Single-neuron discrimination in neural circuit formation
| Project/Area Number |
24500375
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Gunma University |
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Principal Investigator |
Kaneko Ryosuke 群馬大学, 医学(系)研究科(研究院), 助教 (40390695)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 神経回路形成 / 小脳 / 局所回路 / 神経ネットワーク / 運動学習 / GABA / 遺伝子改変マウス / プルキンエ細胞 / バスケット細胞 / tdTomato |
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| Outline of Final Research Achievements |
We have discovered that each neurons express random repertoire of clustered protocadherins (Pcdh). In this study, we examined hypothesis “Neurons with the same Pcdh allow connection.” The neural circuit of basket cell-to-Purkinje cell in mouse cerebellum was used as model system. Our aims are: (i)Pcdh-deficient results in neural circuit abnormality, and (ii) connected neuron pairs express the same repertoire of Pcdhs. We have obtained preliminary data supporting our hypothesis.
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Report
(5 results)
Research Products
(23 results)
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[Journal Article] Genetic mapping in mice reveals the involvement of Pcdh9 in long-term social and object recognition, and sensorimotor development.2015
Author(s)
Bruining H., Matsui A., Oguro-Ando A., Kahn R.S., van `t Spijker H.M., Akkermans G., Stiedl O., van Engeland H., Koopmans B., van Lith H.A., Oppelaar H., Tieland L., Nonkes L.J., Yagi T., Kaneko R., Burbach J.P.H., Yamamoto N., and Kas M.J.
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Journal Title
Biological Phychiatry
Volume: S0006-3223
Issue: 7
Pages: 00087-6
DOI
Related Report
Peer Reviewed / Open Access
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