Detection of molecular targets for childhood cancers using genomics and cellomics: targeting for cancer stem cells

• Project/Area Number: 24249084
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatric surgery
• Research Institution: Hiroshima University
• Principal Investigator: HIYAMA Eiso 広島大学, 自然科学研究支援開発センター, 教授 (00218744)
• Co-Investigator(Kenkyū-buntansha): KANAWA Masami 広島大学, 自然科学研究支援開発センター, 助教 (00284208) ; MASUJIMA Tsutomu 独立行政法人理化学研究所, 生命システム研究センター, チームリーダー (10136054) ; SOTOMARU Yusuke 広島大学, 自然科学研究支援開発センター, 教授 (90309352) ; KAMIMATSUSE Arata 広島大学, 大学病院, 病院助教 (90569881) ; OGURA Kaoru 広島大学, 病院, 講師 (10346653) ; 鬼武 美幸 広島大学, 大学病院, 病院助教 (10448269)
• Co-Investigator(Renkei-kenkyūsha): NAKAGAWARA Akira 地方独立行政法人佐賀県医療センター, 好生館, 理事長 (50117181)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥44,330,000 (Direct Cost: ¥34,100,000、Indirect Cost: ¥10,230,000); Fiscal Year 2014: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000); Fiscal Year 2013: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000); Fiscal Year 2012: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
• Keywords: 癌 / 遺伝子 / ゲノム / マイクロアレイ / トランスレーショナルリサーチ

Outline of Final Research Achievements

Using 42 primary tumor culture cells and 23 cell lines derived from childhood cancer, 6 cancer stem cell fractures were isolated by cell sorting. These separated cells have an in vitro colony formation capacity and an in vivo tumor formation one. Single cell analysis (Cellomics) of these cell revealed approximately 100 proteins upregulated by Mass spectrometry. Genomic aberration and gene expression were also analyze by microarray and next-generation sequencing. Pathway analysis of these data revealed 3 candidate driver genes as molecular targets in childhood cancer treatment.

Research Products

• [Journal Article] 肝芽腫の分子生物学 (2015)
  • Author(s): 檜山英三, 上田祐華, 栗原 将
  • Journal Title: 小児外科 Volume: 47 Pages: 181-188
  • Peer Reviewed / Open Access
• [Journal Article] １細胞メタボローム (2015)
  • Author(s): 升島努
  • Journal Title: 細胞工学 Volume: 34 Pages: 273-277
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] シングルセルレベルでの薬物動態モニタリング (2015)
  • Author(s): 伊達沙智子,升島努、岩渕春男、武井誠、高草英生、泉高司
  • Journal Title: 実験医学 Volume: 33 Pages: 26-32
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The Children’s Hepatic tumors International Collaboration (CHIC): novel global rare tumor database yields new prognostic factors in hepatoblastoma (2015)
  • Author(s): Czauderna P, Haeberle B, Hiyama E
  • Journal Title: Lancet Oncology Volume: in press
  • Peer Reviewed
• [Journal Article] Direct Metabolomics for Plant Single Cells by Live Single Cell Mass Spectrometry (2015)
  • Author(s): Fujii T, Matsuda S, Lorenzo Tejedor M, Esaki , Sakane I, Mizuno H, Tsuyama N, Masujima T
  • Journal Title: Nature Protocols Volume: in press
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hepatoblastoma state of the art: pathology, genetics, risk stratification, and chemotherapy (2014)
  • Author(s): Czauderna P, Lopez-Terrada D, Hiyama E, Häberle B, Malogolowkin MH, Meyers RL
  • Journal Title: Current Opinion in Pediatrics Volume: 26 Issue: 1 Pages: 19-28
  • DOI: 10.1097/mop.0000000000000046
  • Peer Reviewed / Open Access
• [Journal Article] Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium (2014)
  • Author(s): Lopez-Terrada D, Alaggio R, de Davila MT, Czauderna P, Hiyama E, Katzenstein H, Leuschner I, Malogolowkin M, Meyers R, Ranganathan S, Tanaka Y, Tomlinson G, Fabrè M, Zimmermann A, Finegold MJ; Children's Oncology Group Liver Tumor Committee
  • Journal Title: Modern Pathology Volume: 27 Pages: 472-491
  • Peer Reviewed / Open Access
• [Journal Article] Clinical features of ATRX or DAXX mutated neuroblastoma (2014)
  • Author(s): Kurihara S, Hiyama E, Onitake Y, Yamaoka E, Hiyama K
  • Journal Title: Journal of Pediatric Surgery Volume: 49 Issue: 12 Pages: 1835-1838
  • DOI: 10.1016/j.jpedsurg.2014.09.029
  • Peer Reviewed / Open Access
• [Journal Article] FAST-id system for enrichment of cells with TALEN-induced mutations and large deletions (2014)
  • Author(s): Tokumasu D, Sakuma T, Hayashi Y, Hosoi S, Hiyama E, Yamamoto T
  • Journal Title: Genes to Cells Volume: 19 Issue: 5 Pages: 419-431
  • DOI: 10.1111/gtc.12142
  • Peer Reviewed / Open Access
• [Journal Article] Dynamics of genomic 5-hydroxymethylcytosine during mouse oocyte growth (2014)
  • Author(s): Sakashita A, Kobayashi H, Wakai T, Sotomaru Y, Hata K, Kono T
  • Journal Title: Genes to Cells Volume: 19 Pages: 629-636
  • Peer Reviewed
• [Journal Article] Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli. (2014)
  • Author(s): Tanaka S, Miyagi T, Dohi E, Seki T, Hide I, Sotomaru Y, Saeki Y, Antonio Chiocca E, Matsumoto M, Sakai N
  • Journal Title: Neurobiology of Disease Volume: 68 Pages: 215-227
  • Peer Reviewed
• [Journal Article] A study on cryoprotectant solution suitable for vitrification of rat two-cell stage embryos. (2014)
  • Author(s): Eto T, Takahashi R, Kamisako T, Hioki K, Sotomaru Y
  • Journal Title: Cryobiology Volume: 68 Pages: 147-151
  • Peer Reviewed
• [Journal Article] 一細胞質量分析法によるin situ ダイレクト分子群動態追跡 (2014)
  • Author(s): 升島 努
  • Journal Title: 生体の科学 Volume: 65 Pages: 404-405
  • Peer Reviewed
• [Journal Article] Pediatric Hepatoblastoma: diagnosis and treatment (2014)
  • Author(s): Hiyama E
  • Journal Title: Translational Pediatrics Volume: 3 Pages: 293-299
  • Peer Reviewed
• [Journal Article] Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium (2014)
  • Author(s): Lopez-Terrada D, Alaggio R, de Davila MT, Czauderna P, Hiyama E, Katzenstein H, Leuschner I, Malogolowkin M, Meyers R, Ranganathan S, Tanaka Y, Tomlinson G, Fabre M, Zimmermann A, Finegold MJ; Children's Oncology Group Liver Tumor Committee
  • Journal Title: Modern Pathology Volume: 27 Issue: 3 Pages: 472-491
  • DOI: 10.1038/modpathol.2013.80
  • Peer Reviewed / Open Access
• [Journal Article] RASSF1A methylation indicates a poor prognosis in hepatoblastoma patients (2013)
  • Author(s): Honda S, Miyagi H, Suzuki H, Minato M, Haruta M, Kaneko Y, Hatanaka KC, Hiyama E, Kamijo T, Okada T, Taketomi A
  • Journal Title: Pediatric Surgery International Volume: 29 Issue: 11 Pages: 1147-1152
  • DOI: 10.1007/s00383-013-3371-z
  • Peer Reviewed / Open Access
• [Journal Article] Detection of MYCN amplification using blood plasma: noninvasive therapy evaluation and prediction of prognosis in neuroblastoma (2013)
  • Author(s): Kojima M, Hiyama E, Fukuba I, Yamaoka E, Ueda Y, Onitake Y, Kurihara S, Sueda T
  • Journal Title: Pediatric Surgery International Volume: 29 Issue: 11 Pages: 1139-1145
  • DOI: 10.1007/s00383-013-3374-9
  • Peer Reviewed / Open Access
• [Journal Article] A cisplatin plus pirarubicin-based JPLT2 chemotherapy for hepatoblastoma: experience and future of the Japanese Study Group for Pediatric Liver Tumor (JPLT) (2013)
  • Author(s): Hiyama E, Ueda Y, Onitake Y, Kurihara S, Watanabe K, Hishiki T, Tajiri T, Ida K, Yano M, Kondo S, Oue T; Japanese Study Group for Pediatric Liver Tumor
  • Journal Title: Pediatric Surgery International Volume: 29 Issue: 10 Pages: 1071-1075
  • DOI: 10.1007/s00383-013-3399-0
  • Peer Reviewed / Open Access
• [Journal Article] Current therapeutic strategies for childhood hepatic malignant tumors (2013)
  • Author(s): Hiyama E
  • Journal Title: International Journal of Clinical Oncology Volume: 18 Issue: 6 Pages: 943-945
  • DOI: 10.1007/s10147-013-0607-9
  • Peer Reviewed / Open Access
• [Journal Article] Age-dependent decrease in the chondrogenic potential of human bone marrow mesenchymal stromal cells expanded with fibroblast growth factor-2 (2013)
  • Author(s): Kanawa M, Igarashi A, Sainik VR, Higashi Y, Kurihara H, Sugiyama M, Saskianti T, Pan H, Kato Y
  • Journal Title: Cytotherapy Volume: 15 Pages: 1062-1072
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of common marmoset (Callithrix jacchus) bone marrow-derived mesenchymal stem cells (2013)
  • Author(s): Kanda A, Sotomaru Y, Nobukiyo A, Yamaoka E, Hiyama E
  • Journal Title: Folia Histochemica et Cytobiologica Volume: 51 Pages: 292-299
  • Peer Reviewed
• [Journal Article] Long-term serial cultivation of mouse induced pluripotent stem cells in serum-free and feeder-free defined medium (2013)
  • Author(s): Yamasaki S, Nabeshima K, Sotomaru Y, Taguchi Y, Mukasa H, Furue MK, Sato JD, Okamoto T
  • Journal Title: The International Journal of Developmental Biology Volume: 57 Pages: 715-724
  • Peer Reviewed
• [Journal Article] Development of lymphoproliferative diseases by hypoxia inducible factor-1alpha is associated with prolonged lymphocyte survival (2013)
  • Author(s): Sueoka E, Sueoka-Aragane N, Sato A, Ide M, Nakamura H, Sotomaru Y, Taya C, Yonekawa H, Kitagawa T, Kubota Y, Kimura S, Nakachi K, Tanimoto K
  • Journal Title: PLOS ONE Volume: 8
  • Peer Reviewed
• [Journal Article] 一細胞質量分析法による迅速一細胞薬物代謝解析 (2013)
  • Author(s): 伊達沙智子、津山尚宏、升島努
  • Journal Title: 実験医学 Volume: 31 Pages: 443-448
  • Peer Reviewed
• [Journal Article] Proceedings of the Los Angeles COG International Liver Tumors Symposium (2013)
  • Author(s): Lopez-Terrada D
  • Journal Title: Modern Pathology Volume: in press
  • Peer Reviewed
• [Journal Article] Age-dependent decrease in chondrogenic potential of human bone marrow mesenchymal stem cells expanded with fibroblast growth factor-2 (2013)
  • Author(s): Kanawa M
  • Journal Title: Cytotherapy Volume: in press
  • Peer Reviewed
• [Journal Article] Is the prognosis of stage 4s neuroblastoma in patients 12 months of age and older really excellent? (2012)
  • Author(s): DOI:10.1016/j.jpedsurg.2012.05.007.
  • Journal Title: European Journal of Cancer Volume: 48 Issue: 11 Pages: 1107-1112
  • DOI: 10.1016/j.ejca.2012.01.010
  • Peer Reviewed
• [Journal Article] Prognostic significance of telomerase activity and human telomerase reverse transcriptase expression in ampullary carcinoma. (2012)
  • Author(s): Sakabe R, Hiyama E, et al.
  • Journal Title: Annals of Surgical Oncology. Volume: 19 Issue: 9 Pages: 3072-3080
  • DOI: 10.1245/s10434-012-2245-2
  • Peer Reviewed
• [Journal Article] Histological loss of pancreatic exocrine cells correlates with pancreatic exocrine function after pancreatic surgery (2012)
  • Author(s): Yuasa Y, Hiyama E, et al.
  • Journal Title: Pancreas. Volume: 41 Issue: 6 Pages: 928-933
  • DOI: 10.1097/mpa.0b013e31823d837d
  • Peer Reviewed
• [Journal Article] Establishment of ES cells from inbred strain mice by dual inhibition (2i) (2012)
  • Author(s): Kanda A
  • Journal Title: J Reprod Dev Volume: 58 Pages: 77-83
  • Peer Reviewed
• [Journal Article] Clinical feature of anaplastic lymphoma kinase-mutated neuroblastoma (2012)
  • Author(s): Ogura T, Hiyama E, et al
  • Journal Title: Journal of Pediatric Surgery. Volume: 47 Issue: 10 Pages: 1789-1796
  • DOI: 10.1016/j.jpedsurg.2012.05.007
  • Peer Reviewed
• [Journal Article] Surgical strategies for unresectable hepatoblastomas. (2012)
  • Author(s): Tajiri T, Hiyama E, et al
  • Journal Title: Journal of Pediatric Surgery. Volume: 47 Issue: 12 Pages: 2194-2198
  • DOI: 10.1016/j.jpedsurg.2012.09.006
  • Peer Reviewed
• [Journal Article] Metabolomic analysis of dynamic response and drug resistance of gastric cancer cells to 5-fluorouracil (2012)
  • Author(s): Sasada S
  • Journal Title: ONCOLOGY REPORTS Volume: 29 Pages: 925-931
  • Peer Reviewed
• [Journal Article] On-line solid-phase enrichment coupled to packed reactor flow injection analysis in a green analytical procedure to determine low levels of folic acid using fluorescence detection (2012)
  • Author(s): Emara S
  • Journal Title: CHEMISTRY CENTRAL JOURNAL Volume: 6 Issue: 1
  • DOI: 10.1186/1752-153x-6-155
  • Peer Reviewed
• [Journal Article] Drug metabolite heterogeneity in cultured single cells profiled by pico-trapping direct mass spectrometry (2012)
  • Author(s): Fukano Y
  • Journal Title: NANOMEDICINE Volume: 7 Issue: 9 Pages: 1365-1374
  • DOI: 10.2217/nnm.12.34
  • Peer Reviewed
• [Journal Article] Molecular and Functional Analysis of Cellular Phenomena Using Single-Cell Mass Spectrometry (2012)
  • Author(s): Tsuyama N
  • Journal Title: BIOLOGICAL & PHARMACEUTICAL BULLETIN Volume: 35 Pages: 1425-1431
  • Peer Reviewed
• [Journal Article] In Situ Molecular Analysis of Plant Tissues by Live Single Cell Mass Spectrometry (2012)
  • Author(s): Tejedor ML, Mizuno H, Tsuyama N, Harada T, Masujima T
  • Journal Title: Analytical Chemistry Volume: (in press) Issue: 12 Pages: 5221-5228
  • DOI: 10.1021/ac202447t
  • Peer Reviewed
• [Journal Article] Direct Drug Metabolism Monitoring in a Live Single Hepatic Cell by Video Mass Spectrometry (2012)
  • Author(s): Date S
  • Journal Title: ANALYTICAL SCIENCES Volume: 28 Pages: 201-203
  • Peer Reviewed
• [Journal Article] Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks (2012)
  • Author(s): Kobayashi H, Sakurai T, Imai M, Takahashi N, Fukuda A, Yayoi O, Sato S, Nakabayashi K, Hata K, Sotomaru Y, Suzuki Y, Kono T
  • Journal Title: PLoS Genet Volume: 8(1) Issue: 1 Pages: e1002440-e1002440
  • DOI: 10.1371/journal.pgen.1002440
  • NAID: 120005300482
  • Peer Reviewed
• [Journal Article] Feasibility and limitations of the round robin test for assessment of in vitro chondrogenesis evaluation protocol in a tissue-engineered medical product (2012)
  • Author(s): Yokoi M
  • Journal Title: J Tissue Eng Regen Med Volume: 6 Pages: 550-558
  • Peer Reviewed
• [Journal Article] 無血清で増幅した間葉系幹細胞と歯髄細胞 (2012)
  • Author(s): 加藤幸夫
  • Journal Title: 広島歯科医学雑誌 Volume: 39 Pages: 1-8
• [Presentation] Single Cell Drug Discovery (2015)
  • Author(s): Date S, Mizuno H, Esaki T, Fujita A, Masujima T, Iwabuchi H, Takei M, Takakusa H, Izumi T, Fujita S, Matsuda S, Morihara M, Bando K, Deguchi J, Fukuda Y, Tarui N
  • Organizer: 2nd ASMS Conference on Mass Spectrometry
  • Place of Presentation: Baltimore, MD, USA
  • Year and Date: 2015-06-15 – 2015-06-19
  • Invited
• [Presentation] Targetted Analysis of Peptides in Live Single-Cell Mass Spectrometry (2015)
  • Author(s): Fujita A, Mizuno H, Sakane I, Masujima T
  • Organizer: 2nd ASMS Conference on Mass Spectrometry
  • Place of Presentation: Baltimore, MD, USA
  • Year and Date: 2015-06-15 – 2015-06-19
• [Presentation] Live Single-cell Mass Spectrometry for Direct Lipid Analysis of a Stimulated Allergy Cell (2015)
  • Author(s): Mizuno H, Kawai Y, Masujima T
  • Organizer: 2nd ASMS Conference on Mass Spectrometry
  • Place of Presentation: Baltimore, MD, USA
  • Year and Date: 2015-06-15 – 2015-06-19
• [Presentation] Spatial Analysis of Phototropic Metabolites in a Plant Cell by Live Single-cell Mass Spectrometry (2015)
  • Author(s): Fujii T, Esaki T, Date S, Mizuno H, Masujima T
  • Organizer: 2nd ASMS Conference on Mass Spectrometry
  • Place of Presentation: Baltimore, MD, USA
  • Year and Date: 2015-06-15 – 2015-06-19
• [Presentation] Direct Mitochondrial Metabolites Detection in a HepG2 Cell by Live Single-cell Mass Spectrometry (2015)
  • Author(s): Esaki T, Date S, Mizuno H, Fujita A, Masujima T
  • Organizer: 2nd ASMS Conference on Mass Spectrometry
  • Place of Presentation: Baltimore, MD, USA
  • Year and Date: 2015-06-15 – 2015-06-19
• [Presentation] Health Sustaining Components Analysis by LC-MS in Heavy Fermented “Miso” (2015)
  • Author(s): Takahashi A, Watanabe H, Miyasaka Y, Esaki T, Mizuno H, Masujima T
  • Organizer: 2nd ASMS Conference on Mass Spectrometry
  • Place of Presentation: Baltimore, MD, USA
  • Year and Date: 2015-06-15 – 2015-06-19
• [Presentation] 1細胞メタボロミクス (2015)
  • Author(s): 升島 努
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸市
  • Year and Date: 2015-03-26
  • Invited
• [Presentation] Live single cell mass spectrometry (2015)
  • Author(s): Masujima T
  • Organizer: The 2nd International Symposium on Plant Environmental Sensing
  • Place of Presentation: 東京都
  • Year and Date: 2015-03-13 – 2015-03-15
  • Invited
• [Presentation] 肺転移を有した肝芽腫6例の外科的検討 (2014)
  • Author(s): 栗原 将, 鬼武美幸, 三木瑞香, 中村和洋, 小林正夫, 檜山英三
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山市
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] Dlk1-Dio3ドメインBAC-TGマウスに認められる発生異常 (2014)
  • Author(s): 野村圭代、藤原真、高橋望、雉岡めぐみ、隈本 宗一郎、外丸 祐介、河野友宏
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-11-26
• [Presentation] Molecular diagnosis of lung cancer (2014)
  • Author(s): Hiyama E
  • Organizer: APSR2014
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2014-11-13
• [Presentation] Outcome and morbidity of primary resection of hepatoblastoma in JPLT-1 and 2 protocols (2014)
  • Author(s): Hiyama E, Hishiki T, Watanabe K, Ida K, Yano M, Oue T, Iehara T, Hoshino K, Koh K, Tanaka Y, Kurihara S
  • Organizer: SIOP2014
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2014-10-22 – 2014-10-25
• [Presentation] 単一細胞でのリピドミクス (2014)
  • Author(s): 升島 努
  • Organizer: 日本生化学会
  • Place of Presentation: 京都市
  • Year and Date: 2014-10-17
  • Invited
• [Presentation] 小児固形腫瘍における循環遊離DNAと循環がん細胞のがん診断への応用 (2014)
  • Author(s): 檜山英三, 檜山桂子, 林 陽子, 森原なぎさ, 平野尚子, 福場郁子, 山岡絵美, 栗原 将
  • Organizer: 第73回日本癌学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-27
• [Presentation] DNAメチル化解析による肝芽腫の新規予後予測マーカーの確立 (2014)
  • Author(s): 本多昌平, 湊 雅嗣, 鈴木 拓, 春田雅之, 金子安比古, 檜山英三, 武冨紹信
  • Organizer: 第73回日本癌学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-25
• [Presentation] Direct Metabolomics and Molecular Tracing by the Live Single Cell Mass Spectrometry (2014)
  • Author(s): Masujima T
  • Organizer: 一細胞分析技術に関するナイロビ国際シンポジウム
  • Place of Presentation: Nairobi,Kenya
  • Year and Date: 2014-09-10 – 2014-09-11
  • Invited
• [Presentation] 門脈大循環シャントによるガラクトース血症の治療 (2014)
  • Author(s): 檜山英三, 栗原 将, 鬼武美幸, 但馬 剛, 西村 裕, 佐倉伸夫
  • Organizer: 第41回日本マススクリーニング学会
  • Place of Presentation: 広島市
  • Year and Date: 2014-08-22 – 2014-08-23
• [Presentation] NBマス開始前後の変化レトロスペクティブ解析結果 (2014)
  • Author(s): 檜山英三
  • Organizer: 第41回日本マススクリーニング学会
  • Place of Presentation: 広島市
  • Year and Date: 2014-08-22 – 2014-08-23
• [Presentation] Surgical managements for refractory neuroblastoma in young children (2014)
  • Author(s): Hiyama E, Kurihara S, Onitake Y, Ueda Y, Miki M, Kawaguchi H, Nakamura K, Kobayashi M
  • Organizer: BAPS61st Annual Congress
  • Place of Presentation: Edinburgh, Scotland
  • Year and Date: 2014-07-22 – 2014-07-25
• [Presentation] Central venous catheter-related complications in children with malignancy. (2014)
  • Author(s): Kurihara S, Hiyama E, Onitake Y, Miki M, Nakamura K, Kawaguchi H, Kobayashi M
  • Organizer: PAPS2014
  • Place of Presentation: Calgary, Canada
  • Year and Date: 2014-05-25 – 2014-05-29
• [Presentation] Clinical feature of ATRX or DAXX mutated neuroblastoma. (2014)
  • Author(s): Hiyama E, Kurihara S, Onitake Y, Yamaoka E, Fukuba I, Hiyama K
  • Organizer: PAPS2014
  • Place of Presentation: Calgary, Canada
  • Year and Date: 2014-05-25 – 2014-05-29
• [Presentation] Telomere Biology in Neuroblastoma: Focusing on ATRX/DAXX Genes and Alternative-Strengthening of Telomere(ALT) (2014)
  • Author(s): Hiyama E
  • Organizer: ANR Congress 2014
  • Place of Presentation: Cologne, Germany
  • Year and Date: 2014-05-13 – 2014-05-16
• [Presentation] JPLT(肝芽腫) (2014)
  • Author(s): 檜山英三
  • Organizer: 第51回日本小児外科学会
  • Place of Presentation: 大阪市
  • Year and Date: 2014-05-09
• [Presentation] Detection of Cancer Stem Cells in Childhood Cancers (2014)
  • Author(s): Hiyama E
  • Organizer: BIT’S 4th Annual World Congress of Molegular & Cel
  • Place of Presentation: Dailen, China
  • Year and Date: 2014-04-27
• [Presentation] 肝芽腫の縦隔再発に対してICG蛍光法を使用した経験 (2014)
  • Author(s): 栗原 将, 鬼武美幸, 小倉 薫, 檜山英三
  • Organizer: 第55回日本中国四国小児がん研究会
  • Place of Presentation: 広島県福山市
  • Year and Date: 2014-04-26
• [Presentation] １細胞質量分析システムによる１細胞創薬・１細胞診断 (2014)
  • Author(s): 升島努
  • Organizer: 応用物理学会 有機分子バイオエレクトロニクス分科会3月研究会
  • Place of Presentation: 東京都
  • Year and Date: 2014-03-05
  • Invited
• [Presentation] 小児肝腫瘍に対する診断と治療 (2014)
  • Author(s): 檜山英三
  • Organizer: 第39回北海道小児がん研究会
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2014-02-28
  • Invited
• [Presentation] 不均一な細胞群を有する神経芽腫細胞株における癌幹細胞同定のためのマーカー検索 (2013)
  • Author(s): 林 陽子, 森原なぎさ, 田川浩美, 原 隆範, 檜山英三
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸市
  • Year and Date: 2013-12-04
• [Presentation] マウス12番染色体非コードインプリント遺伝子の過剰発現モデルにおける表現型解析 (2013)
  • Author(s): 藤原真、高橋望、平田裕、外丸祐介、河野友宏
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸市
  • Year and Date: 2013-12-04
• [Presentation] マウス卵子形成過程における5‑hydroxymethylcytosine のダイナミクス (2013)
  • Author(s): 坂下陽彦、小林久人、井関陽介、若井拓哉、外丸祐介、河野友宏
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸市
  • Year and Date: 2013-12-04
• [Presentation] FAST-idシステム：TALENによる変異導入細胞および染色体領域欠失細胞の濃縮システムの開発 (2013)
  • Author(s): 徳増大輔, 佐久間 哲史, 林 陽子、檜山 英三, 山本 卓
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸市
  • Year and Date: 2013-12-03
• [Presentation] 腹腔内Desmoplastic small round cell tumorの1小児例 (2013)
  • Author(s): 斎藤 聡志, 松本 惇子, 坂田 園子, 千々松 郁枝, 三木 瑞香, 世羅 康彦, 川口 浩史, 中村 和洋, 上田 祐華, 鬼武 美幸, 小倉 薫, 檜山 英三, 小林 正夫
  • Organizer: 第55回日本小児血液・がん学会学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 2013-12-01
• [Presentation] 次世代シーケンサーを用いた肝芽腫のメチル化解析による予後予測マーカー確立の試み (2013)
  • Author(s): 本多 昌平, 岡田 忠雄, 湊 雅嗣, 春田 雅之, 金子 安比古, 檜山 英三, 武冨 紹信
  • Organizer: 第55回日本小児血液・がん学会学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 2013-11-30
• [Presentation] Wilms腫瘍を合併した縦隔奇形腫の１例 (2013)
  • Author(s): 小倉 薫, 檜山 英三, 鬼武 美幸, 上田 祐華, 千々松 郁枝, 世羅 康彦, 小林 正夫
  • Organizer: 第55回日本小児血液・がん学会学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 2013-11-30
• [Presentation] 高用量シスプラチン療法後に腫瘍全摘を行った門脈浸潤を伴う肝芽腫の一例 (2013)
  • Author(s): 江藤 昌平, 古江 綾, 千々松 郁枝, 三木 瑞香, 世羅 康彦, 川口 浩史, 中村 和洋, 上田 祐華, 鬼武 美幸, 小倉 薫, 檜山 英三, 小林 正夫
  • Organizer: 第55回日本小児血液・がん学会学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 2013-11-29
• [Presentation] 一細胞質量分析の薬物代謝研究への応用 (2013)
  • Author(s): 升島努
  • Organizer: 日本薬物動態学会
  • Place of Presentation: 東京都
  • Year and Date: 2013-10-09 – 2013-10-11
  • Invited
• [Presentation] dentification of Markers of Cancer Stem Cells in Neuroblasotma Cell Line SK-N-SH.（和訳： 神経芽腫細胞株（SK-N-SH）における癌幹細胞同定のためのマーカー探索） (2013)
  • Author(s): Hayashi Y, Hiyama E
  • Organizer: 第72回日本癌学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2013-10-05
• [Presentation] Epigenetic analyses to establish a molecular-genetic marker for treatment outcome in hepatoblastomas. (和訳:肝芽腫メチル化解析による予後予測分子マーカーの確立.) (2013)
  • Author(s): Honda S, Okada T, Suzuki H, Minato M, Haruta M, Kaneko Y, Hiyama E, Taketomi A
  • Organizer: 第72回日本癌学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2013-10-05
• [Presentation] 肺転移巣手術のタイミングに苦慮した高リスク肝芽腫の一例 (2013)
  • Author(s): 栗原 将, 鬼武 美幸, 小倉 薫, 上田 祐華, 檜山 英三, 世羅 康彦, 三木 瑞香, 中村 和洋, 小林 正夫
  • Organizer: 第2回せとうち小児がんセミナー
  • Place of Presentation: 岡山市
  • Year and Date: 2013-10-05
• [Presentation] WARG症候群の2例 (2013)
  • Author(s): 三木 瑞香, 浅野 孝基, 古江 綾, 溝口 洋子, 川口 浩史, 中村 和洋, 檜山 英三, 小林 正夫
  • Organizer: 第2回せとうち小児がんセミナー
  • Place of Presentation: 岡山市
  • Year and Date: 2013-10-05
• [Presentation] 一細胞メタボロミクスで見る生命動態 (2013)
  • Author(s): 升島努
  • Organizer: 薬学の未来を考える京都シンポジウム
  • Place of Presentation: 京都市
  • Year and Date: 2013-10-05
  • Invited
• [Presentation] 体外受精に用いるマウス卵子の超低温保存方法の開発 (2013)
  • Author(s): 江藤智生、神田暁史、上迫努、外丸祐介
  • Organizer: 日本実験動物技術者協会総会第47回総会
  • Place of Presentation: 岡山市
  • Year and Date: 2013-09-28
• [Presentation] CHILDREN'S HEPATIC TUMOR INTERNATIONAL COLLABORATION (CHIC): NEW HEPATOBLASTOMA INTERNATIONAL RISK GROUPS (HB-IRG) (2013)
  • Author(s): Meyers R, Haeberle B, Hiyama E, Maibach R, Krailo M, Feng Y, Yoshimura K, Rinaldi E, Ortali M, Saraceno D, Rangaswami A, Malogolowkin M, Perilongo G, Watanabe K, Schmid I, Aronson D, Von Schweinitz D, Leuschner I, Lopez-Terrada D, Tanaka Y, Czauderna P
  • Organizer: 45th Congress of the International Society of Pediatric Oncology
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2013-09-26
• [Presentation] FURTHER STUDY: IDENTIFICATION OF NEW CANDIDATE GENES IN PROGRESSION OF HEPATOBLASTOMA USING GENOME-WIDE ASSOCIATION STUDY (2013)
  • Author(s): Hiyama E, Ueda Y, Onitake Y, Ida K, Ogura K, Kondo S, Kamijyo T, Watanabe K, Oue T, Hishiki T, Tajiri T, Horie H, Inoue T, Tanaka Y
  • Organizer: 45th Congress of the International Society of Pediatric Oncology
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2013-09-26
• [Presentation] セメント芽細胞が発現するF-spondinの抗炎症作用に関する検討 (2013)
  • Author(s): 北川雅恵、宮内睦美、岡広子、外丸祐介、高田隆
  • Organizer: 歯科基礎医学会
  • Place of Presentation: 岡山市
  • Year and Date: 2013-09-22
• [Presentation] 1細胞みながら網羅分子探索による新しい創薬・医療展開 (2013)
  • Author(s): 升島 努
  • Organizer: 日本分析化学会第62年会
  • Place of Presentation: 大阪府東大阪市
  • Year and Date: 2013-09-10 – 2013-09-12
  • Invited
• [Presentation] Age-dependent changes in multipotency of mesenchymal stem cells (2013)
  • Author(s): Sainik VR, Kanawa M, Kato Y
  • Organizer: IADR-Asia Pacific Region
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2013-08-21 – 2013-08-23
• [Presentation] 細胞1ヶ、生きたまま、すぐに分子分析 (2013)
  • Author(s): 升島努
  • Organizer: 第6回教育研究推進センター講演会
  • Place of Presentation: 北海道旭川市
  • Year and Date: 2013-07-29
  • Invited
• [Presentation] 応用講座2 「１細胞質量分析法の展開」 (2013)
  • Author(s): 升島努
  • Organizer: 第40 回BMS コンファレンス(BMS2013)
  • Place of Presentation: 宮崎市
  • Year and Date: 2013-07-08 – 2013-07-10
  • Invited
• [Presentation] 1細胞質量分析による１細胞内リアルタイム分子追跡と創薬・個別化医療の未来 (2013)
  • Author(s): 升島努
  • Organizer: 第10回知創薬コンソシアム
  • Place of Presentation: 東京都
  • Year and Date: 2013-07-05
  • Invited
• [Presentation] 一細胞創薬，一細胞診断，そして一細胞医療へ (2013)
  • Author(s): 升島努
  • Organizer: 日本毒性学会
  • Place of Presentation: 千葉市
  • Year and Date: 2013-06-17 – 2013-06-19
  • Invited
• [Presentation] Variety and Specificity of Granules in a Cell, Detected by Live Single-Cell Mass Spectrometry (2013)
  • Author(s): Esaki T, Mizuno H, Date S, Tsuyama N, Masujima T
  • Organizer: 61th ASMS Conference
  • Place of Presentation: Minneapolis, MN, ＵＳＡ
  • Year and Date: 2013-06-09 – 2013-06-13
• [Presentation] Survival, surgical respectability, and late effects in the hepatoblastoma patients treated by cisplatin plus pirarubicin(CITA) chemotherapy (2013)
  • Author(s): Hiyama E, Kamimatsuse A, Onitake Y, Ueda Y, Watanabe K, Hishiki T, Tajiri T, Ida K, Yano M, Kondo S, Oue T
  • Organizer: ASCO Annual ’ 13 Meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2013-06-01
• [Presentation] 18 トリソミーに合併した肝芽腫の1 例―染色体異常を合併したJPLT 登録症例の検討を併せて― (2013)
  • Author(s): 鬼武 美幸，檜山 英三，小倉 薫，上松瀬 新, 中村 和洋，古江 綾
  • Organizer: 第50回日本小児外科学会学術集会
  • Place of Presentation: 東京都
  • Year and Date: 2013-05-31
• [Presentation] 術後に心不全の改善を認めた静脈管開存症の1 例 (2013)
  • Author(s): 小倉 薫，檜山 英三，上松瀬 新，鬼武 美幸，上田 祐華
  • Organizer: 第50回日本小児外科学会学術集会
  • Place of Presentation: 東京都
  • Year and Date: 2013-05-31
• [Presentation] 網羅的メチル化解析による肝芽腫の分化度からみた予後予測マーカーを確立する取組み (2013)
  • Author(s): 本多 昌平, 岡田 忠雄，宮城 久之，檜山 英三, 武冨 紹信
  • Organizer: 第50回日本小児外科学会学術集会
  • Place of Presentation: 東京都
  • Year and Date: 2013-05-30
• [Presentation] 血中DNA を用いた神経芽腫の分子診断：予後予測と治療効果判定 (2013)
  • Author(s): 檜山 英三，児島 正人，河島 茉澄，上田 祐華，鬼武 美幸，上松瀬 新，小倉 薫，末田 泰二郎
  • Organizer: 第50回日本小児外科学会学術集会
  • Place of Presentation: 東京都
  • Year and Date: 2013-05-30
• [Presentation] 近未来，なぜ臨床検査の多くが質量分析に (2013)
  • Author(s): 升島 努
  • Organizer: 第62回日本医学検査学会
  • Place of Presentation: 香川県高松市
  • Year and Date: 2013-05-19
  • Invited
• [Presentation] 小児がん (2013)
  • Author(s): 檜山 英三
  • Organizer: がん政策サミット2013春～県計画の好事例を共有し実践していこう～
  • Place of Presentation: 東京都
  • Year and Date: 2013-05-17
  • Invited
• [Presentation] Wnt Signaling and telomerase activation in hepatoblastoma (2013)
  • Author(s): Hiyama E, Ueda Y, Kamimatsuse A, Onitake Y, Ogura K, Hiyama K
  • Organizer: AACR Annual Meeintg2013
  • Place of Presentation: Washington, USA
  • Year and Date: 2013-04-09
• [Presentation] Hepatocellular carcinoma in children and Adolescents:The international Therapeutic experience (2012)
  • Author(s): Marcio H
  • Organizer: 43th APSA Annual Meeting APSA-IPSO SYMPOSIUM
  • Place of Presentation: Texas, USA
• [Presentation] 質量分析法と細胞分析
  • Author(s): 升島 努
  • Organizer: 機器分析セミナー
  • Place of Presentation: 広島市
  • Invited
• [Presentation] Cisplatin plus pirarubicin based chemotherapy for hepatoblastoma: Expe¬rience and future in japanese study group for pediatric liver tumor (JPLT)
  • Author(s): Hiyama E
  • Organizer: The 7th SIOP Asia Congress
  • Place of Presentation: Yogyakarta, Indonesia
  • Invited
• [Presentation] Early detection for neuroblastoma: Japanese experience of screening and new strategies for early detection
  • Author(s): Hiyama E
  • Organizer: The 7th SIOP Asia Congress
  • Place of Presentation: Yogyakarta, Indonesia
  • Invited
• [Presentation] 再発時に膵内転移を認めた胞巣型横紋筋肉腫の1例
  • Author(s): 上松瀬 新
  • Organizer: 第53回中国四国小児がん研究会
  • Place of Presentation: 徳島市
• [Presentation] DSRCTの1例
  • Author(s): 河島茉澄
  • Organizer: 第53回中国四国小児がん研究会
  • Place of Presentation: 徳島市
• [Presentation] １細胞質量分析によるダイレクト分子追跡と創薬応用
  • Author(s): 升島 努
  • Organizer: アスビオファーマ（株）講演
  • Place of Presentation: 神戸市
  • Invited
• [Presentation] 小児固形腫瘍の基礎的研究と治療戦略への展開
  • Author(s): 檜山 英三
  • Organizer: 京都小児固形腫瘍フォーラム
  • Place of Presentation: 京都市
  • Invited
• [Presentation] 肝芽腫の組織型に関するDNAメチル化以上と予後予測マーカー確立の試み
  • Author(s): 本多 昌平
  • Organizer: 第49回日本小児外科学会学術集会
  • Place of Presentation: 横浜市
• [Presentation] 地方大学病院における小児がんの小児外科介入までの期間の検討
  • Author(s): 上松瀬 新
  • Organizer: 第49回日本小児外科学会学術集会
  • Place of Presentation: 横浜市
• [Presentation] ヒト肝初代培養１際オブ薬物代謝追跡とゆらぎ
  • Author(s): 升島 努
  • Organizer: １細胞分析高速創薬フォーラム
  • Place of Presentation: 吹田市
• [Presentation] 1生細胞ビデオ質量分析・分子追跡法による創薬高速化 ～ヒト１細胞ダイレクト薬物代謝・局在追跡から未来へ～
  • Author(s): 升島 努
  • Organizer: 第19回HAB研究機構学術年回
  • Place of Presentation: 東京都
  • Invited
• [Presentation] Development of Direct Micro-Extracting Mass Spectrometry for Analysis of Molecules in Tissue Section
  • Author(s): Date S
  • Organizer: 60th ASMS Conference
  • Place of Presentation: Vancouver, BC, Canada
• [Presentation] Microregional Analysis of Allergic Granule in a RBL-2H3 Cell by Live Single-cell Mass Spectrometry
  • Author(s): Yamamoto Y
  • Organizer: 60th ASMS Conference
  • Place of Presentation: Vancouver, BC, Canada
• [Presentation] In-situ Analysis of Plant Phototropism molecules by Live Singe-cell Mass Spectrometry
  • Author(s): Fujii T
  • Organizer: 60th ASMS Conference
  • Place of Presentation: Vancouver, BC, Canada
• [Presentation] In-situ Analysis of Plant Bioactive Molecules by Live Single-cell Mass Spectrometry
  • Author(s): Matsudai S
  • Organizer: 60th ASMS Conference
  • Place of Presentation: Vancouver, BC, Canada
• [Presentation] Detection of Drug Metabolism Heterogeneity in Primary Human Hepatocytes by Live Single-cell Mass Spectrometry.
  • Author(s): Tsuyama N
  • Organizer: 60th ASMS Conference
  • Place of Presentation: Vancouver, BC, Canada
• [Presentation] Live Single-cell Mass Spectrometry for Organelle Level Metabolomics
  • Author(s): Hajime M
  • Organizer: 60th ASMS Conference
  • Place of Presentation: Vancouver, BC, Canada
• [Presentation] コモンマーモセットにおける体細胞および受精卵クローン胚の発生能
  • Author(s): 外丸 祐介
  • Organizer: 日本実験動物科学・技術 九州2012／第59回日本実験動物学会総会
  • Place of Presentation: 大分県別府市
• [Presentation] ラット初期胚を用いた体外培養培地およびガラス化保存溶液の安定供給の検討
  • Author(s): 柳 美穂
  • Organizer: 日本実験動物科学・技術 九州2012／第59回日本実験動物学会総会
  • Place of Presentation: 大分県別府市
• [Presentation] マーモセット骨髄由来細胞の性状解析
  • Author(s): 神田 暁史
  • Organizer: 日本実験動物科学・技術 九州2012／第59回日本実験動物学会総会
  • Place of Presentation: 大分県別府市
• [Presentation] 各組織由来MSCの均質性と細胞表面マーカーの発現に及ぼす無血清培地(STK培地)の影響
  • Author(s): 長谷川 森一
  • Organizer: 第11回再生医療総会
  • Place of Presentation: 横浜市
• [Presentation] Characterization of common marmoset (Callithrix jacchus) bone marrow-derived cells
  • Author(s): Kanda A
  • Organizer: International Society for Stem Cell Research (ISSCR) 10th Annual Meeting
  • Place of Presentation: 横浜市
• [Presentation] Next-generation sequencing: Integrated exotome analysis in human multiple neuroblastoma
  • Author(s): Hiyama E
  • Organizer: ANR2012
  • Place of Presentation: Tronto, Canada
• [Presentation] Identification of new candidate biomarkers in progression of neuroblastoma cells using differential transcriptome and proteome analysis
  • Author(s): Hiyama E
  • Organizer: ANR2012
  • Place of Presentation: Tronto, Canada
• [Presentation] Changes in clinical feature of neuroblastoma after the cessation of the mass screening in Japan -Analysis of the Neuroblastoma registry data of the Tumor committee of the Japanese Society of Pediatric Surgeons-
  • Author(s): Yoneda A
  • Organizer: ANR2012
  • Place of Presentation: Tronto, Canada
• [Presentation] 一細胞質量分析による細胞動態イメージング・網羅的分子追跡
  • Author(s): 升島 努
  • Organizer: よこはまNMR構造生物学研究会
  • Place of Presentation: 横浜市
  • Invited
• [Presentation] 創薬の未来、臨床分析薬学の未来、分析科学の未来
  • Author(s): 升島 努
  • Organizer: 第25回バイオメディカル分析科学シンポジウム
  • Place of Presentation: 東京都
  • Invited
• [Presentation] In-situ Analysis of Plant Bioactive Molecules by Live Single-cell Mass Spectrometry
  • Author(s): Matsuda S
  • Organizer: IMSC2012 19th International Mass Spectrometry Conference
  • Place of Presentation: 京都市
• [Presentation] In-situ Analysis of Phototropic Molecules in plant by Live Singe-cell Mass Spectrometry
  • Author(s): Fujii T
  • Organizer: IMSC2012 19th International Mass Spectrometry Conference
  • Place of Presentation: 京都市
• [Presentation] Analysis of Specific Molecules in Allergic Granule by Live Single-cell Mass Spectrometry
  • Author(s): Yamamoto Y
  • Organizer: IMSC2012 19th International Mass Spectrometry Conference
  • Place of Presentation: 京都市
• [Presentation] Time Dependent Changes of Intracellular-Signal-Relating Small Compounds in Allergy Model Cell Line, RBL-2H3
  • Author(s): Shinasue T
  • Organizer: IMSC2012 19th International Mass Spectrometry Conference
  • Place of Presentation: 京都市
• [Presentation] Future of Cell Analyses and Mass Spectrometry
  • Author(s): Masujima T
  • Organizer: IMSC2012 19th International Mass Spectrometry Conference
  • Place of Presentation: 京都市
• [Presentation] Echanism of Wnt signal pathway activation in hepatoblastoma
  • Author(s): Ueda Y
  • Organizer: SIOP2012
  • Place of Presentation: ロンドン、イギリス
• [Presentation] ALK activating infant neuroblastoma cases including mass-screening detected cases
  • Author(s): Kawashima M
  • Organizer: SIOP2012
  • Place of Presentation: ロンドン、イギリス
• [Presentation] A genome-wide association study identifies new candidate loci associated with progression of hepatoblastoma in JPLT2 study experience
  • Author(s): Hiyama E
  • Organizer: SIOP2012
  • Place of Presentation: ロンドン、イギリス
• [Presentation] Live Single-cell Mass Spectrometry for Qual-Quant Biology
  • Author(s): 升島 努
  • Organizer: 理研QBiC開所記念国際シンポジウム
  • Place of Presentation: 神戸市
  • Invited
• [Presentation] Cartilage repair with allogeneic synovial mesenchymal stem cells expanded with serum-free media
  • Author(s): 加藤 幸夫
  • Organizer: アジア細胞治療学会
  • Place of Presentation: タイ、チェンマイ
• [Presentation] 肝芽腫メチル化解析による予後予測マーカーの確立
  • Author(s): 本多 昌平
  • Organizer: 第23回日本消化器癌発生学会総会
  • Place of Presentation: 徳島県鳴門市
• [Presentation] 小児肝悪性腫瘍
  • Author(s): 渡邊 健一郎
  • Organizer: 第１回日本小児血液がん学会学術セミナー
  • Place of Presentation: 東京都
  • Invited
• [Presentation] コモンマーモセットにおけるクローン胚の発生能
  • Author(s): 外丸 祐介
  • Organizer: 第2回日本マーモセット研究会大会
  • Place of Presentation: 東京都
• [Presentation] CHICS diagnostic risk grouping presentation
  • Author(s): Piotr Czauderna
  • Organizer: SIOPEL group Spring Meeting
  • Place of Presentation: Bologna, Italy
• [Presentation] Low risk hepatoblastoma
  • Author(s): Hiyama E
  • Organizer: SIOPEL group Spring Meeting
  • Place of Presentation: Bologna, Italy
• [Presentation] Session of the discipline groups to plan for new trials
  • Author(s): Hiyama E
  • Organizer: SIOPEL group Spring Meeting
  • Place of Presentation: Bologna, Italy
• [Presentation] 霊長類におけるクローン技術の開発
  • Author(s): 外丸 祐介
  • Organizer: 第60回日本実験動物学会総会
  • Place of Presentation: 茨城県つくば市
• [Presentation] コモンマーモセットの体外受精における射出精子の採取手段および調整方法の検討
  • Author(s): 畠山 照彦
  • Organizer: 第60回日本実験動物学会総会
  • Place of Presentation: 茨城県つくば市
• [Presentation] 2i/LIF培地で長期培養したマウスES細胞のキメラ形成能の検討
  • Author(s): 神田 暁史
  • Organizer: 第60回日本実験動物学会総会
  • Place of Presentation: 茨城県つくば市
• [Presentation] マウス未受精卵の超低温保存の検討
  • Author(s): 江藤 智生
  • Organizer: 第60回日本実験動物学会総会
  • Place of Presentation: 茨城県つくば市
• [Presentation] マーモセットにおける受精卵および体細胞クローン胚の発生能
  • Author(s): 外丸 祐介
  • Organizer: 第54回日本哺乳動物卵子学会
  • Place of Presentation: 東京都
• [Book] 肝芽腫の診断と治療. 「最新肝癌学」 (2015)
  • Author(s): 上條岳彦, 檜山英三
  • Total Pages: 8
  • Publisher: 日本臨牀社
• [Book] パートナー 分析化学Ⅱ (2013)
  • Author(s): 升島努
  • Total Pages: 328
  • Publisher: 南光堂
• [Book] 質量分析実験ガイド (2012)
  • Author(s): 水野 初
  • Total Pages: 237
  • Publisher: 羊土社
• [Book] アミノ酸・アミン分析 (2012)
  • Author(s): 水野 初
  • Total Pages: 205
  • Publisher: 丸善
• [Book] 創薬の分析化学 (2012)
  • Author(s): 升島 努
  • Total Pages: 309
  • Publisher: 丸善
• [Patent(Industrial Property Rights)] ナノスプレーイオン化・チップの高機能化 (2014)
  • Inventor(s): 升島努
  • Industrial Property Rights Holder: 升島努
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-12-08