• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Thrombotic phenotypes of two antithrombotic factors, protein S and ADAMTS13

Research Project

Project/Area Number 24390250
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Hematology
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

MIYATA TOSHIYUKI  独立行政法人国立循環器病研究センター, 研究所, 部長 (90183970)

Co-Investigator(Kenkyū-buntansha) KOKAME Koichi  独立行政法人国立循環器病研究センター, 研究所, 室長 (40270730)
AKIYAMA Masashi  独立行政法人国立循環器病研究センター, 研究所, 室長 (30298179)
BANNO Fumiaki  独立行政法人国立循環器病研究センター, 研究所, 研究員 (00373514)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords静脈血栓症 / 凝固制御因子 / ADAMTS13 / 血栓性血小板減少性紫斑病 / フォンビルブランド因子 / プロテインS / 血小板凝集 / 静脈血栓塞栓症 / 抗凝固機構 / 血栓症 / 遺伝子変異 / 血小板
Outline of Final Research Achievements

We generated monoclonal antibodies to the protein S K196E mutant and developed a simple and reliable method for the identification of protein S K196E carriers. The novel method allowed identifying mutation carriers even under warfarin treatment or pregnancy. We found that ADAMTS13 deficiency promoted venous thrombus formation induced by the electrolytic stimulation in mouse model. We have performed the candidate gene analysis (C3, CFH, CFB, CFI, MCP, and THBD) in 46 patients with atypical hemolytic uremic syndrome, aHUS. We identified C3 I1157T mutation in multiple aHUS families who are mainly localized in the Kansai area.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (87 results)

All 2015 2014 2013 2012 Other

All Journal Article (43 results) (of which Peer Reviewed: 32 results,  Open Access: 9 results,  Acknowledgement Compliant: 4 results) Presentation (40 results) (of which Invited: 9 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Eculizumab in the treatment of atypical hemolytic uremic syndrome in an infant leads to cessation of peritoneal dialysis and improvement of severe hypertension.2015

    • Author(s)
      Ohta T, Urayama K, Tada Y, Furue T, Imai S, Matsubara K, Ono H, Sakano T, Jinno K, Yoshida Y, Miyata T, Fujimura Y.
    • Journal Title

      Pediatr Nephrol.

      Volume: 30 Issue: 4 Pages: 603-608

    • DOI

      10.1007/s00467-014-2975-4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of factor VIII levels on the APTT and anti-Xa activity under a therapeutic dose of heparin2015

    • Author(s)
      Mitsuguro M, Okamoto A, Shironouchi Y, Sano M, Miyata S, Neki R, Araki T, Hamamoto T, Yoshimatsu J, Miyata T
    • Journal Title

      Int J Hematol

      Volume: 101 Issue: 2 Pages: 119-125

    • DOI

      10.1007/s12185-014-1702-z

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Autoimmune-type atypical hemolytic uremic syndrome treated with eculizumab as first-line therapy2015

    • Author(s)
      Hisano M, Ashida A, Nakano E, Suehiro M, Yoshida Y, Matsumoto M, Miyata T, Fujimura Y, Hattori M.
    • Journal Title

      Pediatrics Int.

      Volume: 57 Issue: 2 Pages: 313

    • DOI

      10.1111/ped.12469

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Familial C3 glomerulonephritis associated with mutations in the gene for complement factor B.2015

    • Author(s)
      Imamura H, Konomoto T, Tanaka E, Hisano S, Yoshida Y, Fujimura Y, Miyata T, Nunoi H.
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 30 Issue: 5 Pages: 862-864

    • DOI

      10.1093/ndt/gfv054

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of ADAMTS13 deficiency on venous thrombosis in mice2015

    • Author(s)
      Tashima Y, Banno F, Akiyama M, Miyata T
    • Journal Title

      Thromb Haemost

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Candidate gene analysis using genomic quantitative PCR: identification of ADAMTS13 large deletions in two patients with Upshaw-Schulman syndrome.2014

    • Author(s)
      Eura Y, Kokame K, Takafuta T, Tanaka R, Kobayashi H, Ishida F, Hisanaga S, Matsumoto M, Fujimura Y, Miyata T.
    • Journal Title

      olecular Genetics & Genomic Medicine.

      Volume: 2 Issue: 3 Pages: 240-244

    • DOI

      10.1002/mgg3.64

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Contribution of ADAMTS13 to the better cell engraftment efficacy in mouse model of bone marrow transplantation2014

    • Author(s)
      Matsui H, Takeda M, Soejima K, Matsunari Y, Kasuda S, Ono S, Nishio K, Shima M, Banno F, Miyata T, Sugimoto M
    • Journal Title

      Haematologica

      Volume: 99 Pages: 211-213

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Postoperative atypical hemolytic uremic syndrome associated with complement c3 mutation.2014

    • Author(s)
      Matsukuma E, Imamura A, Iwata , Takeuchi T, Yoshida Y, Fujimura Y, Fan X, Miyata T, Kuwahara T.
    • Journal Title

      Case Rep Nephrol.

      Volume: 2014 Pages: 784943-784943

    • DOI

      10.1155/2014/784943

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of patients with atypical hemolytic uremic syndrome treated at the Mie University Hospital: Concentration of C3 p.I1157T mutation.2014

    • Author(s)
      Matsumoto T, Fan X, Ishikawa E, Ito M, Amano K, Toyoda H, Komada Y, Ohishi K, Katayama N, Yoshida Y, Matsumoto M, Fujimura Y, Ikejiri M, Wada H, Miyata T.
    • Journal Title

      Int J Hematol.

      Volume: 100 Issue: 5 Pages: 437-442

    • DOI

      10.1007/s12185-014-1655-2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] プロテインC/プロテインSの基礎2014

    • Author(s)
      宮田敏行、水口 純、鈴木敦夫、小嶋哲人
    • Journal Title

      日本血栓止血学会誌

      Volume: 25 Pages: 40-47

    • NAID

      130003393337

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ファーマコゲノミクス2014

    • Author(s)
      田中智貴、長束一行、宮田敏行
    • Journal Title

      分子脳血管病

      Volume: 13 Pages: 42-46

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 補体反応2014

    • Author(s)
      宮田敏行、中村敏子
    • Journal Title

      救急・集中治療

      Volume: 26 Pages: 668-673

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 日本人における先天性血栓性素因 -欧米との比較-2014

    • Author(s)
      宮田敏行、丸山慶子
    • Journal Title

      臨床血液

      Volume: 55 Pages: 908-916

    • NAID

      130004688004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] ターゲット領域の異常を見逃さないゲノム定量PCR法の確立:ダイレクトシークエンシング法の弱点を補う解析方法として2014

    • Author(s)
      樋口(江浦)由佳、小亀浩市、宮田敏行
    • Journal Title

      日本血栓止血学会誌

      Volume: 25 Pages: 615-618

    • NAID

      130004700440

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dysfunction of protein C anticoagulant system, main genetic risk factor for venous thromboembolism in Northeast Asians.2014

    • Author(s)
      Yin T, Miyata T
    • Journal Title

      J Thromb Thrombolysis

      Volume: 37 Issue: 1 Pages: 56-65

    • DOI

      10.1007/s11239-013-1005-x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nonsynonymous mutations in three anticoagulant genes in Japanese patients with adverse pregnancy outcomes.2014

    • Author(s)
      Neki R, Miyata T, Fujita T, Kokame K, Fujita D, Isaka S, Ikeda T, Yoshimatsu J
    • Journal Title

      Thromb Res

      Volume: 133 Issue: 5 Pages: 914-918

    • DOI

      10.1016/j.thromres.2014.02.012

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 非典型HUSにおける補体異常とその解析2014

    • Author(s)
      吉田瑶子、藤村吉博、宮田敏行
    • Journal Title

      細胞

      Volume: 46 Pages: 7-10

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 血栓性血小板減少性紫斑病2014

    • Author(s)
      藤村吉博、松本雅則、石西綾美、八木秀男、小亀浩市、宮田敏行
    • Journal Title

      臨床血液

      Volume: 55 Pages: 93-104

    • NAID

      130004920625

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ADAMTS13 activity and genetic mutations in Japanese subjects.2013

    • Author(s)
      Toshiyuki Miyata, Koichi Kokame, Masanori Matsumoto, and Yoshihiro Fujimura.
    • Journal Title

      Haemostaselolgie

      Volume: 33 Issue: 02 Pages: 131-137

    • DOI

      10.5482/hamo-12-11-0017

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of genetic and predisposing factors in Japanese patients with atypical hemolytic uremic syndrome.2013

    • Author(s)
      Fan X, Yoshida Y, Honda S, et al. (Matsumoto M 4番目)
    • Journal Title

      Mol Immunol.

      Volume: 54 Issue: 2 Pages: 238-246

    • DOI

      10.1016/j.molimm.2012.12.006

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure and enzymatic activity of an ADAMTS13 mutant with the East Asian-specific P475S polymorphism.2013

    • Author(s)
      Masashi Akiyama, Daisuke Nakayama, Soichi Takeda, Koichi Kokame, Junichi Takagi, and Toshiyuki Miyata.
    • Journal Title

      J. Thromb. Haemost.

      Volume: (In press) Issue: 7 Pages: 1399-1406

    • DOI

      10.1111/jth.12279

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long term follow up of congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndorome) on hemodialysis for 19 years: a case report2013

    • Author(s)
      Mise K, Ubara Y, Matsumoto M, Sumida K, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Suwabe T, Hoshino J, Sawa N, Ohashi K, Kokame K, Miyata T, Fujimura Y, Takaichi K.
    • Journal Title

      BMC Nephrol.

      Volume: 14 Issue: 1 Pages: 156-156

    • DOI

      10.1186/1471-2369-14-156

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein S K196E mutation, a genetic risk factor venous thromboembolism, is limited to Japanese.2013

    • Author(s)
      Liu W, Yin T, Okuda H, Harada KH, Li Y, Xu B, Yang J, Wang H, Fan X, Koizumi A, Miyata T
    • Journal Title

      Thromb Res

      Volume: 132 Pages: 314-315

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Budd-Chiari Syndrome with multiple thrombi due to a familial Arg42Ser mutation in the protein C gene.2013

    • Author(s)
      Muratsu J, Morishima A, Mizoguchi K, Ataka K, Yamamoto H, Fan X, Miyata T, Sakaguchi K
    • Journal Title

      Case Reports in Medicine

      Volume: 2013 Pages: 270419-270419

    • DOI

      10.1155/2013/270419

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Integrin-Linked Kinase-PINCH-Parvin Complex Supports Integrin αIIbβ3 Activation2013

    • Author(s)
      Hond S, Shirotani-Ikejima H, Tadokoro S, Tomiyama Y, Miyata T
    • Journal Title

      PLOS ONE

      Volume: 8 Issue: 12 Pages: 1-13

    • DOI

      10.1371/journal.pone.0085498

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 先天性血栓性素因2013

    • Author(s)
      宮田敏行、森下英理子
    • Journal Title

      血栓と循環

      Volume: 21 Pages: 6-11

    • NAID

      10005477772

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 先天性ADAMTS13欠損症2013

    • Author(s)
      宮田敏行、小亀浩市、小久保喜弘
    • Journal Title

      臨床検査

      Volume: 57 Pages: 556-561

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 遺伝子改変血栓モデル:ADAMTS13遺伝子欠損マウスを中心に2013

    • Author(s)
      坂野史明、宮田敏行、藤岡政行、杉本充彦
    • Journal Title

      Thrombosis Medicine

      Volume: 3 Pages: 36-43

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Atypical HUSにおける補体制御異常症診断システムの構築と腎移植2013

    • Author(s)
      芦田 明、吉田瑶子、範 新萍、松本雅則、服部元史、宮田敏行、藤村吉博
    • Journal Title

      日本臨床腎移植学会雑誌

      Volume: 1 Pages: 39-44

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 非典型溶血性尿毒症症候群(aHUS)2013

    • Author(s)
      藤村吉博、吉田瑶子、範 新萍、宮田敏行
    • Journal Title

      臨床血液

      Volume: 54 Pages: 351-360

    • NAID

      10031196335

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 抗CFH抗体陽性およびCFHR1遺伝子欠失を伴うDEAP-HUSの1例2013

    • Author(s)
      岡 政史、大塚泰史、稲田由紀子、佐藤忠司、吉田瑶子、藤村吉博、Fan Xinping、宮田敏行、濱崎雄平
    • Journal Title

      日本小児腎臓病学会雑誌

      Volume: 26 Pages: 109-115

    • NAID

      130004495423

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 東アジア人特有のP475S変異を持つADAMTS13の立体構造と機能解析2013

    • Author(s)
      秋山正志、武田壮一、宮田敏行
    • Journal Title

      日本血栓止血学会誌

      Volume: 24 Pages: 613-618

    • NAID

      130003393326

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ADAMTS13とvon Willebrand因子2013

    • Author(s)
      宮田敏行, 松本雅則
    • Journal Title

      カレントテラピー

      Volume: 31 Pages: 94-94

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Large infarct and high mortality by cerebral ischemia in mice carrying the factor V Leiden mutation2012

    • Author(s)
      Kita T, Banno F, Yanamoto H, Nakajo Y, Iihara K, Miyata T
    • Journal Title

      J Thromb Haemost

      Volume: 10 Issue: 7 Pages: 1453-1455

    • DOI

      10.1111/j.1538-7836.2012.04776.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A second hit for TMA.2012

    • Author(s)
      Miyata T, Fan X
    • Journal Title

      Blood

      Volume: 120 Issue: 6 Pages: 1152-1154

    • DOI

      10.1182/blood-2012-06-433235

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Binding of von Willebr and factor cleaving protease ADAMTS13 to Lys-plasmin(ogen)2012

    • Author(s)
      Yongchol Shin, Masashi Akiyama, Toshiyuki Miyata, et al
    • Journal Title

      Journal of Biochemistry

      Volume: (in press) Issue: 3 Pages: 251-25

    • DOI

      10.1093/jb/mvs066

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ADAMTS13 gene deletion enhances plasma high-mobility group box1 elevation and neuroinflammation in brain ischemia-reperfusion iniury2012

    • Author(s)
      M.Fujioka, 他16名
    • Journal Title

      Neurol Sci

      Volume: 33 Issue: 5 Pages: 1107-1115

    • DOI

      10.1007/s10072-011-0913-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ADAMTS13 safeguards the myocardium in a mouse model of acute myocardial infarction.2012

    • Author(s)
      Masaaki Doi, Hideto Matsui, Yukiji Takeda, Yoshihiko Saito, Maiko Takeda, Yasunori Matsunari, Kenji Nishio, Midori Shima, Fumiaki Banno, Masashi Akiyama, Koichi Kokame, Toshiyuki Miyata, and Mitsuhiko Sugimoto.
    • Journal Title

      Thromb. Haemost.

      Volume: 108 Issue: 12 Pages: 1236-1238

    • DOI

      10.1160/th12-09-0674

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] von Willebrand因子とADAMTS132012

    • Author(s)
      宮田敏行,松本雅則
    • Journal Title

      内科

      Volume: 110 Pages: 87-90

    • Related Report
      2012 Annual Research Report
  • [Journal Article] ADAMTS13研究の最先端2012

    • Author(s)
      宮田敏行, 他5名
    • Journal Title

      臨床血液

      Volume: 53 Pages: 672-679

    • NAID

      10030990234

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血栓の病理と病態2012

    • Author(s)
      宮田敏行,樋口由佳
    • Journal Title

      Vascular Lab

      Volume: 9 Pages: 70-73

    • Related Report
      2012 Annual Research Report
  • [Journal Article] マウス急性心筋梗塞モデルにおけるADAMTS13の心筋保護作用2012

    • Author(s)
      杉本充彦, 他3名
    • Journal Title

      日本血栓止血学会誌

      Volume: 23 Pages: 590-593

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 凝固XI因子の構造と機能2012

    • Author(s)
      西村 仁, 平井秀憲, 宮田敏行
    • Journal Title

      日本血栓止血学会誌

      Volume: 23 Pages: 594-598

    • NAID

      130003367333

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 血栓症形成の分子メカニズムとその制御 基礎:凝固系、静脈血栓症2014

    • Author(s)
      宮田敏行
    • Organizer
      2014年度千里ライフサイエンスセミナー
    • Place of Presentation
      千里ライフサイエンスセンター、大阪府、豊中市
    • Year and Date
      2014-11-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] プロテインS K196E (PS徳島)変異特異的ELISA法の構築、Construction of ELISA system for specific detection of protein S K196E (PS Tokushima) mutation2014

    • Author(s)
      Keiko Maruyama, Masashi Akiyama, Koichi Kokame, Eriko Morishita, Toshiyuki Miyata
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪国際会議場、大阪府、大阪市
    • Year and Date
      2014-10-31 – 2014-11-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Thrombotic thrombocytopenic purpura and ADAMTS13”2014

    • Author(s)
      Toshiyuki Miyata
    • Organizer
      2014 Suzhou International Symposium on Basic and Translational Vascular Research
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2014-10-11 – 2014-10-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “Registry of congenital TMAs in Japan”2014

    • Author(s)
      Masanori Matsumoto, Toshiyuki Miyata, Yoshihiro Fujimura
    • Organizer
      The 8th congress of Asia Pacific Society on Thrombosis and Haemostasis- 2014
    • Place of Presentation
      Hanoi, Vietnam
    • Year and Date
      2014-10-09 – 2014-10-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 日本人の非典型溶血性尿毒症症候群患者41人の遺伝子解析2014

    • Author(s)
      宮田敏行、内田裕美子、吉田瑶子、池島裕子、Fan Xinping、芦田明、和田英夫、大塚泰史、中村健治、石川智朗、八田和大、服部元史、久野正貴、才田謙、西尾健治、瀧本智仁、幡谷浩史、大原敦子、川村尚久、波多江健、松本雅則、加藤秀樹、南学正臣、藤村吉博
    • Organizer
      第51回補体シンポジウム
    • Place of Presentation
      神戸常盤大学、兵庫県、神戸市
    • Year and Date
      2014-08-22 – 2014-08-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 日本人に高頻度に見られるプラスミノーゲン栃木変異をもつ遺伝子改変マウスの血栓傾向の解析2014

    • Author(s)
      田嶌優子、坂野史明、喜多俊行、松田泰幸、柳本広二、宮田敏行
    • Organizer
      第19回日本病態プロテアーゼ学会学術集会
    • Place of Presentation
      千里ライフサイエンスセンター、大阪府、豊中市
    • Year and Date
      2014-08-08 – 2014-08-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] プロテインS徳島は日本人に特有の変異なのか?2014

    • Author(s)
      宮田敏行
    • Organizer
      第36回日本血栓止血学会学術集会
    • Place of Presentation
      大阪国際交流センター、大阪府、大阪市
    • Year and Date
      2014-05-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 静脈血栓症のリスクとなるプロテインS K196E変異の地理的分布2014

    • Author(s)
      宮田敏行、Wanyang Liu、Tong Yin、 奥田裕子、原田浩二、Xinping Fan、小泉昭夫
    • Organizer
      第36回日本血栓止血学会学術集会
    • Place of Presentation
      大阪国際交流センター、大阪府、大阪市
    • Year and Date
      2014-05-29 – 2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] デジタルPCRを用いたADAMTS13遺伝子変異ヘテロ接合性の解析2014

    • Author(s)
      小亀浩市、樋口(江浦)由佳、松本雅則、藤村吉博、宮田敏行
    • Organizer
      第36回日本血栓止血学会学術集会
    • Place of Presentation
      大阪国際交流センター、大阪府、大阪市
    • Year and Date
      2014-05-29 – 2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 定量的溶血試験と遺伝子解析を用いた本邦aHUS患者の病態解析2014

    • Author(s)
      吉田瑶子、範 新萍、古久保哲朗、岩本顕聰、森 俊雄、松本雅則、池島裕子、宮田敏行、藤村吉博
    • Organizer
      第36回日本血栓止血学会学術集会
    • Place of Presentation
      大阪国際交流センター、大阪府、大阪市
    • Year and Date
      2014-05-29 – 2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] ダイレクトシークエンシング,定量PCR,次世代シークエンシングを用いたTTP患者の遺伝子解析2014

    • Author(s)
      樋口(江浦)由佳、小亀浩市、高蓋寿朗、田中亮二郎、小林 光、石田文宏、久永修一、松本雅則、藤村吉博、宮田敏行
    • Organizer
      第36回日本血栓止血学会学術集会
    • Place of Presentation
      大阪国際交流センター、大阪府、大阪市
    • Year and Date
      2014-05-29 – 2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] ADAMTS13遺伝子欠損マウスの静脈血栓塞栓症状の解析2014

    • Author(s)
      田嶌優子、坂野史明、小亀浩市、宮田敏行
    • Organizer
      第36回日本血栓止血学会学術集会
    • Place of Presentation
      大阪国際交流センター、大阪府、大阪市
    • Year and Date
      2014-05-29 – 2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 腎障害を示した先天性血栓性血小板減少性紫斑病患者の補体制御因子の遺伝子解析2014

    • Author(s)
      池島裕子、Xinping Fan、平井秀憲、本田繁則、吉田瑶子、藤村吉博、Johanna A. Kremer Hovinga、Bernhard Lammle、宮田敏行
    • Organizer
      第36回日本血栓止血学会学術集会
    • Place of Presentation
      大阪国際交流センター、大阪府、大阪市
    • Year and Date
      2014-05-29 – 2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] TTPとHUS(総会長シンポジウム)、TTP/HUSの遺伝子解析2014

    • Author(s)
      宮田敏行
    • Organizer
      第62回日本輸血・細胞治療学会総会
    • Place of Presentation
      奈良県新公会堂、奈良県、奈良市
    • Year and Date
      2014-05-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Symposium 2, Thrombosis, leukocytes and vascular cells, Registry of hereditary thrombotic microangiopathies in Japan2014

    • Author(s)
      Toshiyuki Miyata, Yoshihiro Fujimura
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      都メッセ、京都府、京都市
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Analysis of mice carrying northeast Asian-specific genetic mutations in thrombosis2014

    • Author(s)
      Fumiaki Banno, Yuko Tashima, Toshiyuki Kita, Yasuyuki Matsuda, Hiroji Yanamoto, Koichi Kokame, Toshiyuki Miyata
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      都メッセ、京都府、京都市
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 血栓性細小血管障害症の分子機構2013

    • Author(s)
      宮田敏行
    • Organizer
      TTMフォーラム(
    • Place of Presentation
      東京都(招待講演)
    • Year and Date
      2013-03-09
    • Related Report
      2012 Annual Research Report
  • [Presentation] Thrombophilia and venous thromboembolism.2013

    • Author(s)
      Toshiyuki Miyata
    • Organizer
      Sysmex Scientific Seminar
    • Place of Presentation
      Taipei(招待講演)
    • Year and Date
      2013-03-02
    • Related Report
      2012 Annual Research Report
  • [Presentation] sHUSの遺伝子解析2013

    • Author(s)
      宮田敏行
    • Organizer
      日本血栓止血学会SSCシンポジウム2013VWD/TTP部会
    • Place of Presentation
      東京都(招待講演)
    • Year and Date
      2013-01-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] Pharmacogenomicsは抗血小板剤の個別化医療の救世主となり得るか?2013

    • Author(s)
      宮田敏行、宮田茂樹、長束一行
    • Organizer
      第35回日本血栓止血学会学術集会
    • Place of Presentation
      山形市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ADAMTS13の正常な分泌にはシクロフィリンBによるプロリン残基異性化が必要である2013

    • Author(s)
      小亀浩市、秋山正志、宮田敏行
    • Organizer
      第35回日本血栓止血学会学術集会
    • Place of Presentation
      山形市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 哺乳類細胞を用いたADAMTS13ドメインの一過性大量発現2013

    • Author(s)
      平井秀憲、秋山正志、宮田敏行
    • Organizer
      第13回日本蛋白質科学会年会
    • Place of Presentation
      鳥取市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Registry of congenital atypical HUS in Japan2013

    • Author(s)
      Yoshihiro Fujimura, Yoko Yoshida, Xinping Fan, Toshiyuki Miyata
    • Organizer
      XXIV Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Amsterdam,Netherlands
    • Related Report
      2013 Annual Research Report
  • [Presentation] Familial screening in the case of Budd-Chiari syndrome with multiple thrombi due to Arg42Ser mutation in the protein C gene2013

    • Author(s)
      Jun Muratsu, Atsuyuki Morishima, Masayoshi Kukida, Anzu Tanaka, Xinping Fan, Toshiyuki Miyata, Katsuhiko Sakaguchi
    • Organizer
      XXIV Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2013 Annual Research Report
  • [Presentation] 凝固系・補体系の接点としての血管内皮細胞障害2013

    • Author(s)
      宮田敏行
    • Organizer
      第50回補体シンポジウム
    • Place of Presentation
      旭川市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 日本における先天性ADAMTS13欠損症の遺伝子解析2013

    • Author(s)
      樋口(江浦)由佳, 小亀浩市, 松本雅則, 藤村吉博, 宮田敏行
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 血栓性細小血管障害症の発症機構と診断・治療2013

    • Author(s)
      宮田敏行
    • Organizer
      第33回ヒューマンサイエンス基礎研究講習会
    • Place of Presentation
      吹田市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] A long-term phenotype analysis of 51 patients with Upshaw–Schulman syndrome in Japan, with special references to pregnancy and renal failure that requires hemodialysis2013

    • Author(s)
      Yoshihiro Fujimura, Yumi Yoshii, Masanori Matsumoto, Ayami Isonishi, Hideo Yagi, Koichi Kokame, Toshiyuki Miyata
    • Organizer
      55th American Society of Hematology Annual Meeting and Exposition
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Atypical Hemolytic Uremic Syndrome In Japan Characterized By The Inhibitory Antibody-Based Hemolytic Assay and The Gene Analysis2013

    • Author(s)
      Yoko Yoshida, Xinping Fan, Yoshifumi Ohyama, Tetsuro Kokubo, Masanori Matsumoto, Hideo Yagi, Hiroko Shirotani-Ikejima, Toshiyuki Miyata, Yoshihiro Fujimura
    • Organizer
      55th American Society of Hematology Annual Meeting and Exposition
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 日本人の遺伝的血栓性リスクを有するモデルマウスの作製と解析2012

    • Author(s)
      坂野史明, 他4名
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡市
    • Year and Date
      2012-12-16
    • Related Report
      2012 Annual Research Report
  • [Presentation] 非定型溶血性尿毒症症候群の遺伝的背景2012

    • Author(s)
      宮田敏行, 他25名
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡市
    • Year and Date
      2012-12-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] 血栓形成の分子機構2012

    • Author(s)
      宮田敏行
    • Organizer
      日本バイオマテリアル学会シンポジウム2012
    • Place of Presentation
      仙台市(招待講演)
    • Year and Date
      2012-11-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] 非定型溶血性尿毒症症候群を発症した日本人5例の遺伝子解析2012

    • Author(s)
      Fan Xinping, 他16名
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2012-10-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] プロテインS徳島(K196E)変異がマウスの肺塞栓症および虚血性脳梗塞に及ぼす影響2012

    • Author(s)
      坂野史明, 他4名
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2012-10-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] 日本人の非典型溶血性尿毒症症候群患者10名の遺伝子解析2012

    • Author(s)
      Xinping Fan, 他19名
    • Organizer
      第49回補体シンポジウム
    • Place of Presentation
      大阪市
    • Year and Date
      2012-08-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] 本邦でのaHUS患者のdiagnostic pathwayと登録状況2012

    • Author(s)
      藤村吉博, 他5名
    • Organizer
      第49回補体シンポジウム
    • Place of Presentation
      大阪市(招待講演)
    • Year and Date
      2012-08-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] Establishment of a comprehensive approach to genetic analysis in patients with aHUS.2012

    • Author(s)
      Xinping Fan, 他9名
    • Organizer
      第34回日本血栓止血学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2012-06-08
    • Related Report
      2012 Annual Research Report
  • [Presentation] 血栓性素因の成因と病態2012

    • Author(s)
      宮田敏行
    • Organizer
      第35回シスメックス学術セミナー
    • Place of Presentation
      神戸市(招待講演)
    • Year and Date
      2012-06-02
    • Related Report
      2012 Annual Research Report
  • [Presentation] Strategy and algorithm for diagnosis of typical/atypical hemolytic uremic syndrome.2012

    • Author(s)
      Akira Ashida, 他5名
    • Organizer
      日韓小児腎セミナー
    • Place of Presentation
      東京都
    • Year and Date
      2012-05-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] 本邦における非定型溶血性尿毒症症候群(aHUS)の患者登録と解析状況2012

    • Author(s)
      吉田瑤子, 他9名
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2012-04-21
    • Related Report
      2012 Annual Research Report
  • [Book] よくわかる血栓・止血異常の診療2014

    • Author(s)
      宮田敏行、田嶌優子
    • Total Pages
      297
    • Publisher
      中山書店
    • Related Report
      2014 Annual Research Report
  • [Book] Annual Review 血液20142014

    • Author(s)
      宮田敏行、坂野史明
    • Total Pages
      240
    • Publisher
      中外医学社
    • Related Report
      2013 Annual Research Report
  • [Remarks] 国立循環器病研究センター研究所分子病態部

    • URL

      http://www.ncvc.go.jp/res/divisions/etiology/index.html

    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] プロテインS K196E変異検出法2014

    • Inventor(s)
      宮田敏行、秋山正志、丸山慶子、森下英理子
    • Industrial Property Rights Holder
      国立循環器病研究センター、栄研化学株式会社、金沢大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-194080
    • Filing Date
      2014-09-24
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi