Virus-host coevolution and new virus prediction

• Project/Area Number: 24405045
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Applied veterinary science
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: ARAI SATORU 国立感染症研究所, その他部局等, 研究員 (80321868)
• Co-Investigator(Kenkyū-buntansha): OHDACHI SATOSHI 北海道大学, 低温科学研究所, 助教 (60292041) ; SUZUKI HITOSHI 北海道大学, 地球環境科学研究科, 教授 (40179239) ; KAWADA SHINICHIRO 国立科学博物館, 動物研究部, 研究員 (30415608) ; FUKUI DAI 東京大学, 農学生命科学研究科, 助教 (60706670)
• Co-Investigator(Renkei-kenkyūsha): MORIKAWA SHIGERU 国立感染症研究所, 獣医科学部, 部長 (00167686)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
• Keywords: 共進化 / ウイルス予測 / 新型ウイルス / ハンタウイルス / 翼手目 / 翼手目由来ウイルス / 系統解析 / ウイルス進化予測 / ウイルス感染 / 進化予測

Outline of Final Research Achievements

During this research, we conducted the filed investigation of small animals in Vietnam and Myanmar for nine times. We captured a total of 1,039 rodents, shrews and bats animals. The infected virus in the animals, novel hantavirus RNAs were successfully detected in two species of insectivore bats, captured in Vietnam in 2012 and 2015. We conducted phylogenetic analysis based on the sequence data of newly-discovered viruses and deposited ones in GenBank. It showed that chiroptera-borne hantaviruses consisted of one cluster and also co-evolved with host mammalian animals. Detailed phylogenetic analyses, based on partial and full-length genomes of previously described rodent-borne and newly detected non-rodent-borne hantaviruses indicate an Eurasian origin and support the emerging concept that ancestral non-rodent mammals may have served as the hosts of primordial hantaviruses. The results of phylogenetic analysis would be able to be used for virus prediction in near future.

Research Products

• [Int'l Joint Research] Inst. of Ecol. and Biolol. Resources(ベトナム)
• [Int'l Joint Research] University of Veterinary Science(Myanmar)
• [Journal Article] Description of a new species of the genus Aselliscus (Chiroptera, Hipposideridae) from Vietnam. (2015)
  • Author(s): VUONG TAN TU, GÁBOR CSORBA, TAMÁS GÖRFÖL, SATORU ARAI, NGUYEN TRUONG SON, HOANG TRUNG THANH, and ALEXANDRE HASANIN
  • Journal Title: Acta Chiropterologica Volume: 17 Issue: 2 Pages: 233-254
  • DOI: 10.3161/15081109acc2015.17.2.002
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Reconstructing the evolutionary origins and phylogeography of hantaviruses. (2014)
  • Author(s): Bennett, S. N., Gu, S. H., Kang, H. J., Arai, S., Yanagihara, R.
  • Journal Title: Trends in Microbiolology Volume: 22 Issue: 8 Pages: 473-482
  • DOI: 10.1016/j.tim.2014.04.008
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Molecular phylogeny of hantaviruses harbored by insectivorous bats in Côte d'Ivoire and Vietnam. (2014)
  • Author(s): Gu, S. H., Lim, B. K., Kadjo, B., Arai, S., Kim, J. A., Nicolas, V., Lalis, A., Denys, C., Cook, J. A., Dominguez, S. R., Holmes, K. V., Urushadze, L., Sidamonidze, K., Putkaradze, D., Kuzmin, IV., Kosoy, M. Y., Song, J. W., Yanagihara, R.
  • Journal Title: Viruses Volume: 6 Issue: 5 Pages: 1897-1910
  • DOI: 10.3390/v6051897
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The currently known bat species composition of Khau Ca species and habitat conservation area, Ha Giang province. (2014)
  • Author(s): Thanh H.T., Fukui D., Arai S., Son N.T., Huan N.X. and Thong V.D.
  • Journal Title: VNU Journal of Science Volume: 30 Pages: 103-109
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hantaviruses: Rediscovery and new beginnings (2014)
  • Author(s): Richard Yanagihara, Se Hun Gu, Satoru Arai, Hae Ji Kang, Jin-Won Song
  • Journal Title: Virus Research Volume: XX Pages: 6-14
  • DOI: 10.1016/j.virusres.2013.12.038
  • Peer Reviewed
• [Journal Article] Mc1r 変異に基づくクマネズミ外来系統の日本列島における移入と浸透交雑の把握 (2013)
  • Author(s): 神戸嘉一、鈴木莊介、矢部辰男、中田勝士、前園泰徳、阿部愼太郎、石田健、谷川 力、橋本琢磨、武田美加子、土屋公幸、吉松組子、鈴木仁
  • Journal Title: 哺乳類科学 Volume: 53 Pages: 289-298
  • NAID: 130003393448
  • Peer Reviewed
• [Journal Article] Molecular phylogenetic analysis of Orientia tsutsugamushi based on the groES and groEL genes (2013)
  • Author(s): Satoru Arai, Kenji Tabara, Norishige Yamamoto, Hiromi Fujita, Asao Itagaki, Marina Kon, Hiroshi Satoh, Kazuko Araki, Keiko Tanaka-Taya, Nobuhiro Takada, Yasuhiro Yoshikawa, Chiaki Ishihara, Nobuhiko Okabe, and Kazunori Oishi
  • Journal Title: Vector Borne and Zoonotic Diseases
  • Peer Reviewed
• [Journal Article] Novel Bat-borne Hantavirus, Vietnam (2013)
  • Author(s): Satoru Arai, Son Truong Nguyen, Bazartseren Boldgiv, Dai Fukui, Kazuko Araki, Can Ngoc Dang, Satoshi D. Ohdachi. Nqhia Xuan Nguven, Tien Duc Pham, Bazartseren Boldbaatar, Hiroshi Satoh, Yasuhiro Yoshikawa, Shigeru Morikawa, Keiko Tanaka-Taya, Richard Yanagihara, Kazunori Oishi
  • Journal Title: Emerging Infectious Diseases Volume: 19 Issue: 7 Pages: 1159-1161
  • DOI: 10.3201/eid1907.121549
  • Peer Reviewed
• [Journal Article] Novel serological tools for detection of Thottapalayam virus, a Soricomorpha-borne hantavirus. (2012)
  • Author(s): Mathias Schlegel, Erdenesaikhan Tegshduuren, Kumiko Yoshimatsu, Rasa Petraityte, Kestutis Sasnauskas, Barbel Hammerschmidt, Robert Friedrich, Marc Mertens, Martin H. Groschup, Satoru Arai, Rika Endo, Kenta Shimizu, Takaaki Koma, Shumpei Yasuda, Chiaki Ishihara, Rainer G. Ulrich, Jiro Arikawa, Bernd Kollner
  • Journal Title: Archives Virology Volume: 157 Issue: 11 Pages: 2179-2187
  • DOI: 10.1007/s00705-012-1405-9
  • Peer Reviewed
• [Presentation] ベトナムの翼手目由来に確認されたハンタウイルスの多様性 (2014)
  • Author(s): 新井 智，池山優，Se Hun Gu，Son Truong Nguyen，福井大，大舘智志，吉川泰弘，森川茂，荒木和子，佐藤弘，多屋馨子，Richard Yanagihara，大石和徳
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 神奈川県、横浜市
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] モンゴルのトガリネズミに確認された遺伝的に異なるハンタウイルスの共循環 (2014)
  • Author(s): 新井智，池山優，Bazartseren Boldgiv，Bazartseren Boldbaatar，荒木和子，佐藤弘，多屋磬子，森川茂，Richard Yanagihara，大石和徳
  • Organizer: 第157回日本獣医学会学術集会
  • Place of Presentation: 北海道、札幌市
  • Year and Date: 2014-09-09 – 2014-09-12
• [Presentation] XVIth International Congress of Virology (2014)
  • Author(s): Ikeyama, Y., Arai, S., Boldgiv, B., Boldbaatar, B., Araki, K., Satoh, H., Tanaka-Taya, K., Morikawa, S., Yanagihara, R., Oishi, K.
  • Organizer: International Union of Microbiology Scieties
  • Place of Presentation: Montreal, Canada.
  • Year and Date: 2014-07-27 – 2014-08-01
• [Presentation] Amga virus, a newfound hantavirus harbored by the Laxmann’s shrew (Sorex caecutiens) in Russia and Japan (2013)
  • Author(s): Satoru Arai, Hae Ji Kang, Satoshi D. Ohdachi, Joseph A. Cook, Keiko Tanaka-Taya, Shigeru Morikawa, Nobuhiko Okabe, Richard Yanagihara
  • Organizer: IX International conference on HERS, HPS &Hantaviruses
  • Place of Presentation: Beijing, China
• [Presentation] Newfound hantavirus in the Pomona roundleaf bat (Hipposideros pomona) in Vietnam (2013)
  • Author(s): Satoru Arai, Son Truong Nguyen2, Dai Fukui, Satoshi D. Ohdachi, Yasuhiro Yoshikawa, Shigeru Morikawa, Keiko Tanaka-Taya, Richard Yanagihara, Kazunori Oishi
  • Organizer: IX International conference on HERS, HPS &Hantaviruses
  • Place of Presentation: Beijing, China
• [Presentation] Genetic diversity and phylogeography of Asama virus in the Japanese shrew mole (Urotrichus talpoides). (2012)
  • Author(s): Satoru Arai, Kimura, T., Asakawa, M., Shannon N. Bennett, Satoshi D. Ohdachi, Keiko Tanaka-Taya, Shigeru Morikawa, Nobuhiko Okabe, Richard Yanagihara
  • Organizer: XVIII International Congress on Tropical Medicine and Malaria.
  • Place of Presentation: Rio de Janeiro, Brazil.
• [Presentation] ウイルスの宿主転換と哺乳類との共進化 (2012)
  • Author(s): 新井智
  • Organizer: 日本哺乳類学会2012年度大会
  • Place of Presentation: 神奈川県町田市(自由集会)
• [Presentation] ミャンマー産ネズミ亜科４種の分子系統学的把握
  • Author(s): 鈴木仁、Saw Bown、片倉賢
  • Organizer: 日本哺乳類学会大会
  • Place of Presentation: 岡山県