A combination therapy with hyperthermia and immunotherapy using dextran magnetic nanoparticle for esophageal cancer

• Project/Area Number: 24501328
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor immunology
• Research Institution: Chiba University
• Principal Investigator: AKUTSU Yasunori 千葉大学, 医学(系)研究科(研究院), 講師 (00375677)
• Co-Investigator(Kenkyū-buntansha): TAMURA Yutaka 千葉大学, 大学院医学研究院, 准教授 (50263174)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 免疫療法 / 温熱療法 / 樹状細胞 / ヒートショックプロテイン / 食道癌 / 扁平上皮癌 / 細胞療法 / ナノテクノロジー

Outline of Final Research Achievements

(1)We developed a combination therapy with hyperthermia and direct intratumoral administration of dendritic cells. When compared with dendriti cell therapy alone, a combination therapy showed strong antitumor effect. Furtheremore, we elucidated the molecular mechanism. The expression of heat shock protein was enhanced by hyperthermia.(2)We also developed ICG-Liposome as an enhancer of PDT. ICG-Liposome was accumulated in the tumor by EPR effect. By near infrared, tumor specific heating was possible.

Research Products

• [Journal Article] Treatment of near-infrared photodynamic therapy using a liposomally formulated indocyanine green derivative for squamous cell carcinoma (2015)
  • Author(s): Maruyama T, Akutsu Y, Suganami A, Tamura Y, Fujito H, Ouchi T, Akanuma N, Isozaki Y, Takeshita N, Hoshino I, Uesato M, Toyota T, Hayashi H, Matsubara H
  • Journal Title: PLoS One Volume: 10 Issue: 4 Pages: e0122849-e0122849
  • DOI: 10.1371/journal.pone.0122849
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A COX-2 inhibitor enhances the antitumor effects of chemotherapy and radiotherapy for esophageal squamous cell carcinoma. (2014)
  • Author(s): Yusup G, Akutsu Y. et al
  • Journal Title: Int J Oncol Volume: 44 Issue: 4 Pages: 1146-52
  • DOI: 10.3892/ijo.2014.2300
  • Peer Reviewed
• [Journal Article] Modulated electro-hyperthermia enhances dendritic cell therapy through an abscopal effect in mice (2014)
  • Author(s): Qin W, Akutsu Y, Andocs G, Suganami A, Hu X, Yusup G, Komatsu-Akimoto A, Hoshino I, Hanari N, Mori M, Isozaki Y, Akanuma N, Tamura Y, Matsubara H
  • Journal Title: Oncol Rep Volume: 32 Issue: 6 Pages: 2373-9
  • DOI: 10.3892/or.2014.3500
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 新規温熱治療の基礎と臨床（招待講演） (2013)
  • Author(s): 阿久津泰典
  • Organizer: 日本ハイパーサーミア学会第30回大会
  • Place of Presentation: 横浜市
  • Invited
• [Presentation] ナノ粒子ICG-Liposomeと光線力学的による扁平上皮癌に対する温熱療法の開発 (2012)
  • Author(s): 丸山 哲郎, 阿久津 泰典, 星野 敢, 森 幹人, 羽成 直行, 藤戸 廣迪, 菅波 晃子, 田村 裕, 林 秀樹, 松原 久裕
  • Organizer: 第66回日本食道学会総会
  • Place of Presentation: 軽井沢市
• [Presentation] A novel Dendritic Cell Therapy with Oncothermia Therapy mediated by abscopal effect (2012)
  • Author(s): Wei Qin, Yasunori Akutsu, Yutaka Tamura, Gabor Andocs, Gulbostan Yusup, Xin Hu, Hisahiro Matsubara
  • Organizer: Conference of the International Clinical Hyperthermia Society,2012
  • Place of Presentation: ハンガリー・ブタペスト市