• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular mechanism of Takotsubo cardiomyopathy

Research Project

Project/Area Number 24249048
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKeio University

Principal Investigator

Fukuda Keiichi  慶應義塾大学, 医学部, 教授 (20199227)

Co-Investigator(Kenkyū-buntansha) ARAI TAKAHIDE  慶應義塾大学, 医学部, 助教 (00383894)
KANAZAWA HIDEAKI  慶應義塾大学, 医学部, 特任講師 (40338033)
SUKEGAWA HIROAKI  慶應義塾大学, 医学部, 助教 (60535607)
TABEI RYOTA  慶應義塾大学, 医学部, 助教 (20573322)
MUNAKATA MASAHITO  慶應義塾大学, 医学部, 共同研究員 (40445284)
木村 謙介  慶應義塾大学, 医学部, 講師(非常勤) (40276233)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2014: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2013: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2012: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Keywords脳心連関 / ストレス / サイトカイン / 神経伝達物質 / ストレス心筋症 / カテコールアミン / 炎症 / 臓器連関
Outline of Final Research Achievements

Big emotional or physical stress may lead to an imbalance in the brain, resulting in Takotsubo cardiomyopathy (TC), transient left ventricular (LV) apical ballooning. We first confirmed the central neurons of cardiac sympathetic nerves in the hypothalamus innervating the LV apex, and investigated the changes in gene expression in an animal model of TC induced by epilepsy, a clinical trigger of TC. We found that chemokine ligand 2 (Ccl2) strongly stimulated the central neurons of the cardiac sympathetic nerves. Consequent upstream sympathetic activation induced significant upregulation of neuropeptide Y (NPY) in the left stellate ganglion (LSG) and cardiac sympathetic nerves. Administration of Ccl2 into the central neurons evoked TC and increased NPY at LSG. Overall, our results provide the first evidence as to how emotional or physical stress translates into molecular signals in the brain, leading to LV apical ballooning.

Report

(4 results)
  • 2015 Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report

Research Products

(25 results)

All 2016 2015 2014 2013 2012

All Journal Article Presentation Book

  • [Journal Article] Molecular and cellular neurocardiology: Development, cellular and molecular adaptations to heart disease.2016

    • Author(s)
      Habecker BA, Anderson ME, Birren SJ, Fukuda K, Herring N, Hoover DB, Kanazawa H, Paterson DJ, Ripplinger CM.
    • Journal Title

      Journal of Physiology

      Volume: in press

    • DOI

      10.1113/jp271840

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cardiac Sympathetic Nerve Plasticity and Heart Failure.2016

    • Author(s)
      Hideaki Kanazawa, Keiichi Fukuda.
    • Journal Title

      J Pain Relief

      Volume: 5 Pages: 223-223

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiac innervation and sudden cardiac death2015

    • Author(s)
      Fukuda K, Kanazawa H, Aizawa Y, Ardell JL, Shivkumar K.
    • Journal Title

      Circulation Research

      Volume: 116(12) Pages: 2005-19

    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Journal Article] Cardiac innervation and sudden cardiac death.2015

    • Author(s)
      Fukuda K, Kanazawa H, Aizawa Y, Ardell JL, Shivkumar K
    • Journal Title

      Circ Res

      Volume: 116 Pages: 2005-19

    • DOI

      10.1161/circresaha.116.304679

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A massive floating culture system with metabolic purification for human induced pluripotent stem cellderived2014

    • Author(s)
      Natsuko Hemmi, Shugo Tohyama, Kazuaki Nakajima, Hideaki Kanazawa,
    • Journal Title

      Stem Cells Translational Medicine.

      Volume: 3 Pages: 1473-1483

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Derivation of Transgene-free Human Induced Pluripotent Stem Cells from Human Peripheral T Cells in Defined Culture Conditions.2014

    • Author(s)
      Yoshikazu Kishino, Tomohisa Seki, Jun Fujita, Shinsuke Yuasa, Shugo
    • Journal Title

      PLoS One.

      Volume: 9

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Regulatory Role of Dendritic Cells in Post-Infarction Healing and Left Ventricular Remodeling.2012

    • Author(s)
      Anzai A, Anzai T, Nagai S, Maekawa Y, Naito K, Kaneko H, Sugano Y, Takahashi T, Abe H, Mochizuki S, Sano M, Yoshikawa T, Okada Y, Koyasu S, Ogawa S, Fukuda K.
    • Journal Title

      Circulation

      Volume: 125 Pages: 1234-45

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of induced pluripotent stem cells from a small amount of human peripheral blood using a combination of activated T cells and Sendai virus.2012

    • Author(s)
      Seki T, Yuasa S, Fukuda K.
    • Journal Title

      Nat Protoc

      Volume: 7 Pages: 718-28

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disease characterization using LQTS-specific induced pluripotent stem cells.2012

    • Author(s)
      Egashira T, Yuasa S, Suzuki T, Aizawa Y, Yamakawa H, Matsuhashi T, Ohno Y, Tohyama S, Okata S, Seki T, Kuroda Y, Yae K, Hashimoto H, Tanaka T, Hattori F, Sato T, Miyoshi S, Takatsuki S, Murata M, Kurokawa J, Furukawa T, Makita N, Aiba T, Shimizu W, Horie M, Kamiya K, Kodama I, Ogawa S, Fukuda K.
    • Journal Title

      Cardiovasc Res.

      Volume: 95 Pages: 419-29

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of cardiomyocyte-like cells in infarct hearts by gene transfer of gata4, mef2c, and tbx5.2012

    • Author(s)
      Inagawa K, Miyamoto K, Yamakawa H, Muraoka N, Sadahiro T, Umei T, Wada R, Katsumata Y, Kaneda R, Nakade K, Kurihara C, Obata Y, Miyake K, Fukuda K, Ieda M
    • Journal Title

      Circ Res

      Volume: 111 Pages: 1147-56

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Implantation of the right ventricular lead of an implantable cardioverter-defibrillator complicated by apical myocardial infarction.2012

    • Author(s)
      Nishiyama N, Takatsuki S, Kimura T, Aizawa Y, Fukumoto K, Hagiwara Y, Tanimoto K, Fukuda K.
    • Journal Title

      Circulation

      Volume: 126 Pages: 1314-5

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 心臓交感神経から心臓病を診る2014

    • Author(s)
      金澤英明、木村謙介、荒井隆秀、福田恵一
    • Organizer
      第35回日本循環制御医学会総会(招待講演)
    • Place of Presentation
      九州大学医学部百年講堂
    • Year and Date
      2014-07-04 – 2014-07-05
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 心不全における心臓交感神経の適応機構2014

    • Author(s)
      金澤英明、木村謙介、荒井隆秀、家田真樹、福田恵一
    • Organizer
      第87回日本内分泌学会学術総会(招待講演)
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-04-25
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Generation of human iPS cells from a single drop of peripheral blood using Sendai virus without genome destruction2012

    • Author(s)
      Fukuda K, Seki T, Shinsuke Yuasa S
    • Organizer
      The Asian Pacific Heart Rhythm Society 2012.
    • Place of Presentation
      Taipei
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Disease characterization of long QT syndrome using iPS cell-derived cardiomyocytes.2012

    • Author(s)
      Fukuda K
    • Organizer
      The Asian Pacific Heart Rhythm Society 2012.
    • Place of Presentation
      Taipei
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Cell Therapy in clinical practice. “iPS cells as a source of cardiomyocyte regeneration and its application for cell transplantation”2012

    • Author(s)
      Fukuda K
    • Organizer
      World congress of Cardiology 2012
    • Place of Presentation
      Dubai,UAE
    • Related Report
      2012 Annual Research Report
  • [Presentation] 『iPS細胞を用いた家族性突然死症候群の病態解明:現状と展望』2012

    • Author(s)
      福田恵一
    • Organizer
      第27回日本不整脈学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 『メタボローム解析を利用した心筋細胞と多能性幹細胞の分離精製法の開発』2012

    • Author(s)
      福田恵一
    • Organizer
      第11回日本再生医療学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Book] 『精神・身体ストレスに対する心臓交感神経の応答』、腎・高血圧の最新医療2016

    • Author(s)
      荒井隆秀、宗形昌儒、金澤英明、福田恵一
    • Total Pages
      6
    • Publisher
      フジメディカル出版
    • Related Report
      2014 Annual Research Report
  • [Book] 『ストレス心筋症と心臓交感神経』、細胞2015

    • Author(s)
      宗形昌儒、金澤英明、荒井隆秀、福田恵一
    • Total Pages
      4
    • Publisher
      ニューサイエンス社
    • Related Report
      2014 Annual Research Report
  • [Book] 第48回 河口湖心臓討論会『精神・身体ストレスに対する心臓交感神経の応答』、心臓 Vol 47 No. 22015

    • Author(s)
      金澤英明、福田恵一
    • Total Pages
      8
    • Publisher
      公益財団法人 日本心臓財団
    • Related Report
      2014 Annual Research Report
  • [Book] 循環制御2014

    • Author(s)
      金澤英明、木村謙介、荒井隆秀、福田恵一
    • Publisher
      小玉株式会社出版部
    • Related Report
      2013 Annual Research Report
  • [Book] 臨床神経科学Clinical Neuroscience2014

    • Author(s)
      金澤英明、福田恵一
    • Publisher
      中外医学社
    • Related Report
      2013 Annual Research Report
  • [Book] Cardiac Regeneration using Stem Cells2013

    • Author(s)
      Hideaki Kanazawa, Keiichi Fukuda
    • Total Pages
      100
    • Publisher
      CRC Press
    • Related Report
      2013 Annual Research Report
  • [Book] 実験医学2013

    • Author(s)
      木村謙介、金澤英明、福田恵一
    • Publisher
      羊土社
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-15   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi