Yuji Teramura
    • Organizer
      Biomaterials International 2016
    • Place of Presentation
      Kenting, Taiwan
    • Year and Date
      2016-10-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Advanced surface modifications of blood analysis devices by biocompatible polymer2016

    • Author(s)
      Madoka Takai
    • Organizer
      The 3rd International Conference on Universal Village (UV2016)
    • Place of Presentation
      Nagoya Univ., Aichi
    • Year and Date
      2016-10-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] リン脂質およびリン脂質ポリマーとタンパク質の相互作用2016

    • Author(s)
      高井まどか、島内寿徳
    • Organizer
      平成28年度 生理研研究会「生体界面研究会」
    • Place of Presentation
      生理研研究所(明大時地区)、愛知
    • Year and Date
      2016-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] Soft-interface Design for highly Sensitive Biosensor2016

    • Author(s)
      Madoka Takai
    • Organizer
      CIMTEC 2016
    • Place of Presentation
      Perugia, Italy
    • Year and Date
      2016-06-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ブロックポリマーブラシの非接触層が細胞接着に与える影響2016

    • Author(s)
      東倫之、寺村裕治、高井まどか
    • Organizer
      第65回高分子学会年次大会
    • Place of Presentation
      神戸国際会議場・展示場、神戸市
    • Year and Date
      2016-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 両親媒性ブロックコポリマーによるナノ相分離構造のパターンによる吸着タンパク質解析2016

    • Author(s)
      平口侑香里、久代京一郎、寺村裕治、高井まどか
    • Organizer
      第65回高分子学会年次大会
    • Place of Presentation
      神戸国際会議場・展示場、神戸市
    • Year and Date
      2016-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Biocompatible phosphorylcholine-based copolymer for biomedical devices2016

    • Author(s)
      Madoka Takai
    • Organizer
      Taiwan-Japan Bilateral Polymer Symposium 2016
    • Place of Presentation
      NTHU, Taiwan
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of non-contacting sublayer of di-block polymer brush on cell behavior2016

    • Author(s)
      Tomoyuki Azuma, Yuji Teramura, Madoka Takai
    • Organizer
      The 11th SPSJ International Polymer Conference (IPC 2016)
    • Place of Presentation
      Fukuoka International Congress Center, Fukuoka
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高分子ナノ薄膜の粘弾性の違いが上皮細胞の接着に与える影響2016

    • Author(s)
      東倫之、寺村裕治、久代京一郎、高井まどか
    • Organizer
      日本バイオマテリアル学会シンポジウム2016
    • Place of Presentation
      福岡国際会議場、福岡市
    • Related Report
      2015 Annual Research Report
  • [Presentation] Implantation of artificial heart with MPC polymer-coated silicone surface2016

    • Author(s)
      Yeh ShuYun, 寺村裕治、高井まどか、圦本晃海、原伸太郎、磯山隆、阿部裕輔
    • Organizer
      日本バイオマテリアル学会シンポジウム2016
    • Place of Presentation
      福岡国際会議場、福岡市
    • Related Report
      2015 Annual Research Report
  • [Presentation] 親疎水ナノ相分離表面での細胞接着/非接着2016

    • Author(s)
      高井まどか
    • Organizer
      表面技術協会第61回『ナノテク部会』研究会
    • Place of Presentation
      東京ビックサイト
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] PMPCポリマーのアミロイド形成抑制効果2016

    • Author(s)
      島内寿徳、岩村美樹、高井まどか、木村幸敬
    • Organizer
      化学工学会第81年会
    • Place of Presentation
      関西大学、千里山キャンパス、吹田市
    • Related Report
      2015 Annual Research Report
  • [Presentation] Stable surface coating of silicone elastomer with phosphorylcholine and organosilane copolymer with cross-linking for medical devices,2015

    • Author(s)
      Koji Nagahashi, Yuji Teramura, Madoka Takai
    • Organizer
      The 4th International Symposium on Materials Science and Surface Technology 2015
    • Place of Presentation
      KGU Kannai Media Center, Yokohama, Japan
    • Year and Date
      2015-08-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cell adhesion behavior on the surface of nano-domain structure by amphiphilic block-copolymers,2015

    • Author(s)
      Madoka Takai
    • Organizer
      International Symposium on Nanoarchitectonics for Mechanobiology
    • Place of Presentation
      Tsukuba, Auditorium WPI-MANA building
    • Year and Date
      2015-07-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ナノ相分離構造を用いた吸着タンパク質の吸着形態による細胞接着挙動2015

    • Author(s)
      平口侑香里、林智広、久代京一郎、高井まどか
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター、札幌
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] セラミックへの防汚性付与を目指した親水性ポリマー表面の創製2015

    • Author(s)
      野口礼、長橋考治、宇都宮健、平本浩二、井須紀文、高井まどか
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター、札幌
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 埋め込みデバイスへの応用を目指したカーボン系材料への生体親和性ポリマー修飾2015

    • Author(s)
      高井まどか、黄士恭、久代京一郎
    • Organizer
      第76回応用物理学会秋季学術講演会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Related Report
      2015 Annual Research Report
  • [Presentation] DNAを介したタンパク質‐ホスホリルコリン基間相互作用の解析2015

    • Author(s)
      東倫之、寺村裕治、星徹、高井まどか
    • Organizer
      第64回高分子討論会
    • Place of Presentation
      東北大学川内キャンパス、仙台
    • Related Report
      2015 Annual Research Report
  • [Presentation] ブロックポリマーを用いたナノドメイン構造表面への細胞接着機構解析2015

    • Author(s)
      平口侑香里、久代京一郎、高井まどか
    • Organizer
      2015年真空・表面化学合同講演会
    • Place of Presentation
      つくば国際会議場、つくば
    • Related Report
      2015 Annual Research Report
  • [Presentation] ナノ相分離構造を用いた吸着タンパク質パターンの違いによる細胞接着挙動変化2015

    • Author(s)
      平口侑香里、久代京一郎、高井まどか
    • Organizer
      バイオテクノロジー&エレクトロニクス研究討論会
    • Place of Presentation
      葉工業大学東京スカイツリータウンキャンパス、東京
    • Related Report
      2015 Annual Research Report
  • [Presentation] ナノ界面構造を制御した医療デバイスの開発2015

    • Author(s)
      高井まどか
    • Organizer
      2015年度、第1回 CAC フォーラム
    • Place of Presentation
      日本化学会、化学会館(神田)
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ナノ相分離構造を用いた吸着タンパク質分布状態による細胞腫非依存の接着メカニズム2014

    • Author(s)
      平口侑香里、久代京一郎、高井まどか
    • Organizer
      第36回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀 東京
    • Year and Date
      2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] A strategy of highly sensitive biosensing based on biocompatible materials2014

    • Author(s)
      Madoka Takai
    • Organizer
      International Symposium on Electrochemical Micro & Nanosystem Technologies 2014
    • Place of Presentation
      International Convention Center, Okinawa
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 血液分析チップの開発に向けた機能性ナノバイオ界面創製2014

    • Author(s)
      高井まどか
    • Organizer
      神奈川R&D推進協議会
    • Place of Presentation
      旭硝子中央研究所
    • Year and Date
      2014-11-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] バイオインターフェース:細胞-マテリアル相互作用2014

    • Author(s)
      高井 まどか
    • Organizer
      表面技術協会 関東支部88回講演会
    • Place of Presentation
      東京医科歯科大学 湯島キャンパスM&Dタワー
    • Year and Date
      2014-10-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 生体親和性高分子による医療用デバイスの機能化、~TEM、AFMによるナノ相分離構造解析~2014

    • Author(s)
      高井まどか
    • Organizer
      2014 EPMA・表面分析ユーザーズミーティング(第33回)
    • Place of Presentation
      東京大学武田先端知ホール
    • Year and Date
      2014-10-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Influenza virus infection induced several cellular changings: sialic acid and proteins of endosome2014

    • Author(s)
      Yukari Miyake, Jaebun Cho, Takahiro Kimura, Madoka Takai, Ayae Honda
    • Organizer
      4th International Influenza Meeting
    • Place of Presentation
      Muenster, Germany
    • Year and Date
      2014-09-21
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of protein adsorption on polymer brush interfaces surface-selective vibrational spectroscopy2014

    • Author(s)
      Tomoyuki Azuma, Hidenori Noguchi, Kohei Uosaki and Madoka Takai
    • Organizer
      IUMRS-ICA2014
    • Place of Presentation
      Fukuoka University, Fukuoka
    • Year and Date
      2014-08-26
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cell Adhesion Behavior on Amphiphilic Block-Copolymer with Different Phase Separation,2014

    • Author(s)
      Madoka Takai
    • Organizer
      The 1st International Conference on Cell Encapsulation
    • Place of Presentation
      Daejeon Korea
    • Year and Date
      2014-07-07
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ナノ構造制御された高分子表面でのタンパク質吸着および細胞接着挙動2014

    • Author(s)
      高井まどか
    • Organizer
      第32回高分子表面研究会講座
    • Place of Presentation
      東京理科大学 森戸記念館
    • Year and Date
      2014-07-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ナノ相分離構造表面上での吸着タンパク質の分布状態による細胞接着挙動変化2014

    • Author(s)
      平口侑香里、長橋考治、柴山崇、林智弘、矢野隆章、久代京一郎、高井まどか
    • Organizer
      第63回高分子学会年次大会
    • Place of Presentation
      名古屋 国際会議場
    • Year and Date
      2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] SPRによるイムノイアッセイを目指したナノ相分離構造による表面修飾2014

    • Author(s)
      千村勇祐、林勝義、井上鈴代、岩崎弦、高井まどか
    • Organizer
      化学とマイクロ・ナノシステム学会 第29回研究会
    • Place of Presentation
      東京 日本女子大
    • Year and Date
      2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] High efficiency separation of protein by microchip electrophoresis using PDMS microchannel modified with charged phospholipid polymer2014

    • Author(s)
      Madoka Takai, Kyosuke Nii, Kenji Sueyoshi, Koji Otsuka
    • Organizer
      HPLC2014
    • Place of Presentation
      New Orleans, Luisiana, USA
    • Year and Date
      2014-05-12
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The effect of nanophase-separated domains prepared by amphiphilic block-copolymer on cell adhesion2013

    • Author(s)
      Madoka Takai, Yukari Hiraguchi, Keiichiro Kushiro
    • Organizer
      ICSE2013
    • Place of Presentation
      Buasn, Korea
    • Year and Date
      2013-11-17 – 2013-11-19
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] FABRICATION OF INTEGRATED MICROPATTERN SENSOR CHIP FOR ANALYSIS OF CELL ADHESION DYNAMICS2013

    • Author(s)
      Chih-Hao Lee, Natsuno Matsui, Madoka Takai
    • Organizer
      MicroTAS 2013
    • Place of Presentation
      Freiburg, GERMANY
    • Year and Date
      2013-10-27 – 2013-10-30
    • Related Report
      2013 Annual Research Report
  • [Presentation] Controlling the orientation of immobilized antibodies by the structure of phaseseparation using amphiphilic block copolymer2013

    • Author(s)
      Yusuke Chimura and Madoka Takai
    • Organizer
      JSAP-MRS Joint Symposia
    • Place of Presentation
      Doshisha Univ., Kyoto, Japan
    • Year and Date
      2013-09-18 – 2013-09-19
    • Related Report
      2013 Annual Research Report
  • [Presentation] Design of Soft-Interface Materials for Bio-Sensing Devices2013

    • Author(s)
      Madoka Takai
    • Organizer
      JSAP-MRS Joint Symposia
    • Place of Presentation
      Doshisha Univ., Kyoto, Japan
    • Year and Date
      2013-09-18 – 2013-09-19
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] High efficiency separation of protein by microchip electrophoresis using PDMS microchannel modified with charged phospholipid polymer2013

    • Author(s)
      Madoka Takai , Kyosuke Nii, Kenji Sueyoshi, Koji Otsuka
    • Organizer
      JASIS Conference
    • Place of Presentation
      Makuhari Messe, Japan
    • Year and Date
      2013-09-05
    • Related Report
      2013 Annual Research Report
  • [Presentation] Interfacial Water Structure by Sum Frequency Generation (SFG) Spectroscopy for Elucidating the Machanism of Suppressing Protein Adsorption2013

    • Author(s)
      Daiki Nagasawa, Hidenori Noguchi, Kohei Uosaki and Madoka Takai
    • Organizer
      The 4th Asian Biomaterials Congress
    • Place of Presentation
      HKUST, Hong Kong
    • Year and Date
      2013-06-27 – 2013-06-28
    • Related Report
      2013 Annual Research Report
  • [Presentation] The Analysis of Sialic Acid Expression on the Cancerous Cell Membrane Based on Fluorescence-labeled Polymeric Nanoparticles2013

    • Author(s)
      Jaebum CHO, Keiichiro Kushiro and Madoka Takai
    • Organizer
      The 4th Asian Biomaterials Congress
    • Place of Presentation
      HKUST, Hong Kong
    • Year and Date
      2013-06-27 – 2013-06-28
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cells Adhesion Behavior by Patterning of Protein Adsorption on Nano-Scale Phase-Separating Surface of Block Copolymer2013

    • Author(s)
      Yukari Hiraguchi, Koji Nagahashi, Takashi Shibayama, Keiichiro Kushiro, Madoka Takai
    • Organizer
      The 4th Asian Biomaterials Congress
    • Place of Presentation
      HKUST, Hong Kong
    • Year and Date
      2013-06-27 – 2013-06-28
    • Related Report
      2013 Annual Research Report
  • [Presentation] Analysis of Initial Cell-Material Interaction using PMPC Brush Micro-patterns2013

    • Author(s)
      Chih-Hao Lee, Natuno Matsui, Madoka Takai
    • Organizer
      The 4th Asian Biomaterials Congress
    • Place of Presentation
      HKUST, Hong Kong
    • Year and Date
      2013-06-27 – 2013-06-28
    • Related Report
      2013 Annual Research Report
  • [Presentation] Soft-interfaces for Improving the Structure and Function of Adsorbed Protein

    • Author(s)
      Madoka Takai, Kenji Takasu
    • Organizer
      SIMS 2013
    • Place of Presentation
      福岡、九州大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規バイオマテリアルを活かしたバイオセンサーの開発

    • Author(s)
      高井まどか
    • Organizer
      第60回応用物理学会春季学術講演会
    • Place of Presentation
      神奈川、神奈川工科大学
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Cell adhesion behaviors on the inverted nanoscale phase-separated structure of block copolymer

    • Author(s)
      Madoka Takai, Takashi Shibayama
    • Organizer
      SIMS 2012
    • Place of Presentation
      つくば、国際会議場
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Effect of phase-separated nanodomain structure on protein adsorption and cell adhesion

    • Author(s)
      Madoka Takai
    • Organizer
      IACIS 2012
    • Place of Presentation
      仙台、仙台国際センター
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 親・疎水性高分子の自己組織化ナノドメイン構造表面へのタンパク質吸着および細胞接着

    • Author(s)
      高井まどか・柴山崇・長橋孝治
    • Organizer
      第61回高分子学会年次大会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effect of monomer sequence of amphiphilic polymer on cell adhesion

    • Author(s)
      Madoka Takai, Takashi Shibayama
    • Organizer
      9th World Biomaterials Congress (WBC)
    • Place of Presentation
      Convention center, Chengdu, China
    • Related Report
      2012 Annual Research Report
  • [Presentation] タンパク質の構造機能維持を実現するバイオインターフェースの創製

    • Author(s)
      高須健司・高井まどか
    • Organizer
      第61回高分子討論会
    • Place of Presentation
      名古屋、名古屋工業大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] チタン酸化物ナノファイバーを用いた直接電子移動型バイオセンサー

    • Author(s)
      高井まどか So-Yoon Lee
    • Organizer
      日本機械学会 第4回マイクロ・ナノ工学シンポジウム
    • Place of Presentation
      北九州、国際会議場
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Phospholipid polymer brush interface preserving the structural function of immobilized protein

    • Author(s)
      K.Takasu and M. Takai
    • Organizer
      ISAWAT-1
    • Place of Presentation
      名古屋、名古屋大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 生体親和性ポリマーブラシを用いた好感度バイオセンシング

    • Author(s)
      高井まどか
    • Organizer
      電子情報通信学会
    • Place of Presentation
      沖縄、沖縄県青年会館
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] バイオマテリアル: その基礎と先端研究への展開2016

    • Author(s)
      岡野光夫監修、田畑泰彦, 塙隆夫編著
    • Total Pages
      354
    • Publisher
      東京化学同人
    • Related Report
      2015 Annual Research Report
  • [Book] すごいぞ!身のまわりの表面科学 ツルツル、ピカピカ、ザラザラの不思議2015

    • Author(s)
      日本表面科学会編
    • Total Pages
      272
    • Publisher
      講談社 ブルーバックス
    • Related Report
      2015 Annual Research Report
  • [Book] 医療・ヘルスケア分野向けエレクトロニクス技術の最新展開, 第5節 血液適合性マテリアルを用いたバイオセンシング技術2014

    • Author(s)
      高井まどか(共著)
    • Total Pages
      7
    • Publisher
      情報機構
    • Related Report
      2014 Annual Research Report
  • [Book] 生体適合性制御と要求特性掌握から実践する高分子バイオマテリアルの設計・開発戦略, 第1節 高分子バイオインターフェースとQCM-Dによる細胞の接着挙動解析2014

    • Author(s)
      高井まどか(共著)
    • Total Pages
      8
    • Publisher
      サイエンス&テクノロジー
    • Related Report
      2014 Annual Research Report
  • [Book] バイオセンシング最前線 バイオセンシングの基礎と応用2013

    • Author(s)
      高井まどか
    • Total Pages
      3
    • Publisher
      Nature Interface
    • Related Report
      2013 Annual Research Report
  • [Book] 問題と解説で学ぶ表面科学2013

    • Author(s)
      高井まどか
    • Total Pages
      1
    • Publisher
      共立出版
    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京大学大学院工学系研究科 高井研究室

    • URL

      http://park.itc.u-tokyo.ac.jp/takai/article/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 高井研究室HP

    • URL

      http://park.itc.u-tokyo.ac.jp/takai/index.html

    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 耐汚染性表面修飾剤、及び表面処理方法2015

    • Inventor(s)
      高井まどか・野口礼・井須紀文・長島理・三浦正嗣
    • Industrial Property Rights Holder
      高井まどか・野口礼・井須紀文・長島理・三浦正嗣
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-08-13
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 相分離構造観察方法2014

    • Inventor(s)
      井上鈴代・岩崎弦・林勝義(NTT)・高井まどか・千村勇祐
    • Industrial Property Rights Holder
      井上鈴代・岩崎弦・林勝義(NTT)・高井まどか・千村勇祐
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-07-28
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 医用材料の表面修飾用ポリマー2013

    • Inventor(s)
      高井まどか、長橋孝治
    • Industrial Property Rights Holder
      高井まどか、長橋孝治
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-09-24
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-15   Modified: 2019-07-29  

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