The onset mechanism of neurodegenerative diseases caused by mutation in the genes encoding lamins and nuclear lamina associated proteins.
| Project/Area Number |
24500426
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Nerve anatomy/Neuropathology
|
|---|
| Research Institution | Kansai Medical University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
YAMADA Hisao 関西医科大学, 医学部, 教授 (00142373)
WAKABAYASHI Taketoshi 関西医科大学, 医学部, 准教授 (90302421)
MORI Tetsuji 関西医科大学, 医学部, 准教授 (30285043)
WADA Yukie (HIRAHARA Yukie) 関西医科大学, 医学部, 助教 (70457969)
KUROKAWA Kiyoshi 大阪国際大学, 人間科学部, 教授 (40215083)
KOSAKA Jun 岡山大学, 医歯(薬)学総合研究科, 准教授 (40243216)
KOIKE Taro 関西医科大学, 医学部
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | 神経科学 / 細胞・組織 / 蛋白質 / 脳・神経 / 発生・分化 / 核膜 / 核ラミナ / ラミン / 細胞分化 / ニューロン / グリア細胞 / 細胞骨格 / 脳 / 細胞増殖 |
|---|
| Outline of Final Research Achievements |
Mutations in genes encoding lamins and nuclear lamina associated proteins cause diverse human congenital diseases including neurodegenerative disorders. In this study, we investigated the distribution of lamin and nuclear lamina associated proteins in the central nervous system using immunohistochemical method to reveal the onset mechanism of these neurodegenerative diseases. We have revealed the expression patterns for lamin subtypes during neurogenesis in the adult ferret brain, and the composition of lamin subtypes in glial cell types as well as the composition of nuclear lamina associated proteins in neural cell types in the adult rat brain.
|
Report
(4 results)
Research Products
(28 results)
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 鶏胚脊髄オリゴデンドロサイトO4抗原の実態解析2014
Author(s)
平原幸恵, 若林毅俊, 森徹自, 小池太郎, 高森康晴, 矢尾育子, 伊藤誠二, 後藤仁志, 本家孝一, 小野勝彦, 山田久夫
Organizer
第119回日本解剖学会総会・全国学術集会
Place of Presentation
栃木（自治医科大学キャンパス）
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
