Expression analysis of circadian genes in mouse liver exposed to ionizing radiation
| Project/Area Number |
24510062
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tohoku University |
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Principal Investigator |
Uehara Yoshihiko 東北大学, 医学(系)研究科(研究院), 助教 (30223499)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 概日リズム / 遺伝子発現 / 放射線 |
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| Outline of Final Research Achievements |
Although it is reported that radiation exposure induces the phase shift of circadian rhythm, the mechanism responsible for it is not understood. In this research, we found several circadian genes in which the phase of expression was shifted in the mouse liver using microarray analysis. However, we could not find any essential genes that plays in phase shifting of expression by irradiation in the mouse liver.
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Report
(5 results)
Research Products
(5 results)
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[Journal Article] Inhibition of β-catenin and STAT3 with curcumin analog suppresses gastric carcinogenesis in vivo : a novel candidate for gastric cancer treatment2015
Author(s)
Uehara, Y., Inoue, M., Fukuda, K., Yamakoshi, H., Hosoi, Y., Kanda, H., Oshima, M., Iwabuchi, Y., Shibata, H.
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Journal Title
Gastric Cancer
Volume: 18
Issue: 4
Pages: 774-783
DOI
Description
in press
Related Report
Peer Reviewed / Open Access
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