Environmental and Genetic risk factors of Atopic dermatitis among 7-year old children in birth cohort

• Project/Area Number: 24390152
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Hygiene
• Research Institution: Hokkaido University
• Principal Investigator: ARAKI Atsuko 北海道大学, 環境健康科学研究教育センター, 准教授 (00619885)
• Co-Investigator(Kenkyū-buntansha): NOMURA Toshifumi 北海道大学, 大学院医学研究科, 助教 (50399911) ; KISHI Reiko 北海道大学, 環境健康科学研究教育センター, 特任教授 (80112449) ; SHIMIZU Hiroshi 北海道大学, 大学院医学研究科, 教授 (00146672) ; 多島 秀司 北海道大学, 環境健康科学研究教育センター, 学術研究員 (10619886)
• Co-Investigator(Renkei-kenkyūsha): SASAKI Seiko 北海道大学, 大学院医学研究科, 助教 (30448831)
• Research Collaborator: AIT BAMAI Yu ; TAJIMA Shuji ; UKAWA Shigekazu ; CONG Shi
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2012: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
• Keywords: 環境 / アレルギー・喘息 / アトピー性皮膚炎 / 衛生 / 遺伝子 / フィラグリン遺伝子 / 自宅環境 / ダスト / ダニアレルゲン / 出生コーホート / 遺伝的素因 / 環境用要因

Outline of Final Research Achievements

The present study examined the risk of environmental factors such as mite allergens, phthalates, and organophosphate in house dust and filaggrin (FLG) gene variants on atopic dermatitis (AD) among 7 years old children who are participating in the Hokkaido study on Environment and Children's Health. About 10% of the participants in this study had FLG gene variants, which was consistent with other previous studies. The children with FLG gene variants significantly increased the risk of AD at 2 and 4 years of age, but were not at 7 years of age. Among 7 years old children with high levels of DiNP and without FLG gene variants significantly increased the risk of AD.

Research Products

• [Journal Article] Prenatal maternal blood triglyceride and fatty acid levels in relation to exposure to di(2-ethylhexyl)phthalate: a cross-sectional study (2015)
  • Author(s): Jia X., Harada Y., Tagawa M., Naito H., Hayashi Y., Yetti H., Kato M., Sasaki S., Araki A., Miyashita C., Ikeno T., Kishi R., Nakajima T.
  • Journal Title: Environ Health Prev Med Volume: in press
  • NAID: 210000000370
  • Peer Reviewed / Open Access
• [Journal Article] Comparisons of urinary phthalate metabolites and daily phthalate intakes among Japanese families (2015)
  • Author(s): Yu Ait Bamai, Atsuko Araki, Toshio Kawai, Tazuru Tsuboi, Eiji Yoshioka, Ayako Kanazawa, Shi Cong, Reiko Kishi
  • Journal Title: International Journal of Hygiene and Environmental Health Volume: in press Issue: 5 Pages: 461-470
  • DOI: 10.1016/j.ijheh.2015.03.013
  • NAID: 120005820699
  • Peer Reviewed / Open Access
• [Journal Article] Dermoscopic observation in adenoma of the nipple (2015)
  • Author(s): Takashima S, Fujita Y, Miyauchi T, Nomura T, Nishie W, Hamaoka H, Shimizu H.
  • Journal Title: The Journal of Dermatology Volume: 42(3) Issue: 3 Pages: 341-342
  • DOI: 10.1111/1346-8138.12780
  • Peer Reviewed / Open Access
• [Journal Article] Loss-of-function mutations in the gene encoding filaggrin underlie a Japanese family with food-dependent exercise-induced anaphylaxis (2015)
  • Author(s): Mizuno O, Nomura T, Ohguchi Y, Suzuki S, Nomura Y, Hamade Y, Hoshina D, Sandilands A, Akiyama M, McLean WH, Abe R, Shimizu H.
  • Journal Title: Journal of the European Academy of Dermatology and Venereology Volume: 29(4) Issue: 4 Pages: 805-808
  • DOI: 10.1111/jdv.12441
  • Peer Reviewed / Open Access
• [Journal Article] Association between maternal exposure to di(2-ethylhexyl) phthalate and reproductive hormone levels in fetal blood: The Hokkaido Study on Environment and Children's Health (2014)
  • Author(s): Araki A., Mitsui T., Miyashita C., Nakajima T., Naito H., Ito S., Sasaki S., Cho K., Ikeno T., Nonomura K., Kishi R.
  • Journal Title: PLOS One Volume: 9(10) Issue: 10 Pages: e109039-e109039
  • DOI: 10.1371/journal.pone.0109039
  • NAID: 120005476155
  • Peer Reviewed / Open Access
• [Journal Article] Phosphorus flame retardants in indoor dust and their relation to asthma and allergies of inhabitants (2014)
  • Author(s): Araki A., Saito I., Kanazawa A., Morimoto K., Nakayama K., Shibata E., Tanaka M., Takigawa T., Yoshimura T., Chikara H., Saijo Y., Kishi R
  • Journal Title: Indoor Air Volume: 24 Issue: 1 Pages: 3-15
  • DOI: 10.1111/ina.12054
  • Peer Reviewed / Open Access
• [Journal Article] Associations of phthalate concentrations in floor dust and multi-surface dust with the interior materials in Japanese dwellings (2014)
  • Author(s): Yu Ait Bamai, Atsuko Araki, Toshio Kawai, Tazuru Tsuboi, Ikue Saito, Eiji Yoshioka, Ayako Kanazawa, Shuji Tajima, Cong Shi, Akiko Tamakoshi, Reiko Kishi
  • Journal Title: Science of the Total Environment Volume: 468-469 Pages: 147-157
  • DOI: 10.1016/j.scitotenv.2013.07.107
  • NAID: 120005425356
  • Peer Reviewed / Open Access
• [Journal Article] Detection and intake assessment of organophosphate flame retardants in house dust in Japanese dwellings (2014)
  • Author(s): Tajima S., Araki A., Kawai T., Tsuboi T., Ait Bamai Y., Yoshioka E., Kanazawa A., Cong S., Kishi R.
  • Journal Title: Sci Total Environ Volume: 478C Pages: 190-199
  • DOI: 10.1016/j.scitotenv.2013.12.121
  • NAID: 120005427753
  • Peer Reviewed / Open Access
• [Journal Article] Association of Mechanical Ventilation and Flue Use in Heaters With Asthma Symptoms in Japanese Schoolchildren: A Cross-Sectional Study in Sapporo, Japan (2014)
  • Author(s): Cong S., Araki A., Ukawa S., Ait Bamai Y., Tajima S., Kanazawa A., Yuasa M., Tamakoshi A., Kishi R
  • Journal Title: Journal of Epidemiology Volume: 24 Issue: 3 Pages: 230-238
  • DOI: 10.2188/jea.JE20130135
  • NAID: 130003392103
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Open Access
• [Journal Article] Exposure to house dust phthalates in relation to asthma and allergies in both children and adults (2014)
  • Author(s): Ait Bamai Y., Shibata E., Saito I., Araki A., Kanazawa A., Morimoto K., Nakayama K., Tanaka M., Takigawa T., Yoshimura T., Chikara H., Saijo Y., Kishi R
  • Journal Title: Sci Total Environ Volume: 485-486C Pages: 153-163
  • DOI: 10.1016/j.scitotenv.2014.03.059
  • NAID: 120005425358
  • Peer Reviewed / Open Access
• [Journal Article] Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in patients with atopic dermatitis (2014)
  • Author(s): Yoshida K, Kubo A, Fujita H, Yokouchi M, Ishii K, Kawasaki H, Nomura T, Shimizu H, Kouyama K, Ebihara T, Nagao K, Amagai M.
  • Journal Title: The Journal of Allergy and Clinical Immunology Volume: 134(4) Issue: 4 Pages: 856-864
  • DOI: 10.1016/j.jaci.2014.08.001
  • Peer Reviewed / Open Access
• [Journal Article] A new filaggrin gene mutation in a Korean patient with ichthyosis vulgaris (2014)
  • Author(s): Ohguchi Y, Nomura T, Suzuki S, Mizuno O, Nomura Y, Nemoto-Hasebe I, Okamoto H, Sandilands A, Akiyama M, Mclean WH, Shimizu H.
  • Journal Title: European Journal of Dermatology Volume: 24(4) Issue: 4 Pages: 491-493
  • DOI: 10.1684/ejd.2014.2410
  • Peer Reviewed / Open Access
• [Journal Article] An annexin A1-FPR1 interaction contributes to necroptosis of keratinocytes in severe cutaneous adverse drug reactions. (2014)
  • Author(s): Saito N, Qiao H, Yanagi T, Shinkuma S, Nishimura K, Suto A, Fujita Y, Suzuki S, Nomura T, Nakamura H, Nagao K, Obuse C, Shimizu H, Abe R.
  • Journal Title: Science Translational Medicine Volume: 6 Issue: 245 Pages: 245-295
  • DOI: 10.1126/scitranslmed.3008227
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive screening for a complete set of Japanese-population-specific filaggrin gene mutations (2014)
  • Author(s): Kono M, Nomura T, Ohguchi Y, Mizuno O, Suzuki S, Tsujiuchi H, Hamajima N, McLean WH, Shimizu H, Akiyama M.
  • Journal Title: Allergy Volume: 69(4) Issue: 4 Pages: 537-540
  • DOI: 10.1111/all.12369
  • Peer Reviewed / Open Access
• [Journal Article] Prenatal exposure to perfluoroalkyl acids and allergic diseases in earlychildhood. (2014)
  • Author(s): Okada E, Sasaki S, Kashino I, Matsuura H, Miyashita C, Kobayashi S, Itoh K, Ikeno T, Tamakoshi A, Kishi R.
  • Journal Title: Environment International Volume: 65 Pages: 127-134
  • DOI: 10.1016/j.envint.2014.01.007
  • Peer Reviewed / Open Access
• [Journal Article] Punctate palmoplantar keratoderma type 1: a novel AAGAB mutation and efficacy of etretinate (2014)
  • Author(s): Nomura T, Yoneta A, Pohler E, Suzuki S, Osawa R, Mizuno O, Ohguchi Y, Nomura Y, Yamashita T, McLean WHI, Shimizu H
  • Journal Title: Acta Derm Venereol Volume: in press Issue: 1 Pages: 110-111
  • DOI: 10.2340/00015555-1832
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive screening for a complete set of Japanese-population-specific filaggrin gene mutations (2014)
  • Author(s): Kono M, Nomura T, Ohguchi Y, Mizuno O, Suzuki S, Tsujiuchi H, Hamajima M, McLean WHI, Shimizu H, Akiyama M
  • Journal Title: Allergy Volume: 69 Pages: 537-540
  • Peer Reviewed
• [Journal Article] A novel NCSTN mutation alone may be insufficient for the development of familial hidradenitis suppurativa (2014)
  • Author(s): Nomura Y, Nomura T, Suzuki S, Takeda M, Mizuno O, Ohguchi Y, Abe R, Murata Y, Shimizu H
  • Journal Title: J Dermatol Sci Volume: 74 Pages: 180-182
  • Peer Reviewed
• [Journal Article] Tubular apocrine adenoma clinically and dermoscopically mimicking basal cell carcinoma (2014)
  • Author(s): Ito T, Nomura T, Fujita Y, Abe R, Shimizu H
  • Journal Title: J Am Acad Dermatol Volume: in press
  • Peer Reviewed
• [Journal Article] A new filaggrin gene mutation in a Korean patient with ichthyosis vulgaris (2014)
  • Author(s): Ohguchi Y, Nomura T, Suzuki S, Mizuno O, Nomura Y, Nemoto-Hasebe I, Okamoto H, Sandilands A, Akiyama M, McLean WH, Shimizu H
  • Journal Title: Eur J Dermatol Volume: in press
  • Peer Reviewed
• [Journal Article] Highly prevalent SERPINB7 founder mutation causes pseudodominant inheritance pattern in Nagashima-type palmoplantar keratosis (2014)
  • Author(s): Mizuno O, Nomura T, Suzuki S, Takeda M, Ohguchi Y, Fujita Y, Nishie W, Sugiura K, Akiyama M, Shimizu H
  • Journal Title: Br J Dermatol Volume: 171 Issue: 4 Pages: 847-853
  • DOI: 10.1111/bjd.13076
  • Peer Reviewed / Open Access
• [Journal Article] ネコアレルゲンFel d 1測定Enzyme-Linked Immunosorbent Assayの確立 (2014)
  • Author(s): 深田一剛, 嶋田貴志, 多島秀司, 岸玲子, 榎本雅夫, 安枝浩
  • Journal Title: アレルギー・免疫 Volume: 21 Pages: 522-529
  • NAID: 40019985484
  • Peer Reviewed
• [Journal Article] The relationship between atopic dermatitis and indoor environmental factors: a cross-sectional study among Japanese elementary school children (2013)
  • Author(s): Ukawa S, Araki A, Kanazawa A, Yuasa M, Kishi R
  • Journal Title: Int Arch Occup Environ Health Volume: - Issue: 7 Pages: 777-787
  • DOI: 10.1007/s00420-012-0814-0
  • Peer Reviewed
• [Journal Article] Ten years of progress in the Hokkaido birth cohort study on environment and children's health : cohort profile--updated 2013. (2013)
  • Author(s): Kishi R, Kobayashi S, Ikeno T, Araki A, Miyashita C, Itoh S, Sasaki S, Okada E, Kobayashi S, Kashino I, Itoh K, Nakajima S ; Members of the Hokkaido Study on Environment and Children's Health.
  • Journal Title: Environmental Health and Preventive Medicine Volume: 18 Issue: 6 Pages: 429-450
  • DOI: 10.1007/s12199-013-0357-3
  • Peer Reviewed
• [Journal Article] Dermoscopy of pseudoxanthoma elasticum-like papillary dermal elastosis (2013)
  • Author(s): Ito T, Fujita Y, Nomura T, Abe R, Shimizu H
  • Journal Title: J Am Acad Dermatol Volume: 69 Issue: 4 Pages: e202-e203
  • DOI: 10.1016/j.jaad.2013.04.059
  • Peer Reviewed
• [Journal Article] Impaired epidermal permeability barrier in mice lacking the Elovl1 gene responsible for very long-chain fatty acid production. (2013)
  • Author(s): Sassa T, Ohno Y, Suzuki S, Nomura T, Nishioka C, Kashiwagi T, Hirayama T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A.
  • Journal Title: Mol Cell Biol Volume: 33 Issue: 14 Pages: 2787-2796
  • DOI: 10.1128/mcb.00192-13
  • Peer Reviewed
• [Journal Article] Infantile eczema caused by formula milk (2013)
  • Author(s): Ito T, Nishie W, Fujita Y, Abe R, Shimizu H
  • Journal Title: Lancet Volume: 381 Issue: 9881 Pages: 1958-1958
  • DOI: 10.1016/s0140-6736(13)60684-4
  • Peer Reviewed
• [Journal Article] 札幌市の小学生4,500名を対象とした住環境とアトピー性皮膚炎に関する調査 (2013)
  • Author(s): 鵜川重和, 荒木敦子, 金澤文子, 湯浅資之, 岸玲子
  • Journal Title: 北海道医学雑誌 Volume: 88 Pages: 95-95
  • NAID: 10031165895
• [Journal Article] ハウスダスト中フタル酸エステルと住環境との関連 (2013)
  • Author(s): アイツバマイゆふ, 荒木敦子, 河合俊夫, 坪井樹, 斎藤育江, 吉岡英治, 金澤文子, 多島秀司, 叢石, 玉腰暁子, 岸玲子
  • Journal Title: 北海道医学雑誌 Volume: 88 Pages: 198-198
• [Journal Article] The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes (2012)
  • Author(s): Araki A., Kanazawa A., Kawai T., Eitaki Y., Morimoto K., Nakayama K., Shibata E., Tanaka M., Takigawa T., Yoshimura T., Chikara H., Saijo Y., Kishi R
  • Journal Title: Sci Total Environ Volume: 423 Pages: 18-26
  • DOI: 10.1016/j.scitotenv.2012.02.026
  • NAID: 120004027252
  • Peer Reviewed
• [Journal Article] Validation of the diffusive mini-samplers for aldehyde and VOC and its feasibility to elementally school children's exposure measurements (2012)
  • Author(s): Atsuko Araki, Tazuru Tsuboi, Toshio Kawai, Yu Ait Bamai, Takeda Tomoya, Eiji Yoshioka, Reiko Kishi
  • Journal Title: Journal of Environmental Monitoring Volume: 14 Issue: 2 Pages: 368-374
  • DOI: 10.1039/c1em10624d
  • Peer Reviewed
• [Journal Article] Prenatal exposure to perfluorinated chemicals and relationship with allergies and infectious diseases in infants (2012)
  • Author(s): Okada E, Sasaki S, Saijo Y, Washino N, Miyashita C, Kobayashi S, Konishi K, Ito YM Ito R, Nakata A, Iwasaki Y, Saito K, Nakazawa H, Kishi R.
  • Journal Title: Environ Res. Volume: 112(1) Pages: 118-125
  • DOI: 10.1016/j.envres.2011.10.003
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• [Journal Article] The feasibility of aromatherapy massage to reduce symptoms of Idiopathic Environmental Intolerance: A pilot study (2012)
  • Author(s): Atsuko Araki, Kazuhiko Watanabe, Yoko Eitaki, Toshio Kawai, Reiko Kishi
  • Journal Title: Complementary Therapies in Medicine Volume: 20 Issue: 6 Pages: 400-408
  • DOI: 10.1016/j.ctim.2012.07.005
  • NAID: 120005295681
  • Peer Reviewed
• [Journal Article] 室内空気中フタル酸エステル類曝露とアレルギーへの影響 (2012)
  • Author(s): アイツバマイゆふ、荒木敦子、岸玲子
  • Journal Title: Endocrine Disrupter News Letter Volume: 15 Pages: 2-2
• [Journal Article] Antibodies to pathogenic epitopes on type XVII collagen cause skin fragility in a complement-dependent and independent manner (2012)
  • Author(s): Natsuga K, Nishie W, Shinkuma S, Ujiie H, Nishimura M, Sawamura D, Shimizu H
  • Journal Title: J Immunol Volume: (in press) Issue: 11 Pages: 5792-5799
  • DOI: 10.4049/jimmunol.1003402
  • NAID: 10031131103
  • Peer Reviewed
• [Journal Article] A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency: Possible immunological state of the intrinsic type (2012)
  • Author(s): Kabashima-Kubo R, Nakamura M, Sakabe, J, Sigita K, Hino R, Mori T, Kobayashi M, Bito T, Kabashima K, Ogasawara K, Nomura Y, Nomura T, Akiyama M, Shimizu H, Tokura Y.
  • Journal Title: J Dermatol Sci Volume: 67 Issue: 1 Pages: 37-43
  • DOI: 10.1016/j.jdermsci.2012.04.004
  • Peer Reviewed
• [Journal Article] The β9 Loop Domain of PA-PLA(1)α Has a Crucial Role in Autosomal Recessive Woolly Hair/Hypotrichosis (2012)
  • Author(s): Shinkuma S, Inoue A, Aoki J, Nishie W, Natsuga K, Ujiie H, Nomura T, Abe R, Akiyama M, Shimizu H
  • Journal Title: The Journal of Investigative Dermatology Volume: (印刷中) Issue: 8 Pages: 2093-2095
  • DOI: 10.1038/jid.2012.96
  • Peer Reviewed
• [Journal Article] Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma (2012)
  • Author(s): Pohler E
  • Journal Title: Nat Genet Volume: 44 Issue: 11 Pages: 1272-1276
  • DOI: 10.1038/ng.2444
  • Peer Reviewed
• [Journal Article] A novel splice site mutation in NCSTN underlies a Japanese family with hidradenitis suppurativa. (2012)
  • Author(s): Nomura Y, Nomura T, Mizuno H, Shimizu H, et al
  • Journal Title: Br J Dermatol Volume: 168 Pages: 206-209
  • Peer Reviewed
• [Presentation] 有機塩素系農薬が乳幼児の免疫に与える影響―環境と子どもの健康北海道スタディー (2015)
  • Author(s): 宮下ちひろ，金澤文子，佐々木成子，池野多美子，荒木敦子，伊藤佐智子，小林祥子，水谷太，苣木洋一，岸玲子
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: 和歌山県民文化会館 (和歌山県・和歌山市）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 胎児期の有機塩素系農薬が小児アレルギー発症に与える影響―環境と子どもの健康北海道スタディー (2014)
  • Author(s): 宮下ちひろ，金澤文子，池野多美子，荒木敦子，伊藤佐智子，小林澄貴，湊屋街子，Houman Goudarzi，小林祥子，田村菜穂美，水谷太，苣木洋一，岸玲子
  • Organizer: 第66回北海道公衆衛生学会
  • Place of Presentation: 北海道大学学術交流会館 （北海道・札幌市）
  • Year and Date: 2014-12-02
• [Presentation] Twelve years of progress in the Hokkaido birth cohort study on environment and children's health: malformation, development and allergy (2014)
  • Author(s): Kishi R.
  • Organizer: International Symposium of Environmental Medicine Program
  • Place of Presentation: International Convention Center, Taipei (Taiwan)
  • Year and Date: 2014-10-16 – 2014-10-17
• [Presentation] Phthalates & Phosphate Flame Retardants (PFRs) in house dust and their associations with asthma and allergies (2014)
  • Author(s): Kishi R.
  • Organizer: Summit on Child Health and the Environment 2014
  • Place of Presentation: Hong Kong Academy of Medicine Building, Aberdeen (Hong Kong)
  • Year and Date: 2014-10-11 – 2014-10-13
• [Presentation] Association between maternal exposure to di(2-ethylhexyl) phthalate and sex hormone levels in fetal blood (2014)
  • Author(s): Araki A., Mitsui T., Miyashita C., Nakajima T., Nakazawa H., Sasaki S., Ikeno T., Cho K., Itoh S., Nonomura K., Kishi R.
  • Organizer: 26th Annual International Society for Environmental Epidemiology Conference - From Local to Global: Advancing Science for Policy in Environmental Health
  • Place of Presentation: Husky Union Building, the University of Washington, Seattle (USA)
  • Year and Date: 2014-08-24 – 2014-08-28
• [Presentation] Exposure to house dust phthalates in relation to asthma and allergies in both children and adults (2014)
  • Author(s): Ait Bamai Y., Shibata E., Saito I., Araki A., Kanazawa A., Morimoto K., Nakayama K., Tanaka M., Takigawa T., Yoshimura T., Chikara H., Saijo Y., Kishi R.
  • Organizer: 26th Annual International Society for Environmental Epidemiology Conference - From Local to Global: Advancing Science for Policy in Environmental Health
  • Place of Presentation: Husky Union Building, the University of Washington, Seattle (USA)
  • Year and Date: 2014-08-24 – 2014-08-28
• [Presentation] フタル酸エステル類の胎児期曝露による次世代影響に関する疫学研究 (2014)
  • Author(s): 荒木敦子, 岸玲子
  • Organizer: 第84回日本衛生学会学術総会
  • Place of Presentation: 岡山コンベンションセンター （岡山県・岡山市）
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] DEHPへの胎児期曝露による児の性ホルモン濃度への影響 (2014)
  • Author(s): 荒木敦子, 三井貴彦, 宮下ちひろ, 那須民江, 伊藤佐智子, 佐々木成子, 長和俊, 池野多美子, 野々村克也, 岸玲子
  • Organizer: 第84回日本衛生学会学術総会
  • Place of Presentation: 岡山コンベンションセンター （岡山県・岡山市）
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] 尿中フタル酸代謝物濃度とハウスダスト中フタル酸エステル濃度との関連：札幌市児童における調査 (2013)
  • Author(s): アイツバマイゆふ, 荒木敦子, 河合俊夫, 坪井樹, 多島秀司, 叢石, 湯浅資之, 金澤文子, 玉腰暁子, 岸玲子
  • Organizer: 第65回北海道公衆衛生学会
  • Place of Presentation: 札幌市生涯学習センターちえりあ（札幌市）
• [Presentation] 札幌市内小学生の自宅における暖房、および機械換気の有無と児童の喘息 (2013)
  • Author(s): 叢石, 荒木敦子, 鵜川重和, アイツバマイゆふ, 多島秀司, 金澤文子, 湯浅資之, 玉腰暁子, 岸玲子
  • Organizer: 第65回北海道公衆衛生学会
  • Place of Presentation: 札幌市生涯学習センターちえりあ（札幌市）
• [Presentation] 札幌市128軒のハウスダスト中リン酸トリエステル類濃度と小学生のアレルギー疾患との関連 (2013)
  • Author(s): 多島秀司, 荒木敦子, 河合俊夫, 坪井樹, アイツバマイゆふ, 叢石, 吉岡英治, 岸玲子
  • Organizer: 第65回北海道公衆衛生学会
  • Place of Presentation: 札幌市生涯学習センターちえりあ（札幌市）
• [Presentation] Phthalate metabolites in urine and their relation to asthma and allergy in school children -Exposure assessment to plasticizer and flame retardants (3) (2013)
  • Author(s): Araki A., Kawai T., Tsuboi T., Ait Bamai Y., Yoshioka E., Tajima S, Cong S., Ukawa S., Kishi R.
  • Organizer: Environment and Health - Bridging South, North, East and West Conference of ISEE, ISES and ISIAQ
  • Place of Presentation: Congress Center Basel (Switzerland)
• [Presentation] Relationship between prenatal exposure to perfluorinated compounds and allergic diseases in infants (2013)
  • Author(s): Okada E., Kashino I., Sasaki S., Miyashita C., Ikeno T., Araki A., Yamamoto J., Matsuura H., Matsumura T., Tamakoshi A., Kishi R.
  • Organizer: Environment and Health - Bridging South, North, East and West Conference of ISEE, ISES and ISIAQ
  • Place of Presentation: Congress Center Basel (Switzerland)
• [Presentation] Biological monitoring of environments exposure to DEHP by urine analysis for 2-Ethyl-1-hexanol (2013)
  • Author(s): Kawai T., Tsuboi T., Araki A., Ait Bamai Y., Tajima S., Cong S., Kishi R.
  • Organizer: Environment and Health - Bridging South, North, East and West Conference of ISEE, ISES and ISIAQ
  • Place of Presentation: Congress Center Basel (Switzerland)
• [Presentation] Simultaneous analysis of phthalate and organophosphate triesters' metabolites in urine -Exposure assessment to plastisizer and flame retardants (2013)
  • Author(s): Tsuboi T., Kawai T., Araki A., Ait Bamai Y., Kishi R.
  • Organizer: Environment and Health - Bridging South, North, East and West Conference of ISEE, ISES and ISIAQ
  • Place of Presentation: Congress Center Basel (Switzerland)
• [Presentation] GC/MSによるヒ卜の尿中2-エチルヘキサノールの定量―フタル酸ジエステル類評価としての無水フタル酸：可塑剤・難燃剤曝露と小児の健康影響 (2013)
  • Author(s): 河合俊夫, 坪井樹, 荒木敦子, アイツバマイゆふ, 岸玲子
  • Organizer: 第86回日本産業衛生学会
  • Place of Presentation: ひめぎんホール（愛媛県県民文化会館）(松山市）
• [Presentation] アトピー性皮膚炎と皮膚バリア障害 (2013)
  • Author(s): 乃村俊史
  • Organizer: 函館小児科医会学術講演会
  • Place of Presentation: ベルクラシック函館（函館市）
  • Invited
• [Presentation] AAGAB遺伝子変異を認めた点状掌蹠角化症の3家系 (2013)
  • Author(s): 乃村俊史，米田明弘，木花いづみ，末廣晃宏，秋山真志，W.H.Irwin McLean，清水宏
  • Organizer: 第28回角化症研究会
  • Place of Presentation: 東京商工会議所（東京都）
• [Presentation] （特別講演）アトピー性皮膚炎とフィラグリン遺伝子変異 (2013)
  • Author(s): 清水宏
  • Organizer: 第7回くろしお皮膚談話会
  • Place of Presentation: ホテル日航高知旭ロイヤル（高知市）
• [Presentation] アレルギーとダスト中フタル酸エステル濃度 : 可塑剤・難燃剤曝露と小児の健康影響3 (2013)
  • Author(s): アイツバマイゆふ、荒木敦子、坪井樹、河合俊夫、多島秀司、叢石、吉岡英治、玉腰暁子、岸玲子
  • Organizer: 第83回日本衛生学会
  • Place of Presentation: 金沢大学(金沢市)
• [Presentation] 児童の尿中フタル酸代謝物濃度とアレルギー : 可塑剤、難燃剤の小児への健康影響4 (2013)
  • Author(s): 荒木敦子、坪井樹、河合俊夫、アイツバマイゆふ、多島秀司、叢石、鵜川重和、吉岡英治、岸玲子
  • Organizer: 第83回日本衛生学会
  • Place of Presentation: 金沢大学(金沢市)
• [Presentation] アトピー性皮膚炎の最新の話題 (2012)
  • Author(s): 清水宏
  • Organizer: 苫小牧小児科医会学術講演会
  • Place of Presentation: グランドホテルニュー王子(北海道)(特別講演)
  • Year and Date: 2012-10-30
• [Presentation] フィラグリン遺伝子変異とアトピー性皮膚炎 (2012)
  • Author(s): 乃村俊史
  • Organizer: 第111回日本皮膚科学会総会
  • Place of Presentation: 国立京都国際会館(京都府)(教育講演)
  • Year and Date: 2012-06-02
• [Presentation] Determination of phthalate metabolites in urine of children and their family -Exposure assessment to plasticizer and flame retardants and their risk on children(3)- (2012)
  • Author(s): Atsuko Araki, Toshio Kawai, Tazuru Tsuboi, Yu Ait Bamai, Tomoya Takeda, Eiji Yoshioka, Shuji Tajima, Shigekazu Ukawa, Cong Shi, Reiko Kishi
  • Organizer: International Society of Exposure Science 22nd Annual Meeting
  • Place of Presentation: The Westin Seattle (USA)
• [Presentation] Research plan for 7 year-old survey of the Hokkaido Study (2012)
  • Author(s): Atsuko Araki, Chihiro Miyashita, Tamiko Ikeno, Seiko Sasaki, Shuji Tajima, Yu Ait Bamai, Cong Shi, Shigekazu Ukawa, Toshio Kawai, Tazuru Tsuboi, Emiko Okada, Reiko Kishi
  • Organizer: Birth Cohort Consortium in Asia : BiCCA2012
  • Place of Presentation: National Taiwan University (Taiwan)
• [Presentation] 札幌市の小学生4,500名を対象とした自宅住環境と喘息、アトピー性皮膚炎に関する調査 (2012)
  • Author(s): 鵜川重和、荒木敦子、金澤文子、湯浅資之、吉岡英治、岸玲子
  • Organizer: 第71回日本公衆衛生学会
  • Place of Presentation: 山口市民会館(山口県)
• [Presentation] ハウスダスト中に含まれるリン酸トリエステル類の濃度と住居環境 (2012)
  • Author(s): 多島秀司、荒木敦子、坪井樹、河合俊夫、斎藤育江、アイツバマイゆふ、竹田智哉、鵜川重和、吉岡英治、岸玲子
  • Organizer: 第64回北海道公衆衛生学会
  • Place of Presentation: 札幌医科大学(札幌市)
• [Presentation] 小学生の住宅におけるハウスダスト中のエンドトキシンならびにβ-グルカン量とアレルギー性疾患に関する研究 (2012)
  • Author(s): 叢石、荒木敦子、アイツバマイゆふ、竹田智哉、早川敦司、吉岡英治、多島秀司、鵜川重和、玉腰暁子、岸玲子
  • Organizer: 第64回北海道公衆衛生学会
  • Place of Presentation: 札幌医科大学(札幌市)
• [Book] 公衆衛生、講座 子どもを取り巻く環境と健康 第5回環境化学物質の曝露（4）短半減期化学物質の曝露実態 (2015)
  • Author(s): 荒木敦子、アイツバマイゆふ、岸玲子
  • Publisher: 医学書院
• [Book] 専門医のためのアレルギー学講座 XVI．環境因子とアレルギー ２．環境汚染とアレルギーに関する疫学的知見－特に室内空気質に焦点をあてて－ (2014)
  • Author(s): 荒木敦子、アイツバマイゆふ、岸玲子
  • Publisher: 日本アレルギー学会
• [Book] 空気清浄 「住環境におけるフタル酸エステル類・リン酸トリエステル類の曝露実態と居住者への健康影響 (特集 ハウスダスト中の汚染物質の健康リスク)」 (2014)
  • Author(s): 荒木敦子、アイツバマイゆふ、岸玲子
  • Publisher: 日本空気清浄協会
• [Book] 公衆衛生、特集 公害・環境問題の変貌と新展開 「環境化学物質の次世代影響－出生コーホート研究による成果と今後の課題」 (2014)
  • Author(s): 岸玲子
  • Publisher: 医学書院
• [Book] 産業安全保健ハンドブック, 5.4.8 室内空気質による健康障害 (2013)
  • Author(s): 荒木敦子(著), 岸玲子(著), 小木和孝(編集代表)
  • Publisher: 労働科学研究所出版部
• [Book] １冊でわかる最新皮膚科治療 (2013)
  • Author(s): 五十嵐敦之(ゲスト編集), 宮地良樹(常任編集), 清水宏（常任編集）
  • Total Pages: 328
  • Publisher: 文光堂
• [Book] Hailey-Hailey病. In : 塩原哲夫,宮地良樹,渡辺晋一,佐藤伸一 (eds.) : 今日の皮膚疾患治療指針 (2012)
  • Author(s): 清水宏
  • Publisher: 医学書院
• [Remarks] 北海道大学 環境健康科学教育研究センター 研究業績
  • URL: http://www.cehs.hokudai.ac.jp/research/yearly/
• [Remarks] 環境と健康ひろば
  • URL: http://www.cehs.hokudai.ac.jp/hiroba/
• [Remarks] 環境と子どもに関する北海道研究・北海道スタディ
  • URL: http://www.cehs.hokudai.ac.jp/hokkaidostudy/
• [Remarks] 環境健康科学研究教育センター 研究業績
  • URL: http://www.cehs.hokudai.ac.jp/research/yearly/
• [Remarks] 環境と健康ひろば
  • URL: http://www.cehs.hokudai.ac.jp/hiroba/
• [Remarks]
  • URL: http://www.cehs.hokudai.ac.jp/research/yearly.html
• [Remarks]
  • URL: http://www.cehs.hokudai.ac.jp/research/project.html