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Environmental and Genetic risk factors of Atopic dermatitis among 7-year old children in birth cohort

Research Project

Project/Area Number 24390152
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Hygiene
Research InstitutionHokkaido University

Principal Investigator

ARAKI Atsuko  北海道大学, 環境健康科学研究教育センター, 准教授 (00619885)

Co-Investigator(Kenkyū-buntansha) NOMURA Toshifumi  北海道大学, 大学院医学研究科, 助教 (50399911)
KISHI Reiko  北海道大学, 環境健康科学研究教育センター, 特任教授 (80112449)
SHIMIZU Hiroshi  北海道大学, 大学院医学研究科, 教授 (00146672)
多島 秀司  北海道大学, 環境健康科学研究教育センター, 学術研究員 (10619886)
Co-Investigator(Renkei-kenkyūsha) SASAKI Seiko  北海道大学, 大学院医学研究科, 助教 (30448831)
Research Collaborator AIT BAMAI Yu  
TAJIMA Shuji  
UKAWA Shigekazu  
CONG Shi  
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Keywords環境 / アレルギー・喘息 / アトピー性皮膚炎 / 衛生 / 遺伝子 / フィラグリン遺伝子 / 自宅環境 / ダスト / ダニアレルゲン / 出生コーホート / 遺伝的素因 / 環境用要因
Outline of Final Research Achievements

The present study examined the risk of environmental factors such as mite allergens, phthalates, and organophosphate in house dust and filaggrin (FLG) gene variants on atopic dermatitis (AD) among 7 years old children who are participating in the Hokkaido study on Environment and Children's Health. About 10% of the participants in this study had FLG gene variants, which was consistent with other previous studies. The children with FLG gene variants significantly increased the risk of AD at 2 and 4 years of age, but were not at 7 years of age. Among 7 years old children with high levels of DiNP and without FLG gene variants significantly increased the risk of AD.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (81 results)

All 2015 2014 2013 2012 Other

All Journal Article (39 results) (of which Peer Reviewed: 36 results,  Open Access: 17 results) Presentation (28 results) (of which Invited: 1 results) Book (7 results) Remarks (7 results)

  • [Journal Article] Prenatal maternal blood triglyceride and fatty acid levels in relation to exposure to di(2-ethylhexyl)phthalate: a cross-sectional study2015

    • Author(s)
      Jia X., Harada Y., Tagawa M., Naito H., Hayashi Y., Yetti H., Kato M., Sasaki S., Araki A., Miyashita C., Ikeno T., Kishi R., Nakajima T.
    • Journal Title

      Environ Health Prev Med

      Volume: in press

    • NAID

      210000000370

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparisons of urinary phthalate metabolites and daily phthalate intakes among Japanese families2015

    • Author(s)
      Yu Ait Bamai, Atsuko Araki, Toshio Kawai, Tazuru Tsuboi, Eiji Yoshioka, Ayako Kanazawa, Shi Cong, Reiko Kishi
    • Journal Title

      International Journal of Hygiene and Environmental Health

      Volume: in press Issue: 5 Pages: 461-470

    • DOI

      10.1016/j.ijheh.2015.03.013

    • NAID

      120005820699

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dermoscopic observation in adenoma of the nipple2015

    • Author(s)
      Takashima S, Fujita Y, Miyauchi T, Nomura T, Nishie W, Hamaoka H, Shimizu H.
    • Journal Title

      The Journal of Dermatology

      Volume: 42(3) Issue: 3 Pages: 341-342

    • DOI

      10.1111/1346-8138.12780

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss-of-function mutations in the gene encoding filaggrin underlie a Japanese family with food-dependent exercise-induced anaphylaxis2015

    • Author(s)
      Mizuno O, Nomura T, Ohguchi Y, Suzuki S, Nomura Y, Hamade Y, Hoshina D, Sandilands A, Akiyama M, McLean WH, Abe R, Shimizu H.
    • Journal Title

      Journal of the European Academy of Dermatology and Venereology

      Volume: 29(4) Issue: 4 Pages: 805-808

    • DOI

      10.1111/jdv.12441

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between maternal exposure to di(2-ethylhexyl) phthalate and reproductive hormone levels in fetal blood: The Hokkaido Study on Environment and Children's Health2014

    • Author(s)
      Araki A., Mitsui T., Miyashita C., Nakajima T., Naito H., Ito S., Sasaki S., Cho K., Ikeno T., Nonomura K., Kishi R.
    • Journal Title

      PLOS One

      Volume: 9(10) Issue: 10 Pages: e109039-e109039

    • DOI

      10.1371/journal.pone.0109039

    • NAID

      120005476155

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phosphorus flame retardants in indoor dust and their relation to asthma and allergies of inhabitants2014

    • Author(s)
      Araki A., Saito I., Kanazawa A., Morimoto K., Nakayama K., Shibata E., Tanaka M., Takigawa T., Yoshimura T., Chikara H., Saijo Y., Kishi R
    • Journal Title

      Indoor Air

      Volume: 24 Issue: 1 Pages: 3-15

    • DOI

      10.1111/ina.12054

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations of phthalate concentrations in floor dust and multi-surface dust with the interior materials in Japanese dwellings2014

    • Author(s)
      Yu Ait Bamai, Atsuko Araki, Toshio Kawai, Tazuru Tsuboi, Ikue Saito, Eiji Yoshioka, Ayako Kanazawa, Shuji Tajima, Cong Shi, Akiko Tamakoshi, Reiko Kishi
    • Journal Title

      Science of the Total Environment

      Volume: 468-469 Pages: 147-157

    • DOI

      10.1016/j.scitotenv.2013.07.107

    • NAID

      120005425356

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection and intake assessment of organophosphate flame retardants in house dust in Japanese dwellings2014

    • Author(s)
      Tajima S., Araki A., Kawai T., Tsuboi T., Ait Bamai Y., Yoshioka E., Kanazawa A., Cong S., Kishi R.
    • Journal Title

      Sci Total Environ

      Volume: 478C Pages: 190-199

    • DOI

      10.1016/j.scitotenv.2013.12.121

    • NAID

      120005427753

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of Mechanical Ventilation and Flue Use in Heaters With Asthma Symptoms in Japanese Schoolchildren: A Cross-Sectional Study in Sapporo, Japan2014

    • Author(s)
      Cong S., Araki A., Ukawa S., Ait Bamai Y., Tajima S., Kanazawa A., Yuasa M., Tamakoshi A., Kishi R
    • Journal Title

      Journal of Epidemiology

      Volume: 24 Issue: 3 Pages: 230-238

    • DOI

      10.2188/jea.JE20130135

    • NAID

      130003392103

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exposure to house dust phthalates in relation to asthma and allergies in both children and adults2014

    • Author(s)
      Ait Bamai Y., Shibata E., Saito I., Araki A., Kanazawa A., Morimoto K., Nakayama K., Tanaka M., Takigawa T., Yoshimura T., Chikara H., Saijo Y., Kishi R
    • Journal Title

      Sci Total Environ

      Volume: 485-486C Pages: 153-163

    • DOI

      10.1016/j.scitotenv.2014.03.059

    • NAID

      120005425358

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in patients with atopic dermatitis2014

    • Author(s)
      Yoshida K, Kubo A, Fujita H, Yokouchi M, Ishii K, Kawasaki H, Nomura T, Shimizu H, Kouyama K, Ebihara T, Nagao K, Amagai M.
    • Journal Title

      The Journal of Allergy and Clinical Immunology

      Volume: 134(4) Issue: 4 Pages: 856-864

    • DOI

      10.1016/j.jaci.2014.08.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A new filaggrin gene mutation in a Korean patient with ichthyosis vulgaris2014

    • Author(s)
      Ohguchi Y, Nomura T, Suzuki S, Mizuno O, Nomura Y, Nemoto-Hasebe I, Okamoto H, Sandilands A, Akiyama M, Mclean WH, Shimizu H.
    • Journal Title

      European Journal of Dermatology

      Volume: 24(4) Issue: 4 Pages: 491-493

    • DOI

      10.1684/ejd.2014.2410

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An annexin A1-FPR1 interaction contributes to necroptosis of keratinocytes in severe cutaneous adverse drug reactions.2014

    • Author(s)
      Saito N, Qiao H, Yanagi T, Shinkuma S, Nishimura K, Suto A, Fujita Y, Suzuki S, Nomura T, Nakamura H, Nagao K, Obuse C, Shimizu H, Abe R.
    • Journal Title

      Science Translational Medicine

      Volume: 6 Issue: 245 Pages: 245-295

    • DOI

      10.1126/scitranslmed.3008227

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive screening for a complete set of Japanese-population-specific filaggrin gene mutations2014

    • Author(s)
      Kono M, Nomura T, Ohguchi Y, Mizuno O, Suzuki S, Tsujiuchi H, Hamajima N, McLean WH, Shimizu H, Akiyama M.
    • Journal Title

      Allergy

      Volume: 69(4) Issue: 4 Pages: 537-540

    • DOI

      10.1111/all.12369

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prenatal exposure to perfluoroalkyl acids and allergic diseases in earlychildhood.2014

    • Author(s)
      Okada E, Sasaki S, Kashino I, Matsuura H, Miyashita C, Kobayashi S, Itoh K, Ikeno T, Tamakoshi A, Kishi R.
    • Journal Title

      Environment International

      Volume: 65 Pages: 127-134

    • DOI

      10.1016/j.envint.2014.01.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Punctate palmoplantar keratoderma type 1: a novel AAGAB mutation and efficacy of etretinate2014

    • Author(s)
      Nomura T, Yoneta A, Pohler E, Suzuki S, Osawa R, Mizuno O, Ohguchi Y, Nomura Y, Yamashita T, McLean WHI, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: in press Issue: 1 Pages: 110-111

    • DOI

      10.2340/00015555-1832

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive screening for a complete set of Japanese-population-specific filaggrin gene mutations2014

    • Author(s)
      Kono M, Nomura T, Ohguchi Y, Mizuno O, Suzuki S, Tsujiuchi H, Hamajima M, McLean WHI, Shimizu H, Akiyama M
    • Journal Title

      Allergy

      Volume: 69 Pages: 537-540

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel NCSTN mutation alone may be insufficient for the development of familial hidradenitis suppurativa2014

    • Author(s)
      Nomura Y, Nomura T, Suzuki S, Takeda M, Mizuno O, Ohguchi Y, Abe R, Murata Y, Shimizu H
    • Journal Title

      J Dermatol Sci

      Volume: 74 Pages: 180-182

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tubular apocrine adenoma clinically and dermoscopically mimicking basal cell carcinoma2014

    • Author(s)
      Ito T, Nomura T, Fujita Y, Abe R, Shimizu H
    • Journal Title

      J Am Acad Dermatol

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new filaggrin gene mutation in a Korean patient with ichthyosis vulgaris2014

    • Author(s)
      Ohguchi Y, Nomura T, Suzuki S, Mizuno O, Nomura Y, Nemoto-Hasebe I, Okamoto H, Sandilands A, Akiyama M, McLean WH, Shimizu H
    • Journal Title

      Eur J Dermatol

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highly prevalent SERPINB7 founder mutation causes pseudodominant inheritance pattern in Nagashima-type palmoplantar keratosis2014

    • Author(s)
      Mizuno O, Nomura T, Suzuki S, Takeda M, Ohguchi Y, Fujita Y, Nishie W, Sugiura K, Akiyama M, Shimizu H
    • Journal Title

      Br J Dermatol

      Volume: 171 Issue: 4 Pages: 847-853

    • DOI

      10.1111/bjd.13076

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ネコアレルゲンFel d 1測定Enzyme-Linked Immunosorbent Assayの確立2014

    • Author(s)
      深田一剛, 嶋田貴志, 多島秀司, 岸玲子, 榎本雅夫, 安枝浩
    • Journal Title

      アレルギー・免疫

      Volume: 21 Pages: 522-529

    • NAID

      40019985484

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The relationship between atopic dermatitis and indoor environmental factors: a cross-sectional study among Japanese elementary school children2013

    • Author(s)
      Ukawa S, Araki A, Kanazawa A, Yuasa M, Kishi R
    • Journal Title

      Int Arch Occup Environ Health

      Volume: - Issue: 7 Pages: 777-787

    • DOI

      10.1007/s00420-012-0814-0

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ten years of progress in the Hokkaido birth cohort study on environment and children's health : cohort profile--updated 2013.2013

    • Author(s)
      Kishi R, Kobayashi S, Ikeno T, Araki A, Miyashita C, Itoh S, Sasaki S, Okada E, Kobayashi S, Kashino I, Itoh K, Nakajima S ; Members of the Hokkaido Study on Environment and Children's Health.
    • Journal Title

      Environmental Health and Preventive Medicine

      Volume: 18 Issue: 6 Pages: 429-450

    • DOI

      10.1007/s12199-013-0357-3

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dermoscopy of pseudoxanthoma elasticum-like papillary dermal elastosis2013

    • Author(s)
      Ito T, Fujita Y, Nomura T, Abe R, Shimizu H
    • Journal Title

      J Am Acad Dermatol

      Volume: 69 Issue: 4 Pages: e202-e203

    • DOI

      10.1016/j.jaad.2013.04.059

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired epidermal permeability barrier in mice lacking the Elovl1 gene responsible for very long-chain fatty acid production.2013

    • Author(s)
      Sassa T, Ohno Y, Suzuki S, Nomura T, Nishioka C, Kashiwagi T, Hirayama T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A.
    • Journal Title

      Mol Cell Biol

      Volume: 33 Issue: 14 Pages: 2787-2796

    • DOI

      10.1128/mcb.00192-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Infantile eczema caused by formula milk2013

    • Author(s)
      Ito T, Nishie W, Fujita Y, Abe R, Shimizu H
    • Journal Title

      Lancet

      Volume: 381 Issue: 9881 Pages: 1958-1958

    • DOI

      10.1016/s0140-6736(13)60684-4

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 札幌市の小学生4,500名を対象とした住環境とアトピー性皮膚炎に関する調査2013

    • Author(s)
      鵜川重和, 荒木敦子, 金澤文子, 湯浅資之, 岸玲子
    • Journal Title

      北海道医学雑誌

      Volume: 88 Pages: 95-95

    • NAID

      10031165895

    • Related Report
      2013 Annual Research Report
  • [Journal Article] ハウスダスト中フタル酸エステルと住環境との関連2013

    • Author(s)
      アイツバマイゆふ, 荒木敦子, 河合俊夫, 坪井樹, 斎藤育江, 吉岡英治, 金澤文子, 多島秀司, 叢石, 玉腰暁子, 岸玲子
    • Journal Title

      北海道医学雑誌

      Volume: 88 Pages: 198-198

    • Related Report
      2013 Annual Research Report
  • [Journal Article] The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes2012

    • Author(s)
      Araki A., Kanazawa A., Kawai T., Eitaki Y., Morimoto K., Nakayama K., Shibata E., Tanaka M., Takigawa T., Yoshimura T., Chikara H., Saijo Y., Kishi R
    • Journal Title

      Sci Total Environ

      Volume: 423 Pages: 18-26

    • DOI

      10.1016/j.scitotenv.2012.02.026

    • NAID

      120004027252

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Validation of the diffusive mini-samplers for aldehyde and VOC and its feasibility to elementally school children's exposure measurements2012

    • Author(s)
      Atsuko Araki, Tazuru Tsuboi, Toshio Kawai, Yu Ait Bamai, Takeda Tomoya, Eiji Yoshioka, Reiko Kishi
    • Journal Title

      Journal of Environmental Monitoring

      Volume: 14 Issue: 2 Pages: 368-374

    • DOI

      10.1039/c1em10624d

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal exposure to perfluorinated chemicals and relationship with allergies and infectious diseases in infants2012

    • Author(s)
      Okada E, Sasaki S, Saijo Y, Washino N, Miyashita C, Kobayashi S, Konishi K, Ito YM Ito R, Nakata A, Iwasaki Y, Saito K, Nakazawa H, Kishi R.
    • Journal Title

      Environ Res.

      Volume: 112(1) Pages: 118-125

    • DOI

      10.1016/j.envres.2011.10.003

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The feasibility of aromatherapy massage to reduce symptoms of Idiopathic Environmental Intolerance: A pilot study2012

    • Author(s)
      Atsuko Araki, Kazuhiko Watanabe, Yoko Eitaki, Toshio Kawai, Reiko Kishi
    • Journal Title

      Complementary Therapies in Medicine

      Volume: 20 Issue: 6 Pages: 400-408

    • DOI

      10.1016/j.ctim.2012.07.005

    • NAID

      120005295681

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 室内空気中フタル酸エステル類曝露とアレルギーへの影響2012

    • Author(s)
      アイツバマイゆふ、荒木敦子、岸玲子
    • Journal Title

      Endocrine Disrupter News Letter

      Volume: 15 Pages: 2-2

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Antibodies to pathogenic epitopes on type XVII collagen cause skin fragility in a complement-dependent and independent manner2012

    • Author(s)
      Natsuga K, Nishie W, Shinkuma S, Ujiie H, Nishimura M, Sawamura D, Shimizu H
    • Journal Title

      J Immunol

      Volume: (in press) Issue: 11 Pages: 5792-5799

    • DOI

      10.4049/jimmunol.1003402

    • NAID

      10031131103

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency: Possible immunological state of the intrinsic type2012

    • Author(s)
      Kabashima-Kubo R, Nakamura M, Sakabe, J, Sigita K, Hino R, Mori T, Kobayashi M, Bito T, Kabashima K, Ogasawara K, Nomura Y, Nomura T, Akiyama M, Shimizu H, Tokura Y.
    • Journal Title

      J Dermatol Sci

      Volume: 67 Issue: 1 Pages: 37-43

    • DOI

      10.1016/j.jdermsci.2012.04.004

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The β9 Loop Domain of PA-PLA(1)α Has a Crucial Role in Autosomal Recessive Woolly Hair/Hypotrichosis2012

    • Author(s)
      Shinkuma S, Inoue A, Aoki J, Nishie W, Natsuga K, Ujiie H, Nomura T, Abe R, Akiyama M, Shimizu H
    • Journal Title

      The Journal of Investigative Dermatology

      Volume: (印刷中) Issue: 8 Pages: 2093-2095

    • DOI

      10.1038/jid.2012.96

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma2012

    • Author(s)
      Pohler E
    • Journal Title

      Nat Genet

      Volume: 44 Issue: 11 Pages: 1272-1276

    • DOI

      10.1038/ng.2444

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel splice site mutation in NCSTN underlies a Japanese family with hidradenitis suppurativa.2012

    • Author(s)
      Nomura Y, Nomura T, Mizuno H, Shimizu H, et al
    • Journal Title

      Br J Dermatol

      Volume: 168 Pages: 206-209

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 有機塩素系農薬が乳幼児の免疫に与える影響―環境と子どもの健康北海道スタディー2015

    • Author(s)
      宮下ちひろ,金澤文子,佐々木成子,池野多美子,荒木敦子,伊藤佐智子,小林祥子,水谷太,苣木洋一,岸玲子
    • Organizer
      第85回日本衛生学会学術総会
    • Place of Presentation
      和歌山県民文化会館 (和歌山県・和歌山市)
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胎児期の有機塩素系農薬が小児アレルギー発症に与える影響―環境と子どもの健康北海道スタディー2014

    • Author(s)
      宮下ちひろ,金澤文子,池野多美子,荒木敦子,伊藤佐智子,小林澄貴,湊屋街子,Houman Goudarzi,小林祥子,田村菜穂美,水谷太,苣木洋一,岸玲子
    • Organizer
      第66回北海道公衆衛生学会
    • Place of Presentation
      北海道大学学術交流会館 (北海道・札幌市)
    • Year and Date
      2014-12-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Twelve years of progress in the Hokkaido birth cohort study on environment and children's health: malformation, development and allergy2014

    • Author(s)
      Kishi R.
    • Organizer
      International Symposium of Environmental Medicine Program
    • Place of Presentation
      International Convention Center, Taipei (Taiwan)
    • Year and Date
      2014-10-16 – 2014-10-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Phthalates & Phosphate Flame Retardants (PFRs) in house dust and their associations with asthma and allergies2014

    • Author(s)
      Kishi R.
    • Organizer
      Summit on Child Health and the Environment 2014
    • Place of Presentation
      Hong Kong Academy of Medicine Building, Aberdeen (Hong Kong)
    • Year and Date
      2014-10-11 – 2014-10-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Association between maternal exposure to di(2-ethylhexyl) phthalate and sex hormone levels in fetal blood2014

    • Author(s)
      Araki A., Mitsui T., Miyashita C., Nakajima T., Nakazawa H., Sasaki S., Ikeno T., Cho K., Itoh S., Nonomura K., Kishi R.
    • Organizer
      26th Annual International Society for Environmental Epidemiology Conference - From Local to Global: Advancing Science for Policy in Environmental Health
    • Place of Presentation
      Husky Union Building, the University of Washington, Seattle (USA)
    • Year and Date
      2014-08-24 – 2014-08-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Exposure to house dust phthalates in relation to asthma and allergies in both children and adults2014

    • Author(s)
      Ait Bamai Y., Shibata E., Saito I., Araki A., Kanazawa A., Morimoto K., Nakayama K., Tanaka M., Takigawa T., Yoshimura T., Chikara H., Saijo Y., Kishi R.
    • Organizer
      26th Annual International Society for Environmental Epidemiology Conference - From Local to Global: Advancing Science for Policy in Environmental Health
    • Place of Presentation
      Husky Union Building, the University of Washington, Seattle (USA)
    • Year and Date
      2014-08-24 – 2014-08-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] フタル酸エステル類の胎児期曝露による次世代影響に関する疫学研究2014

    • Author(s)
      荒木敦子, 岸玲子
    • Organizer
      第84回日本衛生学会学術総会
    • Place of Presentation
      岡山コンベンションセンター (岡山県・岡山市)
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] DEHPへの胎児期曝露による児の性ホルモン濃度への影響2014

    • Author(s)
      荒木敦子, 三井貴彦, 宮下ちひろ, 那須民江, 伊藤佐智子, 佐々木成子, 長和俊, 池野多美子, 野々村克也, 岸玲子
    • Organizer
      第84回日本衛生学会学術総会
    • Place of Presentation
      岡山コンベンションセンター (岡山県・岡山市)
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 尿中フタル酸代謝物濃度とハウスダスト中フタル酸エステル濃度との関連:札幌市児童における調査2013

    • Author(s)
      アイツバマイゆふ, 荒木敦子, 河合俊夫, 坪井樹, 多島秀司, 叢石, 湯浅資之, 金澤文子, 玉腰暁子, 岸玲子
    • Organizer
      第65回北海道公衆衛生学会
    • Place of Presentation
      札幌市生涯学習センターちえりあ(札幌市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 札幌市内小学生の自宅における暖房、および機械換気の有無と児童の喘息2013

    • Author(s)
      叢石, 荒木敦子, 鵜川重和, アイツバマイゆふ, 多島秀司, 金澤文子, 湯浅資之, 玉腰暁子, 岸玲子
    • Organizer
      第65回北海道公衆衛生学会
    • Place of Presentation
      札幌市生涯学習センターちえりあ(札幌市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 札幌市128軒のハウスダスト中リン酸トリエステル類濃度と小学生のアレルギー疾患との関連2013

    • Author(s)
      多島秀司, 荒木敦子, 河合俊夫, 坪井樹, アイツバマイゆふ, 叢石, 吉岡英治, 岸玲子
    • Organizer
      第65回北海道公衆衛生学会
    • Place of Presentation
      札幌市生涯学習センターちえりあ(札幌市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Phthalate metabolites in urine and their relation to asthma and allergy in school children -Exposure assessment to plasticizer and flame retardants (3)2013

    • Author(s)
      Araki A., Kawai T., Tsuboi T., Ait Bamai Y., Yoshioka E., Tajima S, Cong S., Ukawa S., Kishi R.
    • Organizer
      Environment and Health - Bridging South, North, East and West Conference of ISEE, ISES and ISIAQ
    • Place of Presentation
      Congress Center Basel (Switzerland)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Relationship between prenatal exposure to perfluorinated compounds and allergic diseases in infants2013

    • Author(s)
      Okada E., Kashino I., Sasaki S., Miyashita C., Ikeno T., Araki A., Yamamoto J., Matsuura H., Matsumura T., Tamakoshi A., Kishi R.
    • Organizer
      Environment and Health - Bridging South, North, East and West Conference of ISEE, ISES and ISIAQ
    • Place of Presentation
      Congress Center Basel (Switzerland)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Biological monitoring of environments exposure to DEHP by urine analysis for 2-Ethyl-1-hexanol2013

    • Author(s)
      Kawai T., Tsuboi T., Araki A., Ait Bamai Y., Tajima S., Cong S., Kishi R.
    • Organizer
      Environment and Health - Bridging South, North, East and West Conference of ISEE, ISES and ISIAQ
    • Place of Presentation
      Congress Center Basel (Switzerland)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Simultaneous analysis of phthalate and organophosphate triesters' metabolites in urine -Exposure assessment to plastisizer and flame retardants2013

    • Author(s)
      Tsuboi T., Kawai T., Araki A., Ait Bamai Y., Kishi R.
    • Organizer
      Environment and Health - Bridging South, North, East and West Conference of ISEE, ISES and ISIAQ
    • Place of Presentation
      Congress Center Basel (Switzerland)
    • Related Report
      2013 Annual Research Report
  • [Presentation] GC/MSによるヒ卜の尿中2-エチルヘキサノールの定量―フタル酸ジエステル類評価としての無水フタル酸:可塑剤・難燃剤曝露と小児の健康影響2013

    • Author(s)
      河合俊夫, 坪井樹, 荒木敦子, アイツバマイゆふ, 岸玲子
    • Organizer
      第86回日本産業衛生学会
    • Place of Presentation
      ひめぎんホール(愛媛県県民文化会館)(松山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] アトピー性皮膚炎と皮膚バリア障害2013

    • Author(s)
      乃村俊史
    • Organizer
      函館小児科医会学術講演会
    • Place of Presentation
      ベルクラシック函館(函館市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] AAGAB遺伝子変異を認めた点状掌蹠角化症の3家系2013

    • Author(s)
      乃村俊史,米田明弘,木花いづみ,末廣晃宏,秋山真志,W.H.Irwin McLean,清水宏
    • Organizer
      第28回角化症研究会
    • Place of Presentation
      東京商工会議所(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] (特別講演)アトピー性皮膚炎とフィラグリン遺伝子変異2013

    • Author(s)
      清水宏
    • Organizer
      第7回くろしお皮膚談話会
    • Place of Presentation
      ホテル日航高知旭ロイヤル(高知市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] アレルギーとダスト中フタル酸エステル濃度 : 可塑剤・難燃剤曝露と小児の健康影響32013

    • Author(s)
      アイツバマイゆふ、荒木敦子、坪井樹、河合俊夫、多島秀司、叢石、吉岡英治、玉腰暁子、岸玲子
    • Organizer
      第83回日本衛生学会
    • Place of Presentation
      金沢大学(金沢市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 児童の尿中フタル酸代謝物濃度とアレルギー : 可塑剤、難燃剤の小児への健康影響42013

    • Author(s)
      荒木敦子、坪井樹、河合俊夫、アイツバマイゆふ、多島秀司、叢石、鵜川重和、吉岡英治、岸玲子
    • Organizer
      第83回日本衛生学会
    • Place of Presentation
      金沢大学(金沢市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] アトピー性皮膚炎の最新の話題2012

    • Author(s)
      清水宏
    • Organizer
      苫小牧小児科医会学術講演会
    • Place of Presentation
      グランドホテルニュー王子(北海道)(特別講演)
    • Year and Date
      2012-10-30
    • Related Report
      2012 Annual Research Report
  • [Presentation] フィラグリン遺伝子変異とアトピー性皮膚炎2012

    • Author(s)
      乃村俊史
    • Organizer
      第111回日本皮膚科学会総会
    • Place of Presentation
      国立京都国際会館(京都府)(教育講演)
    • Year and Date
      2012-06-02
    • Related Report
      2012 Annual Research Report
  • [Presentation] Determination of phthalate metabolites in urine of children and their family -Exposure assessment to plasticizer and flame retardants and their risk on children(3)-2012

    • Author(s)
      Atsuko Araki, Toshio Kawai, Tazuru Tsuboi, Yu Ait Bamai, Tomoya Takeda, Eiji Yoshioka, Shuji Tajima, Shigekazu Ukawa, Cong Shi, Reiko Kishi
    • Organizer
      International Society of Exposure Science 22nd Annual Meeting
    • Place of Presentation
      The Westin Seattle (USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Research plan for 7 year-old survey of the Hokkaido Study2012

    • Author(s)
      Atsuko Araki, Chihiro Miyashita, Tamiko Ikeno, Seiko Sasaki, Shuji Tajima, Yu Ait Bamai, Cong Shi, Shigekazu Ukawa, Toshio Kawai, Tazuru Tsuboi, Emiko Okada, Reiko Kishi
    • Organizer
      Birth Cohort Consortium in Asia : BiCCA2012
    • Place of Presentation
      National Taiwan University (Taiwan)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 札幌市の小学生4,500名を対象とした自宅住環境と喘息、アトピー性皮膚炎に関する調査2012

    • Author(s)
      鵜川重和、荒木敦子、金澤文子、湯浅資之、吉岡英治、岸玲子
    • Organizer
      第71回日本公衆衛生学会
    • Place of Presentation
      山口市民会館(山口県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ハウスダスト中に含まれるリン酸トリエステル類の濃度と住居環境2012

    • Author(s)
      多島秀司、荒木敦子、坪井樹、河合俊夫、斎藤育江、アイツバマイゆふ、竹田智哉、鵜川重和、吉岡英治、岸玲子
    • Organizer
      第64回北海道公衆衛生学会
    • Place of Presentation
      札幌医科大学(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 小学生の住宅におけるハウスダスト中のエンドトキシンならびにβ-グルカン量とアレルギー性疾患に関する研究2012

    • Author(s)
      叢石、荒木敦子、アイツバマイゆふ、竹田智哉、早川敦司、吉岡英治、多島秀司、鵜川重和、玉腰暁子、岸玲子
    • Organizer
      第64回北海道公衆衛生学会
    • Place of Presentation
      札幌医科大学(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Book] 公衆衛生、講座 子どもを取り巻く環境と健康 第5回環境化学物質の曝露(4)短半減期化学物質の曝露実態2015

    • Author(s)
      荒木敦子、アイツバマイゆふ、岸玲子
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] 専門医のためのアレルギー学講座 XVI.環境因子とアレルギー 2.環境汚染とアレルギーに関する疫学的知見-特に室内空気質に焦点をあてて-2014

    • Author(s)
      荒木敦子、アイツバマイゆふ、岸玲子
    • Publisher
      日本アレルギー学会
    • Related Report
      2014 Annual Research Report
  • [Book] 空気清浄 「住環境におけるフタル酸エステル類・リン酸トリエステル類の曝露実態と居住者への健康影響 (特集 ハウスダスト中の汚染物質の健康リスク)」2014

    • Author(s)
      荒木敦子、アイツバマイゆふ、岸玲子
    • Publisher
      日本空気清浄協会
    • Related Report
      2014 Annual Research Report
  • [Book] 公衆衛生、特集 公害・環境問題の変貌と新展開 「環境化学物質の次世代影響-出生コーホート研究による成果と今後の課題」2014

    • Author(s)
      岸玲子
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] 産業安全保健ハンドブック, 5.4.8 室内空気質による健康障害2013

    • Author(s)
      荒木敦子(著), 岸玲子(著), 小木和孝(編集代表)
    • Publisher
      労働科学研究所出版部
    • Related Report
      2013 Annual Research Report
  • [Book] 1冊でわかる最新皮膚科治療2013

    • Author(s)
      五十嵐敦之(ゲスト編集), 宮地良樹(常任編集), 清水宏(常任編集)
    • Total Pages
      328
    • Publisher
      文光堂
    • Related Report
      2013 Annual Research Report
  • [Book] Hailey-Hailey病. In : 塩原哲夫,宮地良樹,渡辺晋一,佐藤伸一 (eds.) : 今日の皮膚疾患治療指針2012

    • Author(s)
      清水宏
    • Publisher
      医学書院
    • Related Report
      2012 Annual Research Report
  • [Remarks] 北海道大学 環境健康科学教育研究センター 研究業績

    • URL

      http://www.cehs.hokudai.ac.jp/research/yearly/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 環境と健康ひろば

    • URL

      http://www.cehs.hokudai.ac.jp/hiroba/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 環境と子どもに関する北海道研究・北海道スタディ

    • URL

      http://www.cehs.hokudai.ac.jp/hokkaidostudy/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 環境健康科学研究教育センター 研究業績

    • URL

      http://www.cehs.hokudai.ac.jp/research/yearly/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 環境と健康ひろば

    • URL

      http://www.cehs.hokudai.ac.jp/hiroba/

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.cehs.hokudai.ac.jp/research/yearly.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.cehs.hokudai.ac.jp/research/project.html

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

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