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Elucidation of lifestyle-related disease prevention effect of local vegetables and its application to the activation of local industry

Research Project

Project/Area Number 24500987
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionOsaka City University

Principal Investigator

KOJIMA-YUASA Akiko  大阪市立大学, 大学院生活科学研究科, 准教授 (90295709)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords健康と食生活 / 生活習慣病 / 食品成分 / アルコール性肝疾患 / 肥満 / 創傷治癒 / なにわ伝統野菜 / 栄養学 / 食品 / 地域連携 / 脂肪細胞 / 肝細胞
Outline of Final Research Achievements

To clarify the scientific knowledge about the preventive effect of lifestyle-related diseases by local traditional vegetables in Osaka, Japan, we examined the effect of an extract of Tamatsukurikuromon-shirouri (TS), a Japanese pickling melon (Cucumis Melo var. Conomon), on ethanol-induced liver injury, obesity and skin wound healing. As a result, the extract of TS had an ability of prevent of ethanol-induced liver injury and obesity. The extract of TS had also the promotive activity of skin wound healing. However, the extract of Shirouri, a popular pickled melon had no effect.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (29 results)

All 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 1 results) Presentation (18 results) (of which Invited: 2 results) Book (2 results)

  • [Journal Article] The synergistic effect of 1'-acetoxychavicol acetate and sodium butyrate on the death of human hepatocellular carcinoma cells2014

    • Author(s)
      Kato, R., Matsui-Yuasa, I., Azuma, H. and Kojima-Yuasa, A.
    • Journal Title

      Chemico-Biological Interactions

      Volume: 212 Pages: 1-10

    • DOI

      10.1016/j.cbi.2014.01.010

    • NAID

      120006546960

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2019726

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Yerba-mate (Ilex paraguariensis) extract prevents ethanol-induced liver injury in rats.2013

    • Author(s)
      Tamura A, Sasaki M, Yamashita H, Matsui-Yuasa I, Saku T, Hikima T, Tabuchi M, Munakata H, Kojima-Yuasa A
    • Journal Title

      J Funct Foods

      Volume: 5 Issue: 4 Pages: 1714-1723

    • DOI

      10.1016/j.jff.2013.07.017

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] AMPK synergizes with the combined treatment of 1'-acetoxychavicol acetate and sodium butyrate to upregulate phase II detoxifying enzyme activities.2013

    • Author(s)
      Yaku, K., Matsui-Yuasa, I., Konishi, Y. and Kojima-Yuasa, A.
    • Journal Title

      Molecular Nutrition & Food Research

      Volume: 57 Issue: 7 Pages: 1198-208

    • DOI

      10.1002/mnfr.201200809

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of mango seed kernel extract on the adipogenesis in 3T3-L1 adipocytes and in rats fed a high fat diet2013

    • Author(s)
      Kobayashi, M., Matsui-Yuasa, I., Fukuda-Shimizu, M., Mandai, Y., Tabuchi, M., Munakata, H. and Kojima-Yuasa, A.
    • Journal Title

      Health

      Volume: 5 Pages: 9-15

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Yerba-mate (Ilex paraguariensis) extract prevents ethanol-induced liver injury in rats2013

    • Author(s)
      Tamura A, Tabuchi M,(他7名)
    • Journal Title

      J Funct Foods

      Volume: 5(4) Issue: 7 Pages: 1714-1723

    • DOI

      10.1016/j.bbagen.2012.02.008

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The enhancement of phase 2 enzyme activities by sodium butyrate in normal intestinal epithelial cells is associated with Nrf2 land p532012

    • Author(s)
      Yaku, K., Enami, Y., Kurajyo, C., Matsui-Yuasa, I., Konishi, Y. and Kojima-Yuasa, A.
    • Journal Title

      Molecular and Cellular Biochemisty

      Volume: 370 Issue: 1-2 Pages: 7-14

    • DOI

      10.1007/s11010-012-1392-x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of 1,5-anhydro-D-fructose on the inhibition of adipogenesis in 3T3-L1 adipocytes2012

    • Author(s)
      Kojima-Yuasa, A., Deguchi, Y., Konishi, Y. and Matsui-Yuasa, I.
    • Journal Title

      Natural Product Communications

      Volume: 7 Pages: 1501-1506

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 1'-acetoxychavicol acetate inhibits adipogenesis in 3T3-L1 adipocytes and in high fat-fed rats.2012

    • Author(s)
      Ohnishi R, et al.
    • Journal Title

      Am J Chin Med

      Volume: 40 Issue: 06 Pages: 1189-1204

    • DOI

      10.1142/s0192415x12500887

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] γ-グルタミルトランスペプチダーゼ (GGT)阻害剤によるコラーゲンおよびエラスチン産生能の亢進効果とそのメカニズム2012

    • Author(s)
      湯浅(小島)明子,林 綸子,韓 立友,渡辺文太,平竹 潤,湯浅 勲
    • Journal Title

      日本香粧品学会誌

      Volume: 36 Pages: 93-100

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 甘苦茶抽出物のアルコール性肝細胞傷害に対する予防効果について2014

    • Author(s)
      長江英世,黄 雪丹,白畑辰弥,小林義典,湯浅 勲,湯浅(小島)明子
    • Organizer
      第68回日本栄養・食糧学会大会
    • Place of Presentation
      酪農学園大学、札幌、北海道
    • Year and Date
      2014-05-30 – 2014-06-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 1’-Acetoxychavicol acetateによるプロテアソーム活性の亢進作用メカニズムについて2014

    • Author(s)
      山本富矢,夜久圭介,山下美咲,湯浅(小島)明子,湯浅 勲
    • Organizer
      第68回日本栄養・食糧学会大会
    • Place of Presentation
      酪農学園大学、札幌、北海道
    • Year and Date
      2014-05-30 – 2014-06-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 甘苦茶抽出物による抗肥満効果について2014

    • Author(s)
      細川裕介,黄 雪丹,白畑辰弥,小林義典,湯浅 勲,湯浅(小島)明子
    • Organizer
      第68回日本栄養・食糧学会大会
    • Place of Presentation
      酪農学園大学、札幌、北海道
    • Year and Date
      2014-05-30 – 2014-06-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 玉造黒門越瓜による皮膚の美容と創傷治癒に対する促進効果2014

    • Author(s)
      小島明子
    • Organizer
      大阪市東成区花と緑の町づくり推進委員会主催講演会
    • Place of Presentation
      大阪市東成区民センター、大阪市
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Protective effect of Yerba-Mate (Ilex paraguariensis) extract against ethanol-induced liver injury in rats2014

    • Author(s)
      Kojima-Yuasa, A., Tamura, A., Saku, T., Hikima, T. and Matsui-Yuasa, I..
    • Organizer
      VI South American Congress of Mate and II International Symposium of Yerba Mate and Health
    • Place of Presentation
      Montevideo, Uruguay
    • Year and Date
      2014-05-08 – 2014-05-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The synergistic effect of 1’-acetoxychavicol acetate and sodium butyrate on the death of human hepatocellular carcinoma cells2014

    • Author(s)
      Matsui-Yuasa, I., Kato, R., Azuma, H. and Kojima-Yuasa, A.
    • Organizer
      Experimental Biology 2014
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-04-26 – 2014-04-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 1’-Acetoxychavicol acetate inhibits adipogenesis in 3T3-L1 adipocytes and in high fat-fed rats2014

    • Author(s)
      Kojima-Yuasa, A., Ohnishi, R., Deguchi, Y., Yaku, K., Tabuchi, M., Munakata, H. and Matsui-Yuasa, I.
    • Organizer
      Experimental Biology 2014
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-04-26 – 2014-04-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Yerba-Mate (Ilex paraguariensis) extract prevents the liver against ethanol-induced liver injury in rats.2013

    • Author(s)
      Kojima-Yuasa, A., Tamura, A., Sasaki, M., Yamashita, H., Saku, T., Hikima, T., Tabuchi, M., Munakata, H. and Matsui-Yuasa, I.
    • Organizer
      Experimental Biology 2013
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Protective effect of Ecklonia cava polyphenol against ethanol-induced liver injury in rat hepatocytes2013

    • Author(s)
      Yamashita, H., Tamura, A., Sasaki, M., Matsui-Yuasa, I., Terada, M. and Kojima-Yuasa, A.
    • Organizer
      Experimental Biology 2013
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Neuroprotective effect of 1’-acetoxychavicol acetate against amyloid β-induced toxicity is related with upregulation of proteasome activity2013

    • Author(s)
      Yaku, K., Matsui-Yuasa, I. and Kojima-Yuasa, A.
    • Organizer
      Experimental Biology 2013
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] The synergistic effect of 1′-acetoxychavicol acetate and sodium butyrate on cell death of human hepatocellular carcinoma cells2013

    • Author(s)
      Kato, R., Matsui-Yuasa, I. Azuma, H. and Kojima-Yuasa, A.
    • Organizer
      Experimental Biology 2013
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Extract of a Japanese pickling melon prevents ethanol-induced liver injury in rats2013

    • Author(s)
      Kojima-Yuasa, A., Hirauchi, E., Tamura, A. and Matsui-Yuasa, I.
    • Organizer
      IUNS 20th International Congress of nutrition
    • Place of Presentation
      Granada, Spain
    • Related Report
      2013 Research-status Report
  • [Presentation] Ecklonia cava抽出物によるアルコール性肝細胞傷害の予防効果について2013

    • Author(s)
      山下治香,湯浅 勲,寺田正樹,湯浅(小島)明子
    • Organizer
      第67回日本栄養・食糧学会大会講演要旨集
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Research-status Report
  • [Presentation] Ecklonia cava polyphenol prevents ethanol-induced liver injury in rats.2012

    • Author(s)
      Kojima-Yuasa, A., Takahashi, M., Satake, N., Yamashita, H., Tamura, A., Yaku, K., Tabuchi, M., Akahoshi, Y., Terada, M. and Matsui-Yuasa, I.
    • Organizer
      Experimental Biology 2012
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Involvement of AMPK on the synergistic upregulation of phase II detoxifying enzyme activities by 1’-acetoxychavicol acetate and sodium butyrate2012

    • Author(s)
      Yaku, K., Matsui-Yuasa, I., Azuma, H. and Kojima-Yuasa, A.
    • Organizer
      Experimental Biology 2012
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Sesaminolによるアルコール性肝疾患の予防効果について2012

    • Author(s)
      佐々木美緒,湯浅 勲,大村文乃,清本邦夫,湯浅(小島)明子
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Research-status Report
  • [Presentation] マテ茶によるアルコール性肝疾患の予防効果について2012

    • Author(s)
      田村彰子,湯浅 勲,佐久太郎,引間忠正,田渕正樹,赤星保光,湯浅(小島)明子
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Research-status Report
  • [Presentation] 1’-acetoxychavicol acetateと酪酸によるphase II酵素活性の相乗的な誘導におけるAMPKの関与2012

    • Author(s)
      夜久圭介,湯浅 勲,湯浅(小島)明子
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Research-status Report
  • [Book] 女性の疾患と美容のための機能性素材の開発2014

    • Author(s)
      湯浅(小島)明子
    • Total Pages
      10
    • Publisher
      シーエムシー出版
    • Related Report
      2014 Annual Research Report
  • [Book] Tea in Health and Disease Prevention2012

    • Author(s)
      Matsui-Yuasa, I. and Kojima-Yuasa, A
    • Total Pages
      1554
    • Publisher
      Elsevier, Oxford, UK
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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