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To control in invasion and metastasis through EMT (Epithelial-Mesenchymal-Transition) functional analysis of CD24 in endometrial cancer

Research Project

Project/Area Number 24390384
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionOsaka Medical College

Principal Investigator

OHMICHI Masahide  大阪医科大学, 医学部, 教授 (10283764)

Co-Investigator(Kenkyū-buntansha) TANABE Akiko  大阪医科大学, 医学部, 非常勤講師 (70454543)
HAYASHI Masami  大阪医科大学, 医学部, 講師 (00551748)
TANAKA Yoshimichi  大阪医科大学, 医学部, 助教 (10625502)
KANEMURA Masanori  大阪医科大学, 医学部, 講師 (40298782)
YAMASHITA Yoshiki  大阪医科大学, 医学部, 非常勤講師 (50268207)
TSUNETOH Satoshi  大阪医科大学, 医学部, 助教 (70388255)
TERAI Yoshito  大阪医科大学, 医学部, 准教授 (90278531)
Research Collaborator NAKAMURA Kiyoko  大阪医科大学, 医学部
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2012: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords子宮内膜癌 / EMT / CD24 / HGF / Met / ABC transporter / ミセル / Foretinib / ミセル / 上皮間葉形態転換
Outline of Final Research Achievements

The development of resistance to chemotherapeutic drugs by cancer cells represents a major challenge in the clinical cure of advanced and metastatic cancers. CD24 has been reported to be a marker for a poor prognosis in several tumors, and we herein examined the functions of CD24 in human endometrioid adenocarcinoma cell lines, and evaluated how it contributes to cancer drug resistance. We demonstrated that CD24 was responsible for the recruitment of phosphorylated-Met to the lipid raft domain of the cell membrane, resulting in amplification of the Met signaling cascade, ultimately leading endometrial cancer cells to express higher levels of ATP binding cassette (ABC) transporters. Our findings suggest that CD24-mediated amplification of the Met cascade may contribute to the drug resistance of endometrial cancer.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (13 results)

All 2015 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (9 results)

  • [Journal Article] Estradiol-mediated hepatocyte growth factor is involved in the implantation of endometriotic cells via the mesothelial-mesenchymal transition in the peritoneum.2015

    • Author(s)
      Ono YJ, Hayashi M, Tanabe A, Hayashi A, Kanemura M, Terai Y, Ohmichi M.
    • Journal Title

      Am J Physiol Endocrinol Metab.

      Volume: Apr 7 Issue: 11 Pages: E950-E959

    • DOI

      10.1152/ajpendo.00573.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decorin induced by progesterone plays a crucial role in suppressing endometriosis.2014

    • Author(s)
      Ono YJ, Terai Y, Tanabe A, Hayashi A, Hayashi M, Yamashita Y, Kyo S, Ohmichi
    • Journal Title

      J Endocrinol

      Volume: 223 Issue: 2 Pages: 203-216

    • DOI

      10.1530/joe-14-0393

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Postmenopausal patients with endometrial cancer of type 1 have elevated serum estradiol levels in the ovarian vein2014

    • Author(s)
      Ashihara K, Tanaka T, Maruoka R, Ono YJ, Tanabe A, Terai Y, Ohmichi M
    • Journal Title

      Int J Gynecol Cancer.

      Volume: 24 Issue: 8 Pages: 1455-1460

    • DOI

      10.1097/igc.0000000000000227

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of EMT (epithelial Mesenchymal-Trasition) related protein expression in endometrial cancer2013

    • Author(s)
      Yoshimichi Tanaka
    • Journal Title

      Cancer Biol Ther

      Volume: 14(1) Issue: 1 Pages: 13-19

    • DOI

      10.4161/cbt.22625

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Epithelial Mesenchymal Transition (EMT) in Endometrial Cancer2014

    • Author(s)
      Tanaka Y, Terai Y, Fujiwara S, Tsunetoh S, Kanemura M, Tanabe A, Ohmichi M.
    • Organizer
      第3回アジア婦人科腫瘍学会 第55回日本婦人科腫瘍学会
    • Place of Presentation
      ウェスティン都ホテル京都
    • Year and Date
      2014-12-13 – 2014-12-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 卵巣癌におけるCD24の発現意義と機能解析について2014

    • Author(s)
      芦原敬允、寺井義人、藤原聡枝、田中良道、恒遠啓示、田辺晃子、金村昌徳、大道正英
    • Organizer
      日本婦人科癌分子標的研究会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2014-04-18 – 2014-04-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 難治性卵巣癌の浸潤・転移に関わる分子をターゲットとして新規治療法の開発2014

    • Author(s)
      寺井義人
    • Organizer
      第66回日本産科婦人科学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2014-04-18 – 2014-04-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 婦人科癌の浸潤転移におけるEMTの意義とEMT制御をターゲットとした新規治療の基礎的研究2013

    • Author(s)
      寺井義人
    • Organizer
      第53回日本婦人科腫瘍学会
    • Place of Presentation
      岡山 岡山コンベンションセンター
    • Related Report
      2013 Annual Research Report
  • [Presentation] 上皮間葉転換を介した浸潤・転移の制御を目指して2013

    • Author(s)
      中村起代子、田中良道、川口浩史、高井雅聡、兪 史夏、藤原聡枝、田中智人、恒遠啓示、田辺晃子、金村昌徳、寺井義人、大道正英
    • Organizer
      第65回日本産科婦人科学会
    • Place of Presentation
      北海道 ロイトン札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 若年性子宮内膜癌・子宮内膜異形増殖症に対するMPA治療法の治療成績2013

    • Author(s)
      田中良道、川口浩史、高井雅聡、兪 史夏、藤原聡枝、田中智人、恒遠啓示、田辺晃子、金村昌徳、寺井義人、大道正英
    • Organizer
      第51回日本癌治療学会
    • Place of Presentation
      京都 京都国際会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] Prognostic impact of EMT (epithelial-mesenchymal-transition) related protein expression in endometrial cancer.2012

    • Author(s)
      田中良道
    • Organizer
      American Association of Cancer Research
    • Place of Presentation
      McCormick Place, Chicago,USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 子宮体癌におけるEMTのマーカーとしてのCD24の有用性2012

    • Author(s)
      田中良道
    • Organizer
      第64回日本産科婦人科学会学術集会
    • Place of Presentation
      神戸国際展示場 兵庫県
    • Related Report
      2012 Annual Research Report
  • [Presentation] 婦人科癌の浸潤転移におけるEMTの意義とEMT制御をターゲットとした新規治療の基礎的研究2012

    • Author(s)
      寺井義人
    • Organizer
      第53回日本婦人科腫瘍学会
    • Place of Presentation
      岡山コンベンションセンター 岡山県
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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