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Role of imflammasome in IgA nephropathy

Research Project

Project/Area Number 24390265
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Pediatrics
Research InstitutionWakayama Medical University

Principal Investigator

YOSHIKAWA Norishige  和歌山県立医科大学, 医学部, 教授 (10158412)

Co-Investigator(Kenkyū-buntansha) NAKANISHI Koichi  和歌山県立医科大学, 医学部, 講師 (50336880)
SHIMA Yuko  和歌山県立医科大学, 医学部, 助教 (60433364)
TOGAWA Hiroko  和歌山県立医科大学, 医学部, 博士研究員 (30445093)
MUKAIYAMA Hironobu  和歌山県立医科大学, 医学部, 助教 (70549740)
HAMA Taketsugu  和歌山県立医科大学, 医学部, 助教 (00508020)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
KeywordsIgA腎症 / インフラマソーム / NLRP3 / caspase 1 / IL-1β / IL-18 / 新治療法 / 開発
Outline of Final Research Achievements

We analyzed gene expression of NLRP3 inflammasome and IL-1 beta, IL-18 produced as a result of activation using renal biopsy tissue of IgA nephropathy patients to clarify it whether NLRP3 inflammasome had a role for glomerulus inflammation in IgA nephropathy.
We examined NLRP3, CASP1 (caspase 1), IL-1 beta and IL-18 gene expression in renal biopsy tissue from IgA nephropathy patients (severe type and mild type, before and after 2-year therapy) and those with asymptomatic proteinuria (controls).
As a result, NLRP3, CASP1, IL-1 beta showed a significant difference between controls with the patients, and the contribution to a disease episode was suggested, and basic data of the disease specific therapy was obtained.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (67 results)

All 2015 2014 2013 2012 Other

All Journal Article (22 results) (of which Peer Reviewed: 18 results,  Open Access: 1 results) Presentation (31 results) (of which Invited: 3 results) Book (14 results)

  • [Journal Article] Risk factors for persistent proteinuria after a 2-year combination therapy for severe childhood IgA nephropathy2015

    • Author(s)
      Kamei K, Nakanishi K, Ito S, Ishikura K, Hataya H, Honda M, Nozu K, Iijima K, Shima Y, Yoshikawa N
    • Journal Title

      Pediatr Nephrol

      Volume: 30 Issue: 6 Pages: 961-967

    • DOI

      10.1007/s00467-014-3019-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A multicenter randomized trial indicates initial prednisolone treatment for childhood nephrotic syndrome for two months is not inferior to six-month treatment2015

    • Author(s)
      Yoshikawa N, Nakanishi K, Sako M, Oba MS, Mori R, Ota E, Ishikura K, Hataya H, Honda M, Ito S, Shima Y, Kaito H, Nozu K, Nakamura H, Igarashi T, Ohashi Y, Iijima K
    • Journal Title

      Kidney Int

      Volume: 87 Issue: 1 Pages: 225-232

    • DOI

      10.1038/ki.2014.260

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Renal biopsy criterion in idiopathic nephrotic syndrome with microscopic hematuria at onset2015

    • Author(s)
      Hama T, Nakanishi K, Shima Y, Sato M, Mukaiyama H, Togawa H, Hamahira K, Tanaka R, Kaito H, Nozu K, Iijima K, Yoshikawa N
    • Journal Title

      Pediatr Nephrol

      Volume: 30 Issue: 3 Pages: 445-450

    • DOI

      10.1007/s00467-014-2946-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclosporine C2 Monitoring for the Treatment of Frequently Relapsing Nephrotic Syndrome in Children: A Multicenter Randomized Phase II Trial.2014

    • Author(s)
      Iijima K, Sako M, Oba MS, Ito S, Hataya H, Tanaka R, Ohwada Y, Kamei K, Ishikura K, Yata N, Nozu K, Honda M, Nakamura H, Nagata M, Ohashi Y, Nakanishi K, Yoshikawa N. : Japanese Study Group of Kidney Disease in Children.
    • Journal Title

      Clin J Am Soc Nephrol

      Volume: 9(2) Issue: 2 Pages: 271-8

    • DOI

      10.2215/cjn.13071212

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Milder clinical aspects of X-linked Alport syndrome in men positive for the collagen IV α5 chain2014

    • Author(s)
      Hashimura Y, Nozu K, Kaito H, Nakanishi K, Fu XJ, Ohtsubo H, Hashimoto F, Oka M, Ninchoji T, Ishimori S, Morisada N, Matsunoshita N, Kamiyoshi N, Yoshikawa N, Iijima K
    • Journal Title

      Kidney Int

      Volume: 85 Issue: 5 Pages: 1208-1213

    • DOI

      10.1038/ki.2013.479

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Natural history of genetically proven autosomal recessive Alport syndrome2014

    • Author(s)
      Oka M, Nozu K, Kaito H, Fu XJ, Nakanishi K, Hashimura Y, Morisada N, Yan K, Matsuo M, Yoshikawa N, Vorechovsky I, Iijima K
    • Journal Title

      Pediatr Nephrol

      Volume: 29 Issue: 9 Pages: 1535-1544

    • DOI

      10.1007/s00467-014-2797-4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 多発性嚢胞腎:診断と治療に関する最新の知見2014

    • Author(s)
      中西浩一, 吉川徳茂
    • Journal Title

      小児科診療

      Volume: 77 Pages: 757-762

    • Related Report
      2014 Annual Research Report
  • [Journal Article] シクロホスファミド【ネフローゼ症候群と治療:エビデンスと使い方】2014

    • Author(s)
      中西浩一, 吉川徳茂
    • Journal Title

      腎と透析

      Volume: 76 Pages: 846-849

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 臨床研究の結果のみかた.2014

    • Author(s)
      中西浩一, 吉川徳茂
    • Journal Title

      小児内科

      Volume: 46増刊 Pages: 12-18

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 酸塩基平衡異常への輸液療法2014

    • Author(s)
      中西浩一, 吉川徳茂
    • Journal Title

      わかる輸液 小児科学レクチャー

      Volume: 4 Pages: 690-695

    • Related Report
      2014 Annual Research Report
  • [Journal Article] First Japanese case of Pierson syndrome with mutations in LAMB22013

    • Author(s)
      Togawa H, Yoshikawa N, et al
    • Journal Title

      Pediatr Int

      Volume: 55 Issue: 2 Pages: 229-231

    • DOI

      10.1111/j.1442-200x.2012.03629.x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prospective 5-year follow-up of cyclosporine treatment in children with steroid-resistant nephrosis2013

    • Author(s)
      Hamasaki Y, Yoshikawa N, et al
    • Journal Title

      Pediatr Nephrol

      Volume: 28 Issue: 5 Pages: 765-771

    • DOI

      10.1007/s00467-012-2393-4

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoplasmic reticulum stress with low-dose cyclosporine in frequently relapsing nephrotic syndrome2013

    • Author(s)
      Hama T, Yoshikawa N, et al
    • Journal Title

      Pediatr Nephrol

      Volume: 28 Issue: 6 Pages: 903-909

    • DOI

      10.1007/s00467-012-2403-6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two-year outcome of the ISKDC regimen and frequent-relapsing risk in children with idiopathic nephrotic syndrome2013

    • Author(s)
      Koichi Nakanishi、Kazumoto Iijima、Kenji Ishikura、Satoshi Sasak、Masataka Honda、Norio Yosikawa
    • Journal Title

      Clin J Am Soc Nephrol

      Volume: Vol.8 Issue: 5 Pages: 756-762

    • DOI

      10.2215/cjn.09010912

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular background of urate transporter geneMolecular background of urate transporter genes in patients with exercise-induced acute kidney injury.2013

    • Author(s)
      Kaito H, Ishimori Kaito H, Ishimori S, Nozu K, Shima Y, Nakanishi K, Yoshikawa N, Iijima K.
    • Journal Title

      Am J Nephrol.

      Volume: 38(4) Issue: 4 Pages: 629-629

    • DOI

      10.1159/000355430

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous remission in children with IgA nephropathy2013

    • Author(s)
      Shima Y, Yoshikawa N, et al
    • Journal Title

      Pediatr Nephrol

      Volume: 28 Issue: 1 Pages: 71-76

    • DOI

      10.1007/s00467-012-2294-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nephrotic-range proteinuria in an infant with thin basement membrane nephropathy2013

    • Author(s)
      Ishimori S, Yoshikawa N, et al
    • Journal Title

      CEN Case Rep

      Volume: 2 Issue: 2 Pages: 194-196

    • DOI

      10.1007/s13730-013-0063-4

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Validity of the Oxford classification of IgA nephropathy in children.2012

    • Author(s)
      Shima Y, Nakanishi K, Hama T, Mukaiyama H, Togawa H, Hashimura Y, Kaito H, Sako M, Iijima K, Yoshikawa N
    • Journal Title

      Pediatr Nephrol.

      Volume: 27(5) Issue: 5 Pages: 783-92

    • DOI

      10.1007/s00467-011-2061-0

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cryo-preserved porcine kidneys are feasible for teaching and training renal biopsy : "the bento kidney"2012

    • Author(s)
      Konno K, Yoshikawa N, et al
    • Journal Title

      Transplantation Research

      Volume: 1 Issue: 1 Pages: 1-4

    • DOI

      10.1186/2047-1440-1-5

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Infantile Immunoglobulin A Nephropathy Showing Features of Membranoproliferative Glomerulonephritis2012

    • Author(s)
      KurosuA, Joh K
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 228 Issue: 3 Pages: 253-258

    • DOI

      10.1620/tjem.228.253

    • NAID

      130004460023

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Renal biopsy criterion in children with asymptomatic constant isolated proteinuria.2012

    • Author(s)
      Hama T, Nakanishi K, Shima Y, Mukaiyama H, Togawa H, Tanaka R, Hamahira K, Kaito H, Iijima K, Yoshikawa N
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 27(8) Issue: 8 Pages: 3186-90

    • DOI

      10.1093/ndt/gfr750

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] for the Japanese Study Group of Renal Disease in Children. Two-Year Follow-Up of a Prospective Clinical Trial of Cyclosporine for Frequently Relapsing Nephrotic Syndrome in Children.2012

    • Author(s)
      Ishikura K, Yoshikawa N, Nakazato H, Sasaki S, Iijima K, Nakanishi K, Matsuyama T, Ito S, Yata N, Ando T, Honda M
    • Journal Title

      Clin J Am Soc Nephrol

      Volume: 7 Issue: 10 Pages: 1576-1583

    • DOI

      10.2215/cjn.00110112

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] IgA nephropathy & Henoch-Schonlein purpura2014

    • Author(s)
      Nakanishi K, Yoshikawa N
    • Organizer
      The XII Asian Congress of Pediatric Nephrology
    • Place of Presentation
      New Delhi, Republic of India
    • Year and Date
      2014-12-04 – 2014-12-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comparison of clinical manifestations between henoch-schonlein purpura nephritis and IgA nephropathy : analysis of Japan renal biopsy registry2014

    • Author(s)
      Komatsu H, Fujimoto S, Yoshikawa N, Kitamura H, Sugiyama H, Yokoyama H
    • Organizer
      47th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2014-11-11 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Smad3 gene deletion ameliorates cyst formation and interstitial fibrosis in cpk mouse, a model of ARPKD2014

    • Author(s)
      Hama T, Nakanishi K, Mukaiyama H, Togawa H, Sato M, Shima Y, Miyajima M, Nozu K, Nagao S, Takahashi H, Iijima K, Yoshikawa N
    • Organizer
      47th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2014-11-11 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] IgA nephropathy with nephrotic syndrome in children2014

    • Author(s)
      Shima Y, Nakanishi K, Hama T, Sato M, Mukaiyama H, Togawa H, Kaito H, Nozu K, Tanaka R, Iijima K, Yoshikawa N
    • Organizer
      47th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2014-11-11 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Autosomal dominant Alport syndrome: molecular analysis of the COL4A3/COL4A4 genes and clinical outcome2014

    • Author(s)
      Kamiyoshi N, Nozu K, Matsunoshita N, Ohtsubo H, Ninchoji T, Kaito H, Nakanishi K, Yoshikawa N, Iijima K
    • Organizer
      47th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2014-11-11 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] The differential diagnosis between inherited salt-losing tubulopathy and pseudo-disorder from clinical characteristics2014

    • Author(s)
      Matsunoshita N, Nozu K, Kamiyoshi N, Nakanishi K, Yoshikawa N, Iijima K
    • Organizer
      47th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2014-11-11 – 2014-11-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Possible contribution of fibrocytes to real fibrosis in cpk mouse, a model of ARPKD2013

    • Author(s)
      Hama T, Yoshikawa N, et al
    • Organizer
      16th Congress of the International Pediatric Nephrology Association
    • Place of Presentation
      Shanghai, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] The relationship between timing of renal biopsy and pathological variables of the Oxford classification [OX] in childhood IgA Nephropathy2013

    • Author(s)
      Shima Y, Yoshikawa N, et al
    • Organizer
      16th Congress of the International Pediatric Nephrology Association
    • Place of Presentation
      Shanghai, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mutation analysis in Japanese patients with congenital and infantile nephrotic syndrome2013

    • Author(s)
      Mukaiyama H, Yoshikawa N, et al
    • Organizer
      16th Congress of the International Pediatric Nephrology Association
    • Place of Presentation
      Shanghai, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] A case of C3 glomerulonephritis in a 6-month-old infant accompanied by glomerular endothelial injury : the expanding spectrum of complement-mediated kidney diseases2013

    • Author(s)
      Matsunoshita N, Yoshikawa N, et al
    • Organizer
      16th Congress of the International Pediatric Nephrology Association
    • Place of Presentation
      Shanghai, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] Actual outcome and problems associated with cyclosporine treatment in children with steroid-sensitive nephrotic syndrome2013

    • Author(s)
      Ninchoji T, Yoshikawa N, et al
    • Organizer
      16th Congress of the International Pediatric Nephrology Association
    • Place of Presentation
      Shanghai, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] Two-year outcome of the ISKDC regimen and frequent-relapsing risk in children with idiopathic nephrotic syndrome2013

    • Author(s)
      Nakanishi K, Yoshikawa N, et al
    • Organizer
      16th Congress of the International Pediatric Nephrology Association
    • Place of Presentation
      Shanghai, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cyclosporine C2 monitoring for the treatment of frequently relapsing nephrotic syndrome in children: A multicenter randomized trial.2013

    • Author(s)
      Sako Nakamura M, Yoshikawa N, et al
    • Organizer
      16th Congress of the International Pediatric Nephrology Association
    • Place of Presentation
      Shanghai, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] Prevention of FSGS recurrence by a combination of pre-transplant bilateral nephrectomy, rituximab and plasma exchange: two case reports2013

    • Author(s)
      Mullyana O, Yoshikawa N, et al
    • Organizer
      16th Congress of the International Pediatric Nephrology Association
    • Place of Presentation
      Shanghai, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] Tri-allelic inheritance of NPHS1 gene in infantile-onset steroid-resistantnephrotic syndrome.2013

    • Author(s)
      Kumagai Y, Yoshikawa N, et al
    • Organizer
      46th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Natural history and protein expression pattern in autosomal recessive alport syndrome based on the comprehensive strategy for genetic analysis2013

    • Author(s)
      Kaito H, Yoshikawa N, et al
    • Organizer
      46th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Smad3 phosphorylated at both linker and COOH-terminal regions in cyst-lining epithelia in cpk mouse, a model of ARPKD.2013

    • Author(s)
      Hama T, Yoshikawa N, et al
    • Organizer
      46th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Investigation of principal mechanism for renal sodium retention in children with idiopathic nephrotic syndrome2013

    • Author(s)
      Ninchoji T, Yoshikawa N, et al
    • Organizer
      46th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Crescentic IgA nephropathy (C-IgAN) in children2013

    • Author(s)
      Shima Y, Yoshikawa N, et al
    • Organizer
      46th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Increased duration and dose of prednisolone (PSL) treatment does not reduce relapses in childhood nephrotic syndrome2013

    • Author(s)
      Yoshikawa N, et al
    • Organizer
      46th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 「よくわかる腎臓病講座」エビデンスに基づいた小児CKDの治療2012

    • Author(s)
      吉川 徳茂
    • Organizer
      第42回日本腎臓学会西部学術大会
    • Place of Presentation
      沖縄
    • Year and Date
      2012-10-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] 「小児科医療におけるEBMと臨床研究の向上のために」大規模臨床試験の実際II2012

    • Author(s)
      吉川 徳茂
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      博多
    • Year and Date
      2012-04-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] EBM確立のための臨床研究2012

    • Author(s)
      吉川 徳茂
    • Organizer
      第34回日本小児腎不全学会学術集会
    • Place of Presentation
      兵庫(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Histological predictors of treatment efficacy in severe childhood IgA Nephropathy (IgAN) : Validation of the oxford classification of IgAN (OX C)2012

    • Author(s)
      Shima Y, Yoshikawa N, et al
    • Organizer
      45th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Genetical and clinical aspects of x-Linked alport syndrome in males with positive staining of the α5(IV) chain2012

    • Author(s)
      Hashimura Y, Yoshikawa N, et al
    • Organizer
      45th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Possible contribution of fibrocytes to renal fibrosis in cpk mouse, a model of ARPKD2012

    • Author(s)
      Hama T, Yoshikawa N, et al
    • Organizer
      45th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Clinical characteristics and mutational pattern of genetically-proven gitelman' s syndrome2012

    • Author(s)
      Ninchoji T, Yoshikawa N, et al
    • Organizer
      45th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Clinicopathological characteristics and kidney outcome of childhood-onset lupus nephritis with acute kidney injury2012

    • Author(s)
      Ishimori S, Yoshikawa N, et al
    • Organizer
      The 45th ESPN Annual Meeting
    • Place of Presentation
      Krakow, Poland
    • Related Report
      2012 Annual Research Report
  • [Presentation] Clinical research activities in children in Japan

    • Author(s)
      Yoshikawa N
    • Organizer
      The 63rd Annual Fall Meeting of The Korean  Pediatric Society
    • Place of Presentation
      Seoul, Korean
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] IgA nephropathy in children

    • Author(s)
      Yoshikawa N
    • Organizer
      20th Annual meeting of Korean Society of Pediatric Nephrology
    • Place of Presentation
      Seoul, Korean
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 「科学研究費獲得のコツ」君は現状に満足するのか?よりよい医療のための研究の奨め

    • Author(s)
      吉川 徳茂
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島
    • Related Report
      2013 Annual Research Report
  • [Book] 今日の治療指針20152015

    • Author(s)
      吉川徳茂
    • Total Pages
      2096
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] 診療ガイドラインUP-TO-DATE 2014-20152014

    • Author(s)
      吉川徳茂
    • Total Pages
      960
    • Publisher
      メディカルレビュー社
    • Related Report
      2014 Annual Research Report
  • [Book] 腎疾患・透析最新の治療 2014-20162014

    • Author(s)
      吉川徳茂
    • Total Pages
      430
    • Publisher
      南江堂
    • Related Report
      2013 Annual Research Report
  • [Book] 臨床腎臓内科学2013

    • Author(s)
      中西浩一, 吉川徳茂
    • Total Pages
      1051
    • Publisher
      南山堂
    • Related Report
      2013 Annual Research Report
  • [Book] 腎臓疾患治療薬マニュアル2013-142013

    • Author(s)
      吉川徳茂
    • Total Pages
      895
    • Publisher
      東京医学社
    • Related Report
      2013 Annual Research Report
  • [Book] 腎臓病薬物療法実践ガイド2013

    • Author(s)
      吉川徳茂
    • Total Pages
      472
    • Publisher
      中山書店
    • Related Report
      2013 Annual Research Report
  • [Book] 小児腎臓病学2012

    • Author(s)
      吉川徳茂
    • Total Pages
      460
    • Publisher
      診断と治療社
    • Related Report
      2012 Annual Research Report
  • [Book] 今日の小児治療指針第15版2012

    • Author(s)
      吉川徳茂
    • Total Pages
      1028
    • Publisher
      医学書院
    • Related Report
      2012 Annual Research Report
  • [Book] 小児内科44増刊号2012

    • Author(s)
      吉川徳茂
    • Total Pages
      960
    • Publisher
      東京医学社
    • Related Report
      2012 Annual Research Report
  • [Book] 小児科診断・治療ガイド2012

    • Author(s)
      中西浩一,吉川徳茂
    • Total Pages
      1132
    • Publisher
      中山書店
    • Related Report
      2012 Annual Research Report
  • [Book] 腎疾患治療マニュアル2012-20132012

    • Author(s)
      中西浩一,吉川徳茂
    • Total Pages
      754
    • Publisher
      東京医学社
    • Related Report
      2012 Annual Research Report
  • [Book] 小児疾患の診断治療基準 第4版 小児内科44増刊号2012

    • Author(s)
      中西浩一,吉川徳茂
    • Total Pages
      960
    • Publisher
      東京医学社
    • Related Report
      2012 Annual Research Report
  • [Book] 小児科診療75巻増刊 【小児の診療手技100】2012

    • Author(s)
      島友子,中西浩一,吉川徳茂
    • Total Pages
      474
    • Publisher
      診断と治療社
    • Related Report
      2012 Annual Research Report
  • [Book] 腎臓症候群(第2版) -その他の腎臓疾患を含めて- 別冊日本臨床 新領域別症候群シリーズ172012

    • Author(s)
      戸川寛子,中西浩一,吉川徳茂
    • Total Pages
      859
    • Publisher
      日本臨牀社
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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