Analysis of coenzyme Q biosynthesis in eukaryotes
| Project/Area Number |
24380056
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAINO Tomohiro 島根大学, 生物資源科学部, 准教授 (90541706)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUO Yasuhiro 島根大学, 生物資源科学部, 助教 (70596832)
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| Research Collaborator |
YANAI Ryota
MOCHIZUKI Shiomi
YOKOMI Kazumasa
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | コエンザイムQ / ユビキノン / 分裂酵母 / 抗酸化物質 / coenzyme Q / ubiquinone / fission yeast / S. pombe / CoQ / PKA / 電子伝達系 / ミトコンドリア / 酵母 / イソプレノイド / 抗酸化物資 / 抗酸化 / 遺伝病 / 生合成 / システイン |
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| Outline of Final Research Achievements |
Coenzyme Q is essential for energy production through the electron transfer system and also acts as antioxidant. This study aims to understand the biosynthetic pathway of coenzyme Q in fission yeast. This analysis also contributes an understanding of human disease involved in CoQ synthesis. When we expressed genes for CoQ biosynthesis from human or plant into fission yeast, they complemented the function of fission yeast corresponding deletion mutants. The analysis of intermediate compounds accumulated in coq mutant was succeeded. The binding site of CoQ10 protein was unveiled in this study.
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Report
(5 results)
Research Products
(20 results)
