Genomic epideological study of age-related macular degenration to develop individualized medicine

• Project/Area Number: 24249083
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyushu University
• Principal Investigator: TATSURO Ishibashi 九州大学, 医学(系)研究科(研究院), 教授 (30150428)
• Co-Investigator(Kenkyū-buntansha): YOSHIDA Shigeo 福岡大学, 医学部, 講師 (50363370) ; ENAIDA Hiroshi 佐賀大学, 医学部, 教授 (00363333) ; IKEDA Yasuhiro 九州大学, 大学病院, 助教 (20380389) ; KUBO Michiaki 独立行政法人理化学研究所, その他部局等, その他 (30442958)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥43,940,000 (Direct Cost: ¥33,800,000、Indirect Cost: ¥10,140,000); Fiscal Year 2014: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000); Fiscal Year 2013: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000); Fiscal Year 2012: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
• Keywords: 加齢黄斑変性 / 遺伝子多型 / 治療反応性 / ゲノム解析 / 危険因子 / 環境要因

Outline of Final Research Achievements

TNFRSF10A was consistently expressed in retinal pigment epithelial cells in human retina. We demonstrated that the susceptible allele of rs13278062 decreased TNFRSF10A expression in mRNA and protein level. We also identified the anti-oxidative role of TNFRSF10A in the pathogenesis of age-related macular degeneration (AMD). We assessed risk scores by combining genetic and environmental factors, which could be useful for predicting development of AMD. We identified 4 SNPs which could associate with response to anti-VEGF therapy in the patients with exudative AMD. This study can facilitate an establishment of preventive and personalized medicine in AMD based on genomic information.

Research Products

• [Journal Article] Full thickness macular hole case after intravitreal aflibercept treatment. (2015)
  • Author(s): Oshima Y, Apte RS, Nakao S, Yoshida S, Ishibashi T.
  • Journal Title: BMC Ophthalmol Volume: 15 Issue: 1 Pages: 30-30
  • DOI: 10.1186/s12886-015-0021-3
  • Peer Reviewed / Open Access
• [Journal Article] ROCK-Isoform-Specific Polarization of Macrophages Associated with Age-Related Macular Degeneration (2015)
  • Author(s): Zandi S, Nakao S, Chun K H, Fiorina P, Sun D, Arita R, Zhao M, Kim E, Schueller O, Campbell S, Taher M, Melhorn M I, Schering A, Gatti F, Tezza S, Xie F, Vergani A, Yoshida S, Ishikawa K, Yamaguchi M, Sasaki F, Schmidt-Ullrich R, Hata Y, Enaida H, Yuzawa M, Yokomizo T, 4名
  • Journal Title: Cell Rep Volume: 10 Issue: 7 Pages: 1173-86
  • DOI: 10.1016/j.celrep.2015.01.050
  • Peer Reviewed / Open Access
• [Journal Article] Microarray analysis of gene expression in fibrovascular membranes excised from patients with proliferative diabetic retinopathy. (2015)
  • Author(s): Ishikawa K, Yoshida S, Kobayashi Y, Zhou Y, Nakama T, Nakao S, Sassa Y, Oshima Y, Niiro H, Akashi K, Kono T, Ishibashi T.
  • Journal Title: Investigative Ophthalmology and Visual Science. Volume: 56 Issue: 2 Pages: 932-946
  • DOI: 10.1167/iovs.14-15589
  • Peer Reviewed
• [Journal Article] Environmental surveillance of poliovirus in sewage water around the introduction period for inactivated polio vaccine in Japan (2015)
  • Author(s): Nakamura T, Hamasaki M, Yoshitomi H, Ishibashi T, Yoshiyama C, Maeda E, Sera N, Yoshida H.
  • Journal Title: Appl Environ Microbiol. Volume: 81 Issue: 5 Pages: 1859
  • DOI: 10.1128/aem.03575-14
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of choroidal fibrovascular membrane formation by new class of RNA interference therapeutic agent targeting periostin. (2015)
  • Author(s): Nakama T, Yoshida S, Ishikawa K, Kobayashi Y, Zhou Y, Nakao S, Sassa Y, Oshima Y, Takao K, Shimahara A, Yoshikawa K, Hamasaki T, Ohgi T, Hayashi H, Matsuda A, Kudo A, Nozaki M, Ogura Y, Kuroda M, Ishibashi T.
  • Journal Title: Gene Therapy. Volume: 22 Issue: 2 Pages: 127-137
  • DOI: 10.1038/gt.2014.112
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Development and evaluation of a visual aid using see-through display for patients with retinitis pigmentosa. (2015)
  • Author(s): Ikeda Y, Suzuki E, Kuramata T, Kozaki T, Koyama T, Kato Y, Murakami Y, Enaida H, Ishibashi T.
  • Journal Title: Jpn J Ophthalmol Volume: 59 Issue: 1 Pages: 43-47
  • DOI: 10.1007/s10384-014-0354-0
  • NAID: 210000174403
• [Journal Article] Brilliant Blue G double staining enhances successful internal limiting membrane peeling with minimal adverse effect by low cellular permeability into live cells. (2015)
  • Author(s): Hisatomi T, Notomi S, Tachibana T, Oishi S, Asato R, Yamashita T, Murakami Y, Ikeda Y, Enaida H, Sakamoto T, Ishibashi T.
  • Journal Title: Retina Volume: 35 Issue: 2 Pages: 310-318
  • DOI: 10.1097/iae.0000000000000289
• [Journal Article] 日本における視覚障害の原因と現状 (2014)
  • Author(s): 若生里奈、安川 力、加藤亜紀、大森豊緑、石田 晋、石橋達朗、小椋祐一郎
  • Journal Title: 日本眼科学会雑誌 Volume: 118 Pages: 495-501
• [Journal Article] EBI3 is pivotal for the initiation of experimental autoimmune uveitis. (2014)
  • Author(s): Takeda A, Hasegawa E, Fukuhara T, Hirakawa S, Yamada H, Yang Y, Yoshimura T, Hisatomi T, Oshima Y, Yoshida H, Sonoda KH, Ishibashi T
  • Journal Title: Exp Eye Res Volume: 125 Pages: 107-113
  • DOI: 10.1016/j.exer.2014.06.004
  • Peer Reviewed
• [Journal Article] Hyphema is a risk factor for failure of trabeculectomy in neovascular glaucoma: a retrospective analysis. (2014)
  • Author(s): Nakatake S, Yoshida S, Nakao S, Arita R, Yasuda M, Kita T,Enaida H, Ohshima Y, Ishibashi T
  • Journal Title: BMC Ophthalmoligy Volume: 14 Issue: 1 Pages: 55-55
  • DOI: 10.1186/1471-2415-14-55
  • Peer Reviewed / Open Access
• [Journal Article] Chromovitrectomy and vital dyes. (2014)
  • Author(s): Enaida H, Hisatomi T, Nakao S, Ikeda Y, Yoshida S, Ishibashi T
  • Journal Title: Dev Ophthalmol Volume: 54 Pages: 120-125
  • DOI: 10.1159/000360457
  • ISBN: 9783318026603, 9783318026610
• [Journal Article] Decreased proteasomal activity causes photoreceptor degeneration in mice. (2014)
  • Author(s): Ando R, Noda K, Tomaru U, Kamoshita M, Ozawa Y, Notomi S, Hisatomi T, Noda M, Kanda A, Ishibashi T, Kasahara M, Ishida S.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 55 Issue: 7 Pages: 4682-4690
  • DOI: 10.1167/iovs.13-13272
  • Peer Reviewed / Open Access
• [Journal Article] Individualized, spectral domain-optical coherence tomography-guided facedown posturing after macular hole surgery: minimizing treatment burden and maximizing outcome. (2014)
  • Author(s): Yamashita T, Sakamoto T, Yamashita T, Sonoda S, Yamakiri K,Otsuka H, Hisatomi T, Imaki H, Ishibashi T, Dugel PU
  • Journal Title: Retina Volume: 34 Issue: 7 Pages: 1367-1375
  • DOI: 10.1097/iae.0000000000000087
  • Peer Reviewed
• [Journal Article] Ultrastructural Changes of the Vitreoretinal Interface During Long-Term Follow-up After Removal of the Internal Limiting Membrane. (2014)
  • Author(s): Hisatomi T, Notomi S, Tachibana T, Sassa Y, Ikeda Y, Nakamura T, Ueno A, Enaida H, Murata T, Sakamoto T, Ishibashi T
  • Journal Title: Am J Ophthalmol Volume: 158 Issue: 3 Pages: 550-556
  • DOI: 10.1016/j.ajo.2014.05.022
  • Peer Reviewed
• [Journal Article] Therapeutic efficacy of topical unoprostone isopropyl in retinitis pigmentosa. (2014)
  • Author(s): Akiyama M, Ikeda Y, Yoshida N, Notomi S, Murakami Y, Hisatomi T,Enaida H, Ishibashi T
  • Journal Title: Acta Ophthalmol Volume: 92
• [Journal Article] 糖尿病黄斑浮腫患者を対象としたペガプタニブナトリウムの国内第Ⅲ相臨床試験 (2014)
  • Author(s): 石橋達朗、湯澤美都子、吉村長久、大路正人、石田 晋、五十川直樹、江坂悦子
  • Journal Title: 日本眼科学会雑誌 Volume: 118 Pages: 773-782
• [Journal Article] Increased expression of M-CSF and IL-13 in vitreous of patients with proliferative diabetic retinopathy: implications for M2 macrophage-involving fibrovascular membrane formation. (2014)
  • Author(s): Yoshida S, Kobayashi Y, Nakama T, Zhou Y, Ishikawa K, Arita R,Nakao S, Miyazaki M, Sassa Y, Oshima Y, Izuhara K, Kono T,Ishibashi T
  • Journal Title: Br J Ophthalmol Volume: 99 Issue: 5 Pages: 629-634
  • DOI: 10.1136/bjophthalmol-2014-305860
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of the long-term efficacy and safety of infliximab treatment for uveitis in Behçet's disease: a multicenter study. (2014)
  • Author(s): Takeuchi M, Kezuka T, Sugita S, Keino H, Namba K, Kaburaki T, Maruyama K, Nakai K, Hijioka K, Shibuya E, Komae K, Hori J, Ohguro N, Sonoda KH, Mizuki N, Okada AA, Ishibashi T, Goto H, Mochizuki M
  • Journal Title: Ophthalmology Volume: 121(10) Issue: 10 Pages: 1877-1884
  • DOI: 10.1016/j.ophtha.2014.04.042
  • Peer Reviewed / Open Access
• [Journal Article] Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy. (2014)
  • Author(s): Ishikawa K, Yoshida S, Nakao S, Nakama T, Kita T, Asato R, Sassa Y, Arita R, Miyazaki M, Enaida H, Oshima Y, Murakami N, Niiro H, Ono J, Matsuda A, Goto Y, Akashi K, Izuhara K, Kudo A, Kono T, Hafezi-Moghadam A, Ishibashi T.
  • Journal Title: FASEB J Volume: 28 Pages: 131-42
  • Peer Reviewed
• [Journal Article] Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration. (2014)
  • Author(s): Murakami Y, Matsumoto H, Roh M, Giani A, Kataoka K, Morizane Y, Kayama M, Thanos A, Nakatake S, Notomi S, Hisatomi T, Ikeda Y, Ishibashi T, Connor KM, Miller JW, Vavvas DG.
  • Journal Title: Cell Death Differ Volume: 21 Pages: 270-7
  • Peer Reviewed
• [Journal Article] IL-10 is significantly involved in HSP70-regulation of experimental subretinal fibrosis. (2013)
  • Author(s): Yang Y, Takeda A, Yoshimura T, Oshima Y, Sonoda KH, Ishibashi T.
  • Journal Title: PLoS One Volume: 8
  • Peer Reviewed
• [Journal Article] Improved brilliant blue G staining of the internal limiting membrane with sharp cut filters of a novel viewing filter system. (2013)
  • Author(s): Enaida H, Yoshida S, Nakao S, Ikeda Y, Hachisuka Y, Oshima Y, Kadonosono K, Ueno A, Ishibashi T
  • Journal Title: Ophthalmologica Volume: 2 Pages: 27-32
  • Peer Reviewed
• [Journal Article] Photoreceptor cell death and rescue in retinal detachment and degenerations. (2013)
  • Author(s): Murakami Y, Notomi S, Hisatomi T, Nakazawa T, Ishibashi T, Miller JW, Vavvas DG.
  • Journal Title: Prog Retin Eye Res Volume: 37 Pages: 114-40
  • Peer Reviewed
• [Journal Article] Maintenance therapy with pegaptanib sodium for neovascular age-related macular degeneration: an exploratory study in Japanese patients (LEVEL-J study). (2013)
  • Author(s): Ishibashi T; LEVEL-J Study Group.
  • Journal Title: Jpn J Ophthalmol Volume: 57 Pages: 417-23
  • NAID: 10031201471
  • Peer Reviewed
• [Journal Article] Wide-field laser ophthalmoscopy for mice: a novel evaluation system for retinal/choroidal angiogenesis in mice. (2013)
  • Author(s): Nakao S, Arita R, Nakama T, Yoshikawa H, Yoshida S, Enaida H, Hafezi-Moghadam A, Matsui T, Ishibashi T.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 54 Pages: 5288-93
  • Peer Reviewed
• [Journal Article] A Novel Platelet-Activating Factor Receptor Antagonist Inhibits Choroidal Neovascularization and Subretinal Fibrosis. (2013)
  • Author(s): Zhang H, Yang Y, Takeda A, Yoshimura T, Oshima Y, Sonoda KH, Ishibashi T.
  • Journal Title: PLoS One Volume: 8
  • Peer Reviewed
• [Journal Article] Therapeutic effect of prolonged treatment with topical dorzolamide for cystoid macular oedema in patients with retinitis pigmentosa. (2013)
  • Author(s): Ikeda Y, Yoshida N, Notomi S, Murakami Y, Hisatomi T, Enaida H, Ishibashi T.
  • Journal Title: Br J Ophthalmol Volume: 97 Pages: 1187-91
  • Peer Reviewed
• [Journal Article] Clinical evaluation and feasibility of changing intraoperative visibility with a novel viewing filter system for human eye. (2013)
  • Author(s): Enaida H, Ikeda Y, Yoshida S, Nakao S, Hachisuka Y, Fujita K, Oshima Y, Kadonosono K, Matsui T, Ishibashi T.
  • Journal Title: Retina Volume: 33 Pages: 1923-30
  • Peer Reviewed
• [Journal Article] Quantitative analysis of vitreous and plasma concentrations of brilliant blue g after use as a surgical adjuvant in chromovitrectomy. (2013)
  • Author(s): Enaida H, Kumano Y, Ueno A, Yoshida S, Nakao S, Numa S, Matsui T, Ishibashi T.
  • Journal Title: Retina. Volume: 33 Pages: 2170-4
  • Peer Reviewed
• [Journal Article] Transconjunctival observation and suturing technique for invisible and insufficiently closed sclerotomy wounds using an inverted surgical contact lens in transconjunctival microincision vitrectomy surgery. (2013)
  • Author(s): Enaida H, Ueno A, Nakao S, Ikeda Y, Yoshida S, Kumano Y, Ishibashi T.
  • Journal Title: Retina Volume: 33 Pages: 1270-2
  • Peer Reviewed
• [Journal Article] Altered vascular microenvironment by bevacizumab in diabetic fibrovascular membrane. (2013)
  • Author(s): Nakao S, Ishikawa K, Yoshida S, Kohno R, Miyazaki M, Enaida H, Kono T, Ishibashi T.
  • Journal Title: Retina Volume: 33 Pages: 957-63
  • Peer Reviewed
• [Journal Article] A key role for ROCK in TNF-α-mediated diabetic microvascular damage. (2013)
  • Author(s): Arita R, Nakao S, Kita T, Kawahara S, Asato R, Yoshida S, Enaida H, Hafezi-Moghadam A, Ishibashi T.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 54 Pages: 2373-83
  • Peer Reviewed
• [Journal Article] Comparison of gene expression profile of epiretinal membranes obtained from eyes with proliferative vitreoretinopathy to that of secondary epiretinal membranes. (2013)
  • Author(s): Asato R, Yoshida S, Ogura A, Nakama T, Ishikawa K, Nakao S, Sassa Y, Enaida H, Oshima Y, Ikeo K, Gojobori T, Kono T, Ishibashi T.
  • Journal Title: PLoS One. Volume: 8
  • NAID: 120005227330
  • Peer Reviewed
• [Journal Article] Dynamic increase in extracellular ATP accelerates photoreceptor cell apoptosis via ligation of P2RX7 in subretinal hemorrhage. (2013)
  • Author(s): Notomi S, Hisatomi T, Murakami Y, Terasaki H, Sonoda S, Asato R, Takeda A, Ikeda Y, Enaida H, Sakamoto T, Ishibashi T.
  • Journal Title: PLoS One Volume: 8
  • Peer Reviewed
• [Journal Article] Bone marrow-derived monocyte lineage cells recruited by MIP-1β promote physiological revascularization in mouse modelof oxygen-induced retinopathy. (2012)
  • Author(s): Ishikawa K
  • Journal Title: Laboratory Investigation Volume: 92 Issue: 1 Pages: 91-101
  • DOI: 10.1038/labinvest.2011.141
  • Peer Reviewed
• [Journal Article] Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration. (2012)
  • Author(s): Murakami Y
  • Journal Title: Proc Natl Acad Sci USA Volume: 109 Issue: 36 Pages: 14598-14603
  • DOI: 10.1073/pnas.1206937109
  • Peer Reviewed
• [Journal Article] The regulatory roles of apoptosis-inducing factor in the formation and regression processes of ocular neovascularization. (2012)
  • Author(s): Hisatomi T
  • Journal Title: Am J Patho Volume: 181 Issue: 1 Pages: 53-61
  • DOI: 10.1016/j.ajpath.2012.03.022
  • Peer Reviewed
• [Journal Article] Heat treatment of retinal pigment epithelium induces production of elastic lamina components and antiangiogenic activity (2012)
  • Author(s): Sekiyama E, Saint-Geniez M, Yoneda K, Hisatomi T, Nakao S, Walshe TE, Maruyama K, Hafezi-Moghadam A, Miller JW, Kinoshita S, D' Amore PA
  • Journal Title: FASEB journal Volume: 26巻 Issue: 2 Pages: 567-575
  • DOI: 10.1096/fj.11-184127
  • Peer Reviewed
• [Journal Article] Antiangiogenic shift in vitreous after vitrectomy in patients with proliferative diabetic retinopathy. (2012)
  • Author(s): Yoshida S, et. al.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 53 Issue: 11 Pages: 6997-7003
  • DOI: 10.1167/iovs.12-9671
  • Peer Reviewed
• [Journal Article] The Clinical Efficacy of a Topical Dorzolamide in the Management of Cystoid Macular Edema in Patients with Retinitis Pigmentosa (2012)
  • Author(s): Ikeda Y
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 250 Issue: 6 Pages: 809-814
  • DOI: 10.1007/s00417-011-1904-5
  • Peer Reviewed
• [Journal Article] Intravitreal anti-VEGF therapy blocks inflammatory cell infiltration and re-entry into the circulation in retinal angiogenesis (2012)
  • Author(s): Nakao S, et al.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 53 Issue: 7 Pages: 885-196
  • DOI: 10.1167/iovs.11-9119
  • Peer Reviewed
• [Journal Article] Larger therapeutic window for steroid vs VEGF-A inhibitor in inflammatory angiogenesis: Surprisingly similar impact on leukocyte infiltration. (2012)
  • Author(s): Nakao S
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 53 Issue: 7 Pages: 3296-3302
  • DOI: 10.1167/iovs.11-8114
  • Peer Reviewed
• [Journal Article] MutT homolog-1 attenuates oxidative DNA damage and delays photoreceptor cell death in inherited retinal degeneration. (2012)
  • Author(s): Murakami Y, Ikeda Y, Yoshida N, Notomi S, Hisatomi T, Oka S, De Luca G, Yonemitsu Y, Bignami M, Nakabeppu Y, Ishibashi T.
  • Journal Title: Am J Pathol Volume: 181 Issue: 4 Pages: 1378-1386
  • DOI: 10.1016/j.ajpath.2012.06.026
  • Peer Reviewed
• [Journal Article] Post-treatment change in the localization of recurrent or persistent macular edema secondary to branch retinal vein occlusion. (2012)
  • Author(s): Arima M
  • Journal Title: Ophthalmologica 228 Volume: 1 Issue: 1 Pages: 1-6
  • DOI: 10.1159/000334620
  • Peer Reviewed
• [Journal Article] Involvement of periostin in regression of hyaloidvascular system during ocular development (2012)
  • Author(s): Arima M, et al.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 53 Issue: 10 Pages: 6495-6503
  • DOI: 10.1167/iovs.12-9684
  • Peer Reviewed
• [Journal Article] IL-27 inhibits pathophysiological intraocular neovascularization due to laser burn (2012)
  • Author(s): Hasegawa E, Oshima Y, Takeda A, Saeki K, Yoshida H, Sonoda KH, Ishibashi T
  • Journal Title: J.Leukoc.Biol. Volume: 91 Issue: 2 Pages: 267-273
  • DOI: 10.1189/jlb.1110603
  • Peer Reviewed
• [Journal Article] Observations of vascular structures within and posterior to sclera in eyes with pathologic myopia by swept-source optical coherence tomography. (2012)
  • Author(s): Ohno-Matsui K
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 53 Issue: 11 Pages: 7290-7298
  • DOI: 10.1167/iovs.12-10371
  • Peer Reviewed
• [Journal Article] Association between shape of sclera and myopic retinochoroidal lesions in patients with pathologic myopia. (2012)
  • Author(s): Ohno-Matsui K
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 53 Issue: 10 Pages: 6046-6061
  • DOI: 10.1167/iovs.12-10161
  • Peer Reviewed
• [Journal Article] Intrachoroidal cavitation in macular area of eyes with pathologic myopia. (2012)
  • Author(s): Ohno-Matsui K
  • Journal Title: Am J Ophthalmol Volume: 154 Issue: 2 Pages: 382-393
  • DOI: 10.1016/j.ajo.2012.02.010
  • Peer Reviewed
• [Journal Article] Acquired Optic Nerve and Peripapillary Pits in Pathologic Myopia. (2012)
  • Author(s): Ohno-Matsui K
  • Journal Title: Ophthalmology Volume: 119 Issue: 8 Pages: 1685-1692
  • DOI: 10.1016/j.ophtha.2012.01.047
  • Peer Reviewed
• [Journal Article] Prevalence and risk factors for myopic retinopathy in a Japanese population: Hisayama Study. (2012)
  • Author(s): Asakuma T
  • Journal Title: Ophthalmology Volume: 119 Issue: 9 Pages: 1760-1765
  • DOI: 10.1016/j.ophtha.2012.02.034
  • Peer Reviewed
• [Journal Article] 北部九州における内因性ぶどう膜炎の統計-1996年～2008年の比較 (2012)
  • Author(s): 疋田伸一
  • Journal Title: 日本眼科学会雑誌 Volume: 116 Pages: 847-855
  • Peer Reviewed
• [Journal Article] A change in treatment from etanercept to infliximab was effective to control scleritis in a patient with rheumatoid arthritis (2011)
  • Author(s): Sassa Y, Kawano YI, Yamana T, Mashima T, Ishibashi T
  • Journal Title: Acta Ophthalmol Volume: 90 Issue: 2 Pages: 161-162
  • DOI: 10.1111/j.1755-3768.2010.02090.x
  • Peer Reviewed
• [Presentation] 糖尿病性眼疾患の現状と最新治療 (2014)
  • Author(s): 石橋達朗
  • Organizer: 第26回日本糖尿病性腎症研究会
  • Place of Presentation: 東京都
  • Year and Date: 2014-12-16
  • Invited
• [Presentation] 糖尿病網膜症と視力障害について (2014)
  • Author(s): 石橋達朗
  • Organizer: 第21回遠賀中間DMカンファランス
  • Place of Presentation: 中間市
  • Year and Date: 2014-10-06
  • Invited
• [Presentation] 糖尿病黄斑浮腫 (2014)
  • Author(s): 石橋達朗
  • Organizer: 第8回北陸オフサルミックフォーラム
  • Place of Presentation: 金沢市
  • Year and Date: 2014-10-04
• [Presentation] 糖尿病黄斑浮腫 (2014)
  • Author(s): 石橋達朗
  • Organizer: 第254回長野県眼科医会集談会
  • Place of Presentation: 松本市
  • Year and Date: 2014-09-14
  • Invited
• [Presentation] 糖尿病黄斑浮腫 (2014)
  • Author(s): 石橋達朗
  • Organizer: 第118回南大阪眼科研究会
  • Place of Presentation: 大阪市
  • Year and Date: 2014-08-16
  • Invited
• [Presentation] 糖尿病網膜症：最近の話題 (2014)
  • Author(s): 石橋達朗
  • Organizer: 第29回東京医科歯科大学眼科学教室同門会集談会
  • Place of Presentation: 東京都
  • Year and Date: 2014-07-21
  • Invited
• [Presentation] 糖尿病網膜症2014 (2014)
  • Author(s): 石橋達朗
  • Organizer: 第122回佐賀大学眼科臨床懇話会
  • Place of Presentation: 佐賀市
  • Year and Date: 2014-07-12
  • Invited
• [Presentation] 網膜色素変性に対する新しい治療法開発 (2014)
  • Author(s): 石橋達朗
  • Organizer: 第56回日本老年医学会学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-06-12
  • Invited
• [Presentation] 糖尿病網膜症：最近の話題 (2014)
  • Author(s): 石橋達朗
  • Organizer: 第18回北海道黄斑疾患研究会
  • Place of Presentation: 札幌
  • Year and Date: 2014-05-17
  • Invited
• [Presentation] Pathogenesis of Vascular Permeability in Diabetic Macular Edema. (2014)
  • Author(s): Ishibashi T
  • Organizer: AOI lecture
  • Place of Presentation: Tokyo
  • Year and Date: 2014-04-04
  • Invited
• [Presentation] Increased Expression of Periostin in Vitreous and Fibrovascular Membranes from Patients with Proliferative Diabetic Retinopathy (2012)
  • Author(s): Ishibashi T
  • Organizer: XXVIIIth Meeting of the Club Jules Gonin
  • Place of Presentation: Reykjavik, celand
  • Invited
• [Presentation] 最近の眼科医療と医師不足？
  • Author(s): 石橋達朗
  • Organizer: LF会
  • Place of Presentation: 福岡市
  • Invited
• [Presentation] 糖尿病黄斑浮腫（網膜血管透過性のメカニズムとその制御）
  • Author(s): 石橋達朗
  • Organizer: 第30回日本眼循環学会（第2回松山賞受賞者講演）
  • Place of Presentation: 東京都
  • Invited
• [Presentation] 網膜色素変性に対する遺伝子治療
  • Author(s): 石橋達朗
  • Organizer: 福岡労災保険指定病院協会学術講演会
  • Place of Presentation: 福岡市
  • Invited
• [Presentation] 網膜色素変性に対する新しい治療法開発
  • Author(s): 石橋達朗
  • Organizer: 第2回新学術領域研究「感覚器の発生・再生・変性」
  • Place of Presentation: 東京都
  • Invited
• [Presentation] 加齢とともに増加する目の病気
  • Author(s): 石橋達朗
  • Organizer: 第29回目の健康講座
  • Place of Presentation: 福岡市
  • Invited
• [Presentation] 疫学と病態について
  • Author(s): 石橋達朗
  • Organizer: 第１回Senju Ophthlmic Seminar in 岡山
  • Place of Presentation: 岡山市
  • Invited
• [Presentation] 研究を臨床に結実させるために-レギュラトリーサイエンスを学ぼう-
  • Author(s): 石橋達朗
  • Organizer: 第67回日本臨床眼科学会
  • Place of Presentation: 横浜市
  • Invited
• [Presentation] 失明につながる眼の病気：加齢黄斑変性
  • Author(s): 石橋達朗
  • Organizer: 第67回日本臨床眼科学会 市民公開講座
  • Place of Presentation: 横浜市
  • Invited
• [Presentation] 失明につながる眼の病気：加齢黄斑変性
  • Author(s): 石橋達朗
  • Organizer: 第109回九州大学第一内科開講記念会
  • Place of Presentation: 福岡市
  • Invited
• [Presentation] 眼の大切さ
  • Author(s): 石橋達朗
  • Organizer: ライオンズクラブ国際協会337-A地区 献眼推進セミナー
  • Place of Presentation: 福岡市
  • Invited
• [Presentation] 抗VEGF治療の最前線
  • Author(s): 石橋達朗
  • Organizer: 新・眼科診療アップデートセミナー2014 in Kyoto
  • Place of Presentation: 京都市
  • Invited
• [Presentation] 加齢黄斑変性：最近の話題
  • Author(s): 石橋達朗
  • Organizer: 第3回石川黄斑疾患講演会
  • Place of Presentation: 金沢市
  • Invited
• [Presentation] 眼科臨床における核酸医薬に関する期待と課題
  • Author(s): 石橋達朗
  • Organizer: 核酸創薬イノベーション～復活するsiRNA医薬～
  • Place of Presentation: 東京
  • Invited
• [Presentation] 糖尿病網膜症：最近の話題
  • Author(s): 石橋達朗
  • Organizer: 第45回道南眼科集談会
  • Place of Presentation: 函館市
  • Invited
• [Presentation] Challenges of AMD in the Asian Population.
  • Author(s): Ishibashi T
  • Organizer: Age-Related Macular Degeneration in 2012
  • Place of Presentation: Baltimore, USA
  • Invited
• [Presentation] Pathology of Polypoidal Choroidal Vasculopathy (PCV)
  • Author(s): Ishibashi T
  • Organizer: Challenge in AMD Study 2012 Beijing
  • Place of Presentation: Beijing, China
  • Invited
• [Presentation] 糖尿病網膜症：最近の話題
  • Author(s): 石橋達朗
  • Organizer: 平成24年度奈良県立医科大学眼科学教室同窓会
  • Place of Presentation: 大阪府
  • Invited
• [Presentation] Pathology of Age-Related Macular Degeneration.
  • Author(s): Ishibashi T
  • Organizer: The 17th Congress of Chinese Ophthalmological Society.
  • Place of Presentation: Nanjing, China
  • Invited
• [Presentation] A New Strategy on the Surgical Treatment for Diabetic Retinopathy
  • Author(s): Ishibashi T
  • Organizer: The 17th Congress of Chinese Ophthalmological Society.
  • Place of Presentation: Nanjing, China
  • Invited
• [Presentation] 眼の大切さ
  • Author(s): 石橋達朗
  • Organizer: ライオンズクラブ 献眼運動推進シンポジウム
  • Place of Presentation: 福岡市
  • Invited
• [Presentation] 六大学研究会のあゆみ
  • Author(s): 石橋達朗
  • Organizer: 第50回六大学合同眼科研究会
  • Place of Presentation: 福岡市
  • Invited
• [Presentation] 糖尿病でなぜ失明するのか？
  • Author(s): 石橋達朗
  • Organizer: 第4回糖尿病市民公開講座
  • Place of Presentation: 中間市
  • Invited
• [Presentation] 加齢黄斑変性2012
  • Author(s): 石橋達朗
  • Organizer: 瀬戸内眼科コロシアム
  • Place of Presentation: 広島市
  • Invited
• [Presentation] 加齢黄斑変性：最近の話題
  • Author(s): 石橋達朗
  • Organizer: 第100回久留米大学眼科研究会
  • Place of Presentation: 久留米市
  • Invited
• [Presentation] 最近増加している眼疾患：加齢黄斑変性
  • Author(s): 石橋達朗
  • Organizer: 第11回イブニングセミナー
  • Place of Presentation: 別府市
  • Invited
• [Presentation] 糖尿病網膜症の最新治療
  • Author(s): 石橋達朗
  • Organizer: 第27回日本糖尿病合併症学会 第18回日本糖尿病学会総会
  • Place of Presentation: 福岡市
  • Invited
• [Presentation] 加齢黄斑変性：最近の話題
  • Author(s): 石橋達朗
  • Organizer: 第2回岐阜眼科アカデミー
  • Place of Presentation: 岐阜市
  • Invited
• [Presentation] 発症者急増中！加齢黄斑変性
  • Author(s): 石橋達朗
  • Organizer: NHK福岡放送局「ぐるっと8県 九州沖縄」
  • Place of Presentation: 福岡市
  • Invited