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the effects of low temperature sauna for end-stage renal failure

Research Project

Project/Area Number 24500632
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKumamoto Health Science University

Principal Investigator

IIYAMA junichi  熊本保健科学大学, 保健科学部, 教授 (00398299)

Co-Investigator(Kenkyū-buntansha) IWASHITA Yoshihiro  熊本保健科学大学, 保健科学部リハビリテーション学科, 講師 (70623510)
Co-Investigator(Renkei-kenkyūsha) KITAMURA Kenichirou  山梨大学, 大学院医学工学総合研究部, 教授 (10304990)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsrehabilitation medicine / physical therapy / renal dysfunction / mild thermal stimulation / renal tubular damage / 慢性腎臓病モデル / 低温サウナ / 尿細管障害 / 蛋白尿 / 血管内皮機能 / 一酸化窒素 / 一酸化窒素合成酵素 / 慢性腎不全 / 温熱 / 腎不全 / 糸球体内圧
Outline of Final Research Achievements

The purpose of our study is to investigate whether mild thermal stimulation (MTS), which causes rectal temperature elevation of approximately 2ºC, would influence on renal ablation model mice. Two weeks after the preparation of 5/6 nephrectomy in mice of the 129x1/SvJ strain background, they were exposed to once-daily MTS for 4 weeks. Serum creatinine and urine albumin levels were reduced significantly in MTS group. Lipocalin-2(NGAL) mRNA and Urine N-acetyl-beta-D-glucosaminidase (NAG) level was decreased without significance. Renal tubular damages were milder in MTS than in non-MTS. MTS exerted protective effects on tubular injury after renal ablation. These results suggest the possibility of systemic thermal stimulation as a potential non-pharmacological therapy against renal failure.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2015 2014 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (5 results)

  • [Journal Article] A Possible Reno-protective Effect of Systemic Thermal Stimulation in a Mouse Remnant Kidney Model2015

    • Author(s)
      Yoshihiro IWASHITA, Yoshiyasu YOZA, Hiroki KAMEYAMA, Masashi MUKOYAMA, Junich IIYAMA, Kenichiro KITAMURA
    • Journal Title

      The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine

      Volume: 78 Issue: 2 Pages: 118-129

    • DOI

      10.11390/onki.78.118

    • NAID

      130005129611

    • ISSN
      0029-0343, 1884-3697
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 低温サウナ治療が5/6腎摘除モデルマウスの尿タンパクを抑制する可能性2014

    • Author(s)
      岩下佳弘 飯山準一 與座義康
    • Organizer
      第49回日本理学療法学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-05-30 – 2014-06-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 慢性腎不全モデルマウスへの温熱刺激による腎保護作用の可能性2013

    • Author(s)
      岩下佳弘
    • Organizer
      腎臓リハビリテーション学会
    • Place of Presentation
      栃木
    • Related Report
      2012 Research-status Report
  • [Presentation] 低温乾式サウナが慢性腎不全マウスに及ぼす影響2013

    • Author(s)
      飯山準一
    • Organizer
      日本温泉気候物理医学会
    • Place of Presentation
      別府
    • Related Report
      2012 Research-status Report
  • [Presentation] 低温乾式サウナが慢性腎不全マウスに及ぼす影響

    • Author(s)
      飯山準一、岩下佳弘、與座嘉康
    • Organizer
      第78回日本温泉気候物理医学会総会・学術集会
    • Place of Presentation
      別府
    • Related Report
      2013 Research-status Report
  • [Presentation] 慢性腎不全モデルマウスへの温熱刺激による腎組織でのeNOS発現

    • Author(s)
      岩下佳弘、與座嘉康、飯山準一
    • Organizer
      第48回日本理学療法学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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