| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Outline of Final Research Achievements |
In the present study we analyzed the functions of ADAM10 and ADAM17 in the musculoskeletal system. Specifically, we found that 1) ADAM17 regulates longitudinal bone growth via indirectly regulating osteoclastic bone resorption, that 2) ADAM17 specifically cleaves the decoy receptor IL-1R2 and thereby positively regulates IL-1 signaling, and that the activity of ADAM17 is not dependent on transcriptional or translational regulation. As for ADAM10, we found that ADAM10 plays an indispensable role in maintaining satellite cells in skeletal muscle. In addition to these study, we also investigated the potential role of ER stress in osteoclasts and identified a stress sensor IRE1α as a novel regulator of osteoclastogenesis.
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