Effects of physical exercise preconditioning on cerebrovascular damage in rat hippocampus.
| Project/Area Number |
24500790
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Takehiro 香川大学, 医学部, 准教授 (80419506)
MIKI Takanori 香川大学, 医学部, 教授 (30274294)
OKADA Hiroki 香川大学, 医学部, 教授 (00243775)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 軽運動 / プレコンディショニング / 脳神経細胞 / 樹状突起 / 脳出血 / 高血圧予防 / マイクログリア / 運動 |
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| Outline of Final Research Achievements |
Physical exercise preconditioning is becoming generalized in patients with hypertension to reduce a risk factor of cerebrovascular diseases Based on such therapeutic framework, we examined whether physical exercise preconditioning prior to the intracranial-hemorrhage can attenuate the cerebrovascular damage in rat hippocampus or not. Present study revealed that physical exercise preconditioning prior to intracranial hemorrhage can attenuate neuronal damages in both young and aged animals. However, precise etiological mechanisms involved in the preconditioning effects on the brain is unknown at present. Further studies are needed to clarify this phenomenon.
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Report
(5 results)
Research Products
(1 results)
