| Project/Area Number |
24390063
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Yabe Chihiro 京都府立医科大学, 医学(系)研究科(研究院), 教授 (70150571)
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| Co-Investigator(Kenkyū-buntansha) |
IWATA Kazumi 京都府立医科大学, 大学院医学研究科, 講師 (60305571)
MATSUMOTO Misaki 京都府立医科大学, 大学院医学研究科, 助教 (80533926)
張 嘉 京都府立医科大学, 医学部, 研究員 (50599222)
沖垣 光彦 京都府立医科大学, 医学研究科, 准教授 (10333197)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
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| Keywords | メタボリックシンドローム / 活性酸素種 / NADPH オキシダーゼ / 慢性腎臓病 / 糖尿病 / 細胞老化 / 腎臓 / 酸化ストレス / 高血圧症 / 肝臓 / 循環器 |
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| Outline of Final Research Achievements |
Increased oxidative stress has been implicated in the development of metabolic syndrome (MS). To develop a new treatment strategy for MS, we studied the possible involvement of superoxide-generating NOX1/NADPH oxidase in the pathogenesis of chronic kidney disease (CKD).
Our findings point out the novel role of NOX1/NADPH oxidase in hyperglycemia-induced renal senescence. NOX1-derived reactive oxygen species positively regulate the p38/p27Kip1 signaling pathway via protein kinase C activation, thereby accelerating glomerular hypertrophy, mesangial matrix expansion and cellular senescence under hyperglycemia. Inhibition of NOX1 may delay premature senescence and protect kidney from the steady progress of CKD.
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