| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
We have discovered that each neurons express random repertoire of clustered protocadherins (Pcdh). In this study, we examined hypothesis “Neurons with the same Pcdh allow connection.” The neural circuit of basket cell-to-Purkinje cell in mouse cerebellum was used as model system. Our aims are: (i)Pcdh-deficient results in neural circuit abnormality, and (ii) connected neuron pairs express the same repertoire of Pcdhs. We have obtained preliminary data supporting our hypothesis.
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