| Project/Area Number |
24390335
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
URAMOTO Hidetaka 産業医科大学, 医学部, 准教授 (90389445)
SO Tomoko 産業医科大学, 医学部, 講師 (00331529)
YONEDA Kazue 産業医科大学, 医学部, 助教 (80724806)
HASEGAWA Seiki 兵庫医科大学, 医学部, 教授 (10252438)
ONAGA Takashi 富山工業技術センター, 中央研究所, 主幹研究員 (10416133)
宗 知子 産業医科大学, 医学部, 講師 (00341529)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 悪性胸膜中皮腫 / バイオマーカー / 循環腫瘍細胞 / 循環内皮細胞 / 中皮腫 / CTC / 胸膜中皮腫 / 血液 / 診断 / 予後 |
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| Outline of Final Research Achievements |
Malignant pleural mesothelioma (MPM) is a highly aggressive tumor associated with asbestos exposure. The present study was conducted to develop useful biomarkers in the diagnosis of MPM. Among a variety of novel biomarkers tested, the most promising biomarker was circulating tumor cell (CTC) evaluated with a novel CTC-chip system, in which tumor cells were captured with micro-spots coated by a variety of antibodies. When an antibody against podoplanin, an antigen expressing on cell surface of MPM cells, was used as coating antibody, the CTC-chip provided a very high sensitivity in detection of MPM cells. Another progress in diagnostic biomarkers achieved in the present study was high sensitivity and specificity (79% and 76%, respectively) in discrimination between MPM and non-malignant pleural diseases with a combination of multiple biomarkers (CTC evaluated with the CellSearch SYSTEM, circulating endothelial cell [CEC], and serum mesothelin-related protein).
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