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Development of a target system and neutron dosimetry for the accelerator boron neutron capture therapy (BNCT)

Research Project

Project/Area Number 24310044
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionHiroshima University

Principal Investigator

HOSHI Masaharu  広島大学, 平和科学研究センター, 名誉教授 (50099090)

Co-Investigator(Kenkyū-buntansha) ONIDUKA Yoshihiko  純真学園大学, 保健医療学部, 教授 (70128544)
ENDO Satoru  広島大学, 工学(系)研究科(研究院), 教授 (90243609)
ISHIKAWA Masayori  北海道大学, 医学(系)研究科(研究院), 教授 (80314772)
SATO Hitoshi  茨城県立医療大学, 保健医療学部, 教授 (90285057)
OHTAKI Megu  広島大学, 原爆放射線医科学研究所, 教授 (20110463)
Research Collaborator HAMANO Tsuyoshi  
SUDA Mitsuru  
KAMADA So  
TAKADA Masashi  
TANAKA Kenichi  
YAMAKAWA Kyohei  
HIGASHIMATA Atsushi  
ARAI Seiji  
ZHUMADILOV Kassym  
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Keywords放射線 / BNCT / リチウムターゲット / 加速器 / 中性子 / ホウ素 / 中性子線量測定 / Liターゲット / 冷却システム / 中性子線量評価
Outline of Final Research Achievements

In the radiation therapy, X rays, gamma rays, protons and so on have been used. In this study we use neutrons. This method is called Boron Neutron Capture Therapy (BNCT). Boron is absorbed in cancer and expose neutrons. Then the boron emits alpha rays of which range is about the size of cancer cells. So each cancer cell will be killed by this method. The traditional way of radiation therapy is as like to say "burn cancer mass". This method is especially useful for the brain tumor which invade in the healthy cells. Before we used reactor neutrons, however in this study we developed a target system and real time neutron measurement system for the proton accelerator, which will be easily installed in each hospital.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (23 results)

All 2015 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (13 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] A TPD and AR based comparison of accelerator neutron irradiation fields between 7Li and W targets for BNCT2014

    • Author(s)
      K. Tanaka, S. Endo, S. Yonai, M. Baba, M. Hoshi
    • Journal Title

      Appl. Radiat. Isot.

      Volume: 88

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutron activation analysis for soils of Hiroshima City and Plaster under roof-tiles of Old Hiroshima House2013

    • Author(s)
      S. Endo, Y. Taguchi, T. Imanaka, S. Fukutani, E. Granovskaya, M. Hoshi, K. Shiraishi, T. Kajimoto, K. Shizuma
    • Journal Title

      Revisit the Hiroshima A-bomb with a Database

      Volume: 2 Pages: 9-14

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of close-in fallout 137Cs deposition level due to the Hiroshima atomic bomb from soil samples under houses built 1-4 years after the explosion2013

    • Author(s)
      M. Yamamoto, M. Hoshi, K. Zhumadilov, S. Endo, A. Sakaguchi, T. Imanaka, Y. Miyamoto
    • Journal Title

      Revisit the Hiroshima A-bomb with a Database

      Volume: 2 Pages: 35-43

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Workshop report on atomic bomb dosimetryvresidual radiation exposure, Recent research and suggestions for future studies2013

    • Author(s)
      G. D. Kerr, S. Endo, M. Hoshi, T. Imanaka, A. Sakaguchi, (Endo6番目, Hoshi7番目, Imanaka8番目, Sakaguchi13番目, 他15名)
    • Journal Title

      Health Phys

      Volume: 105 Issue: 2 Pages: 140-149

    • DOI

      10.1097/hp.0b013e31828ca73a

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutron activation analysis for soils of Hiroshima City and plaster under roof-tiles of Old Hiroshima House2013

    • Author(s)
      Satoru Endo
    • Journal Title

      Revisit the Hiroshima A-bomb with a Database

      Volume: 2 Pages: 9-14

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soil particle size measurements for the calculation of the spread of dusts blown up by the explosion of the Hiroshima atomic bomb2013

    • Author(s)
      Aya Sakaguchi
    • Journal Title

      Revisit the Hiroshima A-bomb with a Database

      Volume: 2 Pages: 15-24

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation on circular asymmetry of geographical distribution in cancer mortality of Hiroshima atomic bomb survivors based on risk maps : analysis of spatial survival data2013

    • Author(s)
      Tetsuji Tonda
    • Journal Title

      Revisit the Hiroshima A-bomb with a Database

      Volume: 2 Pages: 25-34

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of close-in fallout ^<137>Cs deposition level due to the Hiroshima atomic bomb from soil samples under houses built 1-4 years after the explosion2013

    • Author(s)
      Masayoshi Yamamoto
    • Journal Title

      Revisit the Hiroshima A-bomb with a Database

      Volume: 2 Pages: 35-44

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An early survey of the radioactive contamination of soil due to the Fukushima Dai-ichi Nuclear Power Plant accident, with emphasis of plutonium analysis2012

    • Author(s)
      Masayoshi Yamamoto
    • Journal Title

      Geochemical Journal

      Volume: 46 Pages: 341-353

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 熱外中性子線測定用電離箱による中性子場の評価2015

    • Author(s)
      佐藤 斉、川村 拓、須田 充、濱野 毅、遠藤 暁、東又 厚、星 正治
    • Organizer
      第5 回共用施設(PASTA&SPICE、NASBEE)共同研究成果報告会
    • Place of Presentation
      千葉
    • Year and Date
      2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Soil particle size measurements for the calculation of the spread of dusts blown up by the explosion of thee Hiroshima atomic bomb2013

    • Author(s)
      Masaharu Hoshi
    • Organizer
      The 18^<th> Hiroshima International Symposium on "Additional factors in Hiroshima radiation effects due to atomic bomb"
    • Place of Presentation
      Miyajima Coral Hotel, Hiroshima
    • Year and Date
      2013-02-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] Approach to estimation of beta-irradiation dose resulted from nuclear explosions in the atmosphere2013

    • Author(s)
      Mark Orlov
    • Organizer
      The 18^<th> Hiroshima International Symposium on "Additional factors in Hiroshima radiation effects due to atomic bomb"
    • Place of Presentation
      Miyajima Coral Hotel, Hiroshima
    • Year and Date
      2013-02-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] Large-scale radiation accidents : the methodology of individual dose reconstruction in the situation of limited personal information2013

    • Author(s)
      Valeriy Stepanenko
    • Organizer
      The 18^<th> Hiroshima International Symposium on "Additional factors in Hiroshima radiation effects due to atomic bomb"
    • Place of Presentation
      Miyajima Coral Hotel, Hiroshima
    • Year and Date
      2013-02-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] Verification of estimates of individual doses for the Semipalatinsk historical cohort sbjects2013

    • Author(s)
      Evgeniya Granovskaya
    • Organizer
      The 18^<th> Hiroshima International Symposium on "Additional factors in Hiroshima radiation effects due to atomic bomb"
    • Place of Presentation
      Miyajima Coral Hotel, Hiroshima
    • Year and Date
      2013-02-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] Spatial-time trend of cancer mortality among directly exposed A-bomb survivors in Hiroshima2013

    • Author(s)
      Megu Ohtaki
    • Organizer
      The 18^<th> Hiroshima International Symposium on "Additional factors in Hiroshima radiation effects due to atomic bomb"
    • Place of Presentation
      Miyajima Coral Hotel, Hiroshima
    • Year and Date
      2013-01-31
    • Related Report
      2012 Annual Research Report
  • [Presentation] Analysis of cancer mortality among early entrants A-bomb survivors in Hiroshima2013

    • Author(s)
      Keiko Ohtani
    • Organizer
      The 18^<th> Hiroshima International Symposium on "Additional factors in Hiroshima radiation effects due to atomic bomb"
    • Place of Presentation
      Miyajima Coral Hotel, Hiroshima
    • Year and Date
      2013-01-31
    • Related Report
      2012 Annual Research Report
  • [Presentation] Liターゲットを用いた強力中性子源の開発2013

    • Author(s)
      鎌田創、高田真志、須田充、濱野 毅、星正治、遠藤暁、佐藤斉、藤井亮、中村勝、東又厚、新井誠司
    • Organizer
      第10回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      岡山大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of target system for intense neutron source of p-Li reaction2012

    • Author(s)
      So Kamada
    • Organizer
      15^<th> International Congress on Neutron Capture therapy
    • Place of Presentation
      Tsukuba International Congress Center
    • Year and Date
      2012-09-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] Histological and biochemical analysis of DNA damage after BNCT rat tumor model2012

    • Author(s)
      Mitsuko Masutani
    • Organizer
      15^<th> International Congress on Neutron Capture therapy
    • Place of Presentation
      Tsukuba International Congress Center
    • Year and Date
      2012-09-10
    • Related Report
      2012 Annual Research Report
  • [Presentation] 放射線の線量評価とその意義、-広島・長崎、セミパラチンスク、チェルノブイリ、福島-2012

    • Author(s)
      星正治
    • Organizer
      第55回放射線影響学会大会
    • Place of Presentation
      東北大学(招待講演)
    • Year and Date
      2012-09-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] EPR dosimetry investigation for population living in areas of fallout from 4 important events at the Semipalatinsk Nuclear Test Site2012

    • Author(s)
      Masaharu Hoshi
    • Organizer
      The VIII International Conference "Ecology, Radiation, Health
    • Place of Presentation
      Semei State Medical University, Kazakhstan(招待講演)
    • Year and Date
      2012-08-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] Our radiation dosimetry study in Hiroshima2012

    • Author(s)
      Masaharu Hoshi
    • Organizer
      The 25^<th> Health Physics Society meeting
    • Place of Presentation
      Hyatt Regency Sacramento, USA(招待講演)
    • Year and Date
      2012-07-24
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 荷電粒子照射ターゲット冷却装置、荷電粒子照射ターゲット、および中性子発生方法2012

    • Inventor(s)
      高田真志, 鎌田創, 星正治
    • Industrial Property Rights Holder
      放射線医学総合研究所, 三樹工業(株), 星正治
    • Industrial Property Number
      2012-186041
    • Filing Date
      2012-08-27
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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