Endocrine back ground on flutamide-induced hypospadias in rats
Project/Area Number |
24510082
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Risk sciences of radiation/Chemicals
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Research Institution | Tottori University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
IGUCHI Taisen 大学共同利用機関法人自然科学研究機構, 岡崎統合バイオサイエンスセンター, 教授 (90128588)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 尿道下裂 / 内分泌かく乱 / アンチアンドロゲン / フルタミド / 生殖器異常 / ラット |
Outline of Final Research Achievements |
Morphogenesis and endocrine back ground on flutamide-induced hypospadias were examined in male rats. Measurement of a major component of phallus revealed that males given flutamide mimicked a female type during fetal development, and showed no sign of hyposperdias on the day of birth. Hypospadias was evident after 40 days of age. These abnormal developments were elicited in neonates, indicating that flutamide exposure in utero induces malformation of male type reproductive tract in adition to hypospadias in later ages. When the flutamide-treated rats were castrated on 10 days, hypospadias was no longer evident in adulthood, bearing female type of the genitalia. Those given testosterone after the castration exhibited hyposphadias. Serum level of testosterone was not different between the fluatamide-treated and control males. The present study reveals that androgen titer from testes after puberty play an important role on induction of hypospadias in male rats given flutamide in utero.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Differing species responsiveness of estrogenic contaminants in fish is conferred by the ligand binding domain of the estrogen receptor2014
Author(s)
Miyagawa, S., Lange, A., Hirakawa, I., Tohyama, S., Ogino, Y., Mizutani, T., Kagami, Y., Kusano, T., Ihara, M., Tanaka, H., Tatarazako, N., Ohta, Y., Katsu, Y., Tyler, C.R. and Iguchi, T.
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Journal Title
Environ. Sci. Technol.
Volume: 未定
Issue: 9
Pages: 5254-5263
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Sugar expression in the mucosae of the canine uterus and vagina during the oestrous cycle and with pyometa2013
Author(s)
Yasunga, Y., Takeuchi, t., Shimokawa, T., Asano,A., Nabeta, M.and Ohta,Y.
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Journal Title
Vet. J.
Volume: 196
Issue: 1
Pages: 116-118
DOI
Related Report
Peer Reviewed
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[Journal Article] Establishment of transactivation assay systems using fish, amphibian, reptilian and human thyroid hormone receptors2013
Author(s)
Oka, T., Mitsui-Watanabe, N., Tatarazako, N., Onishi, Y., Katsu, Y., Miyagawa, S., Ogino, Y., Yatsu, R., Kohno, S., Takase, M., Kawashima, Y., Aoki, Y., Guillette, L.J.Jr. and Iguchi, T.
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Journal Title
J. Appl. Toxicol
Volume: 33
Issue: 9
Pages: 991-1000
DOI
Related Report
Peer Reviewed
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