Molecular characterization of Colitis Associated Cancer

• Project/Area Number: 24249046
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Keio University
• Principal Investigator: HIBI Toshifumi 慶應義塾大学, 医学部, 名誉教授 (50129623)
• Co-Investigator(Kenkyū-buntansha): HARUHIKO Ogata 慶應義塾大学, 医学部, 教授 (30177117) ; TAKANORI Kanai 慶應義塾大学, 医学部, 教授 (40245478) ; TOSHIRO Sato 慶應義塾大学, 医学部, 特任准教授 (70365245)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000); Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2012: ¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
• Keywords: 下部消化管学 / 下部消化管 / 潰瘍性大腸炎 / 幹細胞 / 大腸がん / 大腸癌

Outline of Final Research Achievements

Inflammatory bowel disease is characterized by chronic mucosal inflammation and the number of patients are increasing in our country. Duration of disease is positively correlated to the occurrence of colorectal cancer, which is referred to as Colitis associated cancer (CAC). CAC exhibit different clinical features and therapeutic response in comparison to sporadic colorectal cancer. To elucidate carcinogenic mechanism for CAC, we attempted to establish organoids from CAC. We established 6 CAC organoids and performed gene expression microarray analysis, exome analysis and copy number variation analysis. We observed less frequent mutations in APC and higher prevalence of TP53 mutations in CAC as compared to sporadic colorectal cancer. The established CAC organoids and their molecular characterization data can be useful resource for basic and translational research for CAC.

Research Products

• [Journal Article] TGF-β1 in tumor microenvironments induces immunosuppression in the tumors and sentinel lymph nodes and promotes tumor progression (2014)
  • Author(s): Nakamura S, Yaguchi T, Kawamura N, Kobayashi A, Sakurai T, Higuchi H, Takaishi H, Hibi T, Kawakami Y
  • Journal Title: J Immunother Volume: 37(2) Issue: 2 Pages: 63-72
  • DOI: 10.1097/cji.0000000000000011
  • Peer Reviewed / Open Access
• [Journal Article] Macrophages and dendritic cells emerge in the liver during intestinal inflammation and predjspose the liver to inflammation. (2014)
  • Author(s): Mikami Y, Mizuno S, Nakamoto N, Hayashi A, Sujino T, Sato T, Kamada N, Matsuoka K, Hisamatsu T, Ebinuma H, Hibi T, Yoshimura A, Kanai T.
  • Journal Title: PLoS One Volume: 9 Issue: 1 Pages: 1-1
  • DOI: 10.1371/journal.pone.0084619
  • Peer Reviewed
• [Journal Article] Use of capsule endoscopy in patients with Crohn's disease in Japan: a multicenter survey. (2014)
  • Author(s): Esaki M, Matsumoto T, Watanabe K, Arakawa T, Naito Y, Matsuura M, Nakase H, Hibi T, Matsumoto T, Nouda S, Higuchi K, Ohmiya N, Goto H, Kurokawa S, Motoya S, Watanabe M.
  • Journal Title: J Gastroenterol Hepatol Volume: 29(1) Issue: 1 Pages: 96-101
  • DOI: 10.1111/jgh.12411
  • Peer Reviewed
• [Journal Article] Endoscopic imaging of parasites in the human digestive tract. (2014)
  • Author(s): Hosoe N, Ogata H, Hibi T.
  • Journal Title: Parasitol Int Volume: 63(1) Issue: 1 Pages: 216-20
  • DOI: 10.1016/j.parint.2013.08.003
  • Peer Reviewed
• [Journal Article] The 2nd edition of consensus statements for the diagnosis and management of intestinal Behcet's disease: indication of anti-TNFα monoclonal antibodies. (2014)
  • Author(s): Hisamatsu T, Ueno F, Matsumoto T, Kobayashi K, Koganei K, Kunisaki R, Hirai F,Nagahori M, Matsushita M, Kobayashi K, Kishimoto M, Takeno M, Tanaka M, Inoue N, Hibi T.
  • Journal Title: J Gastroenterol Volume: 49(1) Issue: 1 Pages: 156-62
  • DOI: 10.1007/s00535-013-0872-4
  • Peer Reviewed
• [Journal Article] Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice (2014)
  • Author(s): Tomita, K. Teratani, T. Suzuki, T. Shimizu, M. Sato, H. Narimatsu, K. Okada, Y. Kurihara, C. Irie, R. Yokoyama, H. Shimamura, K. Usui, S. Ebinuma, H. Saito, H. Watanabe, C. Komoto, S. Kawaguchi, A. Nagao, S. Sugiyama, K. Hokari, R. Kanai, T. Miura, S. Hibi, T.
  • Journal Title: Hepatology Volume: 59 Issue: 1 Pages: 154-169
  • DOI: 10.1002/hep.26604
  • Peer Reviewed
• [Journal Article] Efficacy and safety of adalimumab in Japanese patients with moderately to severely active ulcerative colitis. (2014)
  • Author(s): Suzuki Y,Motoya S,Hanai H,Matsumoto T,Hibi T,Robinson AM,Mostafa NM,Chao J,Arora V,Camez A,Thakkar RB,Watanabe M.
  • Journal Title: J Gastroenterol Volume: 49 Issue: 2 Pages: 283-94
  • DOI: 10.1007/s00535-013-0922-y
  • Peer Reviewed
• [Journal Article] A large-scale,prospective,observational study of leukocytapheresis for ulcerative colitis:treatment outcomes of 847 patients in clinical practice (2014)
  • Author(s): Yokoyama Y, Matsuoka K, Kobayashi T, Sawada K, Fujiyoshi T, Ando T, Ohnishi Y, Ishida T, Oka M, Yamada M, Nakamura T, Ino T, Numata T, Aoki H, Sakou J, Kusada M, Maekawa T, Hibi T.
  • Journal Title: Journal of Crohn's and Colitis Volume: 8 Issue: 9 Pages: 981-91
  • DOI: 10.1016/j.crohns.2014.01.027
  • Peer Reviewed
• [Journal Article] Modified bowel preparation regimen for use in second-generation colon capsule endoscopy in patients with ulcerative colitis (2014)
  • Author(s): Usui S, Hosoe N, Matsuoka K, Kobayashi T, Nakano M, Naganuma M, Ishibashi Y, Kimura K, Yoneno K, Kashiwagi K, Hisamatsu T, Inoue N, Serizawa H, Hibi T, Ogata H, Kanai T.
  • Journal Title: Digestive Endoscopy Volume: 26(5) Issue: 5 Pages: 665-72
  • DOI: 10.1111/den.12269
  • Peer Reviewed
• [Journal Article] Surveillance using trimodal imaging endoscopy after endoscopic submucosal dissection for superficial gastric neoplasia. (2014)
  • Author(s): Imaeda H, Hosoe N, Kashiwagi K, Ida Y, Nakamura R, Suzuki H, Saito Y, Yahagi N, Iwao Y, Kitagawa Y, Hibi T, Ogata H, Kanai T.
  • Journal Title: World Journal of Gastroenterology Volume: 20(43) Issue: 43 Pages: 16311-7
  • DOI: 10.3748/wjg.v20.i43.16311
  • Peer Reviewed / Open Access
• [Journal Article] Continuous low-dose irradiation by I-125 seeds induces apoptosis of gastric cancer cells regardless of histological origin. (2013)
  • Author(s): Takabayashi K, Kashiwagi K, Kawata T, Sato T, Matsuoka K, Hisamatsu T, Takaishi H, Hibi T, Ogata H, Yahagi N, Kitagawa Y, Shigematsu N, Kanai T.
  • Journal Title: Cancer Biol Ther. Volume: 15(1) Issue: 1 Pages: 81-8
  • DOI: 10.4161/cbt.26610
  • Peer Reviewed
• [Journal Article] Subcutaneous golimumab induces clinical response and remission in patients with moderate-to-severe ulcerative colitis. (2013)
  • Author(s): Sandborn WJ, Feagan BG, Marano C, Zhang H, Strauss R, Johanns J, Adedokun OJ, Guzzo C, Colombel JF, Reinisch W, Gibson PR, Collins J, Järnerot G, Hibi T, Rutgeerts P; PURSUIT-SC Study Group.
  • Journal Title: Gastroenterology Volume: 146(1) Issue: 1 Pages: 85-95
  • DOI: 10.1053/j.gastro.2013.05.048
  • Peer Reviewed
• [Journal Article] C-reactive protein is an indicator of serum infliximab level in predicting loss of response in patients with Crohn's disease. (2013)
  • Author(s): Hibi T, Sakuraba A, Watanabe M, Motoya S, Ito H, Sato N, Yoshinari T, Motegi K, Kinouchi Y, Takazoe M, Suzuki Y, Matsumoto T, Kawakami K, Matsumoto T, Hirata I, Tanaka S, Ashida T, Matsui T.
  • Journal Title: J Gastroenterol. Volume: 49(2) Issue: 2 Pages: 254-62
  • DOI: 10.1007/s00535-013-0807-0
  • Peer Reviewed
• [Journal Article] Efficacy and tolerability of oral budesonide in Japanese patients with active Crohn's disease: a multicentre, double-blind, randomized, parallel-group Phase II study (2013)
  • Author(s): Suzuki Y, Motoya S, Takazoe M, Kosaka T, Date M, Nii M, Hibi T.
  • Journal Title: J Crohns Colitis Volume: 7(3) Issue: 3 Pages: 239-47
  • DOI: 10.1016/j.crohns.2012.06.006
  • Peer Reviewed
• [Journal Article] C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice. (2013)
  • Author(s): Chu PS, Nakamoto N, Ebinuma H, Usui S, Saeki K, Matsumoto A, Mikami Y, Sugiyama K, Tomita K, Kanai T, Saito H, Hibi T.
  • Journal Title: Hepatology Volume: 58 Issue: 1 Pages: 337-350
  • DOI: 10.1002/hep.26351
  • Peer Reviewed
• [Journal Article] Musashi-1 post-transcriptionally enhances phosphotyrosine-binding domain- containing m-Numb protein expression in regenerating gastric mucosa. (2013)
  • Author(s): Tetsufumi Takahashi
  • Journal Title: PLoS One Volume: 8 Issue: 1 Pages: 1-13
  • DOI: 10.1371/journal.pone.0053540
  • Peer Reviewed
• [Journal Article] A Single Strain of Clostridium butyricum Induces Intestinal I L-10-Producing Macrophages to Suppress Acute Exlperimental Colitis in Mice. (2013)
  • Author(s): Hayashi A, Sato T, Kamada N, Mikami Y, Matsuoka K, Hisamatsu T, Hlbi T, Roers A, Yagita H, Ohteki T, Yoshimura A, Kanai T.
  • Journal Title: Cell Host Microbe Volume: 13 Issue: 6 Pages: 711-22
  • DOI: 10.1016/j.chom.2013.05.013
  • Peer Reviewed
• [Journal Article] Mucosal healing with oral tacrolimus is associated with favorable medium- and long-term prognosis in steroid-refractory/dependent ulcerative colitis patients. (2013)
  • Author(s): Miyoshi J, Matsuoka K, Inoue N, Hisamatsu T, Ichikawa R, Yajima T, Okamoto S, Naganuma M, Sato T, Kanai T, Ogata H, Iwao Y, Hibi
  • Journal Title: J Crohns Colitis Volume: 7 Issue: 12 Pages: e609-e614
  • DOI: 10.1016/j.crohns.2013.04.018
  • Peer Reviewed
• [Journal Article] IL-22-Producing RORyt-Dependent Innate Lymphoid Cells Play a Novel Protective Role in Murine Acute Hepatitis. (2013)
  • Author(s): Matsumoto A, Kanai T, Mikami Y, Chu PS, Nakamoto N, Ebinuma H, Saito H, Sato T, Yagita H, Hibi T.
  • Journal Title: PLoS One Volume: 8 Issue: 4 Pages: e62853-e62853
  • DOI: 10.1371/journal.pone.0062853
  • Peer Reviewed
• [Journal Article] Mucosal CXCR4+ IgG plasma cells contribute to the pathogenesis of human ulcerative colitis through FcγR-mediated CD14 macrophage activation (2013)
  • Author(s): Uo M
  • Journal Title: Gut Volume: in press Issue: 12 Pages: 1734-44
  • DOI: 10.1136/gutjnl-2012-303063
  • Peer Reviewed
• [Journal Article] 5-aminosalicylic Acid mediates expression of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase to suppress colorectal tumorigenesis. (2012)
  • Author(s): Miyoshi J
  • Journal Title: Anticancer Res. Volume: 32 Pages: 1193-1202
  • Peer Reviewed
• [Journal Article] Reactive Oxygen Species-Induced Autophagic Degradation of Helicobacter pylori CagA Is Specifically Suppressed in Cancer Stem-like Cells (2012)
  • Author(s): Tsugawa H, Suzuki H, Saya H, Hatakeyama M, Hirayama T, Hirata K, Nagano 0, Matsuzaki J, et al.
  • Journal Title: Cell Host & Microbe Volume: 12 Issue: 6 Pages: 764-777
  • DOI: 10.1016/j.chom.2012.10.014
  • Peer Reviewed
• [Journal Article] T-helper 17 and Interleukin-17-Producing Lymphoid Tissue Inducer-Like T Cells Make Different Contributions to Colitis in Mice. (2012)
  • Author(s): Ono Y, Kanai T, Sujino T, Nemoto Y, Kanai Y, Mikami Y, Hayashi A, Matsumoto A, Takaishi H, Ogata H, Matsuoka K, Hisamatsu T, Watanabe M, Hibi T.
  • Journal Title: Gastroenterology Volume: 143 Issue: 5 Pages: 1288-1297
  • DOI: 10.1053/j.gastro.2012.07.108
  • Peer Reviewed
• [Journal Article] ROR_Yt-dependent IL-17A-producing cells in the pathogenesis of intestinal inflammation. (2012)
  • Author(s): Kanai T, Mikami Y, Sujino T, Hisamatsu T, Hibi T.
  • Journal Title: Mucosal Immunology Volume: 5 Issue: 3 Pages: 240-247
  • DOI: 10.1038/mi.2012.6
  • Peer Reviewed
• [Presentation] Usefulness of faecal S100A12 in defining mucosal healing in Ulcerative Colitis (2015)
  • Author(s): T.Kobayashi, O.Takeuchi,S.Kuronuma,M.nakano,S.Umeda,H.Serizawa,N.Watanabe,T.Hibi.
  • Organizer: 10th Congress of ECCO
  • Place of Presentation: バルセロナ（スペイン）
  • Year and Date: 2015-02-18 – 2015-02-21
• [Presentation] Impact of Inflammatory Bowel Disease on Japanese patients` lives : International comparison of patients` views (2015)
  • Author(s): F.Ueno,Y.Nakayama,E.Hagiwara,O.Mikami,A.Inamine-Sasaki,T.Hibi
  • Organizer: 10th Congress of ECCO
  • Place of Presentation: バルセロナ（スペイン）
  • Year and Date: 2015-02-18 – 2015-02-21
• [Presentation] Twice-daily budesonide rectal foam induces complete mucosal healing in Japanese patients with mild to moderate Ulcerative Colitis : Results of multicentre, randomised, double-blind,placebo-controlled trial (2015)
  • Author(s): N.Aoyama,Y.Suzuki,H.Nishino,K.Kobayashi,F.Hirai,K.Watanabe,M,Naganuma,T.Hibi
  • Organizer: 10th Congress of ECCO
  • Place of Presentation: バルセロナ（スペイン）
  • Year and Date: 2015-02-18 – 2015-02-21
• [Presentation] Infliximab therapy for Japanese patients with Ulcerative Colitis : Efficacy,safety,and association between serum infliximab levels and early respnse in a randomized, double-blind,placebo-controlled study (2015)
  • Author(s): Y.Suzuki,S.Motoya,F.Hirai,H.Ogata,H.Ito,N.Sato,K.Ozaki,M.Watanabe,T.Hibi
  • Organizer: 10th Congress of ECCO
  • Place of Presentation: バルセロナ（スペイン）
  • Year and Date: 2015-02-18 – 2015-02-21
• [Presentation] 潰瘍性大腸炎患者に対する大腸カプセル内視鏡前処置の工夫（クエン酸モサプリドの効果） (2015)
  • Author(s): 細江直樹、宮永亮一、三枝慶一郎、小林拓、中野雅、長沼誠、日比紀文、金井隆典、緒方晴彦
  • Organizer: 第8回日本カプセル内視鏡学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-02-15
• [Presentation] 大腸カプセル内視鏡使用経験に関する国内アンケート調査の結果報告-日本カプセル内視鏡学会保健委員会より (2015)
  • Author(s): 樋口和秀、日比紀文、藤山佳秀、松井敏幸、伊藤文生
  • Organizer: 第8回日本カプセル内視鏡学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-02-15
• [Presentation] 当院における炎症性腸疾患に対するチオプリン製剤使用の実態 (2015)
  • Author(s): 梅田智子、小林拓、中野雅、常松令、芹澤宏、渡辺憲明、日比紀文
  • Organizer: 第11回日本消化管学会総会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-02-14
• [Presentation] 教育講演「難病克服に向けた新しい消化管再生医療」 (2015)
  • Author(s): 日比紀文
  • Organizer: 第11回日本消化管学会総会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-02-13
• [Presentation] 潰瘍性大腸炎粘膜治癒評価における便中S100A12の有用性 (2015)
  • Author(s): 小林拓、中野雅、梅田智子、芹澤宏、渡辺憲明、黒沼智、竹内修、日比紀文
  • Organizer: 第11回日本消化管学会総会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-02-13
• [Presentation] 広汎な小腸病変を来した潰瘍性大腸炎の一例 (2014)
  • Author(s): 森川淳、小林拓、筋野智久、中野雅、加藤裕佳子、梅田智子、芹澤宏、日比紀文
  • Organizer: 日本消化器病学会 関東支部第331回例会
  • Place of Presentation: 東京
  • Year and Date: 2014-09-20
• [Presentation] 潰瘍性大腸炎患者に対するクエン酸モサプリドを用いた大腸カプセル内視鏡前処置法 (2014)
  • Author(s): 細江直樹、中野雅、南木康作、三枝慶一郎、碓井真吾、筋野智久、小林拓、松岡克善、長沼誠、久松理一、井上詠、芹澤宏、日比紀文、金井隆典、緒方晴彦
  • Organizer: 第32回 日本大腸検査学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-09-06
• [Presentation] 「総合診療医」とは？-日本での取り組みと消化器分野での診療の実際-炎症性腸疾患診療でのParadigm Shift (2014)
  • Author(s): 日比紀文
  • Organizer: 中日国際消化疾病論壇
  • Place of Presentation: 北京（中国）
  • Year and Date: 2014-08-31 – 2014-09-01
• [Presentation] クローン病狭窄病変に対する内視鏡的バルーン拡張術の短期・長期成績 (2014)
  • Author(s): 小林拓、長沼誠、久松理一、松岡克善、中野雅、緒方晴彦、日比紀文、金井隆典
  • Organizer: 第87回 日本消化器内視鏡学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2014-05-15 – 2014-05-17
• [Presentation] 内視鏡的に特徴的な所見を観察しえた重症腸チフスの1例 (2014)
  • Author(s): 梅田智子、小林拓、筋野智久、加藤裕佳子、清水清香、中野雅、常松令、芹澤宏、渡辺憲明、土本寛二、日比紀文
  • Organizer: 第87回 日本消化器内視鏡学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2014-05-15 – 2014-05-17
• [Presentation] 遠位回腸検索における受動湾曲高伝達挿入部搭載細径大腸内視鏡ＰＣＦ-ＰＱ260Ｌの有用性の検討 (2014)
  • Author(s): 中野雅、小林拓、筋野智久、加藤裕佳子、芹澤宏、渡辺憲明、日比紀文、中里圭宏
  • Organizer: 第87回 日本消化器内視鏡学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2014-05-15 – 2014-05-17
• [Presentation] HUMIRAによる患者参加型治療の実践：生物学的製剤投与法選択のポイント (2014)
  • Author(s): 日比紀文
  • Organizer: HUMIRA IBD Forum
  • Place of Presentation: 東京
  • Year and Date: 2014-05-10
• [Presentation] AJM300, an Oral α4 Integrin Antagonist, for Active Ulcerative Colitis: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2A Study (2014)
  • Author(s): Mamoru Watanabe, Naoki Yoshimura, Satoshi Motoya, Keiichi Tominaga, Ryuichi Iwakiri, Kenji Watanabe, Toshifumi Hibi
  • Organizer: DDW
  • Place of Presentation: 神戸
  • Year and Date: 2014-05-03 – 2014-05-06
• [Presentation] Efficacy and Safety of Rikkunshito, a Japanese Herbal Medicine, on the Treatment of Functional Dyspepsia: A Multi-Center, Double-Blind, Randomized, Placebo-Controlled Study (2014)
  • Author(s): Hidekazu Suzuki, Juntaro Matsuzaki, Yasushi Fukushima, Fumio Suzaki, Kunio Kasugai, Toshihiro Nishizawa, Yuji Naito, Toshihiko Hayakawa, Takeshi Kamiya, Takashi Ando, Hideo Yoshida, Yoshifumi Tokura, Hiroshi Nagata, Masao Kobayakawa, Mikiji Mori, Kimihiko Kato, Hiroshi Hosoda, Toru Takebayashi, Soichiro Miura, Naomi
  • Organizer: DDW
  • Place of Presentation: 神戸
  • Year and Date: 2014-05-03 – 2014-05-06
• [Presentation] Percutaneous Endoscopic Gastrostomy Under Steady Pressure Automatically Controlled Endoscopy (SPACE) (2014)
  • Author(s): Hiroyuki Imaeda, Kiyokazu Nakajima, Naoki Hosoe, Masanori Nakahara, Shinichiro Zushi, Motohiko Kato, Kazuhiro Kashiwagi, Yasushi Matsumoto, Rieko Nakamura, Noihiro Wada, Masahiko Tsujii, Naohisa Yahagi, Toshifumi Hibi, Tetsuo Takahara.
  • Organizer: DDW
  • Place of Presentation: 神戸
  • Year and Date: 2014-05-03 – 2014-05-06
• [Presentation] Efficacy, Safety, and Demographics Factor of Adalimumab Therapy in 1693 Japanese Crohn's Disease Patients (2014)
  • Author(s): Haruhiko Ogata, Mamoru Watanabe, Toshiyuki Matsui, Sadanori Abe, Shigenori Haruna, Toshifumi Hibi
  • Organizer: DDW
  • Place of Presentation: 神戸
  • Year and Date: 2014-05-03 – 2014-05-06
• [Presentation] 本邦から発信する最適なＵＣ治療戦略 (2014)
  • Author(s): 日比紀文
  • Organizer: 第1回 Ｂiologics Workshop on IBD
  • Place of Presentation: 東京
  • Year and Date: 2014-04-26
• [Presentation] 法制化される新たな難病対策における専門医の役割について (2014)
  • Author(s): 日比紀文
  • Organizer: 第100回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-24
• [Presentation] 難治性潰瘍性大腸炎治療におけるタクロリムスの位置づけと適正使用法 (2014)
  • Author(s): 日比紀文
  • Organizer: 第100回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-23
• [Presentation] Current and future treatments of IBD in Japan.Are they different from Westerns? (2014)
  • Author(s): Toshifumi Hibi
  • Organizer: 2014 PUMCH International Digestive Disease Forum
  • Place of Presentation: 北京（中国）
  • Year and Date: 2014-04-19
• [Presentation] The future perspective and issues of IBD in Asia (2013)
  • Author(s): Toshifumi hibi
  • Organizer: 1th AOCC
  • Place of Presentation: Tokyo
• [Presentation] 炎症性腸疾患の専門医を目指す若手医師へのメッセージ (2013)
  • Author(s): 日比紀文
  • Organizer: 第11回ＩＢＤセミナー
  • Place of Presentation: 大阪
• [Presentation] 炎症性腸疾患に対する抗体療法 (2013)
  • Author(s): 日比紀文
  • Organizer: 第107回日本内科学会総会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Diffrences between treatment guidelines in IBD
  • Author(s): Toshifumi hibi
  • Organizer: Falk Symposium 188
  • Place of Presentation: Stuttgart,Germany
• [Presentation] Amino acids and inflammatory bowel disease-as a therapeutic target and a novel biomarker
  • Author(s): Toshifumi hibi
  • Organizer: 8th Asia Pacific Conference
  • Place of Presentation: Tokyo
• [Presentation] 炎症性腸疾患の病態解明と治療の進歩
  • Author(s): 日比紀文
  • Organizer: 第110回日本内科学会
  • Place of Presentation: 東京
• [Presentation] 大きく変化した炎症性腸疾患の診療～その適切な対応は？～
  • Author(s): 日比紀文
  • Organizer: 消化器疾患セミナー
  • Place of Presentation: 大分
• [Presentation] 炎症性腸疾患に対する治療の進歩と“粘膜治癒”の意義
  • Author(s): 日比紀文
  • Organizer: 第85回日本消化器内視鏡学会
  • Place of Presentation: 京都
• [Presentation] 潰瘍性大腸炎の治療－基本から応用まで
  • Author(s): 日比紀文
  • Organizer: 日本大腸肛門病学会第22回教育セミナー講演
  • Place of Presentation: 横浜
• [Presentation] 炎症性腸疾患診療の黎明期・確立期と今後の展開
  • Author(s): 日比紀文
  • Organizer: 第10回千葉ＩＢＤアフェレーシス研究会
  • Place of Presentation: 千葉
• [Presentation] 腹部症状から診たIBDと他疾患の特徴と内視鏡診断
  • Author(s): 日比紀文
  • Organizer: IBD Clinical Conference
  • Place of Presentation: 東京
• [Presentation] 土屋先生の想い出と消化器免疫への提言
  • Author(s): 日比紀文
  • Organizer: 第50回日本消化器免疫学会イブニングセミナー
  • Place of Presentation: 東京
• [Presentation] 炎症性腸疾患診療のパラダイムシフト～カプセル内視鏡の臨床応用と生物学的製剤について～
  • Author(s): 日比紀文
  • Organizer: 東京消化管フォーラム
  • Place of Presentation: 東京
• [Presentation] 生物学製剤全盛時にＧＭＡの位置付けを問う
  • Author(s): 日比紀文
  • Organizer: 第21回ＪＤＤＷ
  • Place of Presentation: 東京
• [Presentation] 日本の炎症性腸疾患研究の歴史と将来への提言
  • Author(s): 日比紀文
  • Organizer: 第68回大腸肛門病学会
  • Place of Presentation: 東京
• [Presentation] 炎症性腸疾患診療のパラダイムシフト
  • Author(s): 日比紀文
  • Organizer: 第8回名古屋市大消化器・代謝内科フォーラム
  • Place of Presentation: 名古屋
• [Presentation] 炎症性腸疾患診療における内視鏡検査の意義
  • Author(s): 日比紀文
  • Organizer: 第97回日本消化器内視鏡学会関東地方会
  • Place of Presentation: 東京
• [Presentation] 下痢・下血を来す疾患の診断から治療まで～その現状と新展開～
  • Author(s): 日比紀文
  • Organizer: 港区内科医会学術講演会
  • Place of Presentation: 東京
• [Presentation] ＩＢＤ領域における治療の現況と展望
  • Author(s): 日比紀文
  • Organizer: 日本化薬社内勉強会
  • Place of Presentation: 東京
• [Presentation] クローン・潰瘍性大腸炎の先進治療に向けて
  • Author(s): 日比紀文
  • Organizer: 第30回わかば会
  • Place of Presentation: 東京
• [Presentation] 日本における炎症性腸疾患薬物療法の現状と新たな治療薬への期待
  • Author(s): 日比紀文
  • Organizer: ＰＭＤＡワークショップ
  • Place of Presentation: 東京
• [Presentation] 炎症性腸疾患診療のパラダイムシフト～カプセル内視鏡の臨床応用と生物学的製剤について～
  • Author(s): 日比紀文
  • Organizer: 目黒区医師会内科部会
  • Place of Presentation: 東京
• [Book] INTESTINE 大腸内視鏡（4）超拡大内視鏡 (2014)
  • Author(s): 小林拓、長沼誠、緒方晴彦、日比紀文、金井隆典
  • Publisher: 日本メディカルセンター
• [Book] IBD Research IBD診療に使用されるインデックスの今後の展望 (2014)
  • Author(s): 小林拓、筋野智久、加藤裕佳子、中野雅、日比紀文
  • Publisher: 先端医学社
• [Book] 日本成人病（生活習慣病）学会準機関誌 潰瘍性大腸炎の内科治療-近年の変化 (2014)
  • Author(s): 日比紀文、小林拓、中野雅
  • Publisher: 日本成人病（生活習慣病）学会
• [Book] 内科 潰瘍性大腸炎 (2014)
  • Author(s): 日比紀文、小林拓、中野雅
  • Publisher: 南江堂
• [Book] 薬局 潰瘍性大腸炎（エキスパートに学ぶ！薬物治療における直腸投与製剤の位置づけと活用のポイント①） (2014)
  • Author(s): 日比紀文、小林拓、中野雅、渡辺憲明
  • Publisher: 南山堂
• [Book] INTESTINE 特集「日常遭遇する大腸炎の鑑別－内視鏡を中心に」「序説」 (2014)
  • Author(s): 日比紀文
  • Publisher: 日本メディカルセンター
• [Book] Rheumatology Clinical Research 特集 生物学的製剤の適応があるリウマチ類縁疾患 炎症性腸疾患 (2014)
  • Author(s): 日比紀文 小林拓 中野雅
  • Publisher: 先端医学社
• [Book] ドクターサロン 実地診療における炎症性腸疾患 (2014)
  • Author(s): 日比紀文
  • Publisher: 杏文堂
• [Book] G.I.Research わたしの研究歴 (2014)
  • Author(s): 日比紀文
  • Publisher: 先端医学社
• [Book] INTESTINE 特集 腸管ベーチェット病と単純性潰瘍 腸管ベーチェット病の治療-改訂コンセンサスを中心に (2014)
  • Author(s): 久松 理一、上野 文昭、日比 紀文
  • Publisher: 日本メディカルセンター