| Project/Area Number |
24390438
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AITA Hideki 北海道医療大学, 歯学部, 准教授 (10301011)
TOYOSHITA Yoshifumi 北海道医療大学, 歯学部, 講師 (20399900)
KAWANISHI Katsuya 北海道医療大学, 歯学部, 講師 (10438377)
KONO Mai 北海道医療大学, 歯学部, 助教 (90586926)
SASAKI Mizuho 北海道医療大学, 歯学部, 助教 (70638410)
額 諭史 北海道医療大学, 歯学部, 助教 (40453261)
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| Research Collaborator |
KAN Yuki
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 咀嚼 / 糖代謝 / GLP-1 / 咬合 / 糖尿病 / 生活習慣 |
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| Outline of Final Research Achievements |
C57Bl/6j mice were maintained for 12 weeks on high fat diet and became diabetes.We examined the change of secretion of glucagon-like peptide 1(GLP-1) by mastication in type 2 diabetes mice.
Mastication promotes secretion of GLP-1 via the autonomic nervous system. Moreover, continual mastication for long period maintains the level of GLP-1 in serum. Accordingly, it is suggested that mastication is effective for improvement of diabetes.
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