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Elucidation of enhanced process in aging central nerve by the running and balance exercise

Research Project

Project/Area Number 24500598
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionSaitama Prefectural University

Principal Investigator

KANEMURA Naohiko  埼玉県立大学, 保健医療福祉学部, 准教授 (20379895)

Co-Investigator(Kenkyū-buntansha) TAKAYANAGI Kiyomi  埼玉県立大学, 保健医療福祉学部, 教授 (20274061)
Co-Investigator(Renkei-kenkyūsha) IMAGITA Hidetaka  畿央大学, 健康科学部, 教授 (00412148)
MORIYAMA Hideki  神戸大学大学院, 保健学研究科, 教授 (10438111)
MAEJIMA Hiroshi  北海道大学院, 保健学研究院, 教授 (60314746)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords老化 / 走行運動 / バランス運動 / 中枢神経可塑性 / 運動 / 神経活性化 / 脊髄神経 / 活性化プロセス
Outline of Final Research Achievements

Moderate exercise, the release of neurotrophic factors is increased , neural activity is activated. In this study, whether it is possible to activate the nervous system that has been decreased by aging and to verify the effect of the running and balance exercise. Activation of the motor neurons stained of the lumbar spinal cord was less change in some exercise. Their expression of neurotrophins, neurogenesis and neurpeptide were enhanced and the activity of apotosis wad down-regulated by locomotor exercise in the spinal cord of the difference of age. Improvements due to the motion, not the nerve itself, it is necessary to consider in the pleiotropic functions for related factors activated neural activity.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2014 2013 2012

All Presentation (5 results)

  • [Presentation] 運動様式の違いが老齢ラット腰髄神経活性化に与える影響2014

    • Author(s)
      金村尚彦,村田健児,国分貴徳, 武本秀徳、今北英高、藤野努、森山英樹,
    • Organizer
      第33回関東甲信越ブロック理学療法士学会
    • Place of Presentation
      千葉
    • Year and Date
      2014-10-25 – 2014-10-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] トレッドミル走行運動がラット脊髄におけるBDNF発現量に与える影響2014

    • Author(s)
      吉野晃平 森下佑里 中島彩 金村尚彦
    • Organizer
      第33回関東甲信越ブロック理学療法士学会
    • Place of Presentation
      千葉
    • Year and Date
      2014-10-25 – 2014-10-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Exercise on a moving platform elicits different gene expression of neurotrophins and receptors in the spinal cord of aged rats2013

    • Author(s)
      Naohiko Kanemura, Hidetaka Imagita, Hiroshi Maejima, Kenji Murata, Takanori Kokubun, Kiyomi Takayanagi
    • Organizer
      Experimantal Biology
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] ラット脊髄におけるグリア細胞株由来栄養因子-受容体mRNA発現量に対するバランス運動の影響2013

    • Author(s)
      金村尚彦,森山英樹,今北英高, 前島洋,武本 秀徳,木藤伸宏, 国分貴徳,村田健児,五味敏昭,高柳清美
    • Organizer
      第48回日本理学療法学術大会
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Research-status Report
  • [Presentation] Locomoter exercise enhances selectively their expression of neurotrphins and receptors in the spinal cord of aged rats2012

    • Author(s)
      Kanemura N, Moriyama H, Takemoto H, Imagita H, Maejima H,Kokubun T ,Nishihara K, Takayanagi K
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      Morial Convention Center,New Orleans, United state of America
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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