Expression analysis of circadian genes in mouse liver exposed to ionizing radiation

• Project/Area Number: 24510062
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Tohoku University
• Principal Investigator: Uehara Yoshihiko 東北大学, 医学(系)研究科(研究院), 助教 (30223499)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 概日リズム / 遺伝子発現 / 放射線

Outline of Final Research Achievements

Although it is reported that radiation exposure induces the phase shift of circadian rhythm, the mechanism responsible for it is not understood. In this research, we found several circadian genes in which the phase of expression was shifted in the mouse liver using microarray analysis. However, we could not find any essential genes that plays in phase shifting of expression by irradiation in the mouse liver.

Research Products

• [Journal Article] Inhibition of β-catenin and STAT3 with curcumin analog suppresses gastric carcinogenesis in vivo : a novel candidate for gastric cancer treatment (2015)
  • Author(s): Uehara, Y., Inoue, M., Fukuda, K., Yamakoshi, H., Hosoi, Y., Kanda, H., Oshima, M., Iwabuchi, Y., Shibata, H.
  • Journal Title: Gastric Cancer Volume: 18 Issue: 4 Pages: 774-783
  • DOI: 10.1007/s10120-014-0434-3
  • Description: in press
  • Peer Reviewed / Open Access
• [Presentation] Synergistic effects of nonsteroidal anti-inflammatory drugs (NSAIDs) and ionizing radiation on ICAM-1 expression in HUVECs. (2015)
  • Author(s): Uehara, Y., Murata, Y., Hosoi, Y.
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto International Conference Center (Kyoto)
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] 非ステロイド性抗炎症薬（NSAIDs）は放射線と相乗的に作用してヒト血管内皮細胞におけるICAM-1の発現を亢進させる (2014)
  • Author(s): 上原芳彦、村田泰彦、細井義夫
  • Organizer: 日本放射線影響学会第57回大会
  • Place of Presentation: かごしま県民交流センター（鹿児島）
  • Year and Date: 2014-10-01 – 2014-10-03
• [Presentation] 低線量率長期照射によるマウス肝臓での遺伝子発現変化の経時的解析 (2013)
  • Author(s): 上原芳彦、王冰、中島徹夫、根井充、中村慎吾、田中聡、一戸一晃、田中公夫、松本恒弥、小木曽洋一、小野哲也、細井義夫
  • Organizer: 第51回日本放射線腫瘍学会生物部会学術大会
  • Place of Presentation: 東北大学艮陵会館
• [Presentation] Kinetic analysis of gene expression profiles in mouse liver after long-term low-dose-rate irradiation (2012)
  • Author(s): 上原芳彦、王冰、中島徹夫、根井充、小野哲也
  • Organizer: 日本放射線影響学会第55回大会
  • Place of Presentation: 仙台
  • Invited