Basic research of BK-SE36 malaria vaccine clinical study

• Project/Area Number: 24249024
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Parasitology (including Sanitary zoology)
• Research Institution: Osaka University
• Principal Investigator: Horii Toshihiro 大阪大学, 微生物病研究所, 教授 (80142305)
• Co-Investigator(Kenkyū-buntansha): TANABE Kazuyuki 大阪大学, 微生物病研究所, 招へい教授 (40047410) ; TOUGAN Takahiro 大阪大学, 微生物病研究所, 助教 (20379093) ; ARISUE Nobuko 大阪大学, 微生物病研究所, 助教 (00242339) ; YAGI Masanori 大阪大学, 微生物病研究所, 特任研究員 (60452463) ; TAI Kumiko 大阪大学, 微生物病研究所, 教務職員 (00187907)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥43,680,000 (Direct Cost: ¥33,600,000、Indirect Cost: ¥10,080,000); Fiscal Year 2015: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000); Fiscal Year 2014: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000); Fiscal Year 2013: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000); Fiscal Year 2012: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
• Keywords: マラリア / ワクチン / 臨床試験 / SERA / IgGサブクラス / IGGサブクラス

Outline of Final Research Achievements

The follow-up study of the clinical trial in Uganda has shown 72 % protective efficacy against symptomatic malaria. When antibody titers increased over 2 fold and 200 units, no malaria infection has occurred. This project focuses on the mechanisms of vaccine efficacy and obtained the results. 1) Vaccine responders showed boost effect after malaria natural infection 2) Epitope analyses of the human antibodies showed both of the N- terminus and central domain of the SE36 protein are protective. 3) Analyses of SERA5 genes showed very limited genetic polymorphism. 4) Phase Ia clinical trial of SE36 vaccine with the novel adjuvant CpG showed its safety and 4 fold increase of the antibody titers. 5) It is also showed antiserum of the subject has a strong growth inhibitory effect on the parasite growth. 6) We have started I/IIb phase clinical trials of 1-5-year-olds children in Burkina Faso. This trial will be continued until the end of 2016 fiscal year.

Research Products

• [Int'l Joint Research] ブルキナファソ国立マラリア研究センター (CNRFP)(ブルキナファソ)
• [Int'l Joint Research] European Vaccine Initiative (EVI)(ドイツ)
• [Int'l Joint Research] Gulu University/Lacor Hospital(ウガンダ)
• [Journal Article] Corrigendum: Plasmodium berghei ANKA causes intestinal malaria associated with dysbiosis. (2016)
  • Author(s): Taniguchi T, Miyauchi E, Nakamura S, Hirai M, Suzue K, Imai T, Nomura T, Handa T, Okada H, Shimokawa C, Onishi R, Olia A, Hirata J, Tomita H, Ohno H, Horii T, Hisaeda H.
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 17248-17248
  • DOI: 10.1038/srep17248
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Recent advances in recombinant protein-based malaria vaccines. (2015)
  • Author(s): Draper SJ, Angov E, Horii T, Miller LH, Srinivasan P, Theisen M, Biswas S.
  • Journal Title: Vaccine Volume: 33(52) Issue: 52 Pages: 7433-43
  • DOI: 10.1016/j.vaccine.2015.09.093
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Contrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort. (2015)
  • Author(s): Dent AE, Malhotra I, Wang X, Babineau D, Yeo KT, Anderson T, Kimmel RJ, Angov E, Lanar DE, Narum D, Dutta S, Richards J, Beeson JG, Crabb BS, Cowman AF, Horii T, Muchiri E, Mungai PL, King CL, Kazura JW.
  • Journal Title: Clin Vaccine Immunol. Volume: 23(2) Issue: 2 Pages: 104-116
  • DOI: 10.1128/cvi.00452-15
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Plasmodium berghei ANKA causes intestinal malaria associated with dysbiosis (2015)
  • Author(s): Taniguchi T, Miyauchi E, Nakamura S, Hirai M, Suzue K, Imai T, Nomura T, Handa T, Okada H, Shimokawa C, Onishi R, Olia A, Hirata J, Tomita H, Ohno H, Horii T, Hisaeda H
  • Journal Title: Scientific Reports Volume: 5:15699 Issue: 1 Pages: 1-12
  • DOI: 10.1038/srep15699
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Contrasting infection susceptibility of the Japanese macaques and cynomolgus macaques to closely related malaria parasites, Plasmodium vivax and Plasmodium cynomolgi. (2014)
  • Author(s): Tachibana SI, Kawai S, Katakai Y, Takahashi H, Nakade T, Yasutomi Y, Horii T, Tanabe K.
  • Journal Title: Parasitol Int. Volume: S1383-5769 Issue: 3 Pages: 140-148
  • DOI: 10.1016/j.parint.2014.10.004
  • Peer Reviewed / Open Access
• [Journal Article] Protective epitopes of the Plasmodium falciparum SERA5 malaria vaccine reside in intrinsically unstructured N-terminal repetitive sequences. (2014)
  • Author(s): Yagi M, Bang G, Tougan T, Palacpac NM, Arisue N, Aoshi T, Matsumoto Y, Ishii KJ, Egwang TG, Druilhe P, Horii T.
  • Journal Title: PLoS One Volume: 9 Issue: 6 Pages: e98460-e98460
  • DOI: 10.1371/journal.pone.0098460
  • Peer Reviewed / Open Access
• [Journal Article] Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria. (2014)
  • Author(s): H. Zhao, T. Aoshi, S. Kawai, Y. Mori, A. Konishi, M. Ozkan, Y. Fujita, Y. Haseda, M. Shimizu, M. Kohyama, K. Kobiyama, K. Eto, J. Nabekura, T. Horii, T. Ishino, M. Yuda, H. Hemmi, T. Kaisho, S. Akira, M. Kinoshita, K. Tohyama, Y. Yoshioka, K. J. Ishii, C. Coban
  • Journal Title: Cell Host Microbe Volume: 15 Issue: 5 Pages: 551-563
  • DOI: 10.1016/j.chom.2014.04.008
  • Peer Reviewed / Open Access
• [Journal Article] Hematological and biochemical data obtained in rural northern Uganda. (2014)
  • Author(s): Nirianne M. Q. Palacpac, Edward Ntege, Betty Balikagala, Adoke Yeka, Hiroki Shirai, Nahoko Suzuki, Christopher Nsereko, Bernard Kanoi, Takuya Okada, Thomas G. Egwang, Toshihiro Horii
  • Journal Title: IJERPH Volume: 11 Issue: 5 Pages: 4870-4885
  • DOI: 10.3390/ijerph110504870
  • Peer Reviewed / Open Access
• [Journal Article] Characteristic age distribution of Plasmodium vivax infections after malaria elimination on Aneityum Island, Vanuatu (2014)
  • Author(s): Kaneko A, Chaves LF, Taleo G, Kalkoa M, Drakeley C, Bjorkman A, Troye-Blomberg M, Tachibana S-I, Tanabe K
  • Journal Title: Infect Immun. Volume: 82 Issue: 1 Pages: 243-252
  • DOI: 10.1128/iai.00931-13
  • Peer Reviewed
• [Journal Article] Ordered accumulation of mutations conferring resistance to sulfadoxine-pyrimethamine in the Plasmodium falciparum parasite. (2014)
  • Author(s): Mita T*, Ohashi J, Venkatesan M, Marma AS., Plowe, CV, Tanabe, K.
  • Journal Title: J Infect Dis Volume: 209 Issue: 1 Pages: 130-139
  • DOI: 10.1093/infdis/jit415
  • Peer Reviewed
• [Journal Article] Plasmodium falciparum: Genetic diversity and complexity of infections in an isolated village in western Thailand (2013)
  • Author(s): K. Tanabe, G. Zollner, J. A. Vaughan, J. Sattabongkot, B. Khuntirat, H. Honma, T. Mita, T. Tsuboi and R. Coleman
  • Journal Title: Parasitol Int Volume: pii: S1383-5769(13) Issue: 3 Pages: 142-146
  • DOI: 10.1016/j.parint.2013.09.011
  • Peer Reviewed / Open Access
• [Journal Article] Plasmodium falciparum mitochondrial genetic diversity exhibits isolation-by-distance patterns supporting a sub-Saharan African origin. (2013)
  • Author(s): Tanabe K, Jombart T, Horibe S, Palacpac N, Honma H, Tachibana S, Nakamura M, Horii T, Kishinod H, Mita T*.
  • Journal Title: Mitochondrion Volume: 13 Issue: 6 Pages: 630-636
  • DOI: 10.1016/j.mito.2013.08.008
  • Peer Reviewed
• [Journal Article] Endemic Burkitt lymphoma is associated with strength and diversity of Plasmodium falciparummalaria stage-specific antigen antibody response (2013)
  • Author(s): Aka P, Vila MC, Jariwala A, Nkrumah F, Emmanuel B, Yagi M, Palacpac NM, Periago MV, Neequaye J, Kiruthu C, Tougan T, Levine PH, Biggar RJ, Pfeiffer RM, Bhatia K, Horii T, Bethony JM, Mbulaiteye SM
  • Journal Title: Blood Volume: 122(5) Issue: 5 Pages: 629-635
  • DOI: 10.1182/blood-2012-12-475665
  • Peer Reviewed
• [Journal Article] Phase 1b randomized trial and follow-up study in Uganda of the blood-stage malaria vaccine candidate BK-SE36. (2013)
  • Author(s): Palacpac N.M.Q., Ntege E., Yeka A. Balikagala B., Suzuki N., Shirai H., Yagi M., Ito K., Fukushima W., Hirota Y., Nsereko C., Okada T., Kanoi B.N., Tetsutani K., Arisue N., Itagak S., Tougan T., Ishii K.J., Ueda S., Egwang T.G., and Horii T.
  • Journal Title: PLoS ONE. Volume: 8(5) Issue: 5 Pages: e64073-e64073
  • DOI: 10.1371/journal.pone.0064073
  • Peer Reviewed
• [Journal Article] Association of naturally acquired IgG antibodies against Plasmodium falciparum serine repeat antigen-5 with reduced placental parasitemia and increased birth weight in pregnant Ugandan women: A pilot study. (2013)
  • Author(s): Owalla TJ, Palacpac NM, Shirai H, Horii T, Egwang TG.
  • Journal Title: Parasitol Int. Volume: 62(3) Issue: 3 Pages: 237-239
  • DOI: 10.1016/j.parint.2013.01.006
  • Peer Reviewed
• [Journal Article] Within-population genetic diversity of Plasmodium falciparum vaccine candidate antigens reveals geographic distance from a Central sub-Saharan African origin. (2013)
  • Author(s): Tanabe K., Mita T., Palacpac N., Arisue N., Tougan T., Kawai S.,Jombart T., Kobayashi F., Horii T.
  • Journal Title: Vaccine Volume: 31 Issue: 9 Pages: 1334-9
  • DOI: 10.1016/j.vaccine.2012.12.039
  • Peer Reviewed
• [Journal Article] TLR9 adjuvants enhance immunogenicity and protective efficacy of the SE36/AHG malaria vaccine in nonhuman primate models (2013)
  • Author(s): Tougan T, Aoshi T, Coban C, Katakai Y, Kai C, Yasutomi Y, Ishii KJ, Horii T
  • Journal Title: Hum Vaccin Immunother Volume: 9(2) Issue: 2 Pages: 283-290
  • DOI: 10.4161/hv.22950
  • Peer Reviewed
• [Journal Article] Lipocalin 2 bolsters innate and adaptive immune responses to blood-stage malaria infection by reinforcing host iron metabolism. (2012)
  • Author(s): Hong Zhao
  • Journal Title: Cell Host & Microbe Volume: 12 Issue: 5 Pages: 705-716
  • DOI: 10.1016/j.chom.2012.10.010
  • Peer Reviewed
• [Journal Article] The in silico screening and X-ray structure analysis of the inhibitor complex of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase. (2012)
  • Author(s): Takashima Y, Mizohata E, Krungkrai SR, Fukunishi Y, Kinoshita T, Sakata T, Matsumura H, Krungkrai J, Horii T, Inoue T.
  • Journal Title: J Biochem. Volume: 152(2) Issue: 2 Pages: 133-138
  • DOI: 10.1093/jb/mvs070
  • NAID: 10031166122
  • Peer Reviewed
• [Journal Article] Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade (2012)
  • Author(s): S-I.Tachibana, et al.
  • Journal Title: Nature Genetics Volume: 44(9) Issue: 9 Pages: 1051-1055
  • DOI: 10.1038/ng.2407
  • Peer Reviewed
• [Presentation] BK-SE36/CpGマラリアワクチンの臨床開発 (2016)
  • Author(s): 堀井 俊宏
  • Organizer: 第85回日本寄生虫学会大会
  • Place of Presentation: 宮崎市民プラザ（宮崎県宮崎市）
  • Year and Date: 2016-03-19
• [Presentation] マラリア原虫感染赤血球における血清タンパク質の取り込みメカニズムの解明 (2016)
  • Author(s): 東岸 任弘
  • Organizer: 第85回日本寄生虫学会大会
  • Place of Presentation: 宮崎市民プラザ（宮崎県宮崎市）
  • Year and Date: 2016-03-19
• [Presentation] BK-SE36 malaria vaccine candidate for young children (2016)
  • Author(s): Toshihiro Horii
  • Organizer: Symposium for Promotion of science and technology cooperation between Africa and Japan and Symposium for Innovate Network for Pan-African Surveillance of NTD and Infectious Diseases Program
  • Place of Presentation: Weston Hotel, Nairobi, Kenya
  • Year and Date: 2016-01-14
• [Presentation] Clinical Development of BK-SE36 malaria vaccine (2015)
  • Author(s): 堀井 俊宏
  • Organizer: 第56回日本熱帯学会大会
  • Place of Presentation: 大阪大学コンベンションセンター（大阪府吹田市）
  • Year and Date: 2015-12-04
  • Invited
• [Presentation] マラリア原虫の寄生戦略の新規解析法の開発 (2015)
  • Author(s): 東岸 任弘
  • Organizer: BMB2015（第38回日本分子生物学会年会・第88回日本生化学会大会・合同大会）
  • Place of Presentation: 神戸ポートアイランド（兵庫県神戸市）
  • Year and Date: 2015-12-01
• [Presentation] Identification and characterization of host proteins associated with N-terminal domain (P47) of SERA5 of P. falciparum (2015)
  • Author(s): 東岸 任弘
  • Organizer: 感染症若手フォーラム 2015
  • Place of Presentation: アテーナ海月（兵庫県淡路市）
  • Year and Date: 2015-09-06
• [Presentation] サルマラリア原虫Plasmodium gonderiのゲノム解析－マラリア原虫の系統関係解明に向けて－ (2015)
  • Author(s): 有末 伸子
  • Organizer: 第23回分子寄生虫学ワークショップ&第13回分子寄生虫・マラリア研究フォーラム
  • Place of Presentation: 帯広畜産大学（北海道帯広市）
  • Year and Date: 2015-08-30
• [Presentation] BK-SE36 malaria vaccine candidate for young children (2015)
  • Author(s): Toshihiro Horii
  • Organizer: Malaria R&D in a Time of Global Partnerships
  • Place of Presentation: 東京大学（東京都）
  • Year and Date: 2015-06-26
  • Invited
• [Presentation] ワクチン候補抗原 SERA5 結合タンパク質の同定とその解析 (2015)
  • Author(s): 東岸 任弘、堀井 俊宏
  • Organizer: 第84回日本寄生虫学会大会
  • Place of Presentation: 東京
  • Year and Date: 2015-03-22 – 2015-03-23
• [Presentation] 赤血球期ステージマラリアワクチンBK-SE36のウガンダにおける臨床開発 (2014)
  • Author(s): 堀井 俊宏
  • Organizer: 第55回日本熱帯医学会大会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-01 – 2014-11-03
  • Invited
• [Presentation] Clinical Development of Blood-stage Malaria Vaccine BK=SE36 in Ugand (2014)
  • Author(s): T. Horii and T.G, Egwang
  • Organizer: 2014SASA ANNUAL MEETING
  • Place of Presentation: Kampala, Uganda
  • Year and Date: 2014-05-06 – 2014-05-10
• [Presentation] Worldwide Distribution of Polymorphisms Associated with Delayed Clearance of Malaria Parasites Following Arteminsinin-Based Combination Therapy (2014)
  • Author(s): T. Mita, M. Sakurai, S. Yatsushiro, M. Kataoka and T. Horii
  • Organizer: 2014SASA ANNUAL MEETING
  • Place of Presentation: Kampala, Uganda
  • Year and Date: 2014-05-06 – 2014-05-10
• [Presentation] マラリアワクチンBK-SE36に対する抗体応答と感染・発症防御効果の解析 (2014)
  • Author(s): 八木 正典、Nirianne M. Q. Palacpac、東岸 任弘、伊藤 一弥、Betty Balikagala、Edward Ntege、Adoke Yeka、Bernard N. Kanoi、Osbert Katuro、白井 宏樹、福島 若葉、廣田 良夫、Thomas G. Egwang、堀井 俊宏
  • Organizer: 第83回日本寄生虫学会大会
  • Place of Presentation: 松山市
• [Presentation] アピコプラストゲノムにコードされた30タンパク遺伝子配列に基づくマラリア原虫の進化系統解析 (2014)
  • Author(s): 有末伸子、橋本哲男、川合 覚、田邊和裄、堀井俊宏
  • Organizer: 第83回日本寄生虫学会大会
  • Place of Presentation: 松山市
• [Presentation] 熱帯熱マラリア原虫SERA5のN末端反復配列は天然変性の特徴をもつ防御エピトープである (2013)
  • Author(s): 八木 正典、Gilles Bang、有末 伸子、東岸 任弘、Nirianne M.Q. Palacpac、青枝 大貴、石井 健、Thomas G. Egwang、Pierre Druilhe、堀井 俊宏
  • Organizer: 第11回分子寄生虫マラリア研究フォーラム
  • Place of Presentation: 長崎市
• [Presentation] SE36 マラリアワクチン抗原遺伝子sera5の多型解析 (2013)
  • Author(s): 有末伸子, Nirianne M. Q. Palacpac, 八木正典, 東岸任弘, Betty Balikagala, Adoke Yeka, Edward Ntege, Bernard Kanoi, Katuro Osbert, Tom Egwang, 堀井俊宏
  • Organizer: 第11回分子寄生虫マラリア研究フォーラム
  • Place of Presentation: 長崎市
• [Presentation] N-terminal repetitive sequences of Plasmodium falciparum SERA5 are malaria protective epitopes with an intrinsically unstructured nature in Ugandan adults (2013)
  • Author(s): Masanori Yagi, Gilles Bang, Nobuko Arisue, Takahiro Tougan, Nirianne M.Q. Palacpac, Taiki Aoshi, Ken J. Ishii, Thomas G. Egwang, Pierre Druilhe, Toshihiro Horii
  • Organizer: The 12th Awaji International Forum on Infection and Immunity
  • Place of Presentation: 淡路市
• [Presentation] No allele specific immune response to Plasmodium falciparum SERA5 in participants that experienced malaria infection during the BK-SE36 malaria vaccine trial. (2013)
  • Author(s): Nobuko Arisue, Nirianne M. Q. Palacpac, Masanori Yagi, Takahiro Tougan, Betty Balikagala Adoke Yeka, Edward Ntege, Bernard Kanoi, Katuro Osbert, Tom Egwang and Toshihiro Horii
  • Organizer: The 12th Awaji International Forum on Infection and Immunity
  • Place of Presentation: 淡路市
• [Presentation] African HLA genes in a population that participated in the Phase 1b trial of BK-SE36 (2013)
  • Author(s): Takahiro Tougan, Nirianne Q. Palacpac, Masanori Yagi, Thomas G Egwang and Toshihiro Horii
  • Organizer: The 12th Awaji International Forum on Infection and Immunity
  • Place of Presentation: 淡路市
• [Presentation] A blood-stage vaccine clinical trial and follow-up study in Uganda: The promise of BK-SE36 (2013)
  • Author(s): Nirianne Marie Q. Palacpac, Edward Ntege, Betty Balikagala, Adoke Yeka, Nahoko Suzuki, Hiroki Shirai, Kazuya Ito, Masanori Yagi, Christopher Nsereko, Bernard Kanoi, Takuya Okada, Kohhei Tetsutani, Wakaba Fukushima, Yoshio Hirota, Nobuko Arisue, Sawako Itagaki and Toshihiro Horii
  • Organizer: The 12th Awaji International Forum on Infection and Immunity
  • Place of Presentation: 淡路市
• [Presentation] Development of SE36 malaria vaccine 3: Immunogenicity of SE36 and boosting effect following natural infection (2013)
  • Author(s): Masanori YAGI, Nirianne M. Q. PALACPAC, Takahiro TOUGAN,Nobuko ARISUE, Toshihiro HORII
  • Organizer: Forum Cheju-16
  • Place of Presentation: ソウル
• [Presentation] Polymorphism of the Plasmodium falciparum sera5 gene. (2013)
  • Author(s): Nobuko ARISUE, Nirianne M. Q. PALACPAC, Masanori YAGI, Takahiro TOUGAN, Betty BALIKAGALA, Adoke YEKA, Edward NTEGE, Bernard KANOI, Katuro OSBERT, Tom EGWANG, Toshihiro HORII
  • Organizer: Forum Cheju-16
  • Place of Presentation: ソウル
• [Presentation] African HLA genes in a population that participated in the Phase 1b trial of BK-SE36 (2013)
  • Author(s): Takahiro Tougan, Nirianne Q. Palacpac, Masanori Yagi, Thomas G Egwang and Toshihiro Horii
  • Organizer: Forum Cheju 16
  • Place of Presentation: ソウル
• [Presentation] Development of SE36 malaria vaccine 2: Phase1b clinical trial and follow-up research in Uganda for BK-SE36 malaria vaccine (2013)
  • Author(s): Nirianne Q. Palacpac, Takahiro Tougan, Masanori Yagi, Thomas G Egwang and Toshihiro HoriiNirianne Q. Palacpac, Takahiro Tougan, Masanori Yagi, Thomas G Egwang and Toshihiro Horii
  • Organizer: Forum Cheju 16
  • Place of Presentation: ソウル
• [Presentation] Malaria: Innovating prophylactic vaccine pipeline for tropical infectious diseases -Clinical Development of SE36 Malaria Vaccine- (2013)
  • Author(s): Toshihiro Horii
  • Organizer: World Vaccine Congress Asia 2013
  • Place of Presentation: シンガポール
• [Presentation] 次世代SE36マラリアワクチンの開発と実用化：モデル動物としてのカニクイザル・リスザルの利用 (2013)
  • Author(s): 東岸任弘、青枝大貴、Cevayir Coban、片貝祐子、保富康宏、甲斐知恵子、石井健、堀井俊宏
  • Organizer: 第60回日本実験動物学会総会
  • Place of Presentation: つくば市
• [Presentation] The Phase 1b clinical trial in Uganda for the blood-stage malaria vaccine candidate BK-SE36. (2013)
  • Author(s): T. Horii, N.M.Q. Palacpac, A.Yeka, H.Shirai, E.Ntege, N.Suzuki B.Balikagala, T.Okada, T.Kohhei, S.Ueda, K.J.Ishii, T.G.Egwang
  • Organizer: アジア・アフリカリサーチフォーラム
  • Place of Presentation: 東京都文京区／日本
• [Presentation] 抗SE36抗体の誘導とマラリア抵抗性に関与する遺伝的バックグラウンドの研究 (2013)
  • Author(s): 東岸任弘、Nirianne Q. Palacpac、八木正典、中村昇太、後藤和義、Thomas G. Egwang、堀井俊宏
  • Organizer: 感染症若手フォーラム 2013
  • Place of Presentation: 北海道北広島市/日本
• [Presentation] 新規アジュバント添加による次世代SE36マラリアワクチンの開発と実用化：旅行者用ワクチンへのアプローチ (2013)
  • Author(s): 東岸任弘、青枝大貴、Coban Cevayir、片貝祐子、甲斐知恵子、保富康宏、石井健、堀井俊宏
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 神奈川県横浜市/日本
• [Presentation] 抗SE36抗体の誘導とマラリア抵抗性に関与する遺伝的バックグラウンドの研究 (2013)
  • Author(s): 東岸任弘、ニリアン・Q・パラックパック、八木正典、中村昇太、後藤和義、トーマス・G・エグワン、堀井俊宏
  • Organizer: 第82回日本寄生虫学会大会
  • Place of Presentation: 東京都文京区/日本
• [Presentation] マラリア原虫の抗原遺伝子seraの多型解析 (2013)
  • Author(s): 有末伸子、田邊和裄、Nirianne M. Q. Palacpac、堀井俊宏
  • Organizer: 第82回寄生虫学会大会
  • Place of Presentation: 東京都文京区／日本
• [Presentation] Immunogenicity of SE36 and boosting effect following infection in a clinical trial in Uganda (2013)
  • Author(s): Masanori Yagi, Nirianne Marie Q. Palacpac, Hiroki Shirai, Nobuko Arisue, Sawako Itagaki, Takahiro Tougan, Ken J. Ishii, Thomas Egwang, Toshihiro Horii
  • Organizer: アジア・アフリカリサーチフォーラム
  • Place of Presentation: 東京都文京区／日本
• [Presentation] ウガンダにおけるマラリアワクチンBK-SE36第Ib相臨床試験での抗体応答と自然感染後のブースト効果についての解析 (2013)
  • Author(s): 八木正典、Nirianne M. Q. Palacpac、白井宏樹、有末伸子、板垣佐和子、東岸任弘、石井健、Thomas G. Egwang、堀井俊宏
  • Organizer: 感染症若手フォーラム2013
  • Place of Presentation: 北海道北広島市／日本
• [Presentation] ウガンダにおけるマラリアワクチンBK-SE36第Ib相臨床試験での抗体応答とマラリア感染後のブースト効果についての解析 (2013)
  • Author(s): 八木正典、Nirianne M. Q. Palacpac、白井宏樹、有末伸子、板垣佐和子、東岸任弘、石井健、Thomas G. Egwang、堀井俊宏
  • Organizer: 第82回日本寄生虫学会大会
  • Place of Presentation: 東京都文京区／日本
• [Presentation] マラリア原虫のアキレス腱を標的とするSE36 マラリアワクチン開発 (2012)
  • Author(s): 堀井俊宏
  • Organizer: 第60回 日本化学療法学会学術集会／第86回日本感染症学会学術集会
  • Place of Presentation: 長崎県長崎市／日本
  • Invited
• [Presentation] Safety and protection of BK-SE36 malaria vaccine in the phase 1B trial in Uganda (2012)
  • Author(s): Toshihiro Horii
  • Organizer: 8TH WORLD CONGRESS ON VACCINES, IMMUNISATION AND IMMUNOTHERAPY, WCVII2012 Spain
  • Place of Presentation: Barcelona, Spain
• [Presentation] ウガンダで実施した BK-SE36 マラリアワクチン臨床試験における安全性と効果に ついて (2012)
  • Author(s): 堀井俊宏
  • Organizer: 第16回日本ワクチン学会学術集会
  • Place of Presentation: 神奈川県横浜市/日本
• [Presentation] Learning from interfacing studies on SE36: a candidate malaria vaccine that targets the Achilles’ heel antigen of Plasmodium falciparum. (2012)
  • Author(s): Toshihiro Horii and Thomas G. Egwang
  • Organizer: KEYSTONE SYMPOSIA, Immunological Mechanisum of Vaccine
  • Place of Presentation: Otawa, Canada
• [Presentation] Squirrel monkey has a single IgG and no IgG subclasses (2012)
  • Author(s): Takahiro Tougan, Shota Nakamura, Chin-Heng Paku, Yuko Katakai, Yasuhiro Yasutomi, Taro Tachibana and Toshihiro Horii
  • Organizer: 5th International CVRDC-RIMD Joint Symposium
  • Place of Presentation: 済州島/韓国
• [Presentation] リスザルは1種類のIgGを持ち、サブクラスを持たない (2012)
  • Author(s): 東岸任弘、中村昇太、朴辰幸、片貝祐子、保富康宏、立花太郎、堀井俊宏
  • Organizer: NGS現場の会 第２回研究会
  • Place of Presentation: 大阪府吹田市/日本
• [Presentation] リスザルは1種類のIgGを持ち、サブクラスを持たない (2012)
  • Author(s): 東岸任弘、中村昇太、朴辰幸、片貝祐子、保富康宏、立花太郎、堀井俊宏
  • Organizer: 日本実験動物科学・技術・九州 2012
  • Place of Presentation: 大分県別府市/日本
• [Presentation] Absence of antigenic variation and limited polymorphism makes Plasmodium falciparum SERA5 a promising vaccine. Nobuko Arisue (2012)
  • Author(s): Nobuko Arisue
  • Organizer: Forum Cheju 15,Current Trends in Parasitology Research in Japan and Korea
  • Place of Presentation: 宮崎県、青島市／日本
• [Presentation] Absence of antigenic variation and limited polymorphism makes Plasmodium falciparum SERA5 a promising vaccine (2012)
  • Author(s): Nobuko Arisue, Nirianne M. Q. Palacpac, Kazuyuki Tanabe, Toshihiro Horii
  • Organizer: The 11th Awaji International Forum on Infection and Immunity
  • Place of Presentation: 兵庫県淡路市／日本
• [Presentation] アピコプラストゲノムに基づくヒトマラリア原虫の系統的位置の推測 (2012)
  • Author(s): 有末伸子、橋本哲男、川合 覚、田邊和裄、堀井俊宏
  • Organizer: 第７２回日本寄生虫学会東日本支部会／第１０回分子寄生虫マラリアフォーラム
  • Place of Presentation: 群馬県前橋市／日本
• [Presentation] Immunogenicity of SE36 and boosting effect following infection in a clinical trial in Uganda (2012)
  • Author(s): M.Yagi, N.M.Q.Palacpac, E.Ntege, A.Yeka, B.Balikagala, N.Suzuki, H.Shirai, C.Nsereko, T.Okada, K.Tetsutani, N.Arisue, S.Itagaki, T.Tougan, K.J. .Ishii, S.Ueda, T.G. .Egwang, T.Horii
  • Organizer: 第11回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 兵庫県淡路市／日本
• [Presentation] ウガンダにおけるマラリアワクチンBK-SE36第Ib相臨床試験での抗体応答とマラリア感染後のブースト効果についての解析 (2012)
  • Author(s): 八木正典、Nirianne Marie Q. Palacpac、白井宏樹、有末伸子、板垣佐和子、東岸任弘、石井健、Thomas Egwang、堀井俊宏
  • Organizer: 第72回日本寄生虫学会東日本支部会・第10回分子寄生虫マラリアフォーラム合同大会
  • Place of Presentation: 群馬県前橋市／日本
• [Remarks] 大阪大学微生物病研究所
  • URL: http://www.biken.osaka-u.ac.jp
• [Remarks] 大阪大学微生物病研究所分子原虫学分野
  • URL: http://www.biken.osaka-u.ac.jp/lab/protozool/index.html
• [Remarks] 大阪大学微生物病研究所
  • URL: http://www.biken.osaka-u.ac.jp/index.html
• [Remarks] 大阪大学微生物病研究所 分子原虫学分野
  • URL: http://www.biken.osaka-u.ac.jp/lab/protozool/
• [Remarks] 大阪大学微生物病研究所
  • URL: http://www.biken.osaka-u.ac.jp/index.html
• [Remarks] 大阪大学微生物病研究所難治感染症対策研究センター 分子原虫学分野
  • URL: http://www.biken.osaka-u.ac.jp/lab/protozool/
• [Remarks] 大阪大学微生物病研究所
  • URL: http://www.biken.osaka-u.ac.jp/index.html
• [Remarks] 大阪大学微生物病研究所分子原虫学分野
  • URL: http://www.biken.osaka-u.ac.jp/lab/protozool/index.html
• [Patent(Industrial Property Rights)] 新規マラリアワクチン (2012)
  • Inventor(s): 堀井 俊宏、石井 健、東岸 任弘
  • Industrial Property Rights Holder: 堀井 俊宏、石井 健、東岸 任弘
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-04-30
  • Acquisition Date: 2015-05-22