Development of a control method of protein function within cell using photodegradable nanoparticles and its medical applications
| Project/Area Number |
24390007
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Kato Masaru 東京大学, 薬学研究科(研究院), 准教授 (30332943)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Keywords | ナノ粒子 / タンパク質 / 細胞 / 光 / 機能制御 / 病態モデル |
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| Outline of Final Research Achievements |
To examine the cellular reaction, we developed photodegradable nanoparticles that penetrate cellular membrane with encapsulated molecule and released the encapsulated molecule by light stimulus. We compared the cellular response after releasing the different amount of protein within cell using the nanoparticles. Our results indicated that the nanoparticles is a useful tool for the study of cellular reaction.
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Report
(5 results)
Research Products
(26 results)
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[Journal Article] NanoPARCEL : a method for controlling cellular behavior with external light.2012
Author(s)
Murayama, M., Su, B., Okabe, K., Kishimura, A., Osada, K., Miura, M., Funatsu, T., Kataoka, K., and Kato, M
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Journal Title
Chem Comm.
Volume: 48
Issue: 67
Pages: 8380-8382
DOI
Related Report
Peer Reviewed
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