Comprehensive Analysis of Emerging Risk Factors of Coronary Heart Disease in Young Population of South Asia: a multidisciplinary and multifaceted investigation for prevention strategy
Project/Area Number |
24406026
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 海外学術 |
Research Field |
General internal medicine (including Psychosomatic medicine)
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Research Institution | Research Institute, International Medical Center of Japan |
Principal Investigator |
MOROI Masao 独立行政法人国立国際医療研究センター, その他部局等, その他 (30256721)
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Co-Investigator(Kenkyū-buntansha) |
JESMIN Subrina 筑波大学, 医学医療系, 助教 (60374261)
水谷 太郎 筑波大学, 医学医療系, 教授 (80181890)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2012: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
|
Keywords | 南アジア / 若年冠動脈疾患 / 危険因子 / 予防法 / 若年冠動脈 / 日本 / 比較 / バイオマーカー |
Outline of Final Research Achievements |
We found prevalence of important cardiovascular risk factors in Bangladeshi population is as follows: (behavioral risk factors); 86.9% unhealthy diets, 53.5% tobacco use, 21.7% smoking, 41.4% physical inactivity, 0.7% alcohol consumption; (physical risk factors): 28.5% elevated blood pressure, 24.1% overweight, 19.7% abdominal obesity; (cardio metabolic risk factors): 10.2% elevated fasting blood glucose, 65.7% low HDL cholesterol, 35.64% raised total cholesterol, 33.8% raised triglyceride. % of acute coronary syndrome (ACS) was higher in male compared to female in Bangladesh. The prevalence of important cardio metabolic risk factors in young ACS patients in Bangladesh is: diabetes (17.4%); hypertension (28.77%); low HDL (61.19%); elevated triglyceride (44.29%); overweight (19.49%); obese (4.73%). The prevalence in old ACS patients is: diabetes (24.6%); hypertension (34.42%); low HDL (56%); elevated triglyceride (35.79%); overweight (19.14%) and obese (4.46%).
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Report
(4 results)
Research Products
(121 results)
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[Journal Article] Higher circulatory level of endothelin-1 in hypertensive subjects screened through a cross-sectional study of rural Bangladeshi women.2015
Author(s)
Akter S, Jesmin S, Iwashima Y, Hideaki S, Rahman MA, Islam MM, Moroi M, Shimojo N, Yamaguchi N, Miyauchi T, Kawano S, Mizutani T, Kawano Y.
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Journal Title
Hypertens Res.
Volume: 38(3)
Issue: 3
Pages: 208-212
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Assessment of circulatory levels of endothelin-1 in diabetic subjects screened through a cross sectional study from rural women in Bangladesh.2015
Author(s)
Rahman MA, Jesmin S, Mowa CN, Sohael F, Kamiyama J, Habib AKMA, Shimojo N, Islam MM, Moroi M, Okazaki O, Yamaguchi N, Kawano S, Mizutani T, Iwashima Y.
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Journal Title
International Journal of Diabetes and Clinical Research.
Volume: 2
Pages: 1-1
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Assessment of circulatory endothelin-1 level among pre and post-menopausal rural women in Bangladesh: result from a population-based study.2015
Author(s)
Khatun T, Jesmin S, Yamaguchi N, Kamiyama J, Akter S, Sultana SN, Islam M, Okazaki O, Kawano S, Akashi H, Mizutani T, Miyauchi T, Rahman A, Habib AKMA.
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Journal Title
Annals of Vascular Medicine & Research.
Volume: 2
Pages: 1014-1014
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Myocardial perfusion imaging for predicting cardiac events in Japanese patients with advanced chronic kidney disease: 1-year interim report of the J-ACCESS 3 investigation2014
Author(s)
Joki N, Hase H, Kawano Y, Nakamura S, Nakajima K, Hatta T, Nishimura S, Moroi M, Nakagawa S, Kasai T, Kusuoka H, Takeishi Y, Momose M, Takehana K, Nanasato M, Yoda S, Nishina H, Matsumoto N, Nishimura T.
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Journal Title
Eur J Nucl Med Mol Imaging.
Volume: 41(9)
Issue: 9
Pages: 1701-1709
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Effects of selective endothelin (ET)-A receptor antagonist versus dual ET-A/B receptor antagonist on hearts of streptozotocin-treated diabetic rats.2014
Author(s)
Miyauchi Y, Jesmin S, Sakai S, Kamiyama J, Shimojo N, Rahman A, Islam M, Zaedi S, Maeda S, Maruyama H, Mizutani T, Homma S, Aonuma K, Miyauchi T.
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Journal Title
Life Sciences
Volume: 111(1-2)
Issue: 1-2
Pages: 6-11
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Endothelin-1 and metabolic syndrome in Bangladeshi rural women.2014
Author(s)
Islam MM, Jesmin S, Akter S, Mowa CN, Sakuramoto H, Chowdhury SR, Rahman A, Habib AKMA, Okazaki O, Shimojo N, Miyauchi T, Kawano S, Mizutani T.
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Journal Title
Annals of Vascular Medicine & Research.
Volume: 1
Pages: 1008-1008
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Long fasting is effective in inhibiting physiological myocardial 18F-FDG uptake and for evaluating active lesions of cardiac sarcoidosis2014
Author(s)
Miyako Morooka, Masao Moroi, Kimiichi Uno, Kimiteru Ito, Jin Wu, Takashi Nakagawa, Kazuo Kubota, Ryogo Minamimoto, Yoko Miyata, Momoko Okasaki, Osamu Okazaki, Yoshihito Yamada, Tetsuo Yamaguchi, Michiaki Hiroe
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Journal Title
EJNMMI Research
Volume: 4
Issue: 1
Pages: 1-1
DOI
Related Report
Peer Reviewed
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[Journal Article] Screening for gestational diabetes mellitus in Bogra sadar, Bogra Bangladesh.2013
Author(s)
Jesmin S, Rahman A, Sohael F, Akter S, Islam MM, Khatun MT, Sultana SN, Mamun AA, Akashi H, Habib AKMA.
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Journal Title
Journal of Shaheed Ziaur Rahman Medical College
Volume: 20
Pages: 19-23
Related Report
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[Presentation] National profile of non-communicable disese risk factors in Bangladesh2014
Author(s)
Mamun AA, Jesmin S, Rahman MA, Habib AKMA, Islam MM, Sultana SN, Khatun T, Sohael F, Shimojo N, Okazaki O, Kawano S.
Organizer
Celebration of 2nd Public Health Foundation Day & Scientific Seminar
Place of Presentation
Dhaka, Bangladesh
Year and Date
2014-12-07 – 2014-12-08
Related Report
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[Presentation] Prevalence of metabolic syndrome components among early age oneset acute coronary syndrome patients in Bangladesh2014
Author(s)
Rahman MA, Jesmin S, Habib AKMA,Haider S, Khan Amiruzzaman, Islam MM, Khatun MT, Sultana SN, Sultana SN, Sohael F, Moroi M.
Organizer
Celebration of 2nd Public Health Foundation Day & Scientific Seminar
Place of Presentation
Dhaka, Bangladesh
Year and Date
2014-12-07 – 2014-12-08
Related Report
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[Presentation] Alteration of VEGF angiogenic signaling system in metabolic syndrome: findings from a study conducted in rural Bangladeshi women2014
Author(s)
Jesmin S, Mamun AA, Rahman MA, Islam MM, Akter S, Rahman MM, Sultana SN, Yamaguchi N, Okazaki O, Kawano S
Organizer
10th International Diabetes Federation- Western Pacific Region Congress (10th IDF-WPR Congress)
Place of Presentation
Suntec, Singapore
Year and Date
2014-11-21 – 2014-11-24
Related Report
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[Presentation] National profile of non-communicable disease risk factors in Bangladesh2014
Author(s)
Mamun AA, Jesmin S, Rahman MA, Habib AKMA, Islam MM, Sultana SN, Khatun T, Sohael F, Shimojo N, Okazaki O, Kawano S
Organizer
10th International Diabetes Federation- Western Pacific Region Congress (10th IDF-WPR Congress)
Place of Presentation
Suntec, Singapore
Year and Date
2014-11-21 – 2014-11-24
Related Report
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[Presentation] Innovation of a potential novel biomarker to predict the risk of developing diabetes in postmenopausal women based on the estrogen-VEGF axis2014
Author(s)
Mamun AA, Jesmin S, Rahman MA, Islam MM, Khatun T, Sultana SN, Moroi M, Yamaguchi N, Okazaki O, Kawano S
Organizer
10th International Diabetes Federation- Western Pacific Region Congress (10th IDF-WPR Congress)
Place of Presentation
Suntec, Singapore
Year and Date
2014-11-21 – 2014-11-24
Related Report
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[Presentation] Metabolic syndrome prevalence and its components among rural Bangladeshi women2014
Author(s)
Mamun AA, Jesmin S, Rahman MA, Islam MM, Khatun T, Sultana SN, Yamaguchi N, Moroi M, Okazaki O, Kawano S.
Organizer
10th International Diabetes Federation- Western Pacific Region Congress (10th IDF-WPR Congress)
Place of Presentation
Suntec, Singapore
Year and Date
2014-11-21 – 2014-11-24
Related Report
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[Presentation] Prevalence of metabolic syndrome components among early age onset acute coronary syndrome patients in Bangladesh2014
Author(s)
Jesmin S, Mamun AA, Rahman MA, Habib AKMA, Islam MM, Sultana SN, Khatun T, Sohael F, Okazaki O, Moroi M, Kawano S.
Organizer
10th International Diabetes Federation- Western Pacific Region Congress (10th IDF-WPR Congress)
Place of Presentation
Suntec, Singapore
Year and Date
2014-11-21 – 2014-11-24
Related Report
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[Presentation] Assessment of circulatory level of endothelin-1 in hypertensive subjects screened through a cross-sectional study in rural Bangladeshi women2014
Author(s)
Jesmin S, Iwashima Y, Islam MM, Rahman MA, Akter S, Hideaki S, Shimojo N, Moroi M, Yamaguchi N, Okazaki O, Kawano S, Kawano Y
Organizer
The 37th Annual Scientific Meeting of the Japanese Society of Hypertension
Place of Presentation
横浜
Year and Date
2014-10-19
Related Report
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[Presentation] Nationwide prevalence, awareness, treatment and control of hypertension among the adult population in Bangladesh2014
Author(s)
esmin S, Iwashima Y, Islam MM, Rahman MA, Habib AKMA, Shimojo N, Moroi M, Yamaguchi N, Okazaki O, Kawano S, Kawano Y
Organizer
The 37th Annual Scientific Meeting of the Japanese Society of Hypertension
Place of Presentation
横浜
Year and Date
2014-10-19
Related Report
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[Presentation] National burden of non-communicable disease risk factors in Bangladesh2014
Author(s)
esmin S, Rahman MA, Kamiyama J, Habib AKMA, Islam MM, Sohael F, Khatun T, Sultana SN, Shimojo N, Okazaki O, Moroi M, Yamaguchi N, Kawano S.
Organizer
The 3rd International Congress on Lipid Metabolism & Atherosclerosis (ICLA 2014)
Place of Presentation
Seoul, Korea
Year and Date
2014-09-12 – 2014-09-13
Related Report
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[Presentation] VEGF angiogenic signaling system in metabolic syndrome: Findings from a cross sectional study conducted in rural Bangladeshi women2014
Author(s)
Jesmin S, Rahman MA, Islam MM, Akter S, Rahman MM, Sultana SN, Yamaguchi N, Shimojo N, Okazaki O, Moroi M, Kawano S.
Organizer
The 3rd International Congress on Lipid Metabolism & Atherosclerosis (ICLA 2014)
Place of Presentation
Seoul, Korea
Year and Date
2014-09-12 – 2014-09-13
Related Report
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[Presentation] Higher level of endothelin-1 in hypertensive Rural Women in Bangladesh. Results of a Community based cross-sectional study2014
Author(s)
Rahman MA, Jesmin S, Iwashima Y, Ali A, Akter S, Khan A, Islam MM, Moroi M, Yamaguchi N, Shimojo N, Kawano S.
Organizer
The 3rd International Congress on Lipid Metabolism & Atherosclerosis (ICLA 2014)
Place of Presentation
Seoul, Korea
Year and Date
2014-09-12 – 2014-09-13
Related Report
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[Presentation] Prevalence of Metabolic Syndrome Components Among Early Age onset Acute Coronary Syndrome Patients in Bangladesh2014
Author(s)
Rahman MA, Jesmin S, Habib AKMA, Haider S, Khan A, Islam MM, Khatun T, Sultana SN, Yamaguchi N, Shimojo N, Kawano S, Moroi M.
Organizer
The 3rd International Congress on Lipid Metabolism & Atherosclerosis (ICLA 2014)
Place of Presentation
Seoul, Korea
Year and Date
2014-09-12 – 2014-09-13
Related Report
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[Presentation] An analysis of association between circulatory level of endothelin-1 and metabolic syndrome in Bangladeshi rural women2014
Author(s)
Rahman MA, Jesmin S, Islam MM, Habib AKMA, Akter S, Shimojo N, Sohael F, Zaedi S, Yamaguchi N, Moroi M, Okazaki O, Hiroe M, Kawano S.
Organizer
The 3rd International Congress on Lipid Metabolism & Atherosclerosis (ICLA 2014)
Place of Presentation
Seoul, Korea
Year and Date
2014-09-12 – 2014-09-13
Related Report
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[Presentation] Metabolic syndrome among rural Bangladeshi women2014
Author(s)
Rahman MA, Jesmin S, Islam MM, Khatun T, Sultana SN, Yamaguchi N, Moroi M, Okazaki O, Hiroe M, Kawano S.
Organizer
The 3rd International Congress on Lipid Metabolism & Atherosclerosis (ICLA 2014)
Place of Presentation
Seoul, Korea
Year and Date
2014-09-12 – 2014-09-13
Related Report
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[Presentation] アピキサバン投与により左房内血栓が消失した頻脈性心房細動によるうっ血性心不全の一例2014
Author(s)
能登辰徳, 榎本喜成, 松田 剛, 牧野健治, 山崎健司, 柴 昌徳, 飯島雷輔, 原 英彦, 野呂眞人, 諸井雅男, 中村正人, 杉 薫
Organizer
第233回日本循環器学会関東甲信越地方会
Place of Presentation
東京
Year and Date
2014-09-06
Related Report
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[Presentation] The predictors of cardiovascular events in hemodialysis patients who unserwent stress myocardial perfusion imaging.2013
Author(s)
Furuhashi T, Moroi M, Joki N, Hase H, Minagawa M, Masai H, Kunimasa T, Fukuda H, Sugi K
Organizer
ICNC 11, Nuclear Cardiology and Cardiac CT.
Place of Presentation
Berlin, Germany
Related Report
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[Presentation] Potential association between disrupted VEGF angiogenic signaling and metabolic syndrome in Bangladeshi rural women,2013
Author(s)
Jesmin S, Akter S, Shimojo N, Islam MM, Zaedi S, Yamaguchi N, Moroi M, Kimura S, Okazaki O, Hiroe M, Kawano S, Akashi H, Mizutani T
Organizer
2013 overseas scientific research Festa
Place of Presentation
東京
Related Report
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[Presentation] Comprehensive assessment of metabolic syndrome prevalence and its components among rural Bangladeshi women2013
Author(s)
Akter S, Jesmin S, Shimojo N, Islam MM, Zaedi S, Yamaguchi N, Moroi M, Kimura S, Okazaki O, Hiroe M, Kawano S, Akashi H, Mizutani T
Organizer
2013 overseas scientific research Festa
Place of Presentation
東京
Related Report
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[Presentation] Potential association between circulatory level of endothelin-1 and metabolic syndrome in Bangladeshi rural women: a population-based cross-sectional study2013
Author(s)
Islam M, Jesmin S, Rahman A, Habib AKMA, Akter S, Shimojo N, Zaedi S, Yamaguchi N, Moroi M, Kimura S, Okazaki O, Hiroe M, Miyauchi T, Kawano S, Akashi H, Mizutani T
Organizer
The Thirteenth International Conference on Endothelin
Place of Presentation
東京
Related Report
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[Presentation] Higher circulatory level of endothelin-1 in hypertensive subjects screened through a cross sectional study in rural Bangladeshi women2013
Author(s)
Akter S, Jesmin S, Rahman A, Habib AKMA, Shimojo N, Islam M, Zaedi S, Yamaguchi N, Moroi M, Kimura S, Okazaki O, Miyauchi T, Kawano S, Akashi H, Mizutani T
Organizer
The Thirteenth International Conference on Endothelin
Place of Presentation
東京
Related Report
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[Presentation] Assessment of circulatory endothelin-1 level among pre- and post-menopausal rural women in Bangladesh: result from a population-based study2013
Author(s)
Khatutn T, Jesmin S, Rahman A, Habib AKMA, Shimojo N, Islam M, Zaedi S, Yamaguchi N, Moroi M, Kimura S, Okazaki O, Miyauchi T, Kawano S, Akashi H, Mizutani T
Organizer
The Thirteenth International Conference on Endothelin
Place of Presentation
東京
Related Report
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[Presentation] elective endothelin (ET)-A receptor antagonist and dual ET-A/B receptor antagonist are effective in preventing the decrease in VEGF signaling and inadequate coronary collateral development in the diabetic hearts2013
Author(s)
Miyauchi Y, Jesmin S, Shimojo N, Maeda S, Sakai S, Yokota T, Zaedi S, Mizutani T, Homma S, Aonuma K, Miyauchi T
Organizer
The Thirteenth International Conference on Endothelin
Place of Presentation
東京
Related Report
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[Presentation] Endothelin antagonism and diabetic erectile dysfunction: Changes in VEGF and NO in type I diabetic penis and effects of endothelin antagonism2013
Author(s)
Zaedi S, Jesmin S, Shimojo N, Sakai S, Maeda S, Miyauchi Y, Yokota T, Mizutani T, Homma S, Aonuma K, Miyauchi T
Organizer
The Thirteenth International Conference on Endothelin
Place of Presentation
東京
Related Report
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[Book] Diabetes Mellitus and Human Health Care2014
Author(s)
1.Jesmin S, Mamun AA, Rahman A, Akter S, Iwashima Y, Shimojo N, Yamaguchi N, Hiroe M, Mizutani T, Moroi M(分担)
Total Pages
520
Publisher
Apple Academic press, Canada
Related Report
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[Book] Diabetes Mellitus and Human Health Care - A Holistic Approach to Diagnosis and Treatment Chapter 12: Development of Therapeutic Strategy to Restore Coronary Microcirculation and VEGF Signaling Cascade in Diabetes: A Novel Approach to Prevent Cardiac Complication in Diabetes.2014
Author(s)
Jesmin S, Rahman A, Mamun AA, Sohael F, Akter S, Iwashima Y, Shimojo N, Yamaguchi N, Hiroe M, Mizutani T, Moroi M.
Total Pages
504
Publisher
Apple Academic Press Inc.
Related Report
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