| Project/Area Number |
24390254
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
|
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| Research Institution | Tohoku University |
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Principal Investigator |
KODAMA Eiichi 東北大学, 医学(系)研究科(研究院), 講師 (50271151)
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| Co-Investigator(Kenkyū-buntansha) |
UENO Takamasa 熊本大学, エイズ学研究センター, 准教授 (10322314)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | ＨＩＶ / 抗ウイルス剤 / 免疫淘汰 / スクリーニング / アクセサリータンパク / HIV |
|---|
| Outline of Final Research Achievements |
Treatment of HIV, so far, remains to be insufficient. Therefore, development of efficient and safe therapy for HIV infection is urgently needed. Here, we focus on one of essential accessary viral proteins, Nef that has povital role in escape from host immune system, through immunological, rational drug design, and structural features. We newly identified novel domains for down regulation of MHC class I, and HIV receptors CD4 and CCR5, and established a screening system for Nef antagonists. Furthermore, we revealed impaired Nef functions in the elite controllers. Our findings will provide insights into further successful therapies and development of effective vaccines.
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