| Project/Area Number |
24390265
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Wakayama Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Koichi 和歌山県立医科大学, 医学部, 講師 (50336880)
SHIMA Yuko 和歌山県立医科大学, 医学部, 助教 (60433364)
TOGAWA Hiroko 和歌山県立医科大学, 医学部, 博士研究員 (30445093)
MUKAIYAMA Hironobu 和歌山県立医科大学, 医学部, 助教 (70549740)
HAMA Taketsugu 和歌山県立医科大学, 医学部, 助教 (00508020)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
|
|---|
| Keywords | IgA腎症 / インフラマソーム / NLRP3 / caspase 1 / IL-1β / IL-18 / 新治療法 / 開発 |
|---|
| Outline of Final Research Achievements |
We analyzed gene expression of NLRP3 inflammasome and IL-1 beta, IL-18 produced as a result of activation using renal biopsy tissue of IgA nephropathy patients to clarify it whether NLRP3 inflammasome had a role for glomerulus inflammation in IgA nephropathy.
We examined NLRP3, CASP1 (caspase 1), IL-1 beta and IL-18 gene expression in renal biopsy tissue from IgA nephropathy patients (severe type and mild type, before and after 2-year therapy) and those with asymptomatic proteinuria (controls).
As a result, NLRP3, CASP1, IL-1 beta showed a significant difference between controls with the patients, and the contribution to a disease episode was suggested, and basic data of the disease specific therapy was obtained.
|
