| Project/Area Number |
24500632
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kumamoto Health Science University |
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Principal Investigator |
IIYAMA junichi 熊本保健科学大学, 保健科学部, 教授 (00398299)
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| Co-Investigator(Kenkyū-buntansha) |
IWASHITA Yoshihiro 熊本保健科学大学, 保健科学部リハビリテーション学科, 講師 (70623510)
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| Co-Investigator(Renkei-kenkyūsha) |
KITAMURA Kenichirou 山梨大学, 大学院医学工学総合研究部, 教授 (10304990)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | rehabilitation medicine / physical therapy / renal dysfunction / mild thermal stimulation / renal tubular damage / 慢性腎臓病モデル / 低温サウナ / 尿細管障害 / 蛋白尿 / 血管内皮機能 / 一酸化窒素 / 一酸化窒素合成酵素 / 慢性腎不全 / 温熱 / 腎不全 / 糸球体内圧 |
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| Outline of Final Research Achievements |
The purpose of our study is to investigate whether mild thermal stimulation (MTS), which causes rectal temperature elevation of approximately 2ºC, would influence on renal ablation model mice. Two weeks after the preparation of 5/6 nephrectomy in mice of the 129x1/SvJ strain background, they were exposed to once-daily MTS for 4 weeks. Serum creatinine and urine albumin levels were reduced significantly in MTS group. Lipocalin-2(NGAL) mRNA and Urine N-acetyl-beta-D-glucosaminidase (NAG) level was decreased without significance. Renal tubular damages were milder in MTS than in non-MTS. MTS exerted protective effects on tubular injury after renal ablation. These results suggest the possibility of systemic thermal stimulation as a potential non-pharmacological therapy against renal failure.
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