Single-neuron discrimination in neural circuit formation

2015 Fiscal Year Final Research Report

• Project/Area Number: 24500375
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Gunma University
• Principal Investigator: Kaneko Ryosuke 群馬大学, 医学(系)研究科(研究院), 助教 (40390695)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 神経回路形成 / 小脳 / 局所回路 / 神経ネットワーク / 運動学習

Outline of Final Research Achievements

We have discovered that each neurons express random repertoire of clustered protocadherins (Pcdh). In this study, we examined hypothesis “Neurons with the same Pcdh allow connection.” The neural circuit of basket cell-to-Purkinje cell in mouse cerebellum was used as model system. Our aims are: (i)Pcdh-deficient results in neural circuit abnormality, and (ii) connected neuron pairs express the same repertoire of Pcdhs. We have obtained preliminary data supporting our hypothesis.

Free Research Field

神経発生・再生