Reguratory mechanisms of radiation sensitivity by molecules expressed in epigenetics-dependent manners
Project/Area Number |
24390289
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | The University of Tokyo |
Principal Investigator |
MIYAGAWA Kiyoshi 東京大学, 医学(系)研究科(研究院), 教授 (40200133)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
|
Keywords | 放射線治療生物学 / エピジェネティクス |
Outline of Final Research Achievements |
To explore the possibility that molecules expressed in somatic cells in epigenetics-dependent manners affect the machinery responding to DNA damage induced by radiation and others, we investigated roles of meiosis-specific molecules in somatic cells. Our studies revealed that the meiosis-specific protein SYCE1 is expressed in some types of cancers and induces tolerance to radiation by promoting DNA double-strand break repair mediated by homologous recombinational repair and by nonhomologous end-joining through activation of the genome damage response.
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Report
(4 results)
Research Products
(9 results)
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[Presentation] DNA repair and cancer therapy
Author(s)
Kiyoshi Miyagawa
Organizer
The 3rd Asian Congress of Radiation Research
Place of Presentation
Beijing International Convention Center, Beijing, China
Related Report
Invited