2015 Fiscal Year Final Research Report
Development of a new NOX1-targeted strategy for the treatment of metabolic syndrome
Project/Area Number |
24390063
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
General pharmacology
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Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
Yabe Chihiro (西村千尋) 京都府立医科大学, 医学(系)研究科(研究院), 教授 (70150571)
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Co-Investigator(Kenkyū-buntansha) |
IWATA Kazumi 京都府立医科大学, 大学院医学研究科, 講師 (60305571)
MATSUMOTO Misaki 京都府立医科大学, 大学院医学研究科, 助教 (80533926)
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Keywords | メタボリックシンドローム / 活性酸素種 / NADPH オキシダーゼ / 慢性腎臓病 / 糖尿病 / 細胞老化 |
Outline of Final Research Achievements |
Increased oxidative stress has been implicated in the development of metabolic syndrome (MS). To develop a new treatment strategy for MS, we studied the possible involvement of superoxide-generating NOX1/NADPH oxidase in the pathogenesis of chronic kidney disease (CKD). Our findings point out the novel role of NOX1/NADPH oxidase in hyperglycemia-induced renal senescence. NOX1-derived reactive oxygen species positively regulate the p38/p27Kip1 signaling pathway via protein kinase C activation, thereby accelerating glomerular hypertrophy, mesangial matrix expansion and cellular senescence under hyperglycemia. Inhibition of NOX1 may delay premature senescence and protect kidney from the steady progress of CKD.
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Free Research Field |
病態分子薬理学
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