Review and analysis of mechanism for noise-induced deafness by epidemiological and experimental studies

• Project/Area Number: 24390157
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Hygiene
• Research Institution: Nagoya University
• Principal Investigator: Kato Masashi 名古屋大学, 医学(系)研究科(研究院), 教授 (10281073)
• Co-Investigator(Kenkyū-buntansha): OHGAMI Nobutaka 名古屋大学, 大学院医学系研究科, 講師 (80424919) ; YAJIMA Ichiro 名古屋大学, 大学院医学系研究科, 講師 (80469022) ; YAMANOSHITA Osamu 中部大学, 生命健康科学部, 講師 (50424924)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000); Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: 難聴 / 環境因子 / 騒音 / 聴覚障害 / 予防療法 / 国際研究者交流 / 内耳機能 / 疫学 / 若年者 / MP3プーヤー / 遺伝子改変マウス / 騒音性難聴制御分子

Outline of Final Research Achievements

Our epidemiological study in limited number of subjects showed significant correlation between hearing level of 8k Hz and smoking and barium concentration in toenail but not sound level from personal music players at present moment. We will keep analyzing the correlation between hearing level and sound level from personal music players with increasing the number of subjects. Our experimental study further identified candidates of preventive medicines as well as regulatory molecules for noise-induced deafness. Our experimental study also showed promoted hearing loss in mice by drinking barium. Thus, we provided new insight for environmental factors-mediated deafness by our epidemiological and experimental studies.

Research Products

• [Int'l Joint Research] Vietnam National University(ベトナム)
• [Int'l Joint Research] University of Dhaka(Bangladesh)
• [Journal Article] Commentary to Gorelenkova Miller and Mieyal (2015): Sulfhydryl-mediated redox signaling in inflammation: role in neurodegenerative diseases. (2016)
  • Author(s): Kato M, Ninomiya H, Maeda M, Tanaka N, Ilmiawati C, Yoshinaga M.
  • Journal Title: Arch Toxicol Volume: 90 Issue: 4 Pages: 1017-1018
  • DOI: 10.1007/s00204-016-1662-6
  • Peer Reviewed
• [Journal Article] Epidemiological analysis of the association between hearing and barium in humans (2015)
  • Author(s): Ohgami, N. Mitsumatsu, Y. Ahsan, N. Akhand, A. A. Li, X. Iida, M. Yajima, I. Naito, M. Wakai, K. Ohnuma, S. Kato, M.
  • Journal Title: J Expo Sci Environ Epidemiol Volume: - Issue: 5 Pages: 488-493
  • DOI: 10.1038/jes.2015.62
  • NAID: 120005851029
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Carcinogenic risk of chromium, copper and arsenic in CCA-treated woods. (2015)
  • Author(s): Ohgami N, Yamanoshita O, Thang ND, Yajima I, Nakano C, Wu W, Ohnuma S, Kato M.
  • Journal Title: Environ Pollut Volume: 206 Pages: 456-460
  • DOI: 10.1016/j.envpol.2015.07.041
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Cigarette smoking causes hearing impairment among Bangladeshi population (2015)
  • Author(s): AF. Sumit, A. Das, Z. Sharmin, N. Ahsan, N. Ohgami, M. Kato, AA. Akhand
  • Journal Title: PLoS ONE Volume: 10 Issue: 3 Pages: e0118960-e0118960
  • DOI: 10.1371/journal.pone.0118960
  • Peer Reviewed / Open Access
• [Journal Article] 環境ストレスと関連 する聴覚系疾患の解析 (2015)
  • Author(s): 大神信孝、飯田真智子、小又尉広、中野千尋、呉雯婷、李香、加藤昌志
  • Journal Title: 日本衛生学雑誌 Volume: 70 Pages: 100-104
  • NAID: 130005070847
  • Peer Reviewed
• [Journal Article] Deltex-3-like (DTX3L) stimulates metastasis of melanoma through FAK/PI3K/AKT but not MEK/ERK pathway. (2015)
  • Author(s): Thang ND, Yajima I, Kumasaka M, Iida M, Suzuki T, Kato M.
  • Journal Title: Oncotarget Volume: 6 Issue: 16 Pages: 14290-9
  • DOI: 10.18632/oncotarget.3742
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Cupper oxide nanoparticles reduce vasculogenesis in transgenic zebrafish throufg down-regulation of VEGF expression and induction of apoptosis. (2015)
  • Author(s): Chang J, Ichihara G, Shimada Y, Tada-Oikawa S, Kuroyanagi J, Zhang B, Suzuki Y, Sehsah R, Kato M, Tanaka T, Ichihara S.
  • Journal Title: J Nanosci Nanotechnol Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Prenatal maternal blood triglyceride and fatty acid levels, not term birth dimensions, in relation to exposure to di(2-ethylhexyl)phthalate: a cross-sectional study. (2015)
  • Author(s): Jia X, Harada Y, Tagawa M, Naito H, Hayashi Y, Husna Y, Kato M, Sasaki S, Araki A, Miyashita C, Ikeno T, Kishi R, Nakajima T.
  • Journal Title: Enviorn Health Prev Med Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Arsenic-mediated promotion of anchorage-independent growth through increased level of placental growth factor. (2015)
  • Author(s): Yajima I, Kumasaka MY, Ohnuma S, Ohgami N, Naito H, Shekhar HU, Omata Y, Kato M.
  • Journal Title: J Invest Dermatol Volume: 135 Issue: 4 Pages: 1147-1156
  • DOI: 10.1038/jid.2014.514
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Commentary to Krishna et al. (2014): brain deposition and neurotoxicity of manganese in adult mice exposed via the drinking water. (2014)
  • Author(s): Kumasaka MY, Yajima I, Ohgami N, Naito H, Omata, Kato M.
  • Journal Title: Arch Toxicol Volume: 88 Issue: 5 Pages: 1185-1186
  • DOI: 10.1007/s00204-014-1221-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Synergistic effect of exposure to zinc oxide nanoparticle on inflammatory response to bleomycin-induced pulmonary fibrosis in mice (2014)
  • Author(s): W. Wu, G. Ichihara, N. Hashimoto, Y. Hasegawa, Y. Hayashi, S. Tada-Oikawa, Y. Suzuki, J. Chang, M. Kato, CN. D'Alessandro-Gabazza, EC. Gabazza, S. Ichihara
  • Journal Title: Int J Mol Sci Volume: 16 Issue: 1 Pages: 660-676
  • DOI: 10.3390/ijms16010660
  • Peer Reviewed / Open Access
• [Journal Article] Hearing impairments caused by genetic and environmental factors. (2013)
  • Author(s): Ohgami N, et al.
  • Journal Title: Environ Health Prev Med. Volume: 18 Issue: 1 Pages: 10-15
  • DOI: 10.1007/s12199-012-0300-z
  • NAID: 10031143686
  • Peer Reviewed
• [Journal Article] Difference in urinary arsenic metabolites between diabetic and non-diabetic subjects in Bangladesh (2013)
  • Author(s): Saika Nizam
  • Journal Title: Int. J. Environ. Res. Public Health Volume: 10 Issue: 3 Pages: 1006-1019
  • DOI: 10.3390/ijerph10031006
  • Peer Reviewed
• [Journal Article] Barium inhibits arsenic-mediated apoptotic cell death in human squamous cell carcinoma cells. (2012)
  • Author(s): Yajima I, et al.
  • Journal Title: Arch Toxicol. Volume: 86 Issue: 6 Pages: 961-973
  • DOI: 10.1007/s00204-012-0848-9
  • Peer Reviewed
• [Journal Article] Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells (2012)
  • Author(s): Terme M, Ullrich E, Aymeric L, Meinhardt K, Coudert J, Desbois M, Ghiringhelli F, Viaud S, Ryffel B, Yagita H, Chen L, Mecheri S, Kaplanski G, Prevost-Blondel A, Kato M, Schultze JL, Tartour E, Kroemer G, Degli-Esposti M, Chaput N, Zitvogel L
  • Journal Title: Cancer Res Volume: 72 Issue: 11 Pages: 2757-2767
  • DOI: 10.1158/0008-5472.can-11-3379
  • Peer Reviewed
• [Journal Article] Tumor-Expressed Inducible Nitric Oxide Synthase Controls Induction of Functional Myeloid-Derived (2012)
  • Author(s): Jayaraman P, Parikh F, Lopez-Rivera E, Hailemichael Y, Clark A, Ma G, Cannan D, Ramacher M, Kato M, Overwijk WW, Chen SH, Umansky VY, Sikora AG.
  • Journal Title: J Immunol Volume: 188 Issue: 11 Pages: 5365-5376
  • DOI: 10.4049/jimmunol.1103553
  • Peer Reviewed
• [Journal Article] Exposure to low-dose barium by drinking water causes hearing loss in mice. (2012)
  • Author(s): Ohgami N, et al.
  • Journal Title: Neurotoxicology. Volume: 33 Issue: 5 Pages: 1276-1283
  • DOI: 10.1016/j.neuro.2012.07.008
  • Peer Reviewed
• [Presentation] ヒトの生体サンプルで検出されるバリウムレベルと聴力の関連 (2015)
  • Author(s): 大神信孝、李香、Nazmul Ahsan、Anwarul Azim Akhand、加藤昌志
  • Organizer: フォーラム2015 衛生薬学・環境トキシコロジー
  • Place of Presentation: 神戸学院大学（兵庫県神戸市）
  • Year and Date: 2015-09-17
• [Presentation] ヒトの毛髪に蓄積するバリウムレベルと聴力の関連 (2015)
  • Author(s): 大神信孝 、光松佑時、李香、Nazmul Ahsan、Anwarul Azim Akhand、大沼章子、矢嶋伊知朗、加藤昌志
  • Organizer: 第85回 日本衛生学会学術総会
  • Place of Presentation: 和歌山県和歌山市 和歌山県民文化会館
  • Year and Date: 2015-03-27 – 2015-03-28
• [Presentation] Analysis of an association between arsenic level in hair and hearing in Bangladesh. (2015)
  • Author(s): Xiang Li, Nobutaka Ohgami, Nazmul Ahsan, Anwarul Azim Akhand, Shoko Onuma, Ichiro Yajima, Masashi Kato
  • Organizer: 第85回 日本衛生学会学術総会
  • Place of Presentation: 和歌山県民文化会館（和歌山県和歌山市）
  • Year and Date: 2015-03-27
• [Presentation] ヤーバサンタに含まれるステルビンは tert-butyl hydroperoxide（t-BOOH）による色素細胞の細胞死を抑制する (2015)
  • Author(s): 田口 暢彦、上村規行、加藤昌志
  • Organizer: 第37回 日本薬学会第135年会
  • Place of Presentation: 兵庫県神戸市 神戸学院大学
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] ヤーバサンタに含まれるステルビンは tert-butyl hydroperoxide（t-BOOH）による色素細胞の細胞死を抑制する (2015)
  • Author(s): 田口 暢彦、上村規行、加藤昌志
  • Organizer: 第37回 日本薬学会第135年会
  • Place of Presentation: 神戸学院大学（兵庫県神戸市）
  • Year and Date: 2015-03-25
• [Presentation] ルテオリン は tert-butyl hydroperoxide（t-BOOH）による色素細胞の細胞死を抑制する (2014)
  • Author(s): 田口 暢彦、上村規行、大神信孝、加藤昌志
  • Organizer: 第37回 日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市 パシフィコ横浜
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] ルテオリン は tert-butyl hydroperoxide（t-BOOH）による色素細胞の細胞死を抑制する (2014)
  • Author(s): 田口 暢彦、上村規行、大神信孝、加藤昌志
  • Organizer: 第37回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-11-25
• [Presentation] 低濃度有害重金属の飲水投与による中枢神経系組織における元素分析 (2014)
  • Author(s): 神保佳奈、熊坂真由子、矢嶋伊知朗、飯田真智子、田村青鳥、大神信孝、内藤久雄、加藤昌志
  • Organizer: 第84回 日本衛生学会学術総会
  • Place of Presentation: 岡山県岡山市 岡山コンベンションセンター
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] 低周波騒音曝露による平衡感覚異常の解析 (2013)
  • Author(s): 大神信孝、田村青鳥、飯田真智子、矢嶋伊知朗、加藤昌志
  • Organizer: 第12回分子予防環境医学研究会
  • Place of Presentation: つくばサイエンス・インフォメーションセンター（つくば市）
• [Presentation] 飲水投与した低用量バリウムの聴覚系疾患への影響 (2013)
  • Author(s): 大神信孝、飯田真智子、加藤昌志
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢大学（金沢市）
• [Presentation] 飲水投与した低用量バリウムの聴覚系への影響 (2013)
  • Author(s): 大神信孝、飯田真智子、加藤昌志
  • Organizer: 第133回日本薬学会年会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] Aim of fieldwork for well drinking water (2012)
  • Author(s): Masashi Kato
  • Organizer: JSPS AA Science Platform Program: The 3rd International Symposium of Environmental Health Sciences in Hanoi University of Technology, Vietnam
  • Place of Presentation: Hanoi University of Technology（ベトナム）
  • Invited
• [Presentation] Endothelin receptor B in spiral ganglion neurons partially contributes to postnatal development of hearing. (2012)
  • Author(s): 大神信孝、飯田真智子、田村青鳥、加藤昌志
  • Organizer: 第35回日本神経科学大会/Neuroscience2012
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] 低周波騒音が平衡感覚に与える影響 (2012)
  • Author(s): 大神信孝、田村青鳥、飯田真智子、矢嶋伊知朗、加藤昌志
  • Organizer: フォーラム2012 衛生薬学・環境トキシコロジー
  • Place of Presentation: 名古屋観光ホテル（名古屋市）
• [Presentation] Analysis of endothelin receptor B expressed in spiral ganglion neurons. (2012)
  • Author(s): 大神信孝、飯田真智子、矢嶋伊知朗、加藤昌志
  • Organizer: 第24回日本色素細胞学会学術大会
  • Place of Presentation: 長浜バイオ大学（長浜市）
• [Remarks] 名古屋大学 環境労働衛生学
  • URL: http://www.med.nagoya-u.ac.jp/hygiene/
• [Remarks] 名古屋大学大学院医学系研究科・医学部医学科
  • URL: http://www.med.nagoya-u.ac.jp/medical/2511/index.html
• [Remarks] 名古屋大学大学院医学系研究科 環境労働衛生学
  • URL: http://www.med.nagoya-u.ac.jp/hygiene/
• [Remarks] 名古屋大学大学院医学系研究科 教員詳細
  • URL: http://profs.provost.nagoya-u.ac.jp/view/html/100001262_ja.html?k=%E5%8A%A0%E8%97%A4%E3%80%80%E6%98%8C%E5%BF%97
• [Remarks] 名古屋大学大学院医学系研究科 環境労働衛生学
  • URL: http://www.med.nagoya-u.ac.jp/hygiene/
• [Patent(Industrial Property Rights)] 聴覚障害又は小脳性運動失調症の予防・治療剤 (2012)
  • Inventor(s): 大神信孝、加藤昌志
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-259456
  • Filing Date: 2012-11-28