Relationship between onset of T cell leukemia and immunodeficiency in young age in a mouse model of adult T-cell leukemia
Project/Area Number |
24500493
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory animal science
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Research Institution | Rakuno Gakuen University (2014) Kumamoto University (2012-2013) |
Principal Investigator |
OHSUGI Takeo 酪農学園大学, 獣医学群, 教授 (00211102)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | HTLV-1 / animal model / mice / immunodeficiency / Tax / 遺伝子改変マウス / Dokファミリー / 成人T細胞白血病 / ATL / HAM/TSP / 皮膚炎 / 免疫不全 / ATLL |
Outline of Final Research Achievements |
Transgenic (Tg) mice expressing Tax, a human T-cell leukemia virus type 1 (HTLV-1) developed a mature T-cell leukemia similar to adult T-cell leukemia. While expanding the Tax-Tg mouse colony, we found several mice within 6 months of ages developed infectious dermatitis. These mice could not eliminate the inoculated bacteria in the skin. In addition, Treg cells (CD4+CD25+Foxp3+) counts were increased in these mice. Thus, the mice are considered to be an immunodeficiency state. Next, we investigated to compare the incidence of T cell leukemia between immunodeficiency and normal mice possessed the possibility of elimination of inoculated bacteria in Tax-Tg mice. There was no significant difference for leukemia onset in the two mouse groups.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Natural infection of murine norovirus in conventional and specific pathogen-free laboratory mice.2013
Author(s)
Ohsugi, T., Matsuura, K., Kawabe, S., Nakamura, N., Kumar, J. M., Wakamiya, M., Morikawa, S. and Urano, T.
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Journal Title
Frontiers in Microbiology
Volume: 4
Pages: 12-12
DOI
Related Report
Peer Reviewed
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[Journal Article] Invasion of Histiocytic Sarcoma into the Spinal Cord of HTLV-1 Tax Transgenic Mice with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis-Like Disease.2013
Author(s)
Ohsugi, T., Wakamiya, M., Morikawa, S., Matsuura, K., Kumar, J. M., Kumasaka, T. and Yamaguchi, K.
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Journal Title
Oncology Research
Volume: 20
Issue: 9
Pages: 403-410
DOI
Related Report
Peer Reviewed
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[Journal Article] Viral interference with host mRNA surveillance, the nonsense-mediated mRNA decay (NMD) pathway, through a new function of HTLV-1 Rex: implications for retroviral replication.2013
Author(s)
Nakano, K., Ando, T., Yamagishi, M., Yokoyama, K., Ishida, T., Ohsugi, T., Tanaka, Y., Brighty, D. W. and Watanabe, T.
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Journal Title
Microbes and Infection
Volume: 15
Issue: 6-7
Pages: 491-505
DOI
Related Report
Peer Reviewed
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[Journal Article] Tamoxifen resistant, ER positive MAC 51 cell line with high metastatic potential developed from spontaneous breast cancer mouse model.2012
Author(s)
Kumar, J. M., Shivakumar, P., Nagarajan, P., Subramaniyam, T., Jose, J., Ganapathy, H. S. and Ohsugi, T.
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Journal Title
Cell Tissue Res.
Volume: 350
Pages: 347-360
Related Report
Peer Reviewed
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