Effects and the mechanism of action by remifentanil in the brain protection strategy
| Project/Area Number |
24390364
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Uchida Kanji 東京大学, 医学部附属病院, 准教授 (60302709)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Yoshitsugu 東京大学, 医学部附属病院, 教授 (30166748)
IMAI Hideaki 東京大学, 医学部附属病院, 講師 (70359587)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | レミフェンタニル / 脳保護 / 術後予後 / 開頭手術 / 炎症 / サイトカイン / 虚血再還流 / 白血球 / 手術侵襲 |
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| Outline of Final Research Achievements |
Propensity-matched analysis of administrative claims database indicated that the use of remifentanil associated with improved outcome of the patients undergoing surgical clipping of intracranial aneurysm. Use of remifentanil associated with reduced postoperative death with odds ratio of 0.52 ( 95% CI 0.37-0.74 p<0.001). Animal craniotomy model using rats revealed that the use of intraoperative remifentanil associated with suppressed recruitment of white blood cells to the peripheral blood. We have also standardized GM-CSF autoantibody ELISA and quantify reactivity of circulating neutrophils to exogenous GM-CSF to evaluate GM-CSF bioactivity that is important to the innate immunity agains the invading pathogen, as well as repair of the wound.
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Report
(5 results)
Research Products
(26 results)
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[Journal Article] Standardized serum GM-CSF autoantibody testing for the routine clinical diagnosis of autoimmune pulmonary alveolar proteinosis2014
Author(s)
Uchida K, Nakata K, Carey B, Chalk C, Suzuki T, Sakagami T, Koch DE, Stevens C, Inoue Y, Yamada Y, Trapnell BC.
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Journal Title
J Immunol Methods
Volume: 402
Issue: 1-2
Pages: 57-70
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Peritoneal sepsis impairs efficient recruitment of neutrophils into the alveolar space and augment lung injury after nosocomial infection2016
Author(s)
T. Hiruma, K. Uchida, B.C. Trapnell, Y. Kusakabe, Y. Yamamura, T. Totsu, K. Chang, K. Nakamura, K. Doi, S. Nakajima, N. Yahagi, Y. Yamada
Organizer
American Thoracic Society Annual Meeting
Place of Presentation
San Francisco, USA
Year and Date
2016-05-14
Related Report
Int'l Joint Research
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