Functional analysis of ADAMs in the musculoskeletal and hematopoietic system
| Project/Area Number |
24390358
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YODA Masaki 慶應義塾大学, 医学部, 特任助教 (30464994)
TOHMONDA Takahide 慶應義塾大学, 医学部, 特任助教 (40415237)
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| Co-Investigator(Renkei-kenkyūsha) |
TOYAMA Yoshiaki 慶應義塾大学, 医学部, 教授 (40129549)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Keywords | 骨軟骨代謝 / 筋代謝 / ADAM遺伝子 / 小胞体ストレス / 骨代謝 / ADAM10 / ADAM17 / 小胞体ストレス応答 / TACE/ADAM10 / 造血制御 |
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| Outline of Final Research Achievements |
In the present study we analyzed the functions of ADAM10 and ADAM17 in the musculoskeletal system. Specifically, we found that 1) ADAM17 regulates longitudinal bone growth via indirectly regulating osteoclastic bone resorption, that 2) ADAM17 specifically cleaves the decoy receptor IL-1R2 and thereby positively regulates IL-1 signaling, and that the activity of ADAM17 is not dependent on transcriptional or translational regulation. As for ADAM10, we found that ADAM10 plays an indispensable role in maintaining satellite cells in skeletal muscle. In addition to these study, we also investigated the potential role of ER stress in osteoclasts and identified a stress sensor IRE1α as a novel regulator of osteoclastogenesis.
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Report
(5 results)
Research Products
(34 results)
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[Journal Article] ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function.2015
Author(s)
Cui, D., Arima, M., Takubo, K., Kimura, T., Horiuchi, K., Minagawa, T., Matsuda, S., and Ikeda, E.
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Journal Title
Sci. Rep.
Volume: 5
Issue: 1
Pages: 12796-12796
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Histochemical aspects of the vascular invasion at the erosion zone of the epiphyseal cartilage in MMP-9-deficient mice2013
Author(s)
Kojima, T. Hasegawa, T. de Freitas, P. H. Yamamoto, T. Sasaki, M. Horiuchi, K. Hongo, H. Yamada, T. Sakagami, N. Saito, N. Yoshizawa, M. Kobayashi, T. Maeda, T. Saito, C. Amizuka, N.
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Journal Title
Biomedical Research
Volume: 34
Issue: 3
Pages: 119-128
DOI
NAID
ISSN
0388-6107, 1880-313X
Related Report
Peer Reviewed
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[Journal Article] iRHOM2 is a critical pathogenic mediator of inflammatory arthritis2013
Author(s)
Issuree, P. D. Maretzky, T. McIlwain, D. R. Monette, S. Qing, X. Lang, P. A. Swendeman, S. L. Park-Min, K. H. Binder, N. Kalliolias, G. D. Yarilina, A. Horiuchi, K. Ivashkiv, L. B. Mak, T. W. Salmon, J. E. Blobel, C. P.
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Journal Title
J Clin Invest
Volume: 123
Pages: 928-32
DOI
Related Report
Peer Reviewed
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[Journal Article] Conditional inactivation of TNFα-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones2013
Author(s)
Saito K, Horiuchi K, Kimura T, Mizuno S, Yoda M, Morioka H, Akiyama H, Threadgill D, Okada Y, Toyama Y, Sato K
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Journal Title
PLoS One
Volume: 8(1)
Issue: 1
Pages: e54853-e54853
DOI
Related Report
Peer Reviewed
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