| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Transgenic (Tg) mice expressing Tax, a human T-cell leukemia virus type 1 (HTLV-1) developed a mature T-cell leukemia similar to adult T-cell leukemia. While expanding the Tax-Tg mouse colony, we found several mice within 6 months of ages developed infectious dermatitis. These mice could not eliminate the inoculated bacteria in the skin. In addition, Treg cells (CD4+CD25+Foxp3+) counts were increased in these mice. Thus, the mice are considered to be an immunodeficiency state. Next, we investigated to compare the incidence of T cell leukemia between immunodeficiency and normal mice possessed the possibility of elimination of inoculated bacteria in Tax-Tg mice. There was no significant difference for leukemia onset in the two mouse groups.
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