Investigation for pathophysiology in latent phase of diabetes and development of new interventional method

• Project/Area Number: 24300236
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Juntendo University
• Principal Investigator: KAWAMORI Ryuzo 順天堂大学, 医学(系)研究科(研究院), 教授 (00116021)
• Co-Investigator(Kenkyū-buntansha): KAKEHI Saori 順天堂大学, 医学研究科, 特任助教 (00450560) ; TAMURA Yoshifumi 順天堂大学, 医学部, 准教授 (80420834)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: 糖尿病 / インスリン抵抗性 / 飲酒 / インスリン分泌

Outline of Final Research Achievements

It has been demonstrated that slight increase in fasting plasma glucose (FPG) is risk factor of type 2 diabetes. However, pathophysiology of increase in FPG has not been fully understood. We defined the phase with slight FPG elevation as “latent phase of diabetes” and investigated the mechanism of FPG elevation. We performed cross-sectional study and intervention study and found out that heavy alcohol consumption induce hepatic insulin resistance and contribute to mild elevation of FPG. These data suggested that alcohol cessation may have preventive effect for type 2 diabetes in subjects with latent phase of diabetes.

Research Products

• [Presentation] １週間のアルコール制限は肝臓特異的にインスリン感受性を改善し空腹時血糖値を低下させる (2014)
  • Author(s): 船山 崇, 田村 好史, 竹野 景海, 渡邉 隆宏, 川口美奈子, 山本理沙子, 筧 佐織, 藤谷与士夫, 河盛 隆造, 綿田 裕孝
  • Organizer: 第57回 日本糖尿学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24