| Project/Area Number |
24249065
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Fukui |
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Principal Investigator |
Okazawa Hidehiko 福井大学, 高エネルギー医学研究センター, 教授 (50360813)
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| Co-Investigator(Kenkyū-buntansha) |
KIYONO YASUSHI 福井大学, 高エネルギー医学研究センター, 教授 (50305603)
TSUJIKAWA TETSUYA 福井大学, 高エネルギー医学研究センター, 准教授 (30380033)
MORI TETSUYA 福井大学, 高エネルギー医学研究センター, 助教 (40397287)
KIMURA Hirohiko 福井大学, 医学部, 教授 (10242596)
YOSHIDA YOSHIO 福井大学, 医学部, 教授 (60220688)
SHIOURA HIROKI 福井大学, 医学部附属病院, 講師 (50235488)
OYAMA NOBUYUKI 福井大学, 医学部附属病院, 講師 (20223977)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO KAZUTAKA 福井大学, 高エネルギー医学研究センター, 客員教授 (50158268)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥36,400,000 (Direct Cost: ¥28,000,000、Indirect Cost: ¥8,400,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2014: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2013: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2012: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
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| Keywords | 分子イメージング / ポジトロンCT (PET) / がん治療 / 低酸素イメージング / 治療抵抗性 / がん特異性 / 細胞増殖能 / 受容体イメージング / ﾎﾟｼﾞﾄﾛﾝCT (PET) / ポジトロンCT / 分子ｲﾒｰｼﾞﾝｸﾞ / ポジトロンCT(PET) / 治療効果判定 / 予後予測 / 放射線治療 |
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| Outline of Final Research Achievements |
We developed a new application method of functional PET and MRI imaging for treatment of advanced resistant cancers based on the molecular imaging technique. Various aspects of tumor functions such as proliferation, hypoxia, changes in receptor-phenotype were delineated by the functional PET imaging methods as well as diffusion MRI. The multimodal tumor functional imaging provided useful information before treatment, and prognostic values and aggressiveness of the cancers were able to be estimated.
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