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Effects of physical exercise preconditioning on cerebrovascular damage in rat hippocampus.

Research Project

Project/Area Number 24500790
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Sports science
Research InstitutionKagawa University

Principal Investigator

sumitani kazunori  香川大学, 医学部, その他 (40294772)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Takehiro  香川大学, 医学部, 准教授 (80419506)
MIKI Takanori  香川大学, 医学部, 教授 (30274294)
OKADA Hiroki  香川大学, 医学部, 教授 (00243775)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords軽運動 / プレコンディショニング / 脳神経細胞 / 樹状突起 / 脳出血 / 高血圧予防 / マイクログリア / 運動
Outline of Final Research Achievements

Physical exercise preconditioning is becoming generalized in patients with hypertension to reduce a risk factor of cerebrovascular diseases Based on such therapeutic framework, we examined whether physical exercise preconditioning prior to the intracranial-hemorrhage can attenuate the cerebrovascular damage in rat hippocampus or not. Present study revealed that physical exercise preconditioning prior to intracranial hemorrhage can attenuate neuronal damages in both young and aged animals. However, precise etiological mechanisms involved in the preconditioning effects on the brain is unknown at present. Further studies are needed to clarify this phenomenon.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results)

  • [Presentation] 脳出血モデルでの運動プレコンディショニングの検討2015

    • Author(s)
      住谷和則、三木崇範、宮本賢作、山神眞一、中川真衣、西屋克己、岡田宏基
    • Organizer
      第70回 日本体力医学会大会
    • Place of Presentation
      和歌山県民文化会館・ほてるアバローム紀の国
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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