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Virus-host coevolution and new virus prediction

Research Project

Project/Area Number 24405045
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section海外学術
Research Field Applied veterinary science
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

ARAI SATORU  国立感染症研究所, その他部局等, 研究員 (80321868)

Co-Investigator(Kenkyū-buntansha) OHDACHI SATOSHI  北海道大学, 低温科学研究所, 助教 (60292041)
SUZUKI HITOSHI  北海道大学, 地球環境科学研究科, 教授 (40179239)
KAWADA SHINICHIRO  国立科学博物館, 動物研究部, 研究員 (30415608)
FUKUI DAI  東京大学, 農学生命科学研究科, 助教 (60706670)
Co-Investigator(Renkei-kenkyūsha) MORIKAWA SHIGERU  国立感染症研究所, 獣医科学部, 部長 (00167686)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords共進化 / ウイルス予測 / 新型ウイルス / ハンタウイルス / 翼手目 / 翼手目由来ウイルス / 系統解析 / ウイルス進化予測 / ウイルス感染 / 進化予測
Outline of Final Research Achievements

During this research, we conducted the filed investigation of small animals in Vietnam and Myanmar for nine times. We captured a total of 1,039 rodents, shrews and bats animals. The infected virus in the animals, novel hantavirus RNAs were successfully detected in two species of insectivore bats, captured in Vietnam in 2012 and 2015. We conducted phylogenetic analysis based on the sequence data of newly-discovered viruses and deposited ones in GenBank. It showed that chiroptera-borne hantaviruses consisted of one cluster and also co-evolved with host mammalian animals. Detailed phylogenetic analyses, based on partial and full-length genomes of previously described rodent-borne and newly detected non-rodent-borne hantaviruses indicate an Eurasian origin and support the emerging concept that ancestral non-rodent mammals may have served as the hosts of primordial hantaviruses. The results of phylogenetic analysis would be able to be used for virus prediction in near future.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (19 results)

All 2015 2014 2013 2012 Other

All Int'l Joint Research (2 results) Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Acknowledgement Compliant: 4 results,  Open Access: 1 results) Presentation (8 results)

  • [Int'l Joint Research] Inst. of Ecol. and Biolol. Resources(ベトナム)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Veterinary Science(Myanmar)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Description of a new species of the genus Aselliscus (Chiroptera, Hipposideridae) from Vietnam.2015

    • Author(s)
      VUONG TAN TU, GÁBOR CSORBA, TAMÁS GÖRFÖL, SATORU ARAI, NGUYEN TRUONG SON, HOANG TRUNG THANH, and ALEXANDRE HASANIN
    • Journal Title

      Acta Chiropterologica

      Volume: 17 Issue: 2 Pages: 233-254

    • DOI

      10.3161/15081109acc2015.17.2.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Reconstructing the evolutionary origins and phylogeography of hantaviruses.2014

    • Author(s)
      Bennett, S. N., Gu, S. H., Kang, H. J., Arai, S., Yanagihara, R.
    • Journal Title

      Trends in Microbiolology

      Volume: 22 Issue: 8 Pages: 473-482

    • DOI

      10.1016/j.tim.2014.04.008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Molecular phylogeny of hantaviruses harbored by insectivorous bats in Côte d'Ivoire and Vietnam.2014

    • Author(s)
      Gu, S. H., Lim, B. K., Kadjo, B., Arai, S., Kim, J. A., Nicolas, V., Lalis, A., Denys, C., Cook, J. A., Dominguez, S. R., Holmes, K. V., Urushadze, L., Sidamonidze, K., Putkaradze, D., Kuzmin, IV., Kosoy, M. Y., Song, J. W., Yanagihara, R.
    • Journal Title

      Viruses

      Volume: 6 Issue: 5 Pages: 1897-1910

    • DOI

      10.3390/v6051897

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The currently known bat species composition of Khau Ca species and habitat conservation area, Ha Giang province.2014

    • Author(s)
      Thanh H.T., Fukui D., Arai S., Son N.T., Huan N.X. and Thong V.D.
    • Journal Title

      VNU Journal of Science

      Volume: 30 Pages: 103-109

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hantaviruses: Rediscovery and new beginnings2014

    • Author(s)
      Richard Yanagihara, Se Hun Gu, Satoru Arai, Hae Ji Kang, Jin-Won Song
    • Journal Title

      Virus Research

      Volume: XX Pages: 6-14

    • DOI

      10.1016/j.virusres.2013.12.038

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mc1r 変異に基づくクマネズミ外来系統の日本列島における移入と浸透交雑の把握2013

    • Author(s)
      神戸嘉一、鈴木莊介、矢部辰男、中田勝士、前園泰徳、阿部愼太郎、石田健、谷川 力、橋本琢磨、武田美加子、土屋公幸、吉松組子、鈴木仁
    • Journal Title

      哺乳類科学

      Volume: 53 Pages: 289-298

    • NAID

      130003393448

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular phylogenetic analysis of Orientia tsutsugamushi based on the groES and groEL genes2013

    • Author(s)
      Satoru Arai, Kenji Tabara, Norishige Yamamoto, Hiromi Fujita, Asao Itagaki, Marina Kon, Hiroshi Satoh, Kazuko Araki, Keiko Tanaka-Taya, Nobuhiro Takada, Yasuhiro Yoshikawa, Chiaki Ishihara, Nobuhiko Okabe, and Kazunori Oishi
    • Journal Title

      Vector Borne and Zoonotic Diseases

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel Bat-borne Hantavirus, Vietnam2013

    • Author(s)
      Satoru Arai, Son Truong Nguyen, Bazartseren Boldgiv, Dai Fukui, Kazuko Araki, Can Ngoc Dang, Satoshi D. Ohdachi. Nqhia Xuan Nguven, Tien Duc Pham, Bazartseren Boldbaatar, Hiroshi Satoh, Yasuhiro Yoshikawa, Shigeru Morikawa, Keiko Tanaka-Taya, Richard Yanagihara, Kazunori Oishi
    • Journal Title

      Emerging Infectious Diseases

      Volume: 19 Issue: 7 Pages: 1159-1161

    • DOI

      10.3201/eid1907.121549

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel serological tools for detection of Thottapalayam virus, a Soricomorpha-borne hantavirus.2012

    • Author(s)
      Mathias Schlegel, Erdenesaikhan Tegshduuren, Kumiko Yoshimatsu, Rasa Petraityte, Kestutis Sasnauskas, Barbel Hammerschmidt, Robert Friedrich, Marc Mertens, Martin H. Groschup, Satoru Arai, Rika Endo, Kenta Shimizu, Takaaki Koma, Shumpei Yasuda, Chiaki Ishihara, Rainer G. Ulrich, Jiro Arikawa, Bernd Kollner
    • Journal Title

      Archives Virology

      Volume: 157 Issue: 11 Pages: 2179-2187

    • DOI

      10.1007/s00705-012-1405-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] ベトナムの翼手目由来に確認されたハンタウイルスの多様性2014

    • Author(s)
      新井 智,池山優,Se Hun Gu,Son Truong Nguyen,福井大,大舘智志,吉川泰弘,森川茂,荒木和子,佐藤弘,多屋馨子,Richard Yanagihara,大石和徳
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      神奈川県、横浜市
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] モンゴルのトガリネズミに確認された遺伝的に異なるハンタウイルスの共循環2014

    • Author(s)
      新井智,池山優,Bazartseren Boldgiv,Bazartseren Boldbaatar,荒木和子,佐藤弘,多屋磬子,森川茂,Richard Yanagihara,大石和徳
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道、札幌市
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] XVIth International Congress of Virology2014

    • Author(s)
      Ikeyama, Y., Arai, S., Boldgiv, B., Boldbaatar, B., Araki, K., Satoh, H., Tanaka-Taya, K., Morikawa, S., Yanagihara, R., Oishi, K.
    • Organizer
      International Union of Microbiology Scieties
    • Place of Presentation
      Montreal, Canada.
    • Year and Date
      2014-07-27 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Amga virus, a newfound hantavirus harbored by the Laxmann’s shrew (Sorex caecutiens) in Russia and Japan2013

    • Author(s)
      Satoru Arai, Hae Ji Kang, Satoshi D. Ohdachi, Joseph A. Cook, Keiko Tanaka-Taya, Shigeru Morikawa, Nobuhiko Okabe, Richard Yanagihara
    • Organizer
      IX International conference on HERS, HPS &Hantaviruses
    • Place of Presentation
      Beijing, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] Newfound hantavirus in the Pomona roundleaf bat (Hipposideros pomona) in Vietnam2013

    • Author(s)
      Satoru Arai, Son Truong Nguyen2, Dai Fukui, Satoshi D. Ohdachi, Yasuhiro Yoshikawa, Shigeru Morikawa, Keiko Tanaka-Taya, Richard Yanagihara, Kazunori Oishi
    • Organizer
      IX International conference on HERS, HPS &Hantaviruses
    • Place of Presentation
      Beijing, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] Genetic diversity and phylogeography of Asama virus in the Japanese shrew mole (Urotrichus talpoides).2012

    • Author(s)
      Satoru Arai, Kimura, T., Asakawa, M., Shannon N. Bennett, Satoshi D. Ohdachi, Keiko Tanaka-Taya, Shigeru Morikawa, Nobuhiko Okabe, Richard Yanagihara
    • Organizer
      XVIII International Congress on Tropical Medicine and Malaria.
    • Place of Presentation
      Rio de Janeiro, Brazil.
    • Related Report
      2012 Annual Research Report
  • [Presentation] ウイルスの宿主転換と哺乳類との共進化2012

    • Author(s)
      新井智
    • Organizer
      日本哺乳類学会2012年度大会
    • Place of Presentation
      神奈川県町田市(自由集会)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ミャンマー産ネズミ亜科4種の分子系統学的把握

    • Author(s)
      鈴木仁、Saw Bown、片倉賢
    • Organizer
      日本哺乳類学会大会
    • Place of Presentation
      岡山県
    • Related Report
      2013 Annual Research Report

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Published: 2012-04-24   Modified: 2022-02-01  

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