| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
In this study, to examine the relation between the two different radiopharmaceuticals targeting cancermetabolosm, we compared tumor accumulation and intratumoral distribution of FDG, FLT, acetate and glutamine, administering two radiotracers with different half-lives in combination, [18F]FLT and [14C]FDG for example, into tumor bearing mice. In the double tracer biodistribution study, positive correlation was only observed between FDG and glutamine, and FLT and acetate. The intratumoral distributions of the two tracers in the above two combinations showed similarity, but in the other combinations the two tracers often showed different pattern. From our observation, accumulation and intratumoral distribution of the four PET pharmaceuticals or tracers, FDG, FLT, acetate and glutamine, could be different, although they are all supposed to reflect tumor cell proliferation. Some caution may be necessary when we are interpreting their tumor accumulation.
|
