Super-low-invasive drag Surgery system using photonic DNA nano-machine

• Project/Area Number: 24500546
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical systems
• Research Institution: Osaka University
• Principal Investigator: YAMADA Kenji 大阪大学, 医学(系)研究科(研究院), 教授 (70364114)
• Co-Investigator(Renkei-kenkyūsha): OGURA Yusuke 大阪大学, 大学院情報科学研究科, 准教授 (20346191)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
• Keywords: DNA / 低侵襲治療システム / 内視鏡 / リポソーム / 光ピンセット

Outline of Final Research Achievements

We have proposed a super-low-invasive drag Surgery system using photonic DNA nano-machine. Although it is minimally invasive in screening and treatment by endoscopic for the elderly, the development of diagnostic and treatment technology is desired to be even less in the physical fitness surface. In this study, we aimed to establish a basic element technology to remove the diseased part by photonic DNA nano-machine. This system is able to have clung selectively the affected part is self-assemble.

Research Products

• [Journal Article] ポイントオブケア治療薬物モニタリングに向けた紙製基板を用いた涙液ラマン分光の可能性 (2015)
  • Author(s): 横山萌恵，西村隆宏，山田憲嗣，丁憙勇，木戸倫子，櫻井芳昭，大野ゆう子
  • Journal Title: 看護理工学会誌 Volume: vol. 1, no. 2 Pages: 25-31
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Gastric Contraction Imaging System Using a 3-D Endoscope (2014)
  • Author(s): Kayo Yoshimoto, Kenji Yamada, Kenji Watabe, Maki Takeda, Takahiro Nishimura, Michiko Kido, Toshiaki Nagakura, Hideya Takahashi, Tsutomu Nishida, Hideki Iijima, Masahiko Tsujii, Tetsuo Takehara, Yuko Ohno
  • Journal Title: IEEE Journal of Translational Engineering in Health and Medicine Volume: vol.2, no.1 Pages: 1-8
  • DOI: 10.1109/jtehm.2014.2298852
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Silicone rubber membrane tactile sensor for endoscope based on image processing (2014)
  • Author(s): Yuma Kitanouma, Hideya Takahashi, Kayo Yoshimoto, Kenji Yamada
  • Journal Title: ICIC Express Letters PartB: Applications Volume: vol.5, no.1 Pages: 279-284
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Biomolecule-to-fluorescent-color encoder: modulation of fluorescence emission via DNA structural changes (2014)
  • Author(s): Takahiro Nishimura, Yusuke Ogura, Kenji Yamada, Yuko Ohno, Jun Tanida
  • Journal Title: Biomedical Optics Express 5 Volume: 9;5(7) Issue: 7 Pages: 2082-2090
  • DOI: 10.1364/boe.5.002082
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Raman spectroscopy of tear fluid with paper substrate for Point-of-care therapeutic drug monitoring (2015)
  • Author(s): Moe Yokoyama, Kenji Yamada, Takahiro Nishimura, Michiko Kido, Hieyong Jeong, Yuko Ohno
  • Organizer: SPIE Photonics West 2015
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2015-02-07 – 2015-02-12
• [Presentation] Gastrointestinal tract volume measurement method using a compound eye type endoscope (2015)
  • Author(s): Kayo Yoshimoto, Kenji Yamada, Kenji Watabe, Michiko Kido, Toshiaki Nagakura, Hideya Takahashi, Tsutomu Nishida, Hideki Iijima, Masahiko Tsujii, Tetsuo Takehara, Yuko Ohno
  • Organizer: SPIE Photonics West 2015
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2015-02-07 – 2015-02-12
• [Presentation] 360-degree three-dimensional flat panel display using holographic optical elements (2015)
  • Author(s): Hirofumi Yabu, Yusuke Takeuchi, Kayo Yoshimoto, Hideya Takahashi, Kenji Yamada
  • Organizer: IS&T/SPIE Electronic Imaging 2015
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2015-02-07 – 2015-02-12
• [Presentation] "TOMBOデバイスの医療応用" (2014)
  • Author(s): 山田憲嗣
  • Organizer: 光とレーザーの科学技術フェアー光技術で飛躍する日本へー
  • Place of Presentation: 科学技術館（東京 北の丸公園内）
  • Year and Date: 2014-11-20
  • Invited
• [Presentation] Paper-based Raman spectroscopy for on-site therapeutic drug monitoring (2014)
  • Author(s): Moe Yokoyama, Takahiro Nishimura, Kenji Yamada, Yuko Ohno
  • Organizer: IEEE EMBS Special Topic Conference on Healthcare Innovation & Point-of-Care Technologies (HIC-POCT 2014)
  • Place of Presentation: Seattle, WA, USA
  • Year and Date: 2014-10-08 – 2014-10-10
• [Presentation] 涙液のラマン分光に基づくポイントオブケア治療薬物モニタリング (2014)
  • Author(s): 横山萌恵, 山田憲嗣, 西村隆宏, 木戸倫子, 丁憙勇, 大野ゆう子
  • Organizer: 第2回看護理工学会学術集会
  • Place of Presentation: 大阪大学 豊中キャンパス
  • Year and Date: 2014-10-04 – 2014-10-05
• [Presentation] バイオマーカーの簡易検出に向けた蛍光増幅・カラー符号化法の開発 (2014)
  • Author(s): 西村隆宏, 山田憲嗣, 大野ゆう子
  • Organizer: 第2回看護理工学会学術集会
  • Place of Presentation: 大阪大学 豊中キャンパス
  • Year and Date: 2014-10-04 – 2014-10-05
• [Presentation] 涙液中の薬物モニタリングに向けたラマン分光システム (2014)
  • Author(s): 横山萌恵, 西村隆宏, 山田憲嗣, 大野ゆう子
  • Organizer: 第75回 応用物理学会秋季学術講演会
  • Place of Presentation: 北海道大学
  • Year and Date: 2014-09-17 – 2014-09-20
• [Presentation] Photonic DNA Processors for Optical Communication Between Nano and Macro World (2014)
  • Author(s): Takahiro Nishimura, Yusuke Ogura, Kenji Yamada, Yuko Ohno, Jun Tanida
  • Organizer: 2014 International Symposium on Nonlinear Theory and its Applications
  • Place of Presentation: Luzern, Switzerland
  • Year and Date: 2014-09-14 – 2014-09-18
• [Presentation] Fluorescence amplification based on DNA structural changes for enzyme-free detection of microRNA (2014)
  • Author(s): Takahiro Nishimura, Yusuke Ogura, Kenji Yamada, Yuko Ohno, Jun Tanida
  • Organizer: 2014 World Autmation Congress
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2014-08-03 – 2014-08-07
• [Presentation] Paper-based Raman spectroscopy for on-site therapeutic drug monitoring (2014)
  • Author(s): Moe Yokoyama, Takahiro Nishimura, Kenji Yamada, Michiko Kido, Yoshiaki Sakurai, Daiki Mita, Yoshinori Yamaguchi, Eiichi Tamiya, Toshiaki Nagakura, Yuko Ohno
  • Organizer: 2014 World Autmation Congress
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2014-08-03 – 2014-08-07
• [Presentation] Feasibility Study of Multiplex Biomolecular Detection based on Biomolecule-to-fluorescence-color Encode (2014)
  • Author(s): Takahiro Nishimura, Yusuke Ogura, Kenji Yamada, Yuko Ohno, Jun Tanida
  • Organizer: The 1st Biomedical Imaging and Sensing Conference
  • Place of Presentation: Pacifico Yokohama
  • Year and Date: 2014-04-22 – 2014-04-24
• [Presentation] Evaluation of the three-dimensional endoscope system for assessing the gastrointestinal motility (2014)
  • Author(s): Yoshimoto K, Yamada K, Watabe K, Takeda M, Nishimura T, Kido M, Nagakura T, Takahashi H, Nishida T, Iijima H, Tsujii M, Takehara T, Ohno Y
  • Organizer: SPIE Photonics West 2014
  • Place of Presentation: Moscone Center San Francisco, CA, United States
• [Presentation] Dual-Band Multi-Aperture Enhanced Redox Imaging of Colonic Adenomas for Endoscopes with a High-Performance CMOS Imager (2013)
  • Author(s): Kagawa K, Zhang B, Seo M, Kawahito S, Kominami Y, Yamada K, Yoshida S, Tanaka S
  • Organizer: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Osaka International Convention Center
• [Presentation] Photonic DNA Proces- sors with Fluorescence Resonance Energy Transfer-Based Signaling (2013)
  • Author(s): Nishimura T, Ogura Y, Yamada K, Yamamoto H, Tanida J
  • Organizer: CLEO-PR&OECC/PS 2013
  • Place of Presentation: Kyoto International Conference Center
• [Presentation] Silicone rubber membrane tactile sensor for endoscope based on image processing (2013)
  • Author(s): Kitanouma Y, Takahashi H, Yoshimoto K, Yamada K
  • Organizer: 8th International Conference on Innovative Computing, Information and Control
  • Place of Presentation: Kumamoto City International Center
• [Presentation] Amplification and encoding of biomolecular signals with designed reactions of DNA (2013)
  • Author(s): Nishimura T, Ogura Y, Yamada K, Yamamoto H, Ohno Y,Tanida J
  • Organizer: Biomedical Engineering International Conference 2013
  • Place of Presentation: The Pavilion Queen’s bay HotelKrabi, Thailand
• [Presentation] 蛍光カラー符号化による簡易分子スクリーニング技術の検討 (2013)
  • Author(s): 西村隆宏，小倉裕介，山田憲嗣，大野ゆう子，谷田 純
  • Organizer: 生活生命支援医療福祉工学系連合大会(LIFE2013)
  • Place of Presentation: 山梨大学(甲府キャンパス)
• [Presentation] One-potでの多数生体分子の同時検出に向けた蛍光カラー符号化の検討 (2013)
  • Author(s): 西村隆宏，山田憲司，大野ゆう子
  • Organizer: 第1回看護理工学会学術集会
  • Place of Presentation: 東京大学(本郷キャンパス)
• [Presentation] Evaluation of a compound eye type tactile endoscope (2013)
  • Author(s): Kayo Yoshimoto, Kenji Yamada, Nagisa Sasaki, Maki Takeda, Sachiko Shimizu, Toshiaki Nagakura, Hideya Takahashi, Yuko Ohno
  • Organizer: SPIE Photonics West 2013
  • Place of Presentation: Moscone Center San Francisco, California, USA
• [Presentation] Development of tactile sensor using TOMBO (2012)
  • Author(s): Yamada K，Yoshimoto K，Takeda M，Nagakura T，Ishihara K，Ohno Y
  • Organizer: SPIE Optics+Photonics 2012
  • Place of Presentation: San Diego Convention Center San Diego, California, USA
• [Presentation] Variable Field-Of-View Visible and Near-Infrared Polarization Compound-Eye Endoscope (2012)
  • Author(s): Kagawa K，Shogenji R，Tanaka E，Yamada K，Kawahito S，Tanida J
  • Organizer: 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC2012)
  • Place of Presentation: Hilton San Diego Bayfront San Diego, California, USA
• [Presentation] Compound-eye type tactile endoscope (2012)
  • Author(s): Yoshimoto K，Yamada K，Sasaki N，Takeda M，Shimizu S，Ohno Y
  • Organizer: World Congress on Medical Physics and Biomedical Engineering
  • Place of Presentation: Beijing International Convention Center Beijing, China
• [Presentation] カプセル内視鏡画像の病変部検出に関する基礎検討 (2012)
  • Author(s): 川合真子，瀬戸山浩平，山田憲嗣，吉田成人，高橋秀也，道田智樹，平尾素弘，河原邦光，長倉俊明
  • Organizer: 第51回生体医工学会大会
  • Place of Presentation: 福岡国際会議場 福岡
• [Presentation] 複眼型触覚内視鏡の検討 (2012)
  • Author(s): 吉本佳世，山田憲嗣，佐々木なぎさ，武田真季，清水佐知子，大野ゆう子
  • Organizer: 第51回生体医工学会大会
  • Place of Presentation: 福岡国際会議場 福岡
• [Book] TOMBOデバイスの医療応用 (2014)
  • Author(s): 山田憲嗣, 吉本佳世
  • Publisher: Medical&Imaging
• [Book] 5 ロボット工学との融合，予防とつきあい方シリーズ [改訂版]老年病・認知症～長寿の秘訣～ 老年病 4 新しい医療への期待 (2013)
  • Author(s): 山田憲嗣（分担執筆）
  • Total Pages: 237
  • Publisher: 株式会社メディカルレビュー社
• [Remarks] 大阪大学大学院医学系研究科 ロボティクス&デザイン看工融合共同研究講座
  • URL: http://sahswww.med.osaka-u.ac.jp/~kangoeng/index.html
• [Remarks] 大阪大学大学院医学系研究科 ロボティクス＆デザイン看工融合(Panasonic)共同研究講座
  • URL: http://sahswww.med.osaka-u.ac.jp/~kangoeng/works.html