Analysis of cytokines behavior in allergic disorder using in vivo imaging system

• Project/Area Number: 24249058
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Tokyo University of Science
• Principal Investigator: KUBO Masato 東京理科大学, 生命医科学研究所, 教授 (40277281)
• Co-Investigator(Kenkyū-buntansha): HARADA Yohsuke 東京理科大学, 生命医科学研究所, 助教 (20328579) ; 宮内 浩典 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員 (50619856)
• Co-Investigator(Renkei-kenkyūsha): MIYAUCHI Kosuke 理化学研究所, 統合生命医科学研究センター, 研究員 (50619856)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000); Fiscal Year 2014: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000); Fiscal Year 2013: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000); Fiscal Year 2012: ¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000)
• Keywords: 免疫学 / アレルギー / T細胞 / 免疫関連疾患

Outline of Final Research Achievements

IgE is a critical antibody component in Type I allergic reaction, and we investigate the molecular basis of IgE production in the present work. We demonstrate that follicular helper T cells (TFH), rather than Th2 cells, are main source of IL-4 that control a B cell help for IgE antibody responses. To further ask whether TH2 cells play a role in IgE responses, we identified that TH2 cells were also capable of regulating IgE production after expressing TFH markers, including CXCR5. With respect to innate immune system, we identified an importance of crosstalk between Basophil and group 2 innate lymphoid cells (ILC2s) in the cysteine protease induced asthmatic responses as a prototype of T cell independent allergic responses. Our data demonstrated that the basophil derived IL-4 play a critical role in the airway responses. We also identified the novel role of transcriptional factor, E4bp4 in ILC development by controlling the levels of Id2 expression in common progenitors of ILC.

Research Products

• [Journal Article] Notch signaling enhances FceRI-mediated cytokine production by mast cells through direct and indirect mechanisms (2015)
  • Author(s): Nakano, N., Nishiyama, C., Yagita, H., Hara, M., Motomura, Y., Kubo, M., Okumura, K., and Ogawa, H
  • Journal Title: J. Immunol Volume: 194(9) Issue: 9 Pages: 4535-44
  • DOI: 10.4049/jimmunol.1301850
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Zinc-binding metallothioneins are key modulators of IL-4 production by basophils (2015)
  • Author(s): Ugajin T, Nishida K, Yamasaki S, Suzuki J, Mita M, Kubo M, Yokozeki H, Hirano T
  • Journal Title: Mol Immunol Volume: 66 Issue: 2 Pages: 180-188
  • DOI: 10.1016/j.molimm.2015.03.002
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors (2015)
  • Author(s): Wei Xu, Rita G. Domingues, Diogo Fonseca-Pereira, Manuela Ferreira, Hélder Ribeiro, Silvia Lopez-Lastra, Yasutaka Motomura, Lara Moreira-Santos, Franck Bihl4, Véronique Braud, Barbara Kee, Hugh Brady, Mark C.Coles, Christian Vosshenrich, Kubo, M., James P. Di Santo and Henrique Veiga-Fernandes
  • Journal Title: Cell Report Volume: 10(12) Issue: 12 Pages: 2043-54
  • DOI: 10.1016/j.celrep.2015.02.057
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin. (2014)
  • Author(s): Natsuaki Y, Egawa G, Nakamizo S, Ono S, Hanakawa S, Okada T, Kusuba N, Otsuka A, Kitoh A, Honda T, Nakajima S, Tsuchiya S, Sugimoto Y, Ishii KJ, Tsutsui H, Yagita H, Iwakura Y, Kubo M, Ng Lg, Hashimoto T, Fuentes J, Guttman-Yassky E, Miyachi Y, Kabashima K
  • Journal Title: Nature Immunology Volume: 15 Issue: 11 Pages: 1064-9
  • DOI: 10.1038/ni.2992
  • Peer Reviewed
• [Journal Article] Basophils Promote Innate Lymphoid Cell Responses in Inflamed Skin (2014)
  • Author(s): Brian S. Kim, Mark C. Siracusa, Kelvin Wang, Steven A. Saenz, Kubo, M., and David Artis
  • Journal Title: J. Immunol Volume: 193(7) Issue: 7 Pages: 3717-25
  • DOI: 10.4049/jimmunol.1401307
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells. (2014)
  • Author(s): Ise W, Inoue T, McLachlan JB, Kometani K, Kubo M, Okada T, Kurosaki T
  • Journal Title: Proc Natl Acad Sci U S A Volume: 111 Issue: 32 Pages: 11792-11797
  • DOI: 10.1073/pnas.1404671111
  • Peer Reviewed / Open Access
• [Journal Article] Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers. (2014)
  • Author(s): Moriyama S, Takahashi N, Green JA, Hori S, Kubo M, Cyster JG, Okada T
  • Journal Title: Journal of Experimental Medicine Volume: 211 Issue: 7 Pages: 1297-1305
  • DOI: 10.1084/jem.20131666
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Basophil-derived interleukin-4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation. (2014)
  • Author(s): Motomura Y, Morita H, Moro K, Nakae S, Artis D, Endo TA, Kuroki Y, Ohara O, Koyasu S, Kubo M
  • Journal Title: Immunity Volume: 40 Issue: 5 Pages: 758-771
  • DOI: 10.1016/j.immuni.2014.04.013
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The enzyme cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis. (2014)
  • Author(s): Kurashima Y, Amiya T, Fjisawa K, Shibata N, Suzuki Y, Kogure Y, Hashimoto E, Otsuka A, Kabashima K, Sato S, Sato T, Kubo M, Akira S, Miyake K, Kunisawa J, Kiyono H.
  • Journal Title: Immunity Volume: 40 Issue: 4 Pages: 530-541
  • DOI: 10.1016/j.immuni.2014.01.014
  • Peer Reviewed / Open Access
• [Journal Article] Basophils regulate the recruitment of eosinophils in a murine model of irritant contact dermatitis. a K. (2014)
  • Author(s): Nakashima C, Otsuka A, Kitoh A, Honda T, Egawa G, Nakajima S, Nakamizo S, Arita M, Kubo M, Miyachi Y, Kabashim
  • Journal Title: Journal of Clinical Immunology Volume: 134 Issue: 1 Pages: 100-7
  • DOI: 10.1016/j.jaci.2014.02.026
  • Peer Reviewed
• [Journal Article] Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin-basophil axis (2014)
  • Author(s): Noti, M., Kim, B.S., Siracusa, M.C., Rak, G.D., Kubo, M., Moghaddam, A.E., Sattentau, Q.A., Comeau, M.R., Spergel, J.M., and Artis, D
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: 133(5) Issue: 5 Pages: 1390-9
  • DOI: 10.1016/j.jaci.2014.01.021
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] IL-17A as an Inducer for Th2 Immune Responses in Murine Atopic Dermatitis Models. (2014)
  • Author(s): Nakajima S, Kitoh A, Egawa G, Natsuaki Y, Nakamizo S, Moniaga CS, Otsuka A, Honda T, Hanakawa S, Amano W, Iwakura Y, Nakae S, Kubo M, Miyachi Y, Kabashima K
  • Journal Title: Journal of Investigative Dermatology Volume: 134 Issue: 8 Pages: 2122-30
  • DOI: 10.1038/jid.2014.51
  • Peer Reviewed
• [Journal Article] Nfil3-independent lineage maintenance and antiviral response of natural killer cells (2013)
  • Author(s): Firth, M.A., Madera,S., Aimee M. Beaulieu, A.M., Gasteiger,G., Schluns, K.S., Kubo, M, Rothman, P.B., Vivier, E., and Sun, J.C
  • Journal Title: J.Exp.Med Volume: 210(13) Issue: 13 Pages: 2981-2990
  • DOI: 10.1084/jem.20130417
  • Peer Reviewed
• [Journal Article] Heterogeneous immunologic pathways underlie the pathogenesis of the allergic march (2013)
  • Author(s): Noti, M., Tait, E.D., Wojno, T., Kim, B. S. Siracusa, M.C., Giacomin, P.R., Nair, M.G., Kubo, M., Alain J. Benitez, A.J., Ruymann, K.R., Comeau, M.R., Cianferoni, A., Wang, M., Spergel, J.S., and Artis, D
  • Journal Title: Nature Medicine Volume: 19(8) Issue: 8 Pages: 1005-1013
  • DOI: 10.1038/nm.3281
  • Peer Reviewed
• [Journal Article] Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia. (2013)
  • Author(s): Matsunaga Y., Fukuyama S., Okuno T., Sasaki F., Matsunobu T., Asai Y., Matsumoto K., Saeki K., Oike M., Sadamura Y., Machida K., Nakanishi Y., Kubo M., Yokomizo T., Inoue H.
  • Journal Title: FASEB J. Volume: 27 Issue: 8 Pages: 3306-3314
  • DOI: 10.1096/fj.12-217000
  • Peer Reviewed
• [Journal Article] Therapeutic hope for psoriasis offered by SOCS mimetic peptide (2013)
  • Author(s): Kubo, M
  • Journal Title: Eur. J. Immunol Volume: 43(7) Pages: 1702-1705
  • Peer Reviewed
• [Journal Article] Critical role of p38 and GATA3 in natural helper cell function. (2013)
  • Author(s): Furusawa J, Moro K, Motomura Y, Okamoto K, Zhu J, Takayanagi H, Kubo M, Koyasu S.
  • Journal Title: J Immunol. Volume: 191 Issue: 4 Pages: 1818-26
  • DOI: 10.4049/jimmunol.1300379
  • Peer Reviewed
• [Journal Article] Basophils are required for the induction of Th2 immunity to haptens and peptide antigens. (2013)
  • Author(s): Otsuka A, Nakajima S, Kubo M, Egawa G, Honda T, Kitoh A, Nomura T, Hanakawa S, Sagita Moniaga C, Kim B, Matsuoka S, Watanabe T, Miyachi Y , Kabashima K.
  • Journal Title: Nature Communications Volume: 4 Issue: 1 Pages: 1739-1739
  • DOI: 10.1038/ncomms2740
  • Peer Reviewed
• [Journal Article] Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness (2012)
  • Author(s): Sawaguchi, M., Tanaka, S., Nakatani, Y., Harada, Y., Mukai, K., Matsunaga, Y., Ishiwata, K., Oboki, K., Kambayashi, T., Watanabe, N., Karasuyama, H., Nakae, S., Inoue, H., and Kubo, M
  • Journal Title: J. Immunol Volume: 188(4) Pages: 1809-1818
  • Peer Reviewed
• [Journal Article] The 3′ Enhancer CNS2 is a Critical Regulator of Interleukin-4-Mediated Humoral Immunity in Follicular Helper T Cells (2012)
  • Author(s): Harada, Y., Tanaka, S., Motomura, Y., Harada, Y., Ohno, S., Ohno, S., Yanagi, Y., Inoue, H., and Kubo, M
  • Journal Title: Immunity Volume: 36(2) Pages: 188-200
  • Peer Reviewed
• [Journal Article] Development and Function of Invariant Natural Killer T cells Producing TH2- and TH17-cytokines (2012)
  • Author(s): Watarai, H., Sekine-Kondo, E., Motomura, Y., Yasuda, T., Yoshida, H., Kubo, M., Koseki, H., Taniguchi, M
  • Journal Title: PLoS Biol Volume: 10(2)
  • Peer Reviewed
• [Journal Article] Commensal bacterial–derived signals regulate basophil hematopoiesis and allergic inflammation (2012)
  • Author(s): Hill, D.A., Siracusa, M.C., Abt, M.C., Kim, B.S., Kobuley, D., Kubo, M., Kambayashi, T., Larosa, D.F., Renner, E.D., Orange, J.S., Bushman, F.D., and Artis D
  • Journal Title: Nat. Med Volume: 18(4) Pages: 538-546
  • Peer Reviewed
• [Journal Article] Elevation of Sema4A implicates Th cell skewing and the efficacy of IFN-β therapy in multiple sclerosis (2012)
  • Author(s): Nakatsuji, Y., Okuno, T., Moriya, M., Sugimoto, T., Kinoshita, M., Takamatsu, H., Nojima, S., Kimura, T., Kang, S., Ito, D., Nakagawa, Y., Toyofuku, T., Takata, K., Nakano, M., Kubo, M.
  • Journal Title: J. Immunol Volume: 188(10) Pages: 4858-4865
  • Peer Reviewed
• [Journal Article] Dysregulation of suppressor of cytokine signaling 3 in keratinocytes causes skin inflammation mediated by interleukin-20 receptor-related cytokines (2012)
  • Author(s): Uto-Konomi, A., Miyauchi, K., Ozaki, N., Motomura, Y., Suzuki, Y., Yoshimura, A., Suzuki, S., Cua, D., and Kubo, M
  • Journal Title: PLoS One Volume: 7(7)
  • Peer Reviewed
• [Journal Article] Syk-dependent signaling pathways in neutrophils and macrophages are indispensable in the pathogenesis of anti-collagen antibody-induced arthritis (2012)
  • Author(s): Ozaki, N., Suzuki, S., Ishida, M., Harada, Y., Tanaka, K., Sato, Y., Kono, T., Kubo, M., Kitamura, D., Encinas, J., Hara, H., and Yoshida, H
  • Journal Title: Int. Immunol Volume: 24(9) Pages: 539-550
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• [Journal Article] Transcriptional regulation of anti-inflammatory cytokine, IL-10 in acquired immune cells (2012)
  • Author(s): Kubo, M. & Motomura, Y
  • Journal Title: Front. Immunol. Volume: 3
  • Peer Reviewed
• [Journal Article] Extracellular ATP mediates mast cell–dependent intestinal inflammation through P2X7 purinoceptors (2012)
  • Author(s): Kurashima, Y., Amiya, T., Nochi, T., Fujisawa, K., Haraguchi, T., Iba, H., Tsutsui, H., Sato, S., Nakajima, S., Iijima, H., Kubo, M., Kunisawa, J., and Kiyono, H
  • Journal Title: Nat. Commun Volume: 3
  • Peer Reviewed
• [Journal Article] Toll-like receptor (TLR) 3 as a surrogate sensor of retroviral infection in human cells (2012)
  • Author(s): Miyauchi, K., Urano, E., Takeda, S., Murakami, T., Okada, Y., Cheng, K., Yin, H., Kubo, M., and Komano, J
  • Journal Title: Biochem. Biophys. Res .Commun Volume: 424(3) Pages: 519-523
  • Peer Reviewed
• [Journal Article] PGD2-CRTH2 Pathway Promotes Tubulointerstitial Fibrosis (2012)
  • Author(s): Ito, H., Yan, X., Nagata, N, Aritake, K., Katsumata, Y., Matsuhashi, T., Nakamura, M., Hirai, H., Urade, Y., Asano, K., Kubo, M., Utsunomiya, Y., Hosoya, T., Fukuda, K., and Sano, M
  • Journal Title: J. Am. Soc. Nephrol. Volume: Nov;23(11) Pages: 1797-1809
  • Peer Reviewed
• [Journal Article] Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory (2012)
  • Author(s): Kaji, T., Ishige, A., Hikida, M., Taka, J., Hijikata, A., Kubo, M., Nagashima, T., Takahashi, Y., Kurosaki, T., Okada, M., Ohara, O., Rajewsky, K., Takemori, T
  • Journal Title: J. Exp. Med Volume: 209(11) Pages: 2079-2097
  • Peer Reviewed
• [Journal Article] Thymic Stromal Lymphopoietin-Dependent Basophils Promote Th2 Cytokine Responses following Intestinal Helminth Infection (2012)
  • Author(s): Giacomin, P.R., Siracusa, M.C., Walsh, K.P., Grencis, R.K., Kubo, M., Comeau, M.R., and Artis, D
  • Journal Title: J. Immunol Volume: 189(9) Pages: 4371-4378
  • Peer Reviewed
• [Journal Article] GATA-3によるIL-4・IL-13 (2012)
  • Author(s): 本村泰隆・久保允人
  • Journal Title: 臨床免疫・アレルギー科 Volume: 57(2) Pages: 211-215
• [Journal Article] 転写因子E4BP4によるIL-10とIL-13産生制御 (2012)
  • Author(s): 本村泰隆・久保允人
  • Journal Title: 医学のあゆみ Volume: vol.240 No.11 Pages: 932-933
• [Journal Article] 特集 「慢性アレルギー炎症―免疫系の役者たちの新たな姿 T細胞・好塩基球，サイトカインが織りなす慢性化のメカニズムとワクチン開発」 概要 「アレルギー反応を舞台に活躍する役者たち」 (2012)
  • Author(s): 久保允人
  • Journal Title: 実験医学 Volume: Vol. 30, No.6 Pages: 886-892
• [Journal Article] 特集 「慢性アレルギー炎症―免疫系の役者たちの新たな姿 T細胞・好塩基球，サイトカインが織りなす慢性化のメカニズムとワクチン>開発」 慢性アレルギーに拘わる細胞系列とサイトカイン (2012)
  • Author(s): 久保允人
  • Journal Title: 実験医学 Volume: Vol. 30, No.6 Pages: 893-898
• [Journal Article] アレルギーにおける白血球・リンパ球の役割 (2012)
  • Author(s): 久保允人
  • Journal Title: 理大 科学フォーラム Volume: 334 Pages: 38-4
  • NAID: 40019239053
• [Journal Article] I サイトカインの種類I サイトカインの種類 (2012)
  • Author(s): 久保允人
  • Journal Title: IL-4 増刊号 「サイトカインのすべて」臨床免疫・アレルギー科 Volume: Vol.57 Suppl.21 Pages: 27-32
• [Journal Article] 胸腺内でのT細胞分化とサイトカイン (2012)
  • Author(s): 原田陽介・久保允人
  • Journal Title: 増刊号 「サイトカインのすべて」 臨床免疫・アレルギー科 Volume: Vol.57 Suppl.21 Pages: 664-669
• [Journal Article] 濾胞性T細胞のIL-4産生制御とIgE抗体産生 (2012)
  • Author(s): 原田陽介・久保允人
  • Journal Title: 医学のあゆみ Volume: Vol243 No.8 Pages: 689-690
• [Journal Article] Il4遺伝子の制御とアレルギーとの関与 (2012)
  • Author(s): 本村泰隆・久保允人
  • Journal Title: アレルギーの臨床 Volume: No434, 32巻 Pages: 17-22
• [Journal Article] サイトカインの産生・作用とシグナル伝達分子 マスト細胞と好塩基球におけるIL-4,IL-13遺伝子発現機構の相違 (2012)
  • Author(s): 本村泰隆・久保允人
  • Journal Title: 臨床免疫・アレルギー科 Volume: Vol.59, No3 Pages: 331-337
• [Journal Article] 自己免疫疾患・アレルギー疾患(前篇)免疫学の基礎,検査,治療：T細胞とサブセット (2012)
  • Author(s): 久保允人
  • Journal Title: 最新医学 Volume: 第68巻 3月増刊号
• [Presentation] E4BP4 (NFIL-3) affects the expression level of IFN-γ in Lin-CD127+NKp46- Innate lymphoid cells (2014)
  • Author(s): OMI Ai, MOTOMURA Yasutaka, KUBO Masato
  • Organizer: 第43回日本免疫学会総会
  • Place of Presentation: 京都府（国立京都国際会館）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Notch signaling promotes Tfh memory cell generation by facilitating migration into survival niche (2014)
  • Author(s): HARADA Yohsuke, TOKOYODA Koji, HANAZAWA Asami, KUBO Masato
  • Organizer: 第43回日本免疫学会総会
  • Place of Presentation: 京都府（国立京都国際会館）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] TH2 derived IgE antibody response in germinal center-dependent and independent ways (2014)
  • Author(s): HARADA Yasuyo, TAKEMORI Toshitada, KUBO Masato
  • Organizer: 第43回日本免疫学会総会
  • Place of Presentation: 京都府（国立京都国際会館）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Influenza A virus (IAV) vaccination effectively induces germinal center (2014)
  • Author(s): MIYAUCHI Kosuke, SUGIMOTO-ISHIGE Akiko, TAKAHASHI Yoshimasa, HASEGAWA Hideki, TAKEMORI Toshitada, KUBO Masato
  • Organizer: 第43回日本免疫学会総会
  • Place of Presentation: 京都府（国立京都国際会館）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Role of T follicular helper cells in influenza virus protection (2014)
  • Author(s): KUBO Masato
  • Organizer: France-Japan Immunology meeting
  • Place of Presentation: Cassis, France
  • Year and Date: 2014-10-22 – 2014-10-23
  • Invited
• [Presentation] Influenza virus vaccination effectively induces the protective antibody response independent on germinal centers (2014)
  • Author(s): KUBO Masato
  • Organizer: DRFG IMMUNOLOGY SEMINAR
  • Place of Presentation: Berlin, German
  • Year and Date: 2014-09-12
  • Invited
• [Presentation] Notch regulates reciprocal expression of CCR7 versus CXCR5 to control central memory T cell generation (2014)
  • Author(s): KUBO Masato
  • Organizer: The 2st. International Immunological Memory and Vaccine Forum
  • Place of Presentation: La Jolla, San Diego, CA USA
  • Year and Date: 2014-08-24 – 2014-08-25
  • Invited
• [Presentation] インフルエンザ感染の分子基盤 (2014)
  • Author(s): 久保允人
  • Organizer: 生命医科学研究所 ヒト疾患モデル研究センター 動物実験棟竣工記念シンポジウム
  • Place of Presentation: 東京理科大学野田キャンパス 薬学部講堂
  • Year and Date: 2014-07-12
  • Invited
• [Presentation] 好塩基球とナチュラルヘルパー細胞によるアレルギー性気道炎症の制御 (2014)
  • Author(s): 久保允人
  • Organizer: 第79回サイトカイン・インターフェロン学会
  • Place of Presentation: 北大医学部講堂 札幌
  • Year and Date: 2014-06-19 – 2014-06-20
  • Invited
• [Presentation] Cytokine regulation of antibody responses in influenza virus infection (2014)
  • Author(s): KUBO Masato
  • Organizer: Tsinghua University IMMUNOLOGY SEMINAR
  • Place of Presentation: Beijing
  • Year and Date: 2014-05-12
  • Invited
• [Presentation] Understanding a role of cytokine signaling in homeostatic skin regulation (2014)
  • Author(s): KUBO Masato
  • Organizer: Shanghai Immunodermatology Forum 2014
  • Place of Presentation: Shanghai
  • Year and Date: 2014-05-10
  • Invited
• [Presentation] Molecualr Mechanism of Immune Responses (2013)
  • Author(s): 久保允人
  • Organizer: The 86th Annual Meeting of the Biochemistry International session
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Invited
• [Presentation] Cytokine regulation in T follicular helper (2013)
  • Author(s): Masato Kubo
  • Organizer: Tfh Gordon Conference
  • Place of Presentation: Hong Kong
  • Invited
• [Presentation] 慢性炎症におけるIL-10働きとその制御 (2013)
  • Author(s): 久保允人
  • Organizer: 第45回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル（東京都）
  • Invited
• [Presentation] Roles of follicular helper T (TFH) cells in antibody based protective immunity against influenza virus. (2013)
  • Author(s): 久保允人
  • Organizer: International Workshop of Kyoto T cell Conference 2013
  • Place of Presentation: 紫蘭会館（京都府）
  • Invited
• [Presentation] Distinct roles of TFH and TH1 cells in humoral responses against influenza A virus infection (2013)
  • Author(s): Kosuke Miyauchi, Akiko Ishige, Tomohiro Kaji, Yohsuke Harada, Hideki Hasegawa, Yoshimasa Takahashi, Toshitada Takemori, Masato Kubo
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ（千葉県）
• [Presentation] Role of follicular helper T (TFH) cell in humeral responses against influenza A virus infection (2013)
  • Author(s): Kosuke Miyauchi, Tomohiro Kaji, Toshitada Takemori, Masato Kubo
  • Organizer: 第78回日本インターフェロン・サイトカイン学会/第21回マクロファージ分子細胞生物学国際シンポジウム
  • Place of Presentation: 都市センターホテル（東京都）
• [Presentation] 抗体はどこでつくられるか？ そしてワクチンへ (2013)
  • Author(s): 久保允人
  • Organizer: 第9回宮崎サイエンスキャンプ
  • Place of Presentation: シーガイヤコンベンションセンター 宮崎
  • Invited
• [Presentation] 濾胞型ヘルパーT細胞（TFH細胞）による抗体産生制御 (2012)
  • Author(s): 久保允人
  • Organizer: 第77回日本サイトカイン・インターフェロン学会
  • Place of Presentation: 神戸
  • Invited
• [Presentation] 時計制御分子による抗炎症性サイトカインIL-10の転写制御 (2012)
  • Author(s): 久保允人
  • Organizer: 第3回 Molecular Cardiovascular Conference
  • Place of Presentation: ホテルピアノ 北海道・キロロ
  • Invited
• [Presentation] Regulation of cytokine expression in Follicular helper T cell and humoral immunity (2012)
  • Author(s): Masato Kubo
  • Organizer: RIKEN Research Center for Allergy and Immunology RCAI-JSI International Symposium on Immunology
  • Place of Presentation: Yokohama
  • Invited
• [Presentation] Critical role of follicular helper T cells in the humoral immunity to T-D antigens and influenza virus (2012)
  • Author(s): Masato Kubo
  • Organizer: 3rd Internatinal Conference of Treg and Th subsets
  • Place of Presentation: Shanghai
  • Invited
• [Presentation] The 3’ enhancer, CNS2 is a crucial regulator of IL-4 mediated humoral immunity in follicular helper T cells (2012)
  • Author(s): 原田陽介、本村泰隆、原田康代、久保允人
  • Organizer: 第22回京都T細胞会議
  • Place of Presentation: 京都
• [Presentation] Functions of Tfh cells in influenza virus infection and airway hyperreactivity (2012)
  • Author(s): 宮内浩典、原田康代、加地友弘、鈴木芳枝、井上博雅、竹森利忠、久保允人
  • Organizer: 第22回京都T細胞会議
  • Place of Presentation: 京都
• [Presentation] The 3’ enhancer, CNS2 is a crucial regulator of IL-4 mediated humoral immunity in follicular helper T cells (2012)
  • Author(s): Harada, Y., Harada, Y., Honjo, T., Takemori, T., Kubo, M
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] :Critical role of follicular helper T cells in the IgE response to T-D antigens and serum neutralization activity in virus infection (2012)
  • Author(s): Miyauchi, K., Harada, Y., Motomura, Y., Kaji, T., Takemori, T., Kubo, M
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] :Folicular helper T cells arise from type 2helper T cells and control humoral immune responses (2012)
  • Author(s): Harada,Y., Harada,Y., Kubo, M
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Role of follicular helper T (TFH) cell in influenza A virus infection and vaccination (2012)
  • Author(s): Miyauchi, K., Kaji, T., Takemori, T., and Kubo, M
  • Organizer: Keystone Symposia Vaccination Conference
  • Place of Presentation: Ottawa
• [Presentation] 好塩基球とナチュラルヘルパー細胞によるアレルギー制御
  • Author(s): 本村泰隆、茂呂和代、小安重夫、久保允人
  • Organizer: 東京免疫フォーラム
  • Place of Presentation: 東京大学（東京都）
• [Presentation] 好塩基球とナチュラルヘルパー細胞によるアレルギー性気道炎症の制御
  • Author(s): 久保允人
  • Organizer: 第6回ドライアイ・アレルギージョイントセミナー
  • Place of Presentation: シャングリ・ラ ホテル東京（東京都）
  • Invited
• [Presentation] インフルエンザに対する抗体産生メカニズム
  • Author(s): 久保允人
  • Organizer: 化血研KIKUCHIバイオセミナー
  • Place of Presentation: 化血研（熊本県）
  • Invited
• [Presentation] 濾胞型ヘルパーT細胞と抗体産生制御
  • Author(s): 久保允人
  • Organizer: 産業医科大学 第一内科大学院特別講義
  • Place of Presentation: 産業医科大学（福岡県）
  • Invited
• [Presentation] サイトカインとシグナル伝達
  • Author(s): 久保允人
  • Organizer: 第57回日本リウマチ学会総会・学術集会
  • Place of Presentation: 京都国際会館（京都府）
• [Presentation] 濾胞型ヘルパーT細胞（TFH細胞）による抗体産生制御
  • Author(s): 久保允人
  • Organizer: 免疫学・アトーピセンターセミナー
  • Place of Presentation: 順天堂大学 東京
  • Invited
• [Presentation] 抗炎症サイトカインIL-10の可塑的発現による抗炎症制御
  • Author(s): 久保允人
  • Organizer: 第33回日本炎症・再生医学会
  • Place of Presentation: ホテル日航福岡
  • Invited
• [Presentation] 「難治性免疫疾患•アレルギー疾患の克服をめざして」 IgE抗体とアレルギー
  • Author(s): 久保允人
  • Organizer: 筑波大学、東京理科大学生命医科学研究所合同シンポジウム
  • Place of Presentation: 学士会館 東京
  • Invited
• [Presentation] サイトカインとアレルギー
  • Author(s): 久保允人
  • Organizer: ＴＵＳフォーラム２０１２「科学は技術を拓き、技術は科学を深める」
  • Place of Presentation: 東京
  • Invited
• [Presentation] Role of follicular helper T cells (TFH) in antibody responses
  • Author(s): Masato Kubo
  • Organizer: Distinguished Lecture Series in MD Anderson
  • Place of Presentation: Huston TX USA
  • Invited
• [Presentation] Role of Notch signal in the generation of follicular helper T cells (TFH) and memory T cell
  • Author(s): Masato Kubo
  • Organizer: The 1st. International Immunological Memory and Vaccine Forum
  • Place of Presentation: Tokyo
  • Invited