Understanding the brain mechanism of hybrid-rehabilitation combining TMS and training

• Project/Area Number: 24300192
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Ritsumeikan University (2015); Kyoto University (2012-2014)
• Principal Investigator: MIMA Tatsuya 立命館大学, 先端総合学術研究科, 教授 (20324618)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000); Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2012: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
• Keywords: リハビリテーション / 可塑性 / 経頭蓋的磁気刺激法 / リハビリテーション医学

Outline of Final Research Achievements

We developed a new hybrid-rehabilitation technique, which combined transcranial magnetic stimulation at 5 Hz and repetitive stretch trainings (Koganemaru, Mima et al., Brain 2010). Extending this previous study, we performed the functional MRI before and after this rehabilitation and found that not only the local stimulated motor cortex but also motor-related network of the brain is changed (Koganemaru, Mima et al., NSR 2015). Our observation is important to develop scientific and objective rehabilitation technique.

Research Products

• [Journal Article] Task-specific brain reorganization in motor recovery induced by a hybrid-rehabilitation combining training with brain stimulation after stroke. (2015)
  • Author(s): Koganemaru S, Sawamoto N, Aso T, Sagara A, Ikkaku T, Shimada K, Kanematsu M, Takahashi R, Domen K, Fukuyama H, Mima T.
  • Journal Title: Neurosci Res. Volume: 92 Pages: 29-38
  • DOI: 10.1016/j.neures.2014.10.004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Water diffusion reveals networks that modulate multiregional morphological plasticity after repetitive brain stimulation (2014)
  • Author(s): Abe, M., H. Fukuyama and T. Mima
  • Journal Title: Proc Natl Acad Sci U S A Volume: 111 Issue: 12 Pages: 4608-4613
  • DOI: 10.1073/pnas.1320223111
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of lip sensory disturbance using somatosensory evoked magnetic fields (2014)
  • Author(s): Maezawa, H., M. Matsuhashi, K. Yoshida, T. Mima, T. Nagamine and H. Fukuyama
  • Journal Title: Clin Neurophysiol Volume: 125 Issue: 2 Pages: 363-369
  • DOI: 10.1016/j.clinph.2013.07.017
  • NAID: 120005397861
  • Peer Reviewed
• [Journal Article] Effects of regularity on the processing of sound omission in a tone sequence in musicians and non-musicians. (2013)
  • Author(s): Ono, K., Matsuhashi, M., Mima, T., Fukuyama, H., & Altmann, C. F.
  • Journal Title: European Journal of Neuroscience Volume: 38 Issue: 5 Pages: 2786-2792
  • DOI: 10.1111/ejn.12254
  • Peer Reviewed
• [Journal Article] Transcranial direct current stimulation changes human endowment effect. (2013)
  • Author(s): Votinov, M., Aso, T., Koganemaru, S., Fukuyama, H., & Mima, T.
  • Journal Title: Neuroscience Research Volume: 76 Issue: 4 Pages: 251-256
  • DOI: 10.1016/j.neures.2013.05.007
  • Peer Reviewed
• [Journal Article] Mirror visual feedback can induce motor learning in patients with callosal disconnection. (2013)
  • Author(s): Nojima, I., Oga, T., Fukuyama, H., Kawamata, T., & Mima, T.
  • Journal Title: Expeimental Brain Research Volume: 227 Issue: 1 Pages: 79-83
  • DOI: 10.1007/s00221-013-3486-4
  • Peer Reviewed
• [Journal Article] Spike-timing dependent plasticity (STDP) ヒトでの連動性対刺激による可塑性を中心に (2013)
  • Author(s): 美馬達哉
  • Journal Title: 医学のあゆみ Volume: 244 Pages: 603-608
• [Journal Article] Bereitschaftspotential augmentation by neuro-feedback training in Parkinson's disease. (2013)
  • Author(s): Fumuro T, Matsuhashi M, Mitsueda T, Inouchi M, Hitomi T, Nakagawa T, Matsumoto R, Kawamata J, Inoue H, Mima T, Takahashi R, Ikeda A.
  • Journal Title: Clin Neurophysiol Volume: 124 Issue: 7 Pages: 1388-405
  • DOI: 10.1016/j.clinph.2013.01.026
  • NAID: 120005296134
  • Peer Reviewed
• [Journal Article] Changes in striatal dopamine release associated with human motor-skill acquisition (2012)
  • Author(s): Kawashima S, Ueki Y, Kato T, Matsukava N, Mima T, Hallett M, Ito K, Ojika K
  • Journal Title: PloS one Volume: 7 Issue: 2 Pages: e31728-e31728
  • DOI: 10.1371/journal.pone.0031728
  • Peer Reviewed
• [Journal Article] Pathophysiology of unilateral asterixis due to thalamic lesion (2012)
  • Author(s): Inoue M, Kojima Y, Mima T, Sawamoto N, Matsuhashi M, Fumuro T, Kinboshi M, Koganemaru S, Kanda M, Shibasaki H
  • Journal Title: Clinical neurophysiology Volume: (in press) Issue: 9 Pages: 1858-64
  • DOI: 10.1016/j.clinph.2012.01.021
  • NAID: 120004873783
  • Peer Reviewed
• [Journal Article] Negative emotion can enhance human motor cortical plasticity. (2012)
  • Author(s): Koganemaru, S., Domen, K., Fukuyama, H., & Mima, T.
  • Journal Title: European Journal of Neuroscience Volume: 35 Issue: 10 Pages: 1637-1645
  • DOI: 10.1111/j.1460-9568.2012.08098.x
  • Peer Reviewed
• [Journal Article] Visual distance cues modulate neuromagnetic auditory N1m responses. (2012)
  • Author(s): Altmann CF, Matsuhashi M, Votinov M, Goto K, Mima T, Fukuyama H
  • Journal Title: Clinical Neurophysiology Volume: 123 Issue: 11 Pages: 2273-2280
  • DOI: 10.1016/j.clinph.2012.04.004
  • Peer Reviewed
• [Journal Article] Common inhibitory prefrontal activation during inhibition of hand and foot responses (2012)
  • Author(s): Tabu H, Mima T, Aso T, Takahashi R, Fukuyama H
  • Journal Title: NeuroImage Volume: 59 Issue: 4 Pages: 3373-3378
  • DOI: 10.1016/j.neuroimage.2011.10.092
  • Peer Reviewed
• [Journal Article] Human motor plasticity induced by mirror visual feedback (2012)
  • Author(s): Nojima I, Mima T, Koganemaru S, Thabit MN, Fukuyama H, Kawamata T
  • Journal Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 32 Issue: 4 Pages: 1293-1300
  • DOI: 10.1523/jneurosci.5364-11.2012
  • Peer Reviewed
• [Journal Article] Writing's Shadow: Corticospinal Activation during Letter Observation (2012)
  • Author(s): Nakatsuka, M., M.N. Thabit, S. Koganemaru, I. Nojima, H. Fukuyama, and T. Mima
  • Journal Title: J Cogn Neurosci Volume: 24 Issue: 5 Pages: 1138-1148
  • DOI: 10.1162/jocn_a_00205
  • Peer Reviewed
• [Journal Article] A practical guide to diagnostic transcranial magnetic stimulation: Report of an IFCN committee. (2012)
  • Author(s): Groppa S, Oliviero A, Eisen A, Quartarone A, Cohen LG, Mall V, Kaelin-
  • Journal Title: Clin Neurophysiol. Volume: 123(5) Issue: 5 Pages: 858-82
  • DOI: 10.1016/j.clinph.2012.01.010
  • Peer Reviewed
• [Presentation] Slow-oscillatory DC stimulation for neurorehabilitation: a new approach. (2014)
  • Author(s): Mima T.
  • Organizer: 5th Conference on Systems Neuroscience and Rehabilitation(SNR2014)
  • Place of Presentation: Tokorozawa
  • Invited
• [Presentation] Transient increase of human neuromagnetic oscillation in the primary motor cortex (M1) following anodal transcranial DC stimulation (tDCS). (2013)
  • Author(s): Mikami Y., Mima T., Matsuhashi M., Fukuyama H.
  • Organizer: The 43rd annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA