Pathological analysis and standardization of iron-induced epileptic lesions

• Project/Area Number: 24500430
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: ARAI Nobutaka 公益財団法人東京都医学総合研究所, 病院等連携研究センター, 副所長 (10167984)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: てんかん / 鉄 / 脳外科治療 / 焦点病理診断 / 海綿状血管腫 / アストロサイト / foamy spheroid body

Outline of Final Research Achievements

This study clarified a form of the astrocytic abnormality (named foamy spheroid body), probably induced by iron composure, with abundant hemosiderin pigments in cases of cavernous hemangioma and post-traumatic lesions. In addition, this study reveled that the much iron composure around the lesions got the epileptogenic nature In the hippocampus of mesial temporal lobe epilepsy after head injuries, many iron-deposits appeared unexpectedly. It was thought that such knowledge would contribute for strategic planning of the epilepsy surgery treatment.

Research Products

• [Journal Article] Surgery for amygdala enlargement with medial temporal lobe epilepsy: pathological findings and seizure outcome (2014)
  • Author(s): Minami N, Morino M, Uda T. komori T, Arai N, Kohmura E, Nakano I
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 33 Issue: 8 Pages: 459-468
  • DOI: 10.1136/jnnp-2014-308383
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Dysembryoplastic neuroeithelial tumor, a pure glial Tumor? Immunohistochemical and morphometric studies (2013)
  • Author(s): Komori T, Arai N
  • Journal Title: Neuropathology Volume: in press Issue: 4 Pages: 459-468
  • DOI: 10.1111/neup.12033
  • Peer Reviewed
• [Journal Article] Classification of epileptogenic cerebral malformation: guide to understand the present conditions (2013)
  • Author(s): Arai N
  • Journal Title: Brain & Nerve Volume: 65 Pages: 531-540
  • NAID: 40019688329
  • Peer Reviewed
• [Journal Article] Good interobserver and intraobserver agreement in the evaluation of the new ILAE classification of focal cortical dysplasia (2012)
  • Author(s): Coras R, Arai N, et al/
  • Journal Title: Epilepsia Volume: 53 Issue: 8 Pages: 1341-1348
  • DOI: 10.1111/j.1528-1167.2012.03508.x
  • Peer Reviewed
• [Presentation] 難治性てんかん焦点部における鉄沈着様式 (2015)
  • Author(s): 新井信隆
  • Organizer: 第49回日本てんかん学会
  • Place of Presentation: 長崎ブリックホール（長崎県）
  • Year and Date: 2015-10-30 – 2015-10-31
• [Presentation] 中枢神経系検索のポイント (2014)
  • Author(s): 新井信隆
  • Organizer: 第65回日本病理学会関東支部学術集会
  • Place of Presentation: 横浜市立大学医学部
  • Year and Date: 2014-12-20
  • Invited
• [Presentation] 鉄リサイクル異常によるてんかん病理
  • Author(s): 新井信隆
  • Organizer: 第55回日本小児神経学会
  • Place of Presentation: 大分市
  • Invited
• [Presentation] 脳神経病理データベースを活用したてんかん病理診断の均霑化
  • Author(s): 新井信隆、関絵里香、植木信子、八木朋子、山西常美、赤沢年一、小森隆司、森野道晴
  • Organizer: 第47回日本てんかん学会
  • Place of Presentation: 北九州市
• [Presentation] 鉄暴露によるてんかん原性病変
  • Author(s): 新井信隆
  • Organizer: 第53回日本小児神経学会
  • Place of Presentation: 大分
  • Invited
• [Book] 臨床てんかん学（分担執筆） (2015)
  • Author(s): 新井信隆
  • Publisher: 医学書院
• [Remarks] 東京都医学研・脳神経病理データベース
  • URL: http://pathologycenter.jp
• [Remarks] 医学研・脳神経病理データベース
  • URL: http://pathologycenter.jp