Elucidation of lifestyle-related disease prevention effect of local vegetables and its application to the activation of local industry

• Project/Area Number: 24500987
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Osaka City University
• Principal Investigator: KOJIMA-YUASA Akiko 大阪市立大学, 大学院生活科学研究科, 准教授 (90295709)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 健康と食生活 / 生活習慣病 / 食品成分 / アルコール性肝疾患 / 肥満 / 創傷治癒 / なにわ伝統野菜 / 栄養学 / 食品 / 地域連携 / 脂肪細胞 / 肝細胞

Outline of Final Research Achievements

To clarify the scientific knowledge about the preventive effect of lifestyle-related diseases by local traditional vegetables in Osaka, Japan, we examined the effect of an extract of Tamatsukurikuromon-shirouri (TS), a Japanese pickling melon (Cucumis Melo var. Conomon), on ethanol-induced liver injury, obesity and skin wound healing. As a result, the extract of TS had an ability of prevent of ethanol-induced liver injury and obesity. The extract of TS had also the promotive activity of skin wound healing. However, the extract of Shirouri, a popular pickled melon had no effect.

Research Products

• [Journal Article] The synergistic effect of 1’-acetoxychavicol acetate and sodium butyrate on the death of human hepatocellular carcinoma cells (2014)
  • Author(s): Kato, R., Matsui-Yuasa, I., Azuma, H. and Kojima-Yuasa, A.
  • Journal Title: Chemico-Biological Interactions Volume: 212 Pages: 1-10
  • DOI: 10.1016/j.cbi.2014.01.010
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Yerba-mate (Ilex paraguariensis) extract prevents ethanol-induced liver injury in rats. (2013)
  • Author(s): Tamura A, Sasaki M, Yamashita H, Matsui-Yuasa I, Saku T, Hikima T, Tabuchi M, Munakata H, Kojima-Yuasa A
  • Journal Title: J Funct Foods Volume: 5 Issue: 4 Pages: 1714-1723
  • DOI: 10.1016/j.jff.2013.07.017
  • Peer Reviewed
• [Journal Article] AMPK synergizes with the combined treatment of 1'-acetoxychavicol acetate and sodium butyrate to upregulate phase II detoxifying enzyme activities. (2013)
  • Author(s): Yaku, K., Matsui-Yuasa, I., Konishi, Y. and Kojima-Yuasa, A.
  • Journal Title: Molecular Nutrition & Food Research Volume: 57 Issue: 7 Pages: 1198-208
  • DOI: 10.1002/mnfr.201200809
  • Peer Reviewed
• [Journal Article] Effect of mango seed kernel extract on the adipogenesis in 3T3-L1 adipocytes and in rats fed a high fat diet (2013)
  • Author(s): Kobayashi, M., Matsui-Yuasa, I., Fukuda-Shimizu, M., Mandai, Y., Tabuchi, M., Munakata, H. and Kojima-Yuasa, A.
  • Journal Title: Health Volume: 5 Pages: 9-15
  • Peer Reviewed
• [Journal Article] Yerba-mate (Ilex paraguariensis) extract prevents ethanol-induced liver injury in rats (2013)
  • Author(s): Tamura A, Tabuchi M,(他7名)
  • Journal Title: J Funct Foods Volume: 5(4) Issue: 7 Pages: 1714-1723
  • DOI: 10.1016/j.bbagen.2012.02.008
  • Peer Reviewed
• [Journal Article] The enhancement of phase 2 enzyme activities by sodium butyrate in normal intestinal epithelial cells is associated with Nrf2 land p53 (2012)
  • Author(s): Yaku, K., Enami, Y., Kurajyo, C., Matsui-Yuasa, I., Konishi, Y. and Kojima-Yuasa, A.
  • Journal Title: Molecular and Cellular Biochemisty Volume: 370 Issue: 1-2 Pages: 7-14
  • DOI: 10.1007/s11010-012-1392-x
  • Peer Reviewed
• [Journal Article] Effect of 1,5-anhydro-D-fructose on the inhibition of adipogenesis in 3T3-L1 adipocytes (2012)
  • Author(s): Kojima-Yuasa, A., Deguchi, Y., Konishi, Y. and Matsui-Yuasa, I.
  • Journal Title: Natural Product Communications Volume: 7 Pages: 1501-1506
  • Peer Reviewed
• [Journal Article] 1'-acetoxychavicol acetate inhibits adipogenesis in 3T3-L1 adipocytes and in high fat-fed rats. (2012)
  • Author(s): Ohnishi R, et al.
  • Journal Title: Am J Chin Med Volume: 40 Issue: 06 Pages: 1189-1204
  • DOI: 10.1142/s0192415x12500887
  • Peer Reviewed
• [Journal Article] γ-グルタミルトランスペプチダーゼ (GGT)阻害剤によるコラーゲンおよびエラスチン産生能の亢進効果とそのメカニズム (2012)
  • Author(s): 湯浅（小島）明子，林 綸子，韓 立友，渡辺文太，平竹 潤，湯浅 勲
  • Journal Title: 日本香粧品学会誌 Volume: 36 Pages: 93-100
  • Peer Reviewed
• [Presentation] 甘苦茶抽出物のアルコール性肝細胞傷害に対する予防効果について (2014)
  • Author(s): 長江英世，黄 雪丹，白畑辰弥，小林義典，湯浅 勲，湯浅（小島）明子
  • Organizer: 第68回日本栄養・食糧学会大会
  • Place of Presentation: 酪農学園大学、札幌、北海道
  • Year and Date: 2014-05-30 – 2014-06-01
• [Presentation] 1’-Acetoxychavicol acetateによるプロテアソーム活性の亢進作用メカニズムについて (2014)
  • Author(s): 山本富矢，夜久圭介，山下美咲，湯浅（小島）明子，湯浅 勲
  • Organizer: 第68回日本栄養・食糧学会大会
  • Place of Presentation: 酪農学園大学、札幌、北海道
  • Year and Date: 2014-05-30 – 2014-06-01
• [Presentation] 甘苦茶抽出物による抗肥満効果について (2014)
  • Author(s): 細川裕介，黄 雪丹，白畑辰弥，小林義典，湯浅 勲，湯浅（小島）明子
  • Organizer: 第68回日本栄養・食糧学会大会
  • Place of Presentation: 酪農学園大学、札幌、北海道
  • Year and Date: 2014-05-30 – 2014-06-01
• [Presentation] 玉造黒門越瓜による皮膚の美容と創傷治癒に対する促進効果 (2014)
  • Author(s): 小島明子
  • Organizer: 大阪市東成区花と緑の町づくり推進委員会主催講演会
  • Place of Presentation: 大阪市東成区民センター、大阪市
  • Year and Date: 2014-05-24
  • Invited
• [Presentation] Protective effect of Yerba-Mate (Ilex paraguariensis) extract against ethanol-induced liver injury in rats (2014)
  • Author(s): Kojima-Yuasa, A., Tamura, A., Saku, T., Hikima, T. and Matsui-Yuasa, I..
  • Organizer: VI South American Congress of Mate and II International Symposium of Yerba Mate and Health
  • Place of Presentation: Montevideo, Uruguay
  • Year and Date: 2014-05-08 – 2014-05-10
  • Invited
• [Presentation] The synergistic effect of 1’-acetoxychavicol acetate and sodium butyrate on the death of human hepatocellular carcinoma cells (2014)
  • Author(s): Matsui-Yuasa, I., Kato, R., Azuma, H. and Kojima-Yuasa, A.
  • Organizer: Experimental Biology 2014
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-04-26 – 2014-04-30
• [Presentation] 1’-Acetoxychavicol acetate inhibits adipogenesis in 3T3-L1 adipocytes and in high fat-fed rats (2014)
  • Author(s): Kojima-Yuasa, A., Ohnishi, R., Deguchi, Y., Yaku, K., Tabuchi, M., Munakata, H. and Matsui-Yuasa, I.
  • Organizer: Experimental Biology 2014
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-04-26 – 2014-04-30
• [Presentation] Yerba-Mate (Ilex paraguariensis) extract prevents the liver against ethanol-induced liver injury in rats. (2013)
  • Author(s): Kojima-Yuasa, A., Tamura, A., Sasaki, M., Yamashita, H., Saku, T., Hikima, T., Tabuchi, M., Munakata, H. and Matsui-Yuasa, I.
  • Organizer: Experimental Biology 2013
  • Place of Presentation: Boston, USA
• [Presentation] Protective effect of Ecklonia cava polyphenol against ethanol-induced liver injury in rat hepatocytes (2013)
  • Author(s): Yamashita, H., Tamura, A., Sasaki, M., Matsui-Yuasa, I., Terada, M. and Kojima-Yuasa, A.
  • Organizer: Experimental Biology 2013
  • Place of Presentation: Boston, USA
• [Presentation] Neuroprotective effect of 1’-acetoxychavicol acetate against amyloid β-induced toxicity is related with upregulation of proteasome activity (2013)
  • Author(s): Yaku, K., Matsui-Yuasa, I. and Kojima-Yuasa, A.
  • Organizer: Experimental Biology 2013
  • Place of Presentation: Boston, USA
• [Presentation] The synergistic effect of 1′-acetoxychavicol acetate and sodium butyrate on cell death of human hepatocellular carcinoma cells (2013)
  • Author(s): Kato, R., Matsui-Yuasa, I. Azuma, H. and Kojima-Yuasa, A.
  • Organizer: Experimental Biology 2013
  • Place of Presentation: Boston, USA
• [Presentation] Extract of a Japanese pickling melon prevents ethanol-induced liver injury in rats (2013)
  • Author(s): Kojima-Yuasa, A., Hirauchi, E., Tamura, A. and Matsui-Yuasa, I.
  • Organizer: IUNS 20th International Congress of nutrition
  • Place of Presentation: Granada, Spain
• [Presentation] Ecklonia cava抽出物によるアルコール性肝細胞傷害の予防効果について (2013)
  • Author(s): 山下治香，湯浅 勲，寺田正樹，湯浅（小島）明子
  • Organizer: 第67回日本栄養・食糧学会大会講演要旨集
  • Place of Presentation: 名古屋大学
• [Presentation] Ecklonia cava polyphenol prevents ethanol-induced liver injury in rats. (2012)
  • Author(s): Kojima-Yuasa, A., Takahashi, M., Satake, N., Yamashita, H., Tamura, A., Yaku, K., Tabuchi, M., Akahoshi, Y., Terada, M. and Matsui-Yuasa, I.
  • Organizer: Experimental Biology 2012
  • Place of Presentation: San Diego, USA
• [Presentation] Involvement of AMPK on the synergistic upregulation of phase II detoxifying enzyme activities by 1’-acetoxychavicol acetate and sodium butyrate (2012)
  • Author(s): Yaku, K., Matsui-Yuasa, I., Azuma, H. and Kojima-Yuasa, A.
  • Organizer: Experimental Biology 2012
  • Place of Presentation: San Diego, USA
• [Presentation] Sesaminolによるアルコール性肝疾患の予防効果について (2012)
  • Author(s): 佐々木美緒，湯浅 勲，大村文乃，清本邦夫，湯浅（小島）明子
  • Organizer: 第66回日本栄養・食糧学会大会
  • Place of Presentation: 東北大学
• [Presentation] マテ茶によるアルコール性肝疾患の予防効果について (2012)
  • Author(s): 田村彰子，湯浅 勲，佐久太郎，引間忠正，田渕正樹，赤星保光，湯浅（小島）明子
  • Organizer: 第66回日本栄養・食糧学会大会
  • Place of Presentation: 東北大学
• [Presentation] 1’-acetoxychavicol acetateと酪酸によるphase II酵素活性の相乗的な誘導におけるAMPKの関与 (2012)
  • Author(s): 夜久圭介，湯浅 勲，湯浅（小島）明子
  • Organizer: 第66回日本栄養・食糧学会大会
  • Place of Presentation: 東北大学
• [Book] 女性の疾患と美容のための機能性素材の開発 (2014)
  • Author(s): 湯浅（小島）明子
  • Total Pages: 10
  • Publisher: シーエムシー出版
• [Book] Tea in Health and Disease Prevention (2012)
  • Author(s): Matsui-Yuasa, I. and Kojima-Yuasa, A
  • Total Pages: 1554
  • Publisher: Elsevier, Oxford, UK