Life-course genetic epidemiological research of adult disease using intergenerational longitudinal twin family data

• Project/Area Number: 24390167
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Ishikawa Prefectural Nursing University
• Principal Investigator: OOKI Syuichi 石川県立看護大学, 看護学部, 教授 (00303404)
• Co-Investigator(Renkei-kenkyūsha): HIKO Kiyomi 石川県立看護大学, 看護学部, 准教授 (80531912)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000); Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
• Keywords: 双生児 / 胎内環境仮説 / ライフコース遺伝疫学 / 世代間伝達 / 生態学的モデル / レコードリンケージ / 生殖補助医療 / 先天異常 / 出生体重

Outline of Final Research Achievements

Developmental Origin of Health and Disease (DOHaD) hypothesis was verified using two intergenerational longitudinal twin family databases from perinatal to adult period. The influence of assisted reproductive technology was intensively analyzed as candidate environmental marker of perinatal and early life period. It was suggested that DOHaD hypothesis is not necessarily applicable in the same manner as singletons in twins in early childhood. But, DOHaD hypothesis was applicable in twins in the long term. The reason was unclear whether this was adoption mechanism specific to twins.

Research Products

• [Journal Article] ライフコース疫学 (2015)
  • Author(s): 大木秀一
  • Journal Title: 実験医学 増刊 Volume: 33 Pages: 1190-1195
• [Journal Article] An Overview of Human Handedness in Twins. (2014)
  • Author(s): Syuichi Ooki
  • Journal Title: Frontiers in Psychology Volume: 5:10
  • DOI: 10.3389/fpsyg.2014.00010
  • Peer Reviewed
• [Journal Article] Twin Database of the Secondary School Attached to the Faculty of Education of the University of Tokyo: Lifecourse Database of Twins (2013)
  • Author(s): Syuichi Ooki
  • Journal Title: Twin Research and Human Genetics Volume: 16(1) Issue: 1 Pages: 226-230
  • DOI: 10.1017/thg.2012.102
  • Peer Reviewed
• [Journal Article] Maternal Age and Birth Defects after the Use of Assisted Reproductive Technology in Japan, 2004-2010. (2013)
  • Author(s): Syuichi Ooki
  • Journal Title: nternInternational Journal of Women's Healthational Journal of Women's Health Volume: 2013:5 Pages: 65-77
  • Peer Reviewed
• [Journal Article] Congenital Hypothyroidism after Assisted Reproductive Technology in Japan: Comparison between Multiples and Singletons, 2005-2009. (2013)
  • Author(s): Syuichi Ooki
  • Journal Title: International Journal of Pediatric Endocrinology Volume: 2013 Issue: 1
  • DOI: 10.1186/1687-9856-2013-5
  • Peer Reviewed
• [Journal Article] Fatal Child Maltreatment Associated with Multiple Births in Japan : Nationwide Data between July 2003 and March 2011. (2013)
  • Author(s): Syuichi Ooki
  • Journal Title: Environmental Health and Preventive Medicine Volume: 18 Issue: 5 Pages: 416-421
  • DOI: 10.1007/s12199-013-0335-9
  • Peer Reviewed
• [Journal Article] Characteristics of Fatal Child Maltreatment Associated with Multiple Births in Japan. (2013)
  • Author(s): Syuichi Ooki
  • Journal Title: Twin Research and Human Genetics Volume: 16 Issue: 3 Pages: 743-750
  • DOI: 10.1017/thg.2013.28
  • Peer Reviewed
• [Journal Article] Estimation of the Contribution of ART and Non-ART Fertility Treatments to Multiple Births during the Last Thirty Years in Japan: 1977-2011. (2012)
  • Author(s): Syuichi Ooki
  • Journal Title: (Proceedings):17th World Congress on Controversies in Obstetrics, Gynecology and Infertility (COGI) Pages: 85-88
• [Presentation] Maternal Age and Birth Defects after the Use of Assisted Reproductive Technology in Japan (2015)
  • Author(s): Syuichi Ooki
  • Organizer: The 21st COGI Innovation in Reproductive Medicine
  • Place of Presentation: フランクフルト（ドイツ）
  • Year and Date: 2015-05-14 – 2015-05-16
• [Presentation] 妊娠の方法別にみた多胎出生の動向（1977-2012年）および単一胚移植の効果 (2014)
  • Author(s): 大木秀一、彦 聖美
  • Organizer: 第73回日本公衆衛生学会
  • Place of Presentation: 宇都宮東武ホテルグランデ（栃木県宇都宮市）
  • Year and Date: 2014-11-05 – 2014-11-07
• [Presentation] The effect of development and nutrition in early life on later body mass index: A twin study. (2014)
  • Author(s): Syuichi Ooki
  • Organizer: The 2nd International Conference on Nutrition and Growth（N&G）
  • Place of Presentation: Barcelona, Spain
• [Presentation] 生殖補助医療が先天異常に与える影響-既存全国データ(2004年-2010年)による単胎児と多胎児の比較- (2013)
  • Author(s): 大木秀一
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪大学コンベンションセンター(大阪府)
  • Year and Date: 2013-01-25
• [Presentation] 自然妊娠と不妊治療別に見た多胎出生の過去30年間（1977-2011年）の動向および単一胚移植の効果 (2013)
  • Author(s): 大木秀一
  • Organizer: 第78回日本民族衛生学会
  • Place of Presentation: 佐賀大学（佐賀県）
• [Presentation] Birth Defects after Assisted Reproductive Technology in Japan: Comparison between Multiples and Singletons, 2004-2010. (2013)
  • Author(s): Syuichi Ooki
  • Organizer: The World Congress on BUILDING CONSENSUS OUT OF CONTROVERSIES IN GYNECOLOGY, INFERTILITY AND PERINATOLOGY （BCGIP-cogi）
  • Place of Presentation: Istanbul, Turkey
• [Presentation] 多胎児家庭の育児に関する全国実態調査 -児の出生年度と年齢による影響- (2012)
  • Author(s): 大木秀一
  • Organizer: 第71回日本公衆衛生学会
  • Place of Presentation: 山口市民会館(山口県)
  • Year and Date: 2012-10-25
• [Presentation] ESTIMATION OF THE CONTRIBUTION OF ART AND NON-ART FERTILITY TREATMENTS TO MULTIPLE BIRTHS DURING THE LAST THIRTY YEARS IN JAPAN: 1977-2011. (2012)
  • Author(s): Syuichi Ooki
  • Organizer: 17th World Congress on Controversies in Obstetrics, Gynecology and Infertility (COGI)
  • Place of Presentation: Lisbon, Portugal
• [Book] Nationwide Study of Assisted Reproductive Technology and Multiple Births with Accompanied Birth Defects. In: Ignatz Sanger (ed) Advances in Reproductive Technology Research (2013)
  • Author(s): Syuichi Ooki (共著)
  • Publisher: Nova Science Publishers