| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
While progranulin (PGRN) has been reported to be involved with cell proliferation, wound healing and inflammation, there were no direct information on the association of progranulin with atherosclerosis. Therefore, we crossed apoE-knockout(KO) mce with PGRN-KO mice to generate double-KO (DKO) mice. DKO mice exhibit more severe atherosclerosis compared with apoE-KO mice. Considering PGRN is associated with various inflammatory diseases, PGRN can be a novel therapeutic target for atherosclerotic and inflammatory diseases.
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