Role of asymmetric gene expression in projection neurons in the lateral striatum

• Project/Area Number: 24500373
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Jichi Medical University
• Principal Investigator: TAKAHASHI Masanori 自治医科大学, 医学部, 講師 (20361074)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 線条体 / 非対称発現 / ラット / カドヘリン / 左右差 / 該当なし

Outline of Final Research Achievements

In this study, I examined the correlation between distribution of Cdh20+ striatal projection neurons and handedness in inbred rats. We found that the ratio of right-handedness and left-handedness was equal and that the number of Cdh20+ striatal projection neurons increased in the right side of the anterior lateral striatum in right-handed rats. In left-handed rats, the number of Cdh20+ striatal projection neurons was similar in both sides of the anterior lateral striatum. Our results suggest that distribution patterns of Cdh20+ striatal projection neurons may link to the handedness in rats.

Research Products

• [Journal Article] Preparation of rat serum suitable for mammalian whole embryo culture. (2014)
  • Author(s): Takahashi M, Makino S, Kikkawa T, Osumi N.
  • Journal Title: J Vis Exp. Volume: 90 Issue: 90
  • DOI: 10.3791/51969
  • Peer Reviewed
• [Journal Article] Ninein is essential for the maintenance of the cortical progenitor character by anchoring the centrosome to microtubules (2013)
  • Author(s): Hiroshi Shinohara, Nobuyuki Sakayori, Masanori Takahashi, Noiko Osumi
  • Journal Title: Biology Open Volume: 2(7) Issue: 7 Pages: 739-749
  • DOI: 10.1242/bio.20135231
  • Peer Reviewed
• [Journal Article] Dmrtal regulates proneural gene expression downstream of Pax6 in the mammalian telencephalon (2013)
  • Author(s): Takako Kikkawa, Takeshi Obayashi, Masanori Takahashi, Urara Fukuzaki-Dohi, Keiko Numayama-Tsuruta, and Noriko Osumi
  • Journal Title: Genes to Cells Volume: 18(8) Issue: 8 Pages: 636-649
  • DOI: 10.1111/gtc.12061
  • Peer Reviewed
• [Journal Article] Penetration and differentiation of cephalic neural crest-derived cells in the developing mouse telencephalon. (2012)
  • Author(s): Yamanishi, E., Takahashi, M., Saga, Y. and Osumi, N.
  • Journal Title: Dev Growth Differ Volume: 54 Issue: 9 Pages: 785-800
  • DOI: 10.1111/dgd.12007
  • Peer Reviewed
• [Journal Article] Penetration and differentiation of neural crest derived cells in the mouse telencephalon. (2012)
  • Author(s): Yamanishi, E., Takahashi, M., Saga, Y., and Osumi, N.
  • Journal Title: Dev. Growth Differ. Volume: 54 Issue: 8 Pages: 785-800
  • DOI: 10.1038/emboj.2012.43
  • Peer Reviewed
• [Presentation] Role of Six1 for cell proliferation in the periodontal ligament tissue. (2015)
  • Author(s): Kawasaki, T., Takahashi, M., Mori, Y., and Kawakami, K.
  • Organizer: 第48回日本発生生物学会
  • Place of Presentation: 筑波
  • Year and Date: 2015-06-03 – 2015-06-04
• [Presentation] Six4 and Six5 are required for ventral body wall closure and morphogenesis of the primary body wall. (2015)
  • Author(s): Takahashi, M. and Kawakami, K.
  • Organizer: 第48回日本発生生物学会
  • Place of Presentation: 筑波
  • Year and Date: 2015-06-03 – 2015-06-04
• [Presentation] Visualization of zebrafish rhombomere-boundary formation using a modified multiple embryo-mounting method and short-time interval time-lapse confocal microscopy. (2014)
  • Author(s): Takahashi, M., Qiling Xu, and David G Wilkinson.
  • Organizer: 第47回日本発生生物学会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-05-29 – 2014-05-30
• [Presentation] Expression of Six1 in the periodontal ligament and the origin of periodontal ligament stem cells. (2013)
  • Author(s): Kawasaki, T., Takahashi, M., Kusama, M., and Kawakami, K.
  • Organizer: Neural Crest and Cranial Placodes, Gordon Research Conferences
  • Place of Presentation: Stone hill, MA, USA
• [Presentation] The doublesex homolog Dmrta1 regulates the production of early-born neurons in the mammalian cerebral cortex.
  • Author(s): Kikkawa,T., Takahashi, M., Katsuyama, Y., and Osumi, N.
  • Organizer: Neuro 2013
  • Place of Presentation: 京都
• [Presentation] Characterization of Six4/Six5 deficient mice as a novel type of animal models for human omphalocele.
  • Author(s): Takahashi, M. and Kawakami, K.
  • Organizer: 自治医科大学シンポジウム
  • Place of Presentation: 下野
• [Presentation] Characterization of Six4/Six5 deficient mice as a novel type of animal models for human omphalocele.
  • Author(s): Takahashi, M. and Kawakami, K.
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸
• [Presentation] Characterization of Six4/Six5 deficient mice as a novel type of animal models for human omphalocele.
  • Author(s): Takahashi, M. and Kawakami, K.
  • Organizer: 第199回日本解剖学会総会
  • Place of Presentation: 下野
• [Book] Gene transfer into cultured mammalian embryos by electroporation. Neuromethods: Electroporation methods and neuroscience. (2015)
  • Author(s): Takahashi, M., Kikkawa, T., and Osumi, N.
  • Total Pages: 199
  • Publisher: Springer
• [Remarks] 自治医科大学分子病態治療研究センター細胞生物研究部
  • URL: http://www.jichi.ac.jp/biol/home.html
• [Remarks] 自治医科大学大学院医学研究科・基礎系大学院本務講座
  • URL: http://www.jichi.ac.jp/kisokei/
• [Remarks] 自治医科大学 分子病態治療研究センター 細胞生物研究部
  • URL: http://www.jichi.ac.jp/biol/home.html